Article ; Online: Effects of bisphosphonates on appendicular fracture repair in rodents.
2022 Volume 164, Page(s) 116542
Abstract: The balance between osteoclastic bone resorption and osteoblastic bone formation is ultimately responsible for maintaining a structural and functional skeleton. Despite their strength, bones do break and the main cause of fractures are trauma and ... ...
| Abstract | The balance between osteoclastic bone resorption and osteoblastic bone formation is ultimately responsible for maintaining a structural and functional skeleton. Despite their strength, bones do break and the main cause of fractures are trauma and decreased bone mineral density as a result of aging and/or pathology that weakens the bone's microarchitecture and subsequently, its material properties. Osteoporosis is a disease marked by increased osteoclast activity and decreased osteoblastic activity tipping the remodeling balance in favor of bone resorption and can be caused by aging, glucocorticoids, disuse and estrogen-deficiency. Ultimately, this leads to brittle and weaker bones which become more prone to trauma or stress-induced fractures. The current treatment for preventing and treating osteoporotic fractures is the use of antiresorptive drugs such as bisphosphonates (BPs) and denosumab, but unfortunately, their long-term use, especially with alendronate and ibandronate, has been associated with increased risk of atypical femoral fractures (AFFs); femoral diaphyseal fractures distal to the lesser trochanter but proximal to the supracondylar flare. The purpose of this review is to examine the information that exists in the literature examining the effects of BPs on fracture repair of long bones in rodent (rat and mouse) models. The focus on rodents stems from the scientific community's unresolved need to develop small animal models to examine the molecular, cellular, tissue and biomechanical mechanisms responsible for the development of AFFs and how best they can be treated. |
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| MeSH term(s) | Alendronate/adverse effects ; Animals ; Bone Density Conservation Agents/adverse effects ; Bone Resorption/chemically induced ; Bone Resorption/drug therapy ; Denosumab/therapeutic use ; Diphosphonates/adverse effects ; Estrogens ; Femoral Fractures/drug therapy ; Fractures, Stress ; Glucocorticoids/adverse effects ; Ibandronic Acid/adverse effects ; Mice ; Rats ; Rodentia |
| Chemical Substances | Bone Density Conservation Agents ; Diphosphonates ; Estrogens ; Glucocorticoids ; Denosumab (4EQZ6YO2HI) ; Ibandronic Acid (UMD7G2653W) ; Alendronate (X1J18R4W8P) |
| Language | English |
| Publishing date | 2022-08-27 |
| Publishing country | United States |
| Document type | Journal Article ; Review ; Research Support, N.I.H., Extramural |
| ZDB-ID | 632515-4 |
| ISSN | 1873-2763 ; 8756-3282 |
| ISSN (online) | 1873-2763 |
| ISSN | 8756-3282 |
| DOI | 10.1016/j.bone.2022.116542 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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