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  1. Article ; Online: Immunodeficiency secondary to biologics.

    Labrosse, Roxane / Haddad, Elie

    The Journal of allergy and clinical immunology

    2023  Volume 151, Issue 3, Page(s) 686–690

    MeSH term(s) Humans ; Biological Products ; Immunosuppressive Agents ; Immunologic Deficiency Syndromes
    Chemical Substances Biological Products ; Immunosuppressive Agents
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.01.012
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.92: Show issues Location:
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  2. Article ; Online: Diagnosis and treatment of cervical spine injuries in children.

    Haddad, Elie / Al Khoury Salem, Hassan / Dohin, Bruno

    Orthopaedics & traumatology, surgery & research : OTSR

    2023  Volume 110, Issue 1S, Page(s) 103762

    Abstract: Cervical spine injuries in children are a common reason for emergency room visits, while bone, ligament or spinal cord cervical lesions are relatively rare (1-1.5% of severe trauma in children) and mainly involve the upper cervical spine. The main causes ...

    Abstract Cervical spine injuries in children are a common reason for emergency room visits, while bone, ligament or spinal cord cervical lesions are relatively rare (1-1.5% of severe trauma in children) and mainly involve the upper cervical spine. The main causes are sports injuries, accidents at home and traffic accidents. Clinical triage is needed to avoid unnecessary radiation exposure from imaging. We propose a protocol to optimize the diagnosis and treatment. In children, conservative treatment using rigid immobilization (cervical collar or halo-vest) is the preferred option in stable and/or minimally displaced injuries. Frequent clinical and radiological monitoring is required to ensure the patient's condition does not deteriorate due to inappropriate or poorly tolerated treatment. In these cases, surgical treatment can be proposed as second-line treatment. Internal fixation is indicated as the first-line treatment if the injury is unstable or a neurological deficit is present. The fixation methods must be adapted to the pediatric population by taking into account the vertebral volume and residual growth potential. Intraoperative CT scans or neuronavigation can make the surgical procedure safer and easier. Clinical, radiographic and CT scan monitoring should continue until the end of growth in a child who underwent surgical treatment to quickly detect any mechanical complications or sagittal imbalance due to poor craniocervical or cervicothoracic alignment. LEVEL OF EVIDENCE: IV.
    MeSH term(s) Humans ; Child ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/surgery ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Cervical Vertebrae/injuries ; Radiography ; Tomography, X-Ray Computed ; Fracture Fixation, Internal/methods ; Spinal Injuries/diagnostic imaging ; Spinal Injuries/surgery
    Language English
    Publishing date 2023-11-20
    Publishing country France
    Document type Journal Article ; Review
    ISSN 1877-0568
    ISSN (online) 1877-0568
    DOI 10.1016/j.otsr.2023.103762
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  3. Article ; Online: STAT3: too much may be worse than not enough!

    Haddad, Elie

    Blood

    2015  Volume 125, Issue 4, Page(s) 583–584

    MeSH term(s) Autoimmune Diseases/genetics ; Female ; Genetic Diseases, Inborn/genetics ; Humans ; Lymphoproliferative Disorders/genetics ; Male ; STAT3 Transcription Factor/genetics
    Chemical Substances STAT3 Transcription Factor ; STAT3 protein, human
    Language English
    Publishing date 2015-01-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2014-11-610592
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    Zs.MO 364: Show issues

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  4. Article: Low Morbidity Anatomical Revascularisation for an Infected Aorto-Bifemoral Graft Using a Staged Hybrid Procedure.

    Ding, Joel / Farah, Sam / Haddad, Elie / Last, Graeme C / Lahham, Yahya

    Cureus

    2023  Volume 15, Issue 3, Page(s) e36805

    Abstract: A 66-year-old woman presented with a right femoral false aneurysm following an aortobifemoral bypass for lifestyle-limiting claudication. A computed tomography (CT) angiogram revealed features of complete aortobifemoral graft infection. A two-stage ... ...

    Abstract A 66-year-old woman presented with a right femoral false aneurysm following an aortobifemoral bypass for lifestyle-limiting claudication. A computed tomography (CT) angiogram revealed features of complete aortobifemoral graft infection. A two-stage procedure was performed. The first hybrid stage involved the excision of only the femoral components and covered stenting of the aortic stump, along with recanalization of bilateral native iliac systems. The second stage, six weeks later, involved aortic stent and graft explant via midline laparotomy with aortic bovine pericardium patch repair (LeMaitre Vascular Inc, Burlington, Massachusetts). Follow-up imaging demonstrated no residual infection, and the patient remained without complication at the 12-month follow-up. This novel approach utilizes hybrid surgical techniques and modern bioprosthetic material to safely manage an infected aortobifemoral bypass graft.
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.36805
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  5. Article ; Online: Correction to: PEGylated Recombinant Adenosine Deaminase Maintains Detoxification and Lymphocyte Counts in Patients with ADA-SCID.

