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  1. Article ; Online: Preliminary

    Hadda, Zebiri / Hélène, Van Den Berghe / Tom, Paunet / Aurélie, Wolf-Mandroux / Audrey, Bethry / Hubert, Taillades / Noël, Yohan Jean / Pirot, Nelly / Catherine, Botteron / Michel, Chammas / Pierre-Emmanuel, Chammas / Xavier, Garric

    Biomaterials science

    2022  Volume 10, Issue 7, Page(s) 1776–1786

    Abstract: Peritendinous adhesions are complications known to occur up to 6 weeks after surgery and cause chronic pain and disability. Anti-adhesion barriers are currently the best option for prevention. In a previous study, we designed two biodegradable membranes, ...

    Abstract Peritendinous adhesions are complications known to occur up to 6 weeks after surgery and cause chronic pain and disability. Anti-adhesion barriers are currently the best option for prevention. In a previous study, we designed two biodegradable membranes, D-PACO1 and D-PACO
    MeSH term(s) Achilles Tendon/pathology ; Achilles Tendon/surgery ; Animals ; Polyesters ; Polymers ; Rats ; Tissue Adhesions/prevention & control ; Wound Healing
    Chemical Substances Polyesters ; Polymers
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d1bm01150b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Preliminary in vivo study of biodegradable PLA–PEU–PLA anti-adhesion membranes in a rat Achilles tendon model of peritendinous adhesions

    Hadda, Zebiri / Hélène, Van Den Berghe / Tom, Paunet / Aurélie, Wolf-Mandroux / Audrey, Bethry / Hubert, Taillades / Noël, Yohan Jean / Pirot, Nelly / Catherine, Botteron / Michel, Chammas / Pierre-Emmanuel, Chammas / Xavier, Garric

    Biomaterials science. 2022 Mar. 29, v. 10, no. 7

    2022  

    Abstract: Peritendinous adhesions are complications known to occur up to 6 weeks after surgery and cause chronic pain and disability. Anti-adhesion barriers are currently the best option for prevention. In a previous study, we designed two biodegradable membranes, ...

    Abstract Peritendinous adhesions are complications known to occur up to 6 weeks after surgery and cause chronic pain and disability. Anti-adhesion barriers are currently the best option for prevention. In a previous study, we designed two biodegradable membranes, D-PACO1 and D-PACO₂, based on new triblock copolymers and conducted in vitro evaluations. The membranes maintained filmogenic integrity, had degradation rates that promoted anti-adhesion and were biocompatible, suggesting their safe and effective use as anti-adhesion devices. To test this hypothesis, we conducted a preliminary in vivo study in a rat model of peritendinous adhesions and evaluated the membranes’ degradation rates, tendon healing and anti-adhesion effect compared to non-surgical and surgical control groups 2 and 10 weeks after surgery. Macroscopic evaluation showed membranes were effective in reducing the extent and severity of adhesions. Membranes acted as physical barriers at 2 weeks and underwent a complete or significant biodegradation at 10 weeks. D-PACO₂ had a longer degradation rate compared to D-PACO1, was more effective in reducing adhesions and is expected to be more effective in promoting tendon healing. The tendency of D-PACO1 to promote tendon healing while D-PACO₂ did not interfere with healing highlights the need to redesign the porosity of the D-PACO membranes for optimal nutrient diffusion, while maintaining their anti-adhesion effect and clinical usability. Preliminary findings revealed that adhesions form beyond the 6 weeks cited in the literature. In this study, adhesion formation continued for up to 10 weeks, underlining the need to increase the experimental period and sample size of future experiments evaluating anti-adhesion membranes.
    Keywords Achilles tendon ; adhesion ; animal models ; biocompatible materials ; biodegradability ; biodegradation ; composite polymers ; pain ; porosity ; rats ; sample size ; surgery
    Language English
    Dates of publication 2022-0329
    Size p. 1776-1786.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d1bm01150b
    Database NAL-Catalogue (AGRICOLA)

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    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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