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  1. Article ; Online: Does recombinant human erythropoietin administration in critically ill COVID-19 patients have miraculous therapeutic effects?

    Hadadi, Azar / Mortezazadeh, Masoud / Kolahdouzan, Kasra / Alavian, Golbarg

    Journal of medical virology

    2020  Volume 92, Issue 7, Page(s) 915–918

    Abstract: An 80-year-old man with multiple comorbidities presented to the emergency department with tachypnea, tachycardia, fever, and critically low ... ...

    Abstract An 80-year-old man with multiple comorbidities presented to the emergency department with tachypnea, tachycardia, fever, and critically low O
    MeSH term(s) Aged, 80 and over ; Anemia/complications ; Anemia/diagnosis ; Anemia/drug therapy ; Anemia/virology ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/genetics ; Betacoronavirus/pathogenicity ; Biomarkers/blood ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Convalescence ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Critical Illness ; Erythropoietin/therapeutic use ; Fever/complications ; Fever/diagnosis ; Fever/drug therapy ; Fever/virology ; Humans ; Iran ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; RNA, Viral/blood ; RNA, Viral/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Tachycardia/complications ; Tachycardia/diagnosis ; Tachycardia/drug therapy ; Tachycardia/virology ; Tachypnea/complications ; Tachypnea/diagnosis ; Tachypnea/drug therapy ; Tachypnea/virology ; Tomography, X-Ray Computed ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Biomarkers ; RNA, Viral ; Erythropoietin (11096-26-7)
    Keywords covid19
    Language English
    Publishing date 2020-04-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effects of angiotensin receptor blockers (ARBs) on clinical outcomes of patients with hypertension and COVID-19: A 7-month follow-up cohort study.

    Hadadi, Azar / Kazemian, Sina / Shafie, Mahan / Ahmadi, Arezoo / Soleimani, Abbas / Ashraf, Haleh

    Journal of cardiovascular and thoracic research

    2022  Volume 14, Issue 4, Page(s) 253–257

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2022-11-26
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2654729-6
    ISSN 2008-6830 ; 2008-5117
    ISSN (online) 2008-6830
    ISSN 2008-5117
    DOI 10.34172/jcvtr.2022.30559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Association between Acute Cardiac Injury and Outcomes of Hospitalized Patients with COVID-19: Long-Term Follow-up Results from the Sina Hospital COVID-19 Registry, Iran.

    Soltani, Danesh / Hadadi, Azar / Karbalai Saleh, Shahrokh / Oraii, Alireza / Sadatnaseri, Azadeh / Roozitalab, Mostafa / Shajari, Zahra / Ghaemmaghami, Shima Sadat / Ashraf, Haleh

    The journal of Tehran Heart Center

    2023  Volume 18, Issue 3, Page(s) 196–206

    Abstract: Background: The present study aimed to investigate the association between acute cardiac injury (ACI) and outcomes in hospitalized patients with coronavirus disease 2019 (COVID-19) in Iran.: Methods: The current cohort study enrolled all consecutive ... ...