    Dorsey, Morna J / Rubinstein, Arye / Lehman, Heather / Fausnight, Tracy / Wiley, Joseph M / Haddad, Elie

    Journal of clinical immunology

    2023  Volume 43, Issue 7, Page(s) 1671–1672

    Language English
    Publishing date 2023-06-09
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-023-01531-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1640: Show issues Location:
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  6. Article ; Online: PEGylated Recombinant Adenosine Deaminase Maintains Detoxification and Lymphocyte Counts in Patients with ADA-SCID.

    Dorsey, Morna J / Rubinstein, Arye / Lehman, Heather / Fausnight, Tracy / Wiley, Joseph M / Haddad, Elie

    Journal of clinical immunology

    2023  Volume 43, Issue 5, Page(s) 951–964

    Abstract: Purpose: Metabolic detoxification with enzyme replacement therapy (ERT) promotes immune recovery in patients with adenosine deaminase (ADA)-deficient severe combined immunodeficiency (ADA-SCID). Elapegademase is a PEGylated recombinant bovine ADA ERT ... ...

    Abstract Purpose: Metabolic detoxification with enzyme replacement therapy (ERT) promotes immune recovery in patients with adenosine deaminase (ADA)-deficient severe combined immunodeficiency (ADA-SCID). Elapegademase is a PEGylated recombinant bovine ADA ERT developed to replace the now-discontinued bovine-derived pegademase. This study was a 1-way crossover from pegademase to elapegademase in 7 patients with ADA-SCID to assess efficacy and safety outcomes for elapegademase.
    Methods: After once-weekly pegademase dosage was adjusted to achieve therapeutic metabolic detoxification and trough ADA activity, patients transitioned to a bioequivalent dose of elapegademase. Maintenance of metabolic detoxification and adequate ADA activity were evaluated periodically.
    Results: One patient withdrew after 2 doses of an early elapegademase formulation due to injection-site pain caused by EDTA. The 6 remaining patients completed 71-216 weeks of elapegademase therapy with a formulation that did not contain EDTA. In these patients, elapegademase improved ADA activity compared with pegademase and maintained metabolic detoxification. Total lymphocyte counts increased for all completer patients from between 1.2- and 2.1-fold at the end of study compared with baseline. Elapegademase had a comparable safety profile to pegademase; no patient developed a severe infectious complication. Three patients had transient, non-neutralizing antibodies to pegademase, elapegademase, and/or polyethylene glycol ≤ 47 weeks of treatment without effect on trough plasma ADA activity or trough erythrocyte deoxyadenosine nucleotide levels.
    Conclusion: Elapegademase was safe, well tolerated, achieved stable trough plasma ADA activity with weekly dosing, was effective in maintaining metabolic detoxification, and was associated with maintenance or improvements in lymphocyte counts compared with pegademase therapy in patients with ADA-SCID.
    MeSH term(s) Humans ; Animals ; Cattle ; Adenosine Deaminase ; Edetic Acid/therapeutic use ; Severe Combined Immunodeficiency ; Lymphocyte Count ; Polyethylene Glycols/therapeutic use
    Chemical Substances Adenosine Deaminase (EC 3.5.4.4) ; Edetic Acid (9G34HU7RV0) ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2023-02-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-022-01426-y
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    Zs.A 1640: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: A novel variant in caspase recruitment domain family member 11 highlights the variability of clinical manifestations and management in a three generation family.

    Cros, Guilhem / Chapdelaine, Hugo / Teira, Pierre / Fernandez, Isabel / Pastore, Yves / Haddad, Elie / Touzot, Fabien

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 10, Page(s) 3265–3268

    MeSH term(s) Humans ; CARD Signaling Adaptor Proteins ; Caspase Activation and Recruitment Domain ; Family
    Chemical Substances CARD Signaling Adaptor Proteins ; CARD11 protein, human (EC 4.6.1.2)
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.06.041
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    Zs.A 7086: Show issues Location:
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  8. Article: Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID).

