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  1. Article ; Online: Differential trends in rising endometrial cancer incidence by age, race, and ethnicity.

    Liu, Lihua / Habeshian, Talar S / Zhang, Juanjuan / Peeri, Noah C / Du, Mengmeng / De Vivo, Immaculata / Setiawan, Veronica Wendy

    JNCI cancer spectrum

    2023  Volume 7, Issue 1

    Abstract: Endometrial cancer (EC) incidence is on the rise. Although early-onset endometrial cancer (EOEC; age at diagnosis <50 years) is relatively uncommon, the incidence of EOEC has been reportedly increasing in recent decades. However, the rising EOEC has not ... ...

    Abstract Endometrial cancer (EC) incidence is on the rise. Although early-onset endometrial cancer (EOEC; age at diagnosis <50 years) is relatively uncommon, the incidence of EOEC has been reportedly increasing in recent decades. However, the rising EOEC has not been thoroughly described with regard to the racial and ethnic disparities and compared with late-onset EC (age at diagnosis ≥50 years). We used the Cancer in North America (CiNA) Analytic File, 1995-2018, from the North American Association of Central Cancer Registries, which allowed us to examine trends in invasive EC incidence by racial and ethnic groups and by age at diagnosis. We found striking differences for demographic and tumor characteristics as well as racial and ethnic patterns and time trends in EC incidence between EOEC and late-onset EC. The faster increases in EOEC incidence rates, especially among non-White women, mirror similar observations in other cancers, pointing to a possible link with rising obesity epidemic in younger generations.
    MeSH term(s) Humans ; Female ; Middle Aged ; Ethnicity ; Incidence ; Endometrial Neoplasms ; Racial Groups ; Registries
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2515-5091
    ISSN (online) 2515-5091
    DOI 10.1093/jncics/pkad001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: DNA methylation markers for risk of metastasis in a cohort of men with localized prostate cancer.

    Habeshian, Talar S / Cannavale, Kimberly L / Slezak, Jeff M / Shu, Yu-Hsiang / Chien, Gary W / Chen, XuFeng / Shi, Feng / Siegmund, Kimberly D / Van Den Eeden, Stephen K / Huang, Jiaoti / Chao, Chun R

    Epigenetics

    2024  Volume 19, Issue 1, Page(s) 2308920

    Abstract: Accurately identifying life-threatening prostate cancer (PCa) at time of diagnosis remains an unsolved problem. We evaluated whether DNA methylation status of selected candidate genes can predict the risk of metastasis beyond clinical risk factors in men ...

    Abstract Accurately identifying life-threatening prostate cancer (PCa) at time of diagnosis remains an unsolved problem. We evaluated whether DNA methylation status of selected candidate genes can predict the risk of metastasis beyond clinical risk factors in men with untreated PCa. A nested case-control study was conducted among men diagnosed with localized PCa at Kaiser Permanente California between 01/01/1997-12/31/2006 who did not receive curative treatments. Cases were those who developed metastasis within 10 years from diagnosis. Controls were selected using density sampling. Ninety-eight candidate genes were selected from functional categories of cell cycle control, metastasis/tumour suppressors, cell signalling, cell adhesion/motility/invasion, angiogenesis, and immune function, and 41 from pluripotency genes. Cancer DNA from diagnostic biopsy blocks were extracted and analysed. Associations of methylation status were assessed using CpG site level and principal components-based analysis in conditional logistic regressions. In 215 cases and 404 controls, 27 candidate genes were found to be statistically significant in at least one of the two analytical approaches. The agreement between the methods was 25.9% (7 candidate genes, including 2 pluripotency markers). The DNA methylation status of several candidate genes was significantly associated with risk of metastasis in untreated localized PCa patients. These findings may inform future risk prediction models for PCa metastasis beyond clinical characteristics.
    MeSH term(s) Male ; Humans ; DNA Methylation ; Case-Control Studies ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Risk Factors
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ISSN 1559-2308
    ISSN (online) 1559-2308
    DOI 10.1080/15592294.2024.2308920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exposure to statins post localized prostate cancer diagnosis and risk of metastasis among men who did not receive curative prostate cancer treatment.

