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  1. Article ; Online: 101 years ago: Hermann Muller's remarkable insight.

    Haber, James E

    Genetics

    2023  Volume 223, Issue 4

    Abstract: More than 20 years before DNA was identified as the hereditary material, the Drosophila geneticist, Hermann Muller, envisioned the fundamental principles that such a molecule must have: to be auto-assembling and to be mutable but then again stable. He ... ...

    Abstract More than 20 years before DNA was identified as the hereditary material, the Drosophila geneticist, Hermann Muller, envisioned the fundamental principles that such a molecule must have: to be auto-assembling and to be mutable but then again stable. He followed his prescient review of these properties with a remarkable prediction: learning about the hereditary material and its properties would not come from studying Drosophila, but from studying bacteria and their bacteriophages.
    MeSH term(s) Animals ; Drosophila/genetics ; Bacteriophages
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/iyad015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 767: Show issues Location:
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  2. Book: Genome stability

    Haber, James E.

    DNA repair and recombination

    2014  

    Author's details James E. Haber
    Keywords Genomic Instability ; DNA Repair ; Models, Molecular ; Recombinational DNA Repair ; DNS-Reparatur ; DNS ; Genetik ; Rekombination
    Subject Ladungsrekombination ; Ladungsneutralisation ; Allgemeine Genetik ; Erbbiologie ; Erbforschung ; Erblehre ; Vererbungslehre ; Vererbungswissenschaft ; Erblichkeitslehre ; Desoxyribonucleinsäure ; DNA ; DNA-Molekül ; Desoxyribonukleinsäure ; DNS ; DNA-Reparatur
    Language English
    Size XVI, 399 S. : zahlr. Ill., graph. Darst.
    Publisher Garland Science
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017705759
    ISBN 978-0-8153-4485-8 ; 0-8153-4485-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2014 A 735 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: A shattering experience.

    Haber, James E

    Molecular cell

    2022  Volume 82, Issue 13, Page(s) 2360–2362

    Abstract: Tang et al. (2022) report that the DNA breaks that provoke chromothripsis-the pulverization and dramatic assembly into a rearranged chromosome-are generated by the base excision repair APE1 endonuclease, triggered by removing deoxyinosines that are ... ...

    Abstract Tang et al. (2022) report that the DNA breaks that provoke chromothripsis-the pulverization and dramatic assembly into a rearranged chromosome-are generated by the base excision repair APE1 endonuclease, triggered by removing deoxyinosines that are created in DNA::RNA hybrids.
    MeSH term(s) Chromothripsis ; DNA/genetics ; DNA Damage ; DNA Repair ; Humans
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.06.018
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  4. Article ; Online: Learning Yeast Genetics from Miro Radman.

    Haber, James E

    Cells

    2021  Volume 10, Issue 4

    Abstract: Miroslav Radman's far-sighted ideas have penetrated many aspects of our study of the repair of broken eukaryotic chromosomes. For over 35 years my lab has studied different aspects of the repair of chromosomal breaks in the budding yeast, ...

    Abstract Miroslav Radman's far-sighted ideas have penetrated many aspects of our study of the repair of broken eukaryotic chromosomes. For over 35 years my lab has studied different aspects of the repair of chromosomal breaks in the budding yeast,
    MeSH term(s) DNA Damage/genetics ; DNA Repair/genetics ; DNA Replication/genetics ; Recombination, Genetic/genetics ; SOS Response, Genetics/genetics ; Saccharomyces cerevisiae/genetics
    Language English
    Publishing date 2021-04-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10040945
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  5. Article: A shattering experience

    Haber, James E.

    Molecular cell. 2022 July 07, v. 82, no. 13

    2022  

    Abstract: Tang et al. (2022) report that the DNA breaks that provoke chromothripsis—the pulverization and dramatic assembly into a rearranged chromosome—are generated by the base excision repair APE1 endonuclease, triggered by removing deoxyinosines that are ... ...