    Abstract Background: The present study aimed to investigate the association between acute cardiac injury (ACI) and outcomes in hospitalized patients with coronavirus disease 2019 (COVID-19) in Iran.
    Methods: The current cohort study enrolled all consecutive hospitalized patients with COVID-19 (≥ 18 y) who had serum high-sensitivity cardiac troponin-I (hs-cTnT) measurements on admission between March 2020 and March 2021. ACI was determined as hs-cTnT levels exceeding the 99th percentile of normal values. Data on demographics, comorbidities, clinical and laboratory characteristics, and outcomes were collected from Web-based electronic health records.
    Results: The study population consisted of 1413 hospitalized patients with COVID-19, of whom 319 patients (22.58%) presented with ACI. The patients with ACI had a significantly higher mortality rate than those without ACI (48.28% vs 15.63%; P<0.001) within a mean follow-up of 218.86 days from symptom onset. ACI on admission was independently associated with mortality (HR, 1.44; P=0.018). In multivariable logistic regression, age (OR, 1.034; P<0.001), preexisting cardiac disease (OR, 1.49; P=0.035), preexisting malignancy (OR, 2.01; P=0.030), oxygen saturation reduced to less than 90% (OR, 2.15; P<0.001), leukocytosis (OR, 1.45; P=0.043), lymphopenia (OR, 1.49; P=0.020), reduced estimated glomerular filtration rates (eGFRs) (OR, 0.99; P=0.008), and treatment with intravenous immunoglobulin during hospitalization (OR, 4.03; P=0.006) were independently associated with ACI development.
    Conclusion: ACI occurrence on admission was associated with long-term mortality in our hospitalized patients with COVID-19. The finding further underscores the significance of evaluating ACI occurrence on admission, particularly in individuals more prone to ACI, including older individuals and those with preexisting comorbidities, reduced oxygen saturation, and increased inflammatory responses.
    Language English
    Publishing date 2023-12-21
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2476998-8
    ISSN 2008-2371 ; 1735-5370 ; 1735-8620
    ISSN (online) 2008-2371
    ISSN 1735-5370 ; 1735-8620
    DOI 10.18502/jthc.v18i3.14114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 in Iran: clinical presentations and outcomes in three different surges of COVID-19 infection

    Hadadi, Azar / Pirzadeh, Marzieh / Kazemian, Sina / Ashraf, Haleh / Ebrahimi, Mehdi / Karbalai Saleh, Shahrokh / Talebpour, Mohammad

    Virol J. 2022 Dec., v. 19, no. 1 p.123-123

    2022  

    Abstract: BACKGROUND: A few studies compared the characteristics and outcomes of COVID-19 patients during the first and second surges of the disease. We aimed to describe the clinical features and outcomes of COVID-19 patients across the first, second, and third ... ...

    Abstract BACKGROUND: A few studies compared the characteristics and outcomes of COVID-19 patients during the first and second surges of the disease. We aimed to describe the clinical features and outcomes of COVID-19 patients across the first, second, and third surges of the disease in Tehran, Iran. METHOD: We conducted a retrospective cohort study of patients with COVID-19 admitted to Sina hospital in Tehran, Iran, during three surges of COVID-19 from February 16 to October 28, 2020. RESULT: Surge 1 patients were younger with more prevalence of hypertension. They also presented with significantly higher oxygen saturation, systolic blood pressure, and respiratory rate on admission. Patients had higher levels of neutrophil to lymphocyte ratio, Urea, CRP, and ESR, in surge 2. The incidence of dyspnea, chest pain, and neurological manifestations followed a significant increasing trend from surge 1 to surge 3. There was no difference in severity and in-hospital mortality between the surges. However, the length of hospital stays and acute cardiac injury (ACI) was less in surge 1 and acute respiratory distress syndrome (ARDS) in surge 2 than in other surges. CONCLUSION: Patients did not significantly differ in disease severity, ICU admission, and mortality between surges; however, length of hospital stay and ACI increased during surges, and the number of patients developing ARDS was significantly less in surge 2 compared to other peaks.
    Keywords COVID-19 infection ; acute respiratory distress syndrome ; chest ; cohort studies ; disease severity ; dyspnea ; hospitals ; hypertension ; mortality ; neutrophils ; oxygen ; pain ; respiratory rate ; systolic blood pressure ; urea ; Iran
    Language English
    Dates of publication 2022-12
    Size p. 123.
    Publishing place BioMed Central
    Document type Article ; Online
    ZDB-ID 2160640-7
    ISSN 1743-422X
    ISSN 1743-422X
    DOI 10.1186/s12985-022-01846-7
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: The face of hypervirulent Klebsiella pneumoniae isolated from clinical samples of two Iranian teaching hospitals.