    Habeshian, Talar S / Shu, Yu-Hsiang / Cannavale, Kimberly L / Slezak, Jeff M / Chien, Gary W / Vandeneeden, Stephen K / Chao, Chun R

    Cancer reports (Hoboken, N.J.)

    2022  Volume 6, Issue 3, Page(s) e1749

    Abstract: Background: Few studies have evaluated the effect of statin exposure on metastasis risk among prostate cancer patients not receiving curative treatment.: Methods: We included men diagnosed with localized prostate cancer at an integrated health care ... ...

    Abstract Background: Few studies have evaluated the effect of statin exposure on metastasis risk among prostate cancer patients not receiving curative treatment.
    Methods: We included men diagnosed with localized prostate cancer at an integrated health care system between 1997 and 2006 who did not receive curative treatment within 6 months of diagnosis. We followed these men until a metastatic event, disenrollment, death, or 12/31/2016. We collected all data from electronic health records supplemented by chart review. We used Cox regressions to examine the association between post-diagnostic statin exposure and metastasis, controlling for clinical characteristics and pre-diagnostic statin exposure.
    Results: There were 4245 men included. Mean age of diagnosis was 68.02 years. 46.6% of men used statins after prostate cancer diagnosis. During follow-up, 192 men developed metastasis (cumulative incidence rate: 14.5%). In the adjusted Cox model, statin use post-prostate cancer diagnosis was not significantly associated with a metastatic event (HR = 0.97, 95% CI = 0.69, 1.36). Pre-diagnostic statin use was also not associated with development of metastasis (HR = 0.76, 95% CI = 0.53, 1.10). We did not observe a dose-response for the proportion of person-time at-risk post-prostate cancer diagnosis on statins (HR = 0.98 per 10% increase in person-time exposed [95% CI = 0.93, 1.03]).
    Conclusions: We did not find an inverse association between post-diagnosis statin exposure and metastasis development in localized prostate cancer patients who did not receive active treatment. Our results did not offer support to the chemopreventive potential of post-diagnostic statin use among men on active surveillance.
    MeSH term(s) Male ; Humans ; Aged ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Follow-Up Studies ; Disease Progression ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/drug therapy ; Prostate/pathology
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Discontinuation of Car Seat Tolerance Screening and Postdischarge Adverse Outcomes in Infants Born Preterm.

    Braun, David / Kaempf, Joseph W / Ho, Ngoc J / Nguyen, Marielle H / Passi, Rohit / Burgos, Anthony E / Volodarskiy, Marianna / Villosis, Maria Fe B / Gupta, Mandhir / Habeshian, Talar S / Tam, Henry K / Litam, Kevin B / Hong, Quinn L / Dong, Calvin C / Getahun, Darios

    The Journal of pediatrics

    2023  Volume 261, Page(s) 113577

    Abstract: Objective: To study the association between discontinuing predischarge car seat tolerance screening (CSTS) with 30-day postdischarge adverse outcomes in infants born preterm.: Study design: Retrospective cohort study involving all infants born ... ...

    Abstract Objective: To study the association between discontinuing predischarge car seat tolerance screening (CSTS) with 30-day postdischarge adverse outcomes in infants born preterm.
    Study design: Retrospective cohort study involving all infants born preterm from 2010 through 2021 who survived to discharge to home in a 14-hospital integrated health care system. The exposure was discontinuation of CSTS. The primary outcome was a composite rate of death, 911 call-triggered transports, or readmissions associated with diagnostic codes of respiratory disorders, apnea, apparent life-threatening event, or brief resolved unexplained events within 30 days of discharge. Outcomes of infants born in the periods of CSTS and after discontinuation were compared.
    Results: Twelve of 14 hospitals initially utilized CSTS and contributed patients to the CSTS period; 71.4% of neonatal intensive care unit (NICU) patients and 26.9% of non-NICU infants were screened. All hospitals participated in the discontinuation period; 0.1% was screened. Rates of the unadjusted primary outcome were 1.02% in infants in the CSTS period (n = 21 122) and 1.06% after discontinuation (n = 20 142) (P = .76). The aOR (95% CI) was 0.95 (0.75, 1.19). Statistically insignificant differences between periods were observed in components of the primary outcome, gestational age strata, NICU admission status groups, and other secondary analyses.
    Conclusions: Discontinuation of CSTS in a large integrated health care network was not associated with a change in 30-day postdischarge adverse outcomes. CSTS's value as a standard predischarge assessment deserves further evaluation.
    MeSH term(s) Infant, Newborn ; Humans ; Infant ; Infant, Premature ; Child Restraint Systems/adverse effects ; Patient Discharge ; Retrospective Studies ; Aftercare ; Intensive Care Units, Neonatal
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2023.113577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hypertension and risk of endometrial cancer: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium (E2C2).