    Abstract Tang et al. (2022) report that the DNA breaks that provoke chromothripsis—the pulverization and dramatic assembly into a rearranged chromosome—are generated by the base excision repair APE1 endonuclease, triggered by removing deoxyinosines that are created in DNA::RNA hybrids.
    Keywords DNA ; DNA repair ; grinding
    Language English
    Dates of publication 2022-0707
    Size p. 2360-2362.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.06.018
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: DNA Repair: The Search for Homology.

    Haber, James E

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2018  Volume 40, Issue 5, Page(s) e1700229

    Abstract: The repair of chromosomal double-strand breaks (DSBs) by homologous recombination is essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51-mediated process to match sequences at the broken end to homologous donor sequences ... ...

    Abstract The repair of chromosomal double-strand breaks (DSBs) by homologous recombination is essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51-mediated process to match sequences at the broken end to homologous donor sequences that can be used as a template to repair the lesion. Here, in reviewing research about DSB repair, I consider the many factors that appear to play important roles in the successful search for homology by several homologous recombination mechanisms. See also the video abstract here: https://youtu.be/vm7-X5uIzS8.
    MeSH term(s) Animals ; DNA Breaks, Double-Stranded ; DNA Repair/genetics ; DNA Repair/physiology ; Humans ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism ; Rec A Recombinases/genetics ; Rec A Recombinases/metabolism ; Recombinational DNA Repair/genetics ; Recombinational DNA Repair/physiology
    Chemical Substances Rad51 Recombinase (EC 2.7.7.-) ; Rec A Recombinases (EC 2.7.7.-)
    Language English
    Publishing date 2018-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.201700229
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  7. Article ; Online: Single-strand template repair: key insights to increase the efficiency of gene editing.

    Gallagher, Danielle N / Haber, James E

    Current genetics

    2021  Volume 67, Issue 5, Page(s) 747–753

    Abstract: DNA double-strand breaks (DSBs) pose a serious hazard for the stability of the genome. CRISPR-Cas9-mediated gene editing intentionally creates a site-specific DSB to modify the genomic sequence, typically from an introduced single-stranded DNA donor. ... ...

    Abstract DNA double-strand breaks (DSBs) pose a serious hazard for the stability of the genome. CRISPR-Cas9-mediated gene editing intentionally creates a site-specific DSB to modify the genomic sequence, typically from an introduced single-stranded DNA donor. However, unlike typical forms of homologous recombination, single-strand template repair (SSTR) is Rad51-independent. Moreover, this pathway is distinct from other previously characterized Rad51-independent processes. Here, we briefly review the work characterizing this pathway, and how these findings can be used to guide and improve current gene editing strategies.
    MeSH term(s) Animals ; DNA Repair ; DNA, Single-Stranded ; Gene Editing ; Humans ; Mutagenesis ; Rad51 Recombinase/physiology ; Saccharomyces cerevisiae/genetics
    Chemical Substances DNA, Single-Stranded ; Rad51 Recombinase (EC 2.7.7.-)
    Language English
    Publishing date 2021-04-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282876-5
    ISSN 1432-0983 ; 0172-8083
    ISSN (online) 1432-0983
    ISSN 0172-8083
    DOI 10.1007/s00294-021-01186-z
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  8. Article ; Online: DNA replication: the recombination connection.

    Epum, Esther A / Haber, James E

    Trends in cell biology

    2021  Volume 32, Issue 1, Page(s) 45–57

    Abstract: Failure to complete DNA replication is one of the major sources of genome instability leading to aneuploidy, chromosome breakage, and chromosome rearrangements that are associated with human cancer. One of the surprising revelations of the past decade is ...