    Sanikhani, Rahimeh / Moeinirad, Mohammad / Solgi, Hamid / Hadadi, Azar / Shahcheraghi, Fereshteh / Badmasti, Farzad

    Annals of clinical microbiology and antimicrobials

    2021  Volume 20, Issue 1, Page(s) 58

    Abstract: Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a pathogen of global concern. In this study, both phenotypic and genotypic tests were used to detect hvKp. Antimicrobial resistance profiles and clonal relatedness of clinical isolates were also ... ...

    Abstract Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a pathogen of global concern. In this study, both phenotypic and genotypic tests were used to detect hvKp. Antimicrobial resistance profiles and clonal relatedness of clinical isolates were also determined. We found that 34.2% (163/477) of the isolates were tellurite resistant, and among them 102 hvKp isolates detected with iucA or iutA or peg-344 as molecular markers. The bla
    MeSH term(s) Drug Resistance, Bacterial ; Hospitals, Teaching ; Humans ; Iran/epidemiology ; Klebsiella Infections/diagnosis ; Klebsiella Infections/epidemiology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/isolation & purification ; Klebsiella pneumoniae/pathogenicity ; Microbial Sensitivity Tests ; Virulence Factors/genetics
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2021-08-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097873-X
    ISSN 1476-0711 ; 1476-0711
    ISSN (online) 1476-0711
    ISSN 1476-0711
    DOI 10.1186/s12941-021-00467-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rationale and Design of a Registry in a Referral and Educational Medical Center in Tehran, Iran

    Talebpour, Mohammad / Hadadi, Azar / Oraii, Alireza / Ashraf, Haleh

    Advanced Journal of Emergency Medicine; In press ; 2588-400X

    Sina Hospital Covid-19 Registry (SHCo-19R)

    2020  

    Abstract: Coronavirus disease 2019 (Covid-19) is caused by the novel coronavirus resulting in a highly contagious respiratory tract infection with an increased risk of acute respiratory distress syndrome (ARDS), which was first seen in Wuhan, China. Thus far, this ...

    Abstract Coronavirus disease 2019 (Covid-19) is caused by the novel coronavirus resulting in a highly contagious respiratory tract infection with an increased risk of acute respiratory distress syndrome (ARDS), which was first seen in Wuhan, China. Thus far, this virus has spread to many countries worldwide, including Iran. Multiple studies have assessed disease characteristics, viral genetics, and complications of Covid-19 in the Chinese population. However, there is limited data regarding patient characteristics and outcomes of infected cases outside of China. Besides, risk factors of adverse outcomes are poorly identified in different populations. Due to limited data in the Iranian population affected by the virus, we aimed to design a registry of patients with Covid-19 at Sina Hospital in Tehran, Iran [Sina Hospital Covid-19 Registry (SHCo-19R)] in this regard, to assess patient characteristics, imaging features, laboratory findings, management strategies, and adverse outcomes of Iranian patients with Covid-19 and their differences with other populations.
    Keywords covid19
    Language English
    Publishing date 2020-03-22
    Publisher Tehran University of Medical Sciences
    Publishing country ir
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Rationale and Design of a Registry in a Referral and Educational Medical Center in Tehran, Iran: Sina Hospital Covid-19 Registry (SHCo-19R)

    Talebpour, Mohammad / Hadadi, Azar / Oraii, Alireza / Ashraf, Haleh

    Advanced Journal of Emergency Medicine

    Abstract: Coronavirus disease 2019 (Covid-19) is caused by the novel coronavirus resulting in a highly contagious respiratory tract infection with an increased risk of acute respiratory distress syndrome (ARDS), which was first seen in Wuhan, China Thus far, this ... ...

