LIVIVO - Search results -

Search results

Result 1 - 10 of total 74

Search options

Article ; Online: Development of a multivariate predictive model for dapsone adverse drug events in people with leprosy under standard WHO multidrug therapy.

de Araujo, Ana Carolina Galvão Dos Santos / Hacker, Mariana de Andrea Vilas-Boas / Pinheiro, Roberta Olmo / Illarramendi, Ximena / Durães, Sandra Maria Barbosa / Nobre, Maurício Lisboa / Moraes, Milton Ozório / Sales, Anna Maria / da Silva, Gilberto Marcelo Sperandio

PLoS neglected tropical diseases

2024 Volume 18, Issue 1, Page(s) e0011901

Abstract: Background: The occurrence of adverse drug events (ADEs) during dapsone (DDS) treatment in patients with leprosy can constitute a significant barrier to the successful completion of the standardized therapeutic regimen for this disease. Well-known DDS- ... ...

Abstract	Background: The occurrence of adverse drug events (ADEs) during dapsone (DDS) treatment in patients with leprosy can constitute a significant barrier to the successful completion of the standardized therapeutic regimen for this disease. Well-known DDS-ADEs are hemolytic anemia, methemoglobinemia, hepatotoxicity, agranulocytosis, and hypersensitivity reactions. Identifying risk factors for ADEs before starting World Health Organization recommended standard multidrug therapy (WHO/MDT) can guide therapeutic planning for the patient. The objective of this study was to develop a predictive model for DDS-ADEs in patients with leprosy receiving standard WHO/MDT. Methodology: This is a case-control study that involved the review of medical records of adult (≥18 years) patients registered at a Leprosy Reference Center in Rio de Janeiro, Brazil. The cohort included individuals that received standard WHO/MDT between January 2000 to December 2021. A prediction nomogram was developed by means of multivariable logistic regression (LR) using variables. The Hosmer-Lemeshow test was used to determine the model fit. Odds ratios (ORs) and their respective 95% confidence intervals (CIs) were estimated. The predictive ability of the LRM was assessed by the area under the receiver operating characteristic curve (AUC). Results: A total of 329 medical records were assessed, comprising 120 cases and 209 controls. Based on the final LRM analysis, female sex (OR = 3.61; 95% CI: 2.03-6.59), multibacillary classification (OR = 2.5; 95% CI: 1.39-4.66), and higher education level (completed primary education) (OR = 1.97; 95% CI: 1.14-3.47) were considered factors to predict ADEs that caused standard WHO/MDT discontinuation. The prediction model developed had an AUC of 0.7208, that is 72% capable of predicting DDS-ADEs. Conclusion: We propose a clinical model that could become a helpful tool for physicians in predicting ADEs in DDS-treated leprosy patients.
MeSH term(s)	Adult ; Humans ; Female ; Dapsone/adverse effects ; Leprostatic Agents/adverse effects ; Rifampin/therapeutic use ; Drug Therapy, Combination ; Case-Control Studies ; Clofazimine/therapeutic use ; Brazil/epidemiology ; Leprosy/drug therapy ; Drug-Related Side Effects and Adverse Reactions ; World Health Organization
Chemical Substances	Dapsone (8W5C518302) ; Leprostatic Agents ; Rifampin (VJT6J7R4TR) ; Clofazimine (D959AE5USF)
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011901
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Housing characteristics of crack cocaine users in Northeast Brazil, 2011-2013.

Santos, Raquel Rodrigues Dos / Hacker, Mariana de Andrea Villas Boas / Mota, Jurema Corrêa da / Bastos, Francisco Inácio

Ciencia & saude coletiva

2021 Volume 27, Issue 6, Page(s) 2407–2416

Abstract: We compared sociodemographic characteristics, substance use patterns, sexual behavior, use of health services, and criminal records of homeless vs. domiciled users. Data are from the Brazilian National Survey on Crack Use. A discriminant model and ... ...

