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  1. Article ; Online: The epistemic harms of direct-to-consumer genetic tests.

    Haddad, Yasmin

    Medicine, health care, and philosophy

    2023  Volume 26, Issue 4, Page(s) 559–571

    Abstract: In this paper, I provide an epistemic evaluation of the harms that result from the widespread marketing of direct-to-consumer (DTC) genetic tests. While genetic tests are a valuable accessory diagnostic tool when ordered by a medical practitioner, there ... ...

    Abstract In this paper, I provide an epistemic evaluation of the harms that result from the widespread marketing of direct-to-consumer (DTC) genetic tests. While genetic tests are a valuable accessory diagnostic tool when ordered by a medical practitioner, there are different implications when they are sold directly to consumers. I aim to show that there are both epistemic and non-epistemic harms associated with the widespread commoditization of DTC genetic tests. I argue that the epistemic harms produced by DTC genetic tests have been disregarded in discussions on the topic. Drawing on the notion of contributory epistemic injustices, I highlight two pertinent epistemic harms: (1) a failure to uptake an individual's articulations about their identity and (2) the presiding reductionist framework dismisses useful hermeneutical resources. I then propose ways to mitigate these harms.
    MeSH term(s) Humans ; Genetic Testing ; Direct-To-Consumer Screening and Testing ; Health Personnel
    Language English
    Publishing date 2023-07-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440052-2
    ISSN 1572-8633 ; 1386-7423
    ISSN (online) 1572-8633
    ISSN 1386-7423
    DOI 10.1007/s11019-023-10164-w
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  2. Article ; Online: A systematic review and meta-analysis of randomized controlled trials comparing arthrocentesis with conservative management for painful temporomandibular joint disorder.

    Thorpe, A R D S / Haddad, Y / Hsu, J

    International journal of oral and maxillofacial surgery

    2023  Volume 52, Issue 8, Page(s) 889–896

    Abstract: The aim of this study was to determine whether arthrocentesis is superior to conservative treatment in the management of painful temporomandibular joint disorders with restricted opening. A systematic review was undertaken of prospective randomized ... ...

    Abstract The aim of this study was to determine whether arthrocentesis is superior to conservative treatment in the management of painful temporomandibular joint disorders with restricted opening. A systematic review was undertaken of prospective randomized controlled trials (RCT) comparing arthrocentesis to conservative management, identified in the MEDLINE and PubMed databases. Inclusion criteria included a 6-month follow-up, with clinical assessment of the patients and painful restricted mouth opening. Data extracted included pain measured on a visual analogue scale and maximum mouth opening measured in millimetres. Risk of bias was assessed using the Cochrane Risk of Bias Tool 2 for RCTs, and a meta-analysis with the random-effects model was undertaken. Of 879 records retrieved, seven met the inclusion criteria; these RCTs reported the results at 6 months for 448 patients. One study had a low risk of bias, four studies had an uncertain risk, and two had a high risk of bias. In the meta-analysis, arthrocentesis was statistically superior to conservative management at 6 months for an increase in maximum mouth opening (1.12 mm, 95% confidence interval 0.45-1.78 mm; P = 0.001; I
    MeSH term(s) Humans ; Arthrocentesis/methods ; Conservative Treatment ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Temporomandibular Joint Disorders/therapy ; Pain ; Temporomandibular Joint ; Range of Motion, Articular
    Language English
    Publishing date 2023-01-31
    Publishing country Denmark
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 353721-3
    ISSN 1399-0020 ; 0901-5027
    ISSN (online) 1399-0020
    ISSN 0901-5027
    DOI 10.1016/j.ijom.2022.12.005
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  3. Article ; Online: Insights into the optoelectronic behaviour of heteroatom doped diamond-shaped graphene quantum dots.

    El Haddad, Yassine / Ouarrad, Hala / Drissi, Lalla Btissam

    RSC advances

    2024  Volume 14, Issue 18, Page(s) 12639–12649

    Abstract: In this study we aim to manipulate the optoelectronic and photoluminescence properties of diamond-shaped graphene quantum dots (DSGQDs) in order to make them suitable for solar cells and photovoltaic devices. Using DFT and performing many-body effects ... ...

    Abstract In this study we aim to manipulate the optoelectronic and photoluminescence properties of diamond-shaped graphene quantum dots (DSGQDs) in order to make them suitable for solar cells and photovoltaic devices. Using DFT and performing many-body effects studies, we investigate the impact of N, B, O, P and S heteroatom doping on DSGQDs in three different positions, namely the zigzag edge, the armchair corner and the surface, in order to identify the most appropriate and promising configurations. All the doped GQDs are found to be chemically stable making it possible to realize them experimentally. Additionally, the obtained results show that substitution with heteroatoms has a remarkable effect on the electronic energy gap, noticeably decreasing it. Doping also has a significant effect on the optical response by shifting the absorption peaks towards the visible energy range. The excitonic behaviour has revealed that these nanostructures are potential candidates for photovoltaic devices. One can deduce that doping DSGQDs with heteroatoms is useful and promising for the targeted applications.
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra00603h
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  4. Article: Stumpfinsuffizienzen nach thoraxchirurgischen anatomischen Lungenresektionen. Bronchusinsufficiency after thoracic anatomic lung resections

    Hillejan, L. / Haddad, Y.

    Chirurgische Praxis

    2019  Volume 85, Issue 4, Page(s) 615

    Language German
    Document type Article
    ZDB-ID 500633-8
    ISSN 0009-4846
    Database Current Contents Medicine

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  5. Article: Trans-Cinnamaldehyde-Fighting

    Ngokwe, Zilefac Brian / Wolfoviz-Zilberman, Amit / Sharon, Esi / Zabrovsky, Asher / Beyth, Nurit / Houri-Haddad, Yael / Kesler-Shvero, Dana

    Pharmaceutics

    2024  Volume 16, Issue 1

    Abstract: Streptococcus ... ...

    Abstract Streptococcus mutans
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16010113
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  6. Article ; Online: Cerebroplacental ratio and neonatal outcome in low-risk pregnancies with reduced fetal movement: A prospective study.

    Aiob, Ala / Toma, Ruba / Wolf, Maya / Haddad, Yosef / Odeh, Marwan

    European journal of obstetrics & gynecology and reproductive biology: X

    2022  Volume 14, Page(s) 100146

    Abstract: Objective: To evaluate the effectiveness of the cerebroplacental ratio (CPR) in predicting poor outcomes in low-risk pregnancies with reduced fetal movements (RFMs).: Study design: This prospective study included singleton pregnancies at 28-40 weeks, ...

    Abstract Objective: To evaluate the effectiveness of the cerebroplacental ratio (CPR) in predicting poor outcomes in low-risk pregnancies with reduced fetal movements (RFMs).
    Study design: This prospective study included singleton pregnancies at 28-40 weeks, presenting with RFM but no additional risk factors. Sub analysis was performed for pregnancies between 36 and 40 weeks. Umbilical artery (UA) and middle cerebral artery (MCA) pulsatility indices (PIs) were measured, and the MCA-PI to UA-PI ratio (CPR) was calculated. Mode of delivery, gestational age, fetal monitoring category, Apgar score at 1 and 5 min, birth weight, presence of meconium, umbilical artery pH, and neonatal intensive care unit (NICU) admission were recorded. Women with good and poor outcomes were compared with doppler indices and pregnancy characteristics.
    Results: Of 96 women, 86 had good outcomes. There was no significant difference in UA-PI (0.871 ± 0.171 vs. 0.815 ± 0.179, P = 0.446), MCA-PI (1.778 ± 0.343 vs. 1.685 ± 0.373, P = 0.309), or CPR (2.107 ± 0.635 vs. 2.09 ± 0.597, P = 0.993) between the poor and good outcome groups. No difference was found in the location of the placenta, biophysical profile (BPP) score, fetal sex, or amniotic fluid index (AFI) at the time of presentation. The proportion of nulliparous patients in the poor outcome group was higher than that of multiparous patients. Sub analysis for 36-40 weeks revealed the same results; no significant difference in UA-PI (0.840 ± 0.184 Vs 0.815 ± 0.195, P = 0.599), MCA-PI (1.724 ± 0.403 vs. 1.626 ± 0.382, P = 0.523), or CPR (2.14 ± 0.762 vs. 2.08 ± 0.655, P = 0.931) between poor and good outcome groups.
    Conclusions: CPR is not predictive of neonatal outcome in low-risk pregnancies with RFM. However, a higher proportion of poor outcomes in nulliparous women warrants further investigation.
    Language English
    Publishing date 2022-03-10
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1613
    ISSN (online) 2590-1613
    DOI 10.1016/j.eurox.2022.100146
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  7. Article ; Online: Practical Cross-Layer Radio Frequency-Based Authentication Scheme for Internet of Things.

    Haenel, Arie / Haddad, Yoram / Laurent, Maryline / Zhang, Zonghua

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 12

    Abstract: The Internet of Things world is in need of practical solutions for its security. Existing security mechanisms for IoT are mostly not implemented due to complexity, budget, and energy-saving issues. This is especially true for IoT devices that are battery ...

    Abstract The Internet of Things world is in need of practical solutions for its security. Existing security mechanisms for IoT are mostly not implemented due to complexity, budget, and energy-saving issues. This is especially true for IoT devices that are battery powered, and they should be cost effective to be deployed extensively in the field. In this work, we propose a new cross-layer approach combining existing authentication protocols and existing Physical Layer Radio Frequency Fingerprinting technologies to provide hybrid authentication mechanisms that are practically proved efficient in the field. Even though several Radio Frequency Fingerprinting methods have been proposed so far, as a support for multi-factor authentication or even on their own, practical solutions are still a challenge. The accuracy results achieved with even the best systems using expensive equipment are still not sufficient on real-life systems. Our approach proposes a hybrid protocol that can save energy and computation time on the IoT devices side, proportionally to the accuracy of the Radio Frequency Fingerprinting used, which has a measurable benefit while keeping an acceptable security level. We implemented a full system operating in real time and achieved an accuracy of 99.8% for the additional cost of energy, leading to a decrease of only ~20% in battery life.
    Language English
    Publishing date 2021-06-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21124034
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  8. Article ; Online: Landing disease: a surprising cytological diagnosis on day 2 of life.

    Bui, Tan Vinh / Berda-Haddad, Yaël

    Blood

    2021  Volume 138, Issue 2, Page(s) 203

    MeSH term(s) Gangliosidosis, GM1/pathology ; Humans ; Infant, Newborn ; Male ; Mutation/genetics ; beta-Galactosidase/genetics
    Chemical Substances GLB1 protein, human (EC 3.2.1.23) ; beta-Galactosidase (EC 3.2.1.23)
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021011448
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  9. Article ; Online: Titanium dioxide nanoparticles: Recent progress in antimicrobial applications.

    Younis, Almotasem Bellah / Haddad, Yazan / Kosaristanova, Ludmila / Smerkova, Kristyna

    Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

    2022  Volume 15, Issue 3, Page(s) e1860

    Abstract: For decades, the antimicrobial applications of nanoparticles (NPs) have attracted the attention of scientists as a strategy for controlling the ever-increasing threat of multidrug-resistant microorganisms. The photo-induced antimicrobial properties of ... ...

    Abstract For decades, the antimicrobial applications of nanoparticles (NPs) have attracted the attention of scientists as a strategy for controlling the ever-increasing threat of multidrug-resistant microorganisms. The photo-induced antimicrobial properties of titanium dioxide (TiO
    MeSH term(s) Anti-Infective Agents/pharmacology ; Nanoparticles ; Titanium/pharmacology ; Nanostructures ; Metal Nanoparticles
    Chemical Substances titanium dioxide (15FIX9V2JP) ; Anti-Infective Agents ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2502698-7
    ISSN 1939-0041 ; 1939-5116
    ISSN (online) 1939-0041
    ISSN 1939-5116
    DOI 10.1002/wnan.1860
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  10. Article ; Online: Induced Inflammatory and Oxidative Markers in Cerebral Microvasculature by Mentally Depressive Stress.

    Zhu, Yuequan / Haddad, Yazeed / Yun, Ho Jun / Geng, Xiaokun / Ding, Yuchuan

    Mediators of inflammation

    2023  Volume 2023, Page(s) 4206316

    Abstract: Background: Cerebrovascular disease (CVD) is recognized as the leading cause of permanent disability worldwide. Depressive disorders are associated with increased incidence of CVD. The goal of this study was to establish a chronic restraint stress (CRS) ...

    Abstract Background: Cerebrovascular disease (CVD) is recognized as the leading cause of permanent disability worldwide. Depressive disorders are associated with increased incidence of CVD. The goal of this study was to establish a chronic restraint stress (CRS) model for mice and examine the effect of stress on cerebrovascular inflammation and oxidative stress responses.
    Methods: A total of forty 6-week-old male C57BL/6J mice were randomly divided into the CRS and control groups. In the CRS group (
    Results: CRS decreased the total distances (
    Conclusions: To our knowledge, this is the first study to demonstrate that CRS induces depressive stress and causes inflammatory and oxidative stress responses in the brain microvasculature.
    MeSH term(s) Animals ; Male ; Mice ; Cardiovascular Diseases ; Hydrogen Peroxide ; Interleukin-6 ; Mice, Inbred C57BL ; Microvessels ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha ; Vascular Cell Adhesion Molecule-1 ; Depressive Disorder
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Interleukin-6 ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha ; Vascular Cell Adhesion Molecule-1
    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2023/4206316
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