    Abstract Coronavirus disease 2019 (Covid-19) is caused by the novel coronavirus resulting in a highly contagious respiratory tract infection with an increased risk of acute respiratory distress syndrome (ARDS), which was first seen in Wuhan, China Thus far, this virus has spread to many countries worldwide, including Iran Multiple studies have assessed disease characteristics, viral genetics, and complications of Covid-19 in the Chinese population However, there is limited data regarding patient characteristics and outcomes of infected cases outside of China Besides, risk factors of adverse outcomes are poorly identified in different populations Due to limited data in the Iranian population affected by the virus, we aimed to design a registry of patients with Covid-19 at Sina Hospital in Tehran, Iran [Sina Hospital Covid-19 Registry (SHCo-19R)] in this regard, to assess patient characteristics, imaging features, laboratory findings, management strategies, and adverse outcomes of Iranian patients with Covid-19 and their differences with other populations
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #679453
    Database COVID19

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  8. Article: Does recombinant human erythropoietin administration in critically ill COVID-19 patients have miraculous therapeutic effects?

    Hadadi, Azar / Mortezazadeh, Masoud / Kolahdouzan, Kasra / Alavian, Golbarg

    J Med Virol

    Abstract: An 80-year-old man with multiple comorbidities presented to the emergency department with tachypnea, tachycardia, fever, and critically low O2 saturation and definitive chest computerized tomography scan findings in favor of COVID-19 and positive PCR ... ...

    Abstract An 80-year-old man with multiple comorbidities presented to the emergency department with tachypnea, tachycardia, fever, and critically low O2 saturation and definitive chest computerized tomography scan findings in favor of COVID-19 and positive PCR results in 48 hours. He received antiviral treatment plus recombinant human erythropoietin (rhEPO) due to his severe anemia. After 7 days of treatment, he was discharged with miraculous improvement in his symptoms and hemoglobin level. We concluded that rhEPO could attenuate respiratory distress syndrome and confront the severe acute respiratory syndrome coronavirus 2 virus through multiple mechanisms including cytokine modulation, antiapoptotic effects, leukocyte release from bone marrow, and iron redistribution away from the intracellular virus.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #47259
    Database COVID19

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  9. Article ; Online: Rationale and Design of a Registry in a Referral and Educational Medical Center in Tehran, Iran

    Talebpour, Mohammad / Hadadi, Azar / Oraii, Alireza / Ashraf, Haleh

    Advanced Journal of Emergency Medicine; Vol 4 No 2s (2020): COVID-19; e53 ; 2588-400X ; 10.22114/ajem.v4i2s

    Sina Hospital Covid-19 Registry (SHCo-19R)

    2020  

    Abstract: Coronavirus disease 2019 (Covid-19) is caused by the novel coronavirus resulting in a highly contagious respiratory tract infection with an increased risk of acute respiratory distress syndrome (ARDS), which was first seen in Wuhan, China. Thus far, this ...

    Abstract Coronavirus disease 2019 (Covid-19) is caused by the novel coronavirus resulting in a highly contagious respiratory tract infection with an increased risk of acute respiratory distress syndrome (ARDS), which was first seen in Wuhan, China. Thus far, this virus has spread to many countries worldwide, including Iran. Multiple studies have assessed disease characteristics, viral genetics, and complications of Covid-19 in the Chinese population. However, there is limited data regarding patient characteristics and outcomes of infected cases outside of China. Besides, risk factors of adverse outcomes are poorly identified in different populations. Due to limited data in the Iranian population affected by the virus, we aimed to design a registry of patients with Covid-19 at Sina Hospital in Tehran, Iran [Sina Hospital Covid-19 Registry (SHCo-19R)] in this regard, to assess patient characteristics, imaging features, laboratory findings, management strategies, and adverse outcomes of Iranian patients with Covid-19 and their differences with other populations.
    Keywords covid19
    Language English
    Publishing date 2020-03-22
    Publisher Tehran University of Medical Sciences
    Publishing country ir
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Does recombinant human erythropoietin administration in critically ill COVID‐19 patients have miraculous therapeutic effects?

    Hadadi, Azar / Mortezazadeh, Masoud / Kolahdouzan, Kasra / Alavian, Golbarg

    Journal of Medical Virology

    2020  Volume 92, Issue 7, Page(s) 915–918

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25839
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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