Title translation	Características de usuários de crack quanto à situação de moradia no Nordeste brasileiro, 2011-2013.
Abstract	We compared sociodemographic characteristics, substance use patterns, sexual behavior, use of health services, and criminal records of homeless vs. domiciled users. Data are from the Brazilian National Survey on Crack Use. A discriminant model and correspondence analysis cross-compared characteristics of users according to their housing status. The logistic model revealed associations between "living in the streets" and female gender and intermittent work. "Homelessness" was also associated with the use of tobacco and "oxi" in the previous 30 days, reliance on soup kitchens, low access to public mental health services, and arrests in the previous year. Correspondence analysis highlighted the spatial proximity of the variables as follows: "having traded sex for drugs", "informal work", "age 31 years or older", "access to public mental health services", "problems with law enforcement", and female gender with homeless crack users. People who smoke crack cocaine in Northeast Brazil are seldom studied. Their profiles, stratified according to their housing conditions, show subgroups with specific characteristics. While domiciled users have access to specialized clinics, homeless users basically reported access to free food and harm reduction services.
MeSH term(s)	Adult ; Brazil/epidemiology ; Crack Cocaine ; Female ; Homeless Persons ; Housing ; Humans ; Sexual Behavior
Chemical Substances	Crack Cocaine
Language	English
Publishing date	2021-12-05
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2078799-6
ISSN	1678-4561 ; 1678-4561
ISSN (online)	1678-4561
ISSN	1678-4561
DOI	10.1590/1413-81232022276.16522021
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Author Correction: Leprosy incidence and risk estimates in a 33-year contact cohort of leprosy patients.

Hacker, Mariana Andrea / Sales, Anna Maria / Duppre, Nádia Cristina / Sarno, Euzenir Nunes / Moraes, Milton Ozório

Scientific reports

2021 Volume 11, Issue 1, Page(s) 8954

Language	English
Publishing date	2021-04-20
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-88096-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Leprosy incidence and risk estimates in a 33-year contact cohort of leprosy patients.

Hacker, Mariana Andrea / Sales, Anna Maria / Duppre, Nádia Cristina / Sarno, Euzenir Nunes / Moraes, Milton Ozório

Scientific reports

2021 Volume 11, Issue 1, Page(s) 1947

Abstract: Reduction in incidence has been associated with the introduction of novel approaches, like chemo/immune-prophylaxis. Incidence determined through follow-up cohort studies can evaluate the implementation of these innovative policies towards control and ... ...

Abstract	Reduction in incidence has been associated with the introduction of novel approaches, like chemo/immune-prophylaxis. Incidence determined through follow-up cohort studies can evaluate the implementation of these innovative policies towards control and prevention. We have assessed the incidence in our contacts cohort over past 33 years, considering the effect of demographic and clinical variables. Survival analysis was used to estimate the risk of leprosy. A total of 9024 contacts were evaluated, of which 192 developed leprosy, resulting in an overall incidence of 1.4/1000 person-years. The multivariate analysis showed that the major risk factors were (i) contact from MB index cases and (ii) consanguinity (iii) intra household contact. Lower risk was detected for contacts with BCG scar who were revaccinated. There was a significant decrease in accumulated risk between the 2011-2019 period compared with 1987, probably linked to the improvement in laboratory tools to monitor contacts, thereby providing early diagnosis of contacts at intake and reduction of transmission. Our findings suggest that a combination of contact surveillance and tracing, adequate neurodermatological examination, and availability of molecular tools is highly effective in supporting early diagnosis, while a second dose of the BCG vaccination can exert extra protection.
MeSH term(s)	Adolescent ; Adult ; BCG Vaccine/administration & dosage ; Child ; Cohort Studies ; Contact Tracing ; Female ; Humans ; Incidence ; Leprosy/epidemiology ; Leprosy/prevention & control ; Leprosy/transmission ; Male ; Middle Aged ; Risk Factors ; Survival Analysis ; Young Adult
Chemical Substances	BCG Vaccine
Language	English
Publishing date	2021-01-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-81643-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Ultrasonography as a diagnostic tool for Neural Pain in Leprosy.

