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  1. Article ; Online: A rare case of reversible splenial lesion in third trimester

    Haddad Saif, MBChB BSc(Hons) MRCP (UK) / Athinodoros Valavanis, MD PHD / Declan Johnson, MbChB MRCP

    Radiology Case Reports, Vol 16, Iss 10, Pp 3081-

    2021  Volume 3083

    Abstract: A 38-year-old female presented with sensory, motor and sphincter deficit in her third trimester. MRI brain demonstrated a focal lesion in the splenium of the corpus callosum which restricted to diffusion. Her symptoms subsequently improved following ... ...

    Abstract A 38-year-old female presented with sensory, motor and sphincter deficit in her third trimester. MRI brain demonstrated a focal lesion in the splenium of the corpus callosum which restricted to diffusion. Her symptoms subsequently improved following delivery. Repeat Imaging showed near complete resolution of lesion. It is important to be aware of this rare entity to avoid unnecessary investigations and interventions.
    Keywords Neuroimaging < Neurology ; Pregnancy < Obstetrics and gynaecology ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: New-onset refractory status epilepticus responsive to VNS: A case report.

    Rodriguez-Villar, Sancho / Ahmed, Mohamed Ahmed / Haddad, Saif / Mantoan, Laura / Singh, Neeraj / Mahdi-Roger, Mohamed / Stavropoulos, Ioannis / Selway, Richard / Valentin, Antonio

    Epileptic disorders : international epilepsy journal with videotape

    2023  Volume 25, Issue 4, Page(s) 571–574

    MeSH term(s) Humans ; Status Epilepticus/diagnosis ; Status Epilepticus/therapy ; Vagus Nerve Stimulation
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2086797-9
    ISSN 1950-6945 ; 1294-9361
    ISSN (online) 1950-6945
    ISSN 1294-9361
    DOI 10.1002/epd2.20064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5740: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Financial implications of laparoscopic hot gallbladder service in a nontertiary District General Hospital.

    Bhattacharya, Sayantan / Richardson, Tom / Naidoo, Gerlin / Gillick, Kieran / Haddad, Saif / Ghosh, Chandrima / Brereton, Paula

    The International journal of health planning and management

    2018  Volume 33, Issue 4, Page(s) e1014–e1021

    Abstract: Introduction: The service of providing index admission laparoscopic cholecystectomy (IALC), as recommended by NIC guidelines, often falls short in nontertiary centres because of a combination of limited resources and financial constraints.: Methods: ... ...

    Abstract Introduction: The service of providing index admission laparoscopic cholecystectomy (IALC), as recommended by NIC guidelines, often falls short in nontertiary centres because of a combination of limited resources and financial constraints.
    Methods: This retrospective study in a single-centre District General Hospital included 50 patients, eligible to undergo IALC, and calculated potential savings from performing IALC on the day of admission by considering admission tariffs, bed, and operating costs.
    Results: The IALC was provided in 19 patients (38%), with a mean delay from admission to operation of (median) 3 days. Mean surplus tariff was £1421 and £1571 in IALC and non-IALC groups, respectively. Performing immediate IALC (on the day of admission) for acute cholecystitis (AC) is predicted to increase mean surplus tariff to £2132 per patient, raising total predicted annual surplus by £53 000. Immediate IALC is also predicted to reduce waiting time for day-case LC by freeing up 53 day-case slots, attracting additional £95 600 annually, along with freeing up many inpatient bed days.
    Conclusions: This study demonstrates that reduction of preoperative stay in AC by expediting operations in every eligible patient promises significant surplus revenue. Additional advantages include reducing inpatient bed days and freeing up operating lists that are otherwise taken up by patients for interval cholecystectomy.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cholecystectomy, Laparoscopic/economics ; Cholecystitis/economics ; Cholecystitis/surgery ; Female ; Hospital Costs/statistics & numerical data ; Hospitals, District/economics ; Hospitals, General/economics ; Humans ; Length of Stay/economics ; Male ; Middle Aged ; Retrospective Studies
    Language English
    Publishing date 2018-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 632786-2
    ISSN 1099-1751 ; 0749-6753
    ISSN (online) 1099-1751
    ISSN 0749-6753
    DOI 10.1002/hpm.2579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2897: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination.

    Ayuso-García, Paula / Sánchez-Rueda, Alejandro / Velasco-Avilés, Sergio / Tamayo-Caro, Miguel / Ferrer-Pinós, Aroa / Huarte-Sebastian, Cecilia / Alvarez, Vanesa / Riobello, Cristina / Jiménez-Vega, Selene / Buendia, Izaskun / Cañas-Martin, Jorge / Fernández-Susavila, Héctor / Aparicio-Rey, Adrián / Esquinas-Román, Eva M / Ponte, Carlos Rodríguez / Guhl, Romane / Laville, Nicolas / Pérez-Andrés, Encarni / Lavín, José L /
    González-Lopez, Monika / Cámara, Nuria Macías / Aransay, Ana M / Lozano, Juan José / Sutherland, James D / Barrio, Rosa / Martinez-Chantar, María Luz / Azkargorta, Mikel / Elortza, Félix / Soriano-Navarro, Mario / Matute, Carlos / Sánchez-Gómez, María Victoria / Bayón-Cordero, Laura / Pérez-Samartín, Alberto / Bravo, Susana B / Kurz, Thimo / Lama-Díaz, Tomas / Blanco, Miguel G / Haddad, Saif / Record, Christopher J / van Hasselt, Peter M / Reilly, Mary M / Varela-Rey, Marta / Woodhoo, Ashwin

    Science advances

    2024  Volume 10, Issue 15, Page(s) eadm7600

    Abstract: Myelination is essential for neuronal function and health. In peripheral nerves, >100 causative mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder that can affect myelin sheaths. Among these, a number of mutations are ... ...

    Abstract Myelination is essential for neuronal function and health. In peripheral nerves, >100 causative mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder that can affect myelin sheaths. Among these, a number of mutations are related to essential targets of the posttranslational modification neddylation, although how these lead to myelin defects is unclear. Here, we demonstrate that inhibiting neddylation leads to a notable absence of peripheral myelin and axonal loss both in developing and regenerating mouse nerves. Our data indicate that neddylation exerts a global influence on the complex transcriptional and posttranscriptional program by simultaneously regulating the expression and function of multiple essential myelination signals, including the master transcription factor EGR2 and the negative regulators c-Jun and Sox2, and inducing global secondary changes in downstream pathways, including the mTOR and YAP/TAZ signaling pathways. This places neddylation as a critical regulator of myelination and delineates the potential pathogenic mechanisms involved in CMT mutations related to neddylation.
    MeSH term(s) Animals ; Mice ; Schwann Cells ; Myelin Sheath/genetics ; Charcot-Marie-Tooth Disease/genetics ; Mutation ; Protein Processing, Post-Translational
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adm7600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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