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  1. Article ; Online: Authors′s Reply

    Haddad Ayham / Abbadi Rabe′a / Marji Ann

    Saudi Journal of Kidney Diseases and Transplantation, Vol 21, Iss 4, Pp 745-

    2010  Volume 745

    Keywords Medicine ; R
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Use of iron sucrose in dialysis patients sensitive to iron dextran.

    Haddad, Ayham / Abbadi, Rabe'a / Marji, Ann

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

    2009  Volume 20, Issue 2, Page(s) 208–211

    Abstract: This study aimed to assess the safety and efficacy of iron sucrose in hemodialysis (HD) patients with documented hypersensitivity reactions to iron dextran. Of 205 HD patients who received low molecular weight iron dextran, 15 (7.3%) patients developed ... ...

    Abstract This study aimed to assess the safety and efficacy of iron sucrose in hemodialysis (HD) patients with documented hypersensitivity reactions to iron dextran. Of 205 HD patients who received low molecular weight iron dextran, 15 (7.3%) patients developed documented hypersensitivity reactions. The patients were treated with iron sucrose (100 mg administered as an intravenous push over 5-10 minutes once a week) for 8 weeks. Complete blood count, serum iron, serum ferritin, and parathyroid hormone were measured at the beginning and at the end of the study (except parathyroid hormone). All patients received subcutaneous erythropoietin at a constant dose of 5000 IU twice weekly unless a change was required. All the patients completed the study period and none of them developed hypersensitivity reactions to iron sucrose. The mean hematocrit increased from 23.8% to 32.27% (p < 0.0001), the mean serum ferritin from 185 ng/mL to 599 ng/mL (p < 0.0001), and the mean serum iron from 29.3 ng/dL to 76.8 ng/dL (p = 0.01). We conclude that iron sucrose is safe and effective in HD patients with documented hypersensitivity reactions to low molecular weight iron dextran.
    MeSH term(s) Adult ; Aged ; Anemia, Iron-Deficiency ; Dialysis Solutions/chemistry ; Dialysis Solutions/pharmacology ; Drug Hypersensitivity ; Female ; Ferric Compounds/pharmacology ; Follow-Up Studies ; Glucaric Acid ; Hematinics/pharmacology ; Humans ; Iron-Dextran Complex/adverse effects ; Iron-Dextran Complex/analysis ; Male ; Middle Aged ; Renal Dialysis/methods ; Treatment Outcome ; Young Adult
    Chemical Substances Dialysis Solutions ; Ferric Compounds ; Hematinics ; Iron-Dextran Complex (9004-66-4) ; ferric oxide, saccharated (FZ7NYF5N8L) ; Glucaric Acid (QLZ991V4A2)
    Language English
    Publishing date 2009-03
    Publishing country Saudi Arabia
    Document type Comparative Study ; Journal Article
    ZDB-ID 1379955-1
    ISSN 1319-2442
    ISSN 1319-2442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Use of iron sucrose in dialysis patients sensitive to iron dextran

    Haddad Ayham / Abbadi Rabe′a / Marji Ann

    Saudi Journal of Kidney Diseases and Transplantation, Vol 20, Iss 2, Pp 208-

    2009  Volume 211

    Abstract: This study aimed to assess the safety and efficacy of iron sucrose in hemodialysis (HD) patients with documented hypersensitivity reactions to iron dextran. Of 205 HD patients who received low molecular weight iron dextran, 15 (7.3%) patients developed ... ...

    Abstract This study aimed to assess the safety and efficacy of iron sucrose in hemodialysis (HD) patients with documented hypersensitivity reactions to iron dextran. Of 205 HD patients who received low molecular weight iron dextran, 15 (7.3%) patients developed documented hypersensitivity reactions. The patients were treated with iron sucrose (100 mg administered as an intravenous push over 5-10 minutes once a week) for 8 weeks. Complete blood count, serum iron, serum ferritin, and parathyroid hormone were measured at the beginning and at the end of the study (except parathyroid hormone). All patients received subcutaneous erythropoietin at a constant dose of 5000 IU twice weekly unless a change was required. All the patients completed the study period and none of them developed hypersensitivity reactions to iron sucrose. The mean hematocrit increased from 23.8% to 32.27% (p < 0.0001), the mean serum ferritin from 185 ng/mL to 599 ng/mL (p < 0.0001), and the mean serum iron from 29.3 ng/dL to 76.8 ng/dL (p = 0.01). We conclude that iron sucrose is safe and effective in HD patients with documented hypersensitivity reactions to low molecular weight iron dextran.
    Keywords Chronic kidney disease ; Hemodialysis ; Anemia ; Iron sucrose ; Low molecular weight iron dextran ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2009-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Functional Status of Patients on Maintenance Hemodialysis

    Akash Nabil / Ghnaimat Mohamad / Haddad Ayham / El-Lozi Mohamad

    Saudi Journal of Kidney Diseases and Transplantation, Vol 10, Iss 4, Pp 481-

    1999  Volume 486

    Abstract: Factors associated with physical well being were examined in adults with end-stage renal disease (ESRD) in two large hemodialysis units of the Royal Medical Services in Jordan. Utilizing the Karnofski scale we measured the functional status of 200 ... ...

    Abstract Factors associated with physical well being were examined in adults with end-stage renal disease (ESRD) in two large hemodialysis units of the Royal Medical Services in Jordan. Utilizing the Karnofski scale we measured the functional status of 200 Patients who had been on maintenance hemodialysis for at least 12 months. A Marnofski scale of less than 70 incidents frank disability (Inability to perform routine living activities without assistance), in addition current vocational status was assessed as well as any existing comorbid conditions. The mean age of the study group was 45.2 years (range 16 to 70) and included 108 (54%) males and 92 (46%) females, there were 39 (19.5%) diabetic patients and 27 (13.5%) patients were receiving erythropoietin (EPO). The mean hematocrit of the entire group was 27.8%. As measured by Karnofski scale, 64 (32%) of the patients were unable to perform routine living activity without assistance; dependence on wheelchair was reported by 9 (4.5%) patients. The mean comorbidity index of patients who scored less than 70 on the Karnofski scale was 1.5 compared to 0.7 for those who scored at least 70 on the same scale (p< 0.001). Analysis of factors showed that age and diabetes mellitus affected functional status. Of the laboratory variables measured, only serum albumin concentration correlated significant with Karnofski scale. Fourteen (21.8%) of the patients who scored below 70, had serum albumin concentration above 40g/L compared to 66 (48.5%) of the patients who scored at least 70 on the Karnofski scale (p< 0.001). We conclude that a significant proportion of patients on maintenance hemodialysis is functionally disabled. The elderly, diabetics, patients with high co-morbidity index and those with low serum albumin are most likely to have poor functional status.
    Keywords Hemodialysis ; Functional ; Rehabilitation ; Albumin ; Comorbidity. ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 1999-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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