Spitz, Clarissa Neves / Mogami, Roberto / Pitta, Izabela Jardim Rodrigues / Hacker, Mariana Andrea Vilas Boas / Sales, Anna Maria / Sarno, Euzenir Nunes / Jardim, Marcia Rodrigues

PLoS neglected tropical diseases

2022 Volume 16, Issue 4, Page(s) e0010393

Abstract: Leprosy is still a prevalent disease in Brazil, representing 93% of all occurrences in the Americas. Leprosy neuropathy is one of the most worrying manifestations of the disease. Acute neuropathy usually occurs during reaction episodes and is called ... ...

Abstract	Leprosy is still a prevalent disease in Brazil, representing 93% of all occurrences in the Americas. Leprosy neuropathy is one of the most worrying manifestations of the disease. Acute neuropathy usually occurs during reaction episodes and is called neuritis. Twenty-two leprosy patients were included in this study. These patients had neural pain associated with ulnar sensory neuropathy, with or without adjunct motor involvement. The neurological picture began within thirty days of the clinical evaluation. The patients underwent a nerve conduction study and the demyelinating findings confirmed the diagnosis of neuritis. Ultrasonographic study (US) of the ulnar nerve was performed in all patients by a radiologist who was blinded to the clinical or neurophysiological results. Morphological characteristics of the ulnar nerve were analyzed, such as echogenicity, fascicular pattern, transverse cross-sectional area (CSA), aspect of the epineurium, as well as their anatomical relationships. The volume of selected muscles referring to the ulnar nerve, as well as their echogenicity, was also examined. Based on this analysis, patients with increased ulnar nerve CSA associated with loss of fascicular pattern, epineurium hyperechogenicity and presence of power Doppler flow were classified as neuritis. Therefore, patients initially classified by the clinical-electrophysiological criteria were reclassified by the imaging criteria pre-established in this study as with and without neuritis. Loss of fascicular pattern and flow detection on power Doppler showed to be significant morphological features in the detection of neuritis. In 38.5% of patients without clinical or neurophysiological findings of neuritis, US identified power Doppler flow and loss of fascicular pattern. The US is a method of high resolution and portability, and its low cost means that it could be used as an auxiliary tool in the diagnosis of neuritis and its treatment, especially in basic health units.
MeSH term(s)	Humans ; Leprosy/complications ; Leprosy/diagnostic imaging ; Neural Conduction ; Neuralgia ; Neuritis/diagnostic imaging ; Neuritis/etiology ; Ulnar Nerve/diagnostic imaging ; Ulnar Neuropathies/diagnostic imaging ; Ultrasonography
Language	English
Publishing date	2022-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0010393
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Progressive neuropathy in patients with lepromatous leprosy after multidrug therapy.

Penna, Patricia Sola / Pitta, Izabela Jardim Rodrigues / Vital, Robson Teixeira / Hacker, Mariana Andrea Vilas Boas / Salles, Ana Maria / Pinheiro, Roberta Olmo / Antunes, Sergio Luiz Gomes / Sarno, Euzenir Nunes / Jardim, Márcia Rodrigues

Memorias do Instituto Oswaldo Cruz

2023 Volume 117, Page(s) e220150

Abstract: Background: The lepromatous pole is a stigmatising prototype for patients with leprosy. Generally, these patients have little or no symptoms of peripheral nerve involvement at the time of their diagnosis. However, signs of advanced peripheral neuropathy ...