    Habeshian, Talar S / Peeri, Noah C / De Vivo, Immaculata / Schouten, Leo J / Shu, Xiao-Ou / Cote, Michele L / Bertrand, Kimberly A / Chen, Yu / Clarke, Megan A / Clendenen, Tess V / Cook, Linda S / Costas, Laura / Dal Maso, Luigino / Freudenheim, Jo L / Friedenreich, Christine M / Gallagher, Grace / Gierach, Gretchen L / Goodman, Marc T / Jordan, Susan J /
    La Vecchia, Carlo / Lacey, James V / Levi, Fabio / Liao, Linda M / Lipworth, Loren / Lu, Lingeng / Matías-Guiu, Xavier / Moysich, Kirsten B / Mutter, George L / Na, Renhua / Naduparambil, Jeffin / Negri, Eva / O'Connell, Kelli / O'Mara, Tracy A / Onieva Hernández, Irene / Palmer, Julie R / Parazzini, Fabio / Patel, Alpa V / Penney, Kathryn L / Prizment, Anna E / Ricceri, Fulvio / Risch, Harvey A / Sacerdote, Carlotta / Sandin, Sven / Stolzenberg-Solomon, Rachael Z / van den Brandt, Piet A / Webb, Penelope M / Wentzensen, Nicolas / Wijayabahu, Akemi T / Wilkens, Lynne R / Xu, Wanghong / Yu, Herbert / Zeleniuch-Jacquotte, Anne / Zheng, Wei / Du, Mengmeng / Setiawan, Veronica Wendy

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2024  

    Abstract: Background: The incidence rates of endometrial cancer (EC) are increasing, which may partly be explained by the rising prevalence of obesity, an established risk factor for EC. Hypertension, another component of metabolic syndrome, is also increasing in ...

    Abstract Background: The incidence rates of endometrial cancer (EC) are increasing, which may partly be explained by the rising prevalence of obesity, an established risk factor for EC. Hypertension, another component of metabolic syndrome, is also increasing in prevalence, and emerging evidence suggests that it may be associated with the development of certain cancers. The role of hypertension independent of other components of metabolic syndrome in the etiology of EC remains unclear. In this study we evaluated hypertension as an independent risk factor for EC and whether this association is modified by other established risk factors.
    Methods: We included 15,631 EC cases and 42,239 controls matched on age, race, and study-specific factors from 29 studies in the Epidemiology of Endometrial Cancer Consortium. We used multivariable unconditional logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the association between hypertension and EC and whether this association differed by study design, race/ethnicity, body mass index, diabetes status, smoking status, or reproductive factors.
    Results: Hypertension was associated with an increased risk of EC (OR=1.14, 95% CI:1.09-1.19). There was significant heterogeneity by study design (Phet<0.01), with a stronger magnitude of association observed among case-control vs. cohort studies. Stronger associations were also noted for pre-/peri-menopausal women and never users of postmenopausal hormone therapy.
    Conclusions: Hypertension is associated with EC risk independently from known risk factors. Future research should focus on biologic mechanisms underlying this association.
    Impact: This study provides evidence that hypertension may be an independent risk factor for EC.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-23-1444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3693: Show issues Location:
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