    Haddad, Elie / Hoenig, Manfred

    Frontiers in pediatrics

    2019  Volume 7, Page(s) 481

    Abstract: Severe Combined Immunodeficiencies (SCID) are a heterogeneous group of monogenetic diseases. We describe the typical clinical presentation of patients with SCID as well as basic principles in diagnosis and therapy by hematopoietic stem cell ... ...

    Abstract Severe Combined Immunodeficiencies (SCID) are a heterogeneous group of monogenetic diseases. We describe the typical clinical presentation of patients with SCID as well as basic principles in diagnosis and therapy by hematopoietic stem cell transplantation. Therapeutic strategies may differ between subtypes and the inherent reduced capacity or inablility to reject a graft have to be considered.
    Language English
    Publishing date 2019-11-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2019.00481
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  9. Article ; Online: Ultrasound as a Tool for Initial Diagnosis of Bone Lesions in Children Has Good Predictive Values: A Prospective Study From a University Hospital.

    Choukri, Kaoutar / Haddad, Elie / Al Khouri Salem, Hassan / Boutet, Claire / Leveques, Virginie / Mteirek, Ahmad / Philbois, Olivier / Scalabre, Aurélien / Cantais, Aymeric

    Clinical pediatrics

    2024  , Page(s) 99228241241894

    Abstract: Pediatric bone injuries are traditionally diagnosed using radiography. However, ultrasonography is emerging as an alternative due to its speed and minimal invasiveness. This study assessed the diagnostic capabilities of ultrasound before radiography in a ...

    Abstract Pediatric bone injuries are traditionally diagnosed using radiography. However, ultrasonography is emerging as an alternative due to its speed and minimal invasiveness. This study assessed the diagnostic capabilities of ultrasound before radiography in a group of 186 children with suspected long bone fractures at Saint Etienne University Hospital (Saint-Priest-en-Jarez, France). Patients with open trauma and severe deformity were excluded. Ultrasonography demonstrated 88.2% sensitivity and 86.4% specificity, with better results for forearm injuries. Of the 186 cases, 162 were consistent with radiography and 24 varied. Factors influencing an accurate diagnosis included the presence of indirect signs, operator experience, and examination duration, while indirect signs often led to misinterpretation. Although ultrasound cannot completely replace radiography due to its limitations in identifying deeper fractures, this study revealed its substantial efficacy and ease, supporting its potential utility in pediatric trauma emergencies.
    Language English
    Publishing date 2024-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/00099228241241894
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    Zs.A 454: Show issues Location:
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  10. Article ; Online: Breaking barriers: Assessing pre-exposure prophylaxis awareness and willingness to use in the Lebanese community.

    Azzi, Akel / Chartouni, Carine / Ibrahim, Racha / Chebel, Zeina Bou / Haddad, Elie / Chehata, Nabil / Choucair, Jacques / Saliba, Gebrael

    International journal of STD & AIDS

    2024  , Page(s) 9564624241240799

    Abstract: Background: In the evolving HIV landscape, the Middle East and Northern Africa (MENA) grapples with data gaps, hindering the 95-95-95 targets. Lebanon, despite progress, falls short. Our study addresses Pre-exposure Prophylaxis (PrEP) gaps for effective ...

    Abstract Background: In the evolving HIV landscape, the Middle East and Northern Africa (MENA) grapples with data gaps, hindering the 95-95-95 targets. Lebanon, despite progress, falls short. Our study addresses Pre-exposure Prophylaxis (PrEP) gaps for effective HIV prevention.
    Methods: Surveying 410 participants via snowball sampling and an online questionnaire, we analyzed data with chi-square and regression over 5 months for insights into PrEP awareness and readiness.
    Results: Summarizing the pivotal statistical outcomes of the study, 22.2% reported awareness of PrEP, showcasing diverse knowledge levels about its purpose and usage. Out of them, 57.1% expressed a willingness to use it; while a mere 5.5% have utilized it. The study reveals diverse demographic profiles, with age influencing PrEP awareness and willingness to use. Positive correlations exist between PrEP discussions within social circles, increased information availability, and elevated willingness. Financial considerations and accessibility at pharmacies emerge as critical determinants, guiding the development of targeted interventions.
    Conclusions: This analysis emphasizes tailored education, community initiatives, and policy enhancements to address PrEP challenges in Lebanon. Guiding public health initiatives, our study considers age, social dynamics, education, and accessibility in HIV prevention.
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/09564624241240799
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