Abstract	Background: The lepromatous pole is a stigmatising prototype for patients with leprosy. Generally, these patients have little or no symptoms of peripheral nerve involvement at the time of their diagnosis. However, signs of advanced peripheral neuropathy would be visible during the initial neurological evaluation and could worsen during and after multidrug therapy (MDT). Disabilities caused by peripheral nerve injuries greatly affect these patients' lives, and the pathophysiological mechanisms underlying nerve damage remain unclear. Objectives: To evaluate the outcome of peripheral neuropathy in patients with lepromatous leprosy (LL) and persistent neuropathic symptoms years after completing MDT. Methods: We evaluated the medical records of 14 patients with LL who underwent nerve biopsies due to worsening neuropathy at least four years after MDT. Findings: Neuropathic pain developed in 64.3% of the patients, and a neurological examination showed that most patients had alterations in the medium- and large-caliber fibers at the beginning of treatment. Neurological symptoms and signs deteriorated despite complete MDT and prednisone or thalidomide use for years. Nerve conduction studies showed that sensory nerves were the most affected. Main conclusions: Patients with LL can develop progressive peripheral neuropathy, which continues to develop even when they are on long-term anti-inflammatory and immunosuppressive therapy.
MeSH term(s)	Humans ; Leprosy, Lepromatous/complications ; Leprosy, Lepromatous/drug therapy ; Leprosy, Lepromatous/pathology ; Drug Therapy, Combination ; Leprostatic Agents/adverse effects ; Leprosy/pathology ; Peripheral Nervous System Diseases/etiology
Chemical Substances	Leprostatic Agents
Language	English
Publishing date	2023-01-16
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	953293-6
ISSN	1678-8060 ; 0074-0276
ISSN (online)	1678-8060
ISSN	0074-0276
DOI	10.1590/0074-02760220150
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.33: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cytokines profile in pure neural leprosy.

Pitta, Izabela Jardim R / Angst, Debora Bartzen Moraes / Pinheiro, Roberta Olmo / Vieira, Joyce Soares da Silva / Spitz, Clarissa Neves / Andrade, Ligia Rocha / Carvalho, Larissa Bittencourt / Hacker, Mariana Andrea / Sarno, Euzenir Nunes / Jardim, Marcia Rodrigues

Frontiers in immunology

2023 Volume 14, Page(s) 1272471

Abstract: Introduction: Pure Neural Leprosy (PNL) is a form of this long time known disease that affects only the peripheral nervous system. Since it is a rare form of the disease, its pathophisiology is still poorly understood.: Objective: Describe the ... ...

Abstract	Introduction: Pure Neural Leprosy (PNL) is a form of this long time known disease that affects only the peripheral nervous system. Since it is a rare form of the disease, its pathophisiology is still poorly understood. Objective: Describe the cytokines profile in patients with PNL. Methods: 30 Patients diagnosed with PNL in the Souza Araujo Outpatient Clinic and with cytokines evaluated were selected. They were evaluated by neurologists and diagnosed after a nerve biopsy. Serum levels of IL-1 β, IL-6, IL-10, IL-17, TNF, CCL-2/MCP-1, IFN-ϒ, CXCL-10/IP-10 and TGF-β were evaluates at the moment of the diagnosis. Results: Neural thickening was a common clinical finding in this groups of patients. Small and medium sensitive fibers signs and symptoms were present in 92% of the patients and motor involvement in 53%. 43% of patients presented neuropathic pain and no one had neuritis TGF-beta, IL-17, CCl-2 and IP-10. CCL-2 levels were associated with demyelinating patters and IP-10 and IL-1o were associated with axonal patterns at NCS. Discussion: PNL patients' cytokine profile appears to be different of other clinical forms of leprosy, with the presence of cytokines described in both tuberculoid and lepromatous leprosy. High levels of CCl-2 may be related to the presence of silent neuritis as well as the presence of IL-10. PNL is unique a form of leprosy, therefore, understanding its immunological profiles essential to better understand the disease itself.
MeSH term(s)	Humans ; Leprosy, Tuberculoid/diagnosis ; Leprosy, Tuberculoid/pathology ; Cytokines ; Interleukin-10 ; Interleukin-17 ; Chemokine CXCL10 ; Leprosy ; Transforming Growth Factor beta ; Neuritis
Chemical Substances	Cytokines ; Interleukin-10 (130068-27-8) ; Interleukin-17 ; Chemokine CXCL10 ; Transforming Growth Factor beta
Language	English
Publishing date	2023-12-05
Publishing country	Switzerland
Document type	Journal Article ; Comment
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1272471
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Low rate of relapse after twelve-dose multidrug therapy for hansen's disease: A 20-year cohort study in a brazilian reference center.

Nery, José A C / Sales, Anna M / Hacker, Mariana A V B / Moraes, Milton O / Maia, Raquel C / Sarno, Euzenir N / Illarramendi, Ximena

PLoS neglected tropical diseases

2021 Volume 15, Issue 5, Page(s) e0009382

Abstract: The World Health Organization has raised concerns about the increasing number of Hansen disease (HD) relapses worldwide, especially in Brazil, India, and Indonesia that report the highest number of recurrent cases. Relapses are an indicator of MDT ... ...