    Abstract Failure to complete DNA replication is one of the major sources of genome instability leading to aneuploidy, chromosome breakage, and chromosome rearrangements that are associated with human cancer. One of the surprising revelations of the past decade is that the completion of replication at so-called common fragile sites (CFS) occurs very late in the cell cycle - at mitosis - through a process termed MiDAS (mitotic DNA synthesis). MiDAS is strongly related to another cancer-promoting phenomenon: the activation of alternative lengthening of telomeres (ALT). Our understanding of the mechanisms of ALT and MiDAS in mammalian cells has drawn heavily from recent advances in the study of break-induced replication (BIR), especially in budding yeast. We provide new insights into the BIR, MiDAS, and ALT pathways and their shared similarities.
    MeSH term(s) Animals ; DNA Repair ; DNA Replication/genetics ; Genomic Instability ; Humans ; Mammals ; Recombination, Genetic/genetics ; Telomere/genetics
    Language English
    Publishing date 2021-08-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2021.07.005
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  9. Article ; Online: Monitoring Gene Conversion in Budding Yeast by Southern Blot Analysis.

    Yamaguchi, Miyuki / Haber, James E

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2153, Page(s) 221–238

    Abstract: By using an inducible site-specific double-strand break (DSB) in budding yeast, it is possible to monitor-in real time-the repair of the break by homologous recombination. A method is described using an ectopic homologous donor sequence to repair an HO ... ...

    Abstract By using an inducible site-specific double-strand break (DSB) in budding yeast, it is possible to monitor-in real time-the repair of the break by homologous recombination. A method is described using an ectopic homologous donor sequence to repair an HO endonuclease-induced DSB. These gene conversion events can occur with or without crossing-over, the products of which are distinguished as different-sized restriction endonuclease fragments. The method of Southern blotting is described in detail.
    MeSH term(s) Blotting, Southern ; DNA ; DNA Restriction Enzymes/metabolism ; DNA, Fungal/genetics ; Gene Conversion ; Saccharomyces cerevisiae/genetics
    Chemical Substances DNA, Fungal ; DNA (9007-49-2) ; DNA Restriction Enzymes (EC 3.1.21.-)
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0644-5_16
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  10. Article ; Online: A Life Investigating Pathways That Repair Broken Chromosomes.

    Haber, James E

    Annual review of genetics

    2016  Volume 50, Page(s) 1–28

    Abstract: Double-strand breaks (DSBs) pose a severe challenge to genome integrity; consequently, cells have developed efficient mechanisms to repair DSBs through several pathways of homologous recombination and other nonhomologous end-joining processes. Much of ... ...

    Abstract Double-strand breaks (DSBs) pose a severe challenge to genome integrity; consequently, cells have developed efficient mechanisms to repair DSBs through several pathways of homologous recombination and other nonhomologous end-joining processes. Much of our understanding of these pathways has come from the analysis of site-specific DSBs created by the HO endonuclease in the budding yeast Saccharomyces cerevisiae. I was fortunate to get in on the ground floor of analyzing the fate of synchronously induced DSBs through the study of what I coined "in vivo biochemistry." I have had the remarkable good fortune to profit from the development of new techniques that have permitted an ever more detailed dissection of these repair mechanisms, which are described here.
    MeSH term(s) Chromosomes, Fungal ; DNA Breaks, Double-Stranded ; DNA End-Joining Repair ; DNA Repair ; DNA Replication ; Deoxyribonucleases, Type II Site-Specific/genetics ; Deoxyribonucleases, Type II Site-Specific/metabolism ; Gene Conversion ; Histones/genetics ; Histones/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Nucleic Acid Heteroduplexes ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Histones ; Homeodomain Proteins ; MATA1 protein, S cerevisiae ; Nucleic Acid Heteroduplexes ; Repressor Proteins ; Saccharomyces cerevisiae Proteins ; Rad51 Recombinase (EC 2.7.7.-) ; SCEI protein, S cerevisiae (EC 3.1.21.-) ; Deoxyribonucleases, Type II Site-Specific (EC 3.1.21.4)
    Language English
    Publishing date 2016-11-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207928-8
    ISSN 1545-2948 ; 0066-4170 ; 0066-4197
    ISSN (online) 1545-2948
    ISSN 0066-4170 ; 0066-4197
    DOI 10.1146/annurev-genet-120215-035043
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