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Article ; Online: Dietary Habits and Oral Hygiene as Determinants of the Incidence and Intensity of Dental Caries-A Pilot Study.

Mazurkiewicz, Dominika / Pustułka, Malwina / Ambrozik-Haba, Jagoda / Bienkiewicz, Maciej

2023 Volume 15, Issue 22

Abstract: Objectives: The aim of this study was to assess the influence of dietary and hygiene habits on the prevalence and intensity of dental caries. A group of 148 adults participated in the study.: Methods: A self-administered nutrition and oral hygiene ... ...

Abstract	Objectives: The aim of this study was to assess the influence of dietary and hygiene habits on the prevalence and intensity of dental caries. A group of 148 adults participated in the study. Methods: A self-administered nutrition and oral hygiene questionnaire was used to assess dietary habits and oral hygiene routine. A preventive diet index (PDI), a cariogenic diet index (CDI), and an oral health hygiene and prevention index (OHHPI) were created based on part of the questions. The intensity of dental caries among the respondents was investigated by the decayed, missing, and filled teeth index (DMFT), which was estimated on the basis of data obtained during the dental examination. Results: The study showed that 97% of the respondents had filled carious cavities, while untreated carious cavities were observed in up to 78% of the study participants. The respondents had an average consumption of preventive products and a low consumption of caries-stimulating foods. The preventive dietary index (PDI) value was higher in the female group than in the male group. A more frequent consumption of caries-inhibiting products was demonstrated by those declaring that they took various types of dietary supplements. The use of health-promoting sugar substitutes by the respondents was associated with a lower intensity of dental caries and a more frequent consumption of preventive products. Conclusions: The analysis of the survey results indicates the need to implement educational activities aimed at increasing public awareness of the prevalence of dental caries among adults.
MeSH term(s)	Humans ; Male ; Female ; Oral Hygiene ; Pilot Projects ; Incidence ; Dental Caries/epidemiology ; Dental Caries/prevention & control ; Feeding Behavior ; Prevalence
Language	English
Publishing date	2023-11-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15224833
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Article ; Online: The Impact of the COVID-19 Pandemic on Poles' Nutritional and Health Behaviour and Quality of Life-A Pilot Study.

Raczkowska, Ewa / Mazurkiewicz, Dominika / Ambrozik-Haba, Jagoda / Godyla-Jabłoński, Michaela

International journal of environmental research and public health

2021 Volume 18, Issue 20

Abstract: The coronavirus (COVID-19) pandemic, which has lasted for over a year, has affected everyone's lives. It is interesting to examine how populations cope with the new situation and to learn about the impact of the epidemic on quality of life. The aim of ... ...

Abstract	The coronavirus (COVID-19) pandemic, which has lasted for over a year, has affected everyone's lives. It is interesting to examine how populations cope with the new situation and to learn about the impact of the epidemic on quality of life. The aim of this study was to assess the impact of the COVID-19 pandemic on changes in selected elements of lifestyle compared to the pre-pandemic period among adult Polish residents. The impact of the COVID-19 pandemic on selected features of quality of life was examined. It was found that, for some distinguishing factors (i.e., quality of life, health status and sleep quality), there were no statistically significant differences. Other distinguishing factors (i.e., ability to perform daily living activities, ability to work and personal relationships) were statistically different. Another part of the study was to assess changes in the frequency of consumption of specific food groups. The vast majority of respondents declared no changes in the frequency of consumption of selected food products. The majority of respondents declared that the COVID-19 pandemic did not cause a change in the frequency of drug use (i.e., cigarettes, alcohol and coffee).
MeSH term(s)	Adult ; COVID-19 ; Health Behavior ; Humans ; Pandemics ; Pilot Projects ; Quality of Life ; SARS-CoV-2
Language	English
Publishing date	2021-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph182010656
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Article: Splenic sarcoidosis: a case report and review of the imaging findings of multiple incidental splenic lesions as the initial presentation of sarcoidosis.

Raber, Earl L / Haba, J / Beck, Paul

Canadian journal of gastroenterology = Journal canadien de gastroenterologie

2011 Volume 25, Issue 9, Page(s) 477–478

Abstract: MRI is helpful in characterizing splenic lesions, but there can be significant variability and overlap in the appearance of both benign and malignant splenic lesions; thus, a confident diagnosis can be presentation and classic imaging appearance , and ... ...

Abstract	MRI is helpful in characterizing splenic lesions, but there can be significant variability and overlap in the appearance of both benign and malignant splenic lesions; thus, a confident diagnosis can be presentation and classic imaging appearance , and further assessment for any other associated findings suggestive of systemic sarcoidosis is critical to avoid missed or delayed diagnosis-specifically, to avoid over-diagnosis of malignant disease because multiple splenic lesions can be the initial presentation of sarcoidosis.
MeSH term(s)	Adult ; Female ; Humans ; Magnetic Resonance Imaging ; Sarcoidosis/diagnostic imaging ; Sarcoidosis, Pulmonary/diagnostic imaging ; Splenic Diseases/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2011-09-07
Publishing country	Canada
Document type	Case Reports ; Journal Article
ZDB-ID	639439-5
ISSN	1916-7237 ; 0835-7900
ISSN (online)	1916-7237
ISSN	0835-7900
DOI	10.1155/2011/748920
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Article ; Online: Electronic health records and patient registries in medical oncology departments in Spain.

Ribelles, N / Alvarez-Lopez, I / Arcusa, A / Chacon, J I / de la Haba, J / García-Corbacho, J / Garcia-Mata, J / Jara, C / Jerez, J M / Lázaro-Quintela, M / Leon-Mateos, L / Ramirez-Merino, N / Tibau, A / Garcia-Palomo, A

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2021 Volume 23, Issue 10, Page(s) 2099–2108

Abstract: Purpose: We aimed to evaluate the current situation of electronic health records (EHRs) and patient registries in the oncology departments of hospitals in Spain.: Methods: This was a cross-sectional study conducted from December 2018 to September ... ...

Abstract	Purpose: We aimed to evaluate the current situation of electronic health records (EHRs) and patient registries in the oncology departments of hospitals in Spain. Methods: This was a cross-sectional study conducted from December 2018 to September 2019. The survey was designed ad hoc by the Outcomes Evaluation and Clinical Practice Section of the Spanish Society of Medical Oncology (SEOM) and was distributed to all head of medical oncology department members of SEOM. Results: We invited 148 heads of oncology departments, and 81 (54.7%) questionnaires were completed, with representation from all 17 Spanish autonomous communities. Seventy-seven (95%) of the respondents had EHRs implemented at their hospitals; of them, over 80% considered EHRs to have a positive impact on work organization and clinical practice, and 73% considered that EHRs improve the quality of patient care. In contrast, 27 (35.1%) of these respondents felt that EHRs worsened the physician-patient relationship and conveyed an additional workload (n = 29; 37.6%). Several drawbacks in the implementation of EHRs were identified, including the limited inclusion of information on both outpatients and inpatients, information recorded in free text data fields, and the availability of specific informed consent. Forty-six (56.7%) respondents had patient registries where they recorded information from all patients seen in the department. Conclusion: Our study indicates that EHRs are almost universally implemented in the hospitals surveyed and are considered to have a positive impact on work organization and clinical practice. However, EHRs currently have several drawbacks that limit their use for investigational purposes. Clinical trial registration: Not applicable.
MeSH term(s)	Attitude of Health Personnel ; Cross-Sectional Studies ; Electronic Health Records/statistics & numerical data ; Electronic Prescribing/statistics & numerical data ; Humans ; Medical Oncology/statistics & numerical data ; Oncology Service, Hospital/statistics & numerical data ; Physician-Patient Relations ; Quality of Health Care ; Registries/statistics & numerical data ; Spain ; Surveys and Questionnaires/statistics & numerical data ; Workload
Language	English
Publishing date	2021-04-17
Publishing country	Italy
Document type	Journal Article ; Multicenter Study
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-021-02614-9
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Article ; Online: Utility of catheter extension devices in coronary artery anomalies.

Rumiz, Eva / Valero, Ernesto / Vilar, Juan Vicente / Almela, Pablo / Haba, Javier

Revista portuguesa de cardiologia

2018 Volume 37, Issue 8, Page(s) 723–724

MeSH term(s)	Aged ; Angioplasty, Balloon, Coronary/methods ; Cardiac Catheterization/instrumentation ; Coronary Stenosis/complications ; Coronary Stenosis/therapy ; Coronary Vessel Anomalies/complications ; Female ; Humans
Language	Portuguese
Publishing date	2018-06-18
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	2646972-8
ISSN	2174-2049 ; 2174-2049
ISSN (online)	2174-2049
ISSN	2174-2049
DOI	10.1016/j.repc.2017.04.011
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Article ; Online: Case of the month #181: Iatrogenic colon perforation during epicardial pacing wire placement.

Haba, Justin / Patel, Shamir / Gray, Robin

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes

2013 Volume 64, Issue 1, Page(s) 77–80

MeSH term(s)	Aged ; Colon/diagnostic imaging ; Colon/injuries ; Colon/surgery ; Diagnosis, Differential ; Humans ; Iatrogenic Disease ; Intestinal Perforation/diagnostic imaging ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery ; Male ; Pacemaker, Artificial/adverse effects ; Tomography, X-Ray Computed
Language	English
Publishing date	2013-02-25
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2068691-2
ISSN	1488-2361 ; 0846-5371
ISSN (online)	1488-2361
ISSN	0846-5371
DOI	10.1016/j.carj.2010.11.004
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Article ; Online: Infantile Aortic Coarctation in an Adult with Heart Failure.

Rumiz, Eva / Valero, Ernesto / Vilar, Juan Vicente / Santas, Enrique / Haba, Javier

Medical principles and practice : international journal of the Kuwait University, Health Science Centre

2017 Volume 26, Issue 2, Page(s) 185–188

Abstract: Objective: The aim of this case report is to highlight the importance of excluding aortic coarctation in a patient with a bicuspid aortic valve.: Clinical presentation and intervention: A 56-year-old woman with hypertension was admitted complaining ... ...

Abstract	Objective: The aim of this case report is to highlight the importance of excluding aortic coarctation in a patient with a bicuspid aortic valve. Clinical presentation and intervention: A 56-year-old woman with hypertension was admitted complaining of progressive dyspnea. Transthoracic echocardiography showed a calcified, bicuspid aortic valve with severe stenosis. Aortography revealed the presence of severe narrowing of the aorta between the carotid and subclavian arteries. The patient was referred for cardiovascular surgery in which successful aortic valve replacement and aortic correction were performed. Conclusion: This case report shows an uncommon finding of infantile aortic coarctation in an adult patient admitted with heart failure.
MeSH term(s)	Aortic Coarctation/diagnosis ; Aortic Coarctation/epidemiology ; Aortic Coarctation/surgery ; Aortography ; Diagnosis, Differential ; Dyspnea/epidemiology ; Echocardiography ; Female ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Humans ; Hypertension/epidemiology ; Middle Aged
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	645108-1
ISSN	1423-0151 ; 1011-7571
ISSN (online)	1423-0151
ISSN	1011-7571
DOI	10.1159/000452953
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Zs.A 2486: Show issues

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Article ; Online: A clinical calculator to predict disease outcomes in women with hormone receptor-positive advanced breast cancer treated with first-line endocrine therapy.

Polley, Mei-Yin C / Dickler, Maura N / Sinnwell, Jason / Tenner, Kathleen / de la Haba, Juan / Loibl, Sibylle / Goetz, Matthew P / Bergh, Jonas / Roberston, John / Couch, Fergus / Ellis, Matthew J / Martin, Miguel

Breast cancer research and treatment

2021 Volume 189, Issue 1, Page(s) 15–23

Abstract: Purpose: Endocrine therapy (ET) is an effective strategy to treat hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC) but nearly all patients eventually progress. Our goal was to develop ... ...

Abstract	Purpose: Endocrine therapy (ET) is an effective strategy to treat hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC) but nearly all patients eventually progress. Our goal was to develop and validate a web-based clinical calculator for predicting disease outcomes in women with HR+ABC who are candidates for receiving first-line single-agent ET. Methods: The meta-database comprises 891 patient-level data from the control arms of five contemporary clinical trials where patients received first-line single-agent ET (either aromatase inhibitor or fulvestrant) for ABC. Risk models were constructed for predicting 24-months progression-free survival (PFS-24) and 24-months overall survival (OS-24). Final models were internally validated for calibration and discrimination using ten-fold cross-validation. Results: Higher number of sites of metastases, measurable disease, younger age, lower body mass index, negative PR status, and prior endocrine therapy were associated with worse PFS. Final PFS and OS models were well-calibrated and associated with cross-validated time-dependent area under the curve (AUC) of 0.61 and 0.62, respectively. Conclusions: The proposed ABC calculator is internally valid and can accurately predict disease outcomes. It may be used to predict patient prognosis, aid planning of first-line treatment strategies, and facilitate risk stratification for future clinical trials in patients with HR+ABC. Future validation of the proposed models in independent patient cohorts is warranted.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols ; Breast Neoplasms/drug therapy ; Female ; Fulvestrant/therapeutic use ; Humans ; Receptor, ErbB-2 ; Receptors, Estrogen
Chemical Substances	Receptors, Estrogen ; Fulvestrant (22X328QOC4) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2021-07-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-021-06319-z
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Zs.A 1655: Show issues

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Article ; Online: Role of germline variants in the metastasis of breast carcinomas.

Santonja, Ángela / Moya-García, Aurelio A / Ribelles, Nuria / Jiménez-Rodríguez, Begoña / Pajares, Bella / Fernández-De Sousa, Cristina E / Pérez-Ruiz, Elísabeth / Del Monte-Millán, María / Ruiz-Borrego, Manuel / de la Haba, Juan / Sánchez-Rovira, Pedro / Romero, Atocha / González-Neira, Anna / Lluch, Ana / Alba, Emilio

Oncotarget

2022 Volume 13, Page(s) 843–862

Abstract: Most cancer-related deaths in breast cancer patients are associated with metastasis, a multistep, intricate process that requires the cooperation of tumour cells, tumour microenvironment and metastasis target tissues. It is accepted that metastasis does ... ...

Abstract	Most cancer-related deaths in breast cancer patients are associated with metastasis, a multistep, intricate process that requires the cooperation of tumour cells, tumour microenvironment and metastasis target tissues. It is accepted that metastasis does not depend on the tumour characteristics but the host's genetic makeup. However, there has been limited success in determining the germline genetic variants that influence metastasis development, mainly because of the limitations of traditional genome-wide association studies to detect the relevant genetic polymorphisms underlying complex phenotypes. In this work, we leveraged the extreme discordant phenotypes approach and the epistasis networks to analyse the genotypes of 97 breast cancer patients. We found that the host's genetic makeup facilitates metastases by the dysregulation of gene expression that can promote the dispersion of metastatic seeds and help establish the metastatic niche-providing a congenial soil for the metastatic seeds.
MeSH term(s)	Breast Neoplasms/genetics ; Genome-Wide Association Study ; Germ-Line Mutation ; Humans ; Neoplasm Metastasis ; Tumor Microenvironment
Language	English
Publishing date	2022-06-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.28250
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Article ; Online: A retrospective, multicenter study of the efficacy of lapatinib plus trastuzumab in HER2-positive metastatic breast cancer patients previously treated with trastuzumab, lapatinib, or both: the Trastyvere study.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2019 Volume 22, Issue 3, Page(s) 420–428

Abstract: Purpose: To evaluate the efficacy and safety of lapatinib (L) and trastuzumab (T) combination in HER2-positive metastatic breast cancer (MBC) patients previously treated with T and/or L.: Materials and methods: We conducted a retrospective, post- ... ...

Abstract	Purpose: To evaluate the efficacy and safety of lapatinib (L) and trastuzumab (T) combination in HER2-positive metastatic breast cancer (MBC) patients previously treated with T and/or L. Materials and methods: We conducted a retrospective, post-authorized, multicenter study including patients with HER2-positive MBC or locally advanced breast cancer (ABC) treated with the combination of L-T. Concomitant endocrine therapy, as well as brain metastasis and/or prior exposure to L, were allowed. Results: One hundred and fifteen patients from 14 institutions were included. The median age was 59.8 years. The median number of prior T regimens in the advanced setting was 3 and 73 patients had received a prior L regimen. The clinical benefit rate (CBR) was 34.8% (95% CI 26.1-43.5). Among other efficacy endpoints, the overall response rate was 21.7%, and median progression-free survival (PFS) and overall survival were 3.9 and 21.6 months, respectively. Heavily pretreated and ≥ 3 metastatic organ patients showed lower CBR and PFS than patients with a low number of previous regimens and < 3 metastatic organs. Moreover, CBR did not significantly change in L-pretreated compared with L-naïve patients (31.5% versus 40.5% for L-pretreated versus L-naïve). Grade 3/4 adverse events were reported in 19 patients (16.5%). Conclusion: The combination of L-T is an effective and well-tolerated regimen in heavily pretreated patients and remains active among patients progressing on prior L-based therapy. Our study suggests that the L-T regimen is a safe and active chemotherapy-free option for MBC patients previously treated with T and/or L.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Female ; Humans ; Lapatinib/therapeutic use ; Middle Aged ; Neoplasm Metastasis ; Protein Kinase Inhibitors/therapeutic use ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/metabolism ; Retrospective Studies ; Spain ; Trastuzumab/therapeutic use ; Treatment Outcome
Chemical Substances	Protein Kinase Inhibitors ; Lapatinib (0VUA21238F) ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2019-06-15
Publishing country	Italy
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-019-02145-4
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