Abstract	The World Health Organization has raised concerns about the increasing number of Hansen disease (HD) relapses worldwide, especially in Brazil, India, and Indonesia that report the highest number of recurrent cases. Relapses are an indicator of MDT effectiveness and can reflect Mycobacterium leprae persistence or re-infection. Relapse is also a potential marker for the development or progression of disability. In this research, we studied a large cohort of persons affected by HD treated with full fixed-dose multibacillary (MB) multidrug therapy (MDT) followed for up to 20 years and observed that relapses are a rare event. We estimated the incidence density of relapse in a cohort of patients classified to receive MB regime (bacillary index (BI) > 0), diagnosed between September 1997 and June 2017, and treated with twelve-dose MB-MDT at a HD reference center in Rio de Janeiro, Brazil. We obtained the data from the data management system of the clinic routine service. We linked the selected cases to the dataset of relapses of the national HD data to confirm possible relapse cases diagnosed elsewhere. We diagnosed ten cases of relapse in a cohort of 713 patients followed-up for a mean of 12.1 years. This resulted in an incidence rate of 1.16 relapse cases per 1000 person-year (95% CI = 0.5915-2.076). The accumulated risk was 0.025 in 20 years. The very low risk observed in this cohort of twelve-dose-treated MB patients reinforces the success of the current MDT scheme.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brazil/epidemiology ; Child ; Child, Preschool ; Clofazimine/therapeutic use ; Dapsone/therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Incidence ; Leprostatic Agents/therapeutic use ; Leprosy, Lepromatous/drug therapy ; Leprosy, Lepromatous/epidemiology ; Male ; Middle Aged ; Mycobacterium leprae/drug effects ; Recurrence ; Retrospective Studies ; Rifampin/therapeutic use ; Skin/microbiology ; Skin/pathology ; Young Adult
Chemical Substances	Leprostatic Agents ; Dapsone (8W5C518302) ; Clofazimine (D959AE5USF) ; Rifampin (VJT6J7R4TR)
Language	English
Publishing date	2021-05-03
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2727
ISSN (online)	1935-2735
ISSN	1935-2727
DOI	10.1371/journal.pntd.0009382
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The red flags of ulnar neuropathy in leprosy.

Jardim, Márcia / Vital, Robson T / Illarramendi, Ximena / Hacker, Mariana / Junqueira, Beatriz / Pitta, Izabela J R / Pinheiro, Roberta O / Sarno, Euzenir N

PloS one

2021 Volume 16, Issue 11, Page(s) e0259804

Abstract: The diagnosis of pure neural leprosy is more challenging because patients share characteristics with other common pathologies, such as ulnar compression, which should be taken into consideration for differential diagnosis. In this study, we identify ... ...

Abstract	The diagnosis of pure neural leprosy is more challenging because patients share characteristics with other common pathologies, such as ulnar compression, which should be taken into consideration for differential diagnosis. In this study, we identify ulnar nerve conduction characteristics to aid in the differential diagnosis of ulnar neuropathy (UN) in leprosy and that of non-leprosy etiology. In addition, we include putative markers to better understand the inflammatory process that may occur in the nerve. Data were extracted from a database of people affected by leprosy (leprosy group) diagnosed with UN at leprosy diagnosis. A non-leprosy group of patients diagnosed with mechanical neuropathy (compressive, traumatic) was also included. Both groups were submitted to clinical, neurological, neurophysiological and immunological studies. Nerve enlargement and sensory impairment were significantly higher in leprosy patients than in patients with compressive UN. Bilateral impairment was significantly higher in the leprosy group than in the non-leprosy group. Leprosy reactions were associated to focal demyelinating lesions at the elbow and to temporal dispersion (TD). Clinical signs such as sensory impairment, nerve enlargement and bilateral ulnar nerve injury associated with eletrodiagnostic criteria such as demyelinating finds, specifically temporal dispersion, could be tools to help us decided on the best conduct in patients with elbow ulnar neuropathy and specifically decide if we should perform a nerve biopsy for diagnosis of pure neural leprosy.
MeSH term(s)	Adolescent ; Adult ; Aged ; Biomarkers ; Brazil/epidemiology ; Cross-Sectional Studies ; Data Management ; Databases, Factual ; Diagnosis, Differential ; Elbow Joint ; Female ; Humans ; Leprosy/diagnosis ; Leprosy/metabolism ; Leprosy, Tuberculoid ; Male ; Middle Aged ; Neural Conduction ; Ulnar Nerve/metabolism ; Ulnar Neuropathies/diagnosis ; Ulnar Neuropathies/physiopathology
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-11-19
Publishing country	United States
Document type	Journal Article ; Observational Study
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0259804
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Whole blood transcriptomics reveals the enrichment of neutrophil activation pathways during erythema nodosum leprosum reaction.

Rosa, Thabatta Leal Silveira Andrezo / Leal-Calvo, Thyago / Tavares, Isabella Forasteiro / Mendes, Mayara Abud / Dias, André Alves / Piauy, Meire Hellen Dos Santos / Barboza, Marcella Feitosa da Silva / Kapuscinski, Marylee / Costa, Fabrício da Mota Ramalho / Marques, Maria Angela M / Belone, Andrea de Faria F / Sales, Anna Maria / Hacker, Mariana de Andrea / Moreira, Marcia de Berredo Pinho / Belisle, John T / Moraes, Milton Ozório / Pessolani, Maria Cristina Vidal / Schmitz, Veronica

Frontiers in immunology

2024 Volume 15, Page(s) 1366125

Abstract: Introduction: Patients with the multibacillary form of leprosy can develop reactional episodes of acute inflammation, known as erythema nodosum leprosum (ENL), which are characterized by the appearance of painful cutaneous nodules and systemic symptoms. ...

Abstract	Introduction: Patients with the multibacillary form of leprosy can develop reactional episodes of acute inflammation, known as erythema nodosum leprosum (ENL), which are characterized by the appearance of painful cutaneous nodules and systemic symptoms. Neutrophils have been recognized to play a role in the pathogenesis of ENL, and recent global transcriptomic analysis revealed neutrophil-related processes as a signature of ENL skin lesions. Methods: In this study, we expanded this analysis to the blood compartment, comparing whole blood transcriptomics of patients with non-reactional lepromatous leprosy at diagnosis (LL, n=7) and patients with ENL before administration of anti-reactional treatment (ENL, n=15). Furthermore, a follow-up study was performed with patients experiencing an ENL episode at the time of diagnosis and after 7 days of thalidomide treatment (THAL, n=10). Validation in an independent cohort (ENL=8; LL=7) was performed by RT-qPCR. Results: An enrichment of neutrophil activation and degranulation-related genes was observed in the ENL group, with the gene for the neutrophil activation marker Discussion: In conclusion, our study reinforces the key role played by neutrophils in ENL pathogenesis and shed lights on potential diagnostic candidates and novel therapeutic targets that could benefit patients with leprosy.
MeSH term(s)	Humans ; Erythema Nodosum/immunology ; Erythema Nodosum/blood ; Neutrophil Activation ; Leprosy, Lepromatous/immunology ; Leprosy, Lepromatous/diagnosis ; Leprosy, Lepromatous/blood ; Adult ; Male ; Neutrophils/immunology ; Neutrophils/metabolism ; Female ; Transcriptome ; Middle Aged ; Gene Expression Profiling ; GPI-Linked Proteins/genetics ; Thalidomide ; Receptors, Cell Surface/genetics ; Leprostatic Agents/therapeutic use ; Leprostatic Agents/pharmacology ; Young Adult ; Biomarkers ; Isoantigens
Chemical Substances	CD177 protein, human ; GPI-Linked Proteins ; Thalidomide (4Z8R6ORS6L) ; Receptors, Cell Surface ; Leprostatic Agents ; Biomarkers ; Isoantigens
Language	English
Publishing date	2024-04-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1366125
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Your last searches

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito