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Article ; Online: Zwanzig Jahre Levosimendan.

Häberle, Helene A

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

2021 Volume 56, Issue 6, Page(s) 414–426

Abstract: Levosimendan is a calcium sensitizer and opens adenosine triphosphate-dependent potassium channels. Since 20 years, it is approved for acute decompensated heart failure. It has been tested in many clinical trials for treatment of at-risk patients in ... ...

Title translation	Levosimendan - a 20-Year Experience.
Abstract	Levosimendan is a calcium sensitizer and opens adenosine triphosphate-dependent potassium channels. Since 20 years, it is approved for acute decompensated heart failure. It has been tested in many clinical trials for treatment of at-risk patients in cardiac surgery, right ventricular failure, pulmonary hypertension, weaning of extracorporeal systems, cardiogenic shock, septic shock, ARDS and others.Levosimendan has diverse positive effects next to positive inotropy. It improves ventriculoarterial coupling, increases peripheral perfusion, increases kidney glomerular filtration rate, coronary blood flow and it reduces preload and afterload as well as pulmonary capillary wedge pressure.Due to the opening of potassium channels, it also acts on mitochondria resulting in organ protection. Levosimendan acts anti-apoptotic. These positive effects were described in many small studies. Although this sounds like a promising drug for a variety of settings, results of several multicentre randomized placebo-controlled studies were frustrating. This review resumes some facts of levosimendan in different diseases.
MeSH term(s)	Cardiotonic Agents/therapeutic use ; Heart Failure ; Humans ; Hydrazones/therapeutic use ; Pyridazines/therapeutic use ; Simendan
Chemical Substances	Cardiotonic Agents ; Hydrazones ; Pyridazines ; Simendan (349552KRHK)
Language	German
Publishing date	2021-06-29
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/a-1214-4485
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Article ; Online: Isolieren wir Keime oder Patienten? Isolationsmaßnahmen unter der Lupe.

Haeberle, Helene A

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

2020 Volume 55, Issue 6, Page(s) 381–393

Abstract: Isolation of patients with multidrug-resistant organisms (MRGN) has been recommended since years. Recent evidence suggests no benefit by this isolation procedure. Furthermore, isolation precautions may have potential negative effects on patient well- ... ...

Title translation	Do we Isolate Patients or Bugs? Challenging Isolation Precautions.
Abstract	Isolation of patients with multidrug-resistant organisms (MRGN) has been recommended since years. Recent evidence suggests no benefit by this isolation procedure. Furthermore, isolation precautions may have potential negative effects on patient well-being and may increase therapeutic error.Rather than blocking patients up in a room, implementing and continuous education about standard precautions as hand washing and contact awareness may decrease spread of MRGN and other resistant bacteria. In this context, evidence about mechanism of resistance transfer between bacteria is still expanding. Education about these mechanisms inside and outside the body may help to corroborate the appreciation about implementation of standard precautions. In addition, the awareness of antibiotic stewardship in this context has to be underlined. Prevention of spreading bacteria is not done by isolation in room. In fact, it is a multifactorial continuous cycle of planning, teaching, surveillance and transfer of knowledge. Combination of education, compliance to standard precautions and continuous education may be a big step forward in fighting MRGN transmission and progression.
MeSH term(s)	Cross Infection ; Drug Resistance, Multiple, Bacterial ; Humans ; Infection Control ; Patient Isolation
Language	German
Publishing date	2020-06-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/a-0967-1264
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Zs.A 257: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Zwanzig Jahre Levosimendan

Häberle, Helene A.

AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie

2021 Volume 56, Issue 06, Page(s) 414–426

Abstract: Vasopressoren kommen besonders in kritischen, nicht selten lebensbedrohlichen Situationen der Anästhesie, Notfall- und Intensivmedizin zum Einsatz. Die Wahl der geeigneten Substanz sowie die Erkennung und Beherrschung möglicher Nebenwirkungen sind von ... ...

Abstract	Vasopressoren kommen besonders in kritischen, nicht selten lebensbedrohlichen Situationen der Anästhesie, Notfall- und Intensivmedizin zum Einsatz. Die Wahl der geeigneten Substanz sowie die Erkennung und Beherrschung möglicher Nebenwirkungen sind von großer Bedeutung. Im folgenden Beitrag sollen daher die klinisch wichtigsten Substanzen vorgestellt und deren pharmakologische Charakteristika beleuchtet werden.
Keywords	Levosimendan ; Herzinsuffizienz ; Kardiochirurgie ; Inotropie ; Sepsis ; levosimendan ; heart failure ; cardiac surgery ; inotropy ; sepsis
Language	German
Publishing date	2021-06-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/a-1214-4485
Database	Thieme publisher's database

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Zs.A 257: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Isolieren wir Keime oder Patienten? Isolationsmaßnahmen unter der Lupe

Haeberle, Helene A.

AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie

2020 Volume 55, Issue 06, Page(s) 381–393

Abstract: Isolationsmaßnahmen zur Prävention der Übertragung multiresistenter Erreger (MRE) gehören in Anbetracht der steigenden Resistenzentwicklung auf Intensivstationen mittlerweile zur Routine. Noch wichtiger sind allerdings Basishygiene und der ... ...

Abstract	Isolationsmaßnahmen zur Prävention der Übertragung multiresistenter Erreger (MRE) gehören in Anbetracht der steigenden Resistenzentwicklung auf Intensivstationen mittlerweile zur Routine. Noch wichtiger sind allerdings Basishygiene und der verantwortungsvolle Umgang mit antiinfektiven Therapien. Dieser Beitrag widmet sich den verschiedenen Präventionsmaßnahmen, die nur in Kombination effektiv und zielführend sind.
Keywords	räumliche Isolation ; Intensivmedizin ; Antibiotic Stewardship ; multiresistente gramnegative Bakterien (MRGN) ; isolation precautions ; intensive care ; antibiotic stewardship ; multidrug-resistant Gram-negative bacteria (MRGN)
Language	German
Publishing date	2020-06-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/a-0967-1264
Database	Thieme publisher's database

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Zs.A 257: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Book ; Thesis: Validität des Aminosäuren-Absorptions-Tests in Abhängigkeit von Stimulation und Aminosäurenbestimmungsmethode

Häberle, Helene Anna

1993

Author's details	Verfasser: Helene Anna Häberle
Language	German
Size	83 S. : graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Ulm, Univ., Diss., 1994
HBZ-ID	HT006481424
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
95 D 71	order for loan	Magazin

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Article: Patient-Related Factors Associated with Adverse Outcomes Following Weaning from Veno-Arterial Extracorporeal Membrane Oxygenation.

Keller, Marius / Gloeckner, Henning / Sari-Yavuz, Sibel / Haeberle, Helene A / Schlensak, Christian / Rosenberger, Peter / Magunia, Harry / Koeppen, Michael

Journal of clinical medicine

2023 Volume 12, Issue 23

Abstract: Background: Veno-arterial extracorporeal membrane oxygenation (vaECMO) removal reflects a critical moment and factors of adverse outcomes are incompletely understood. Thus, we studied various patient-related factors during vaECMO removal to determine ... ...

Abstract	Background: Veno-arterial extracorporeal membrane oxygenation (vaECMO) removal reflects a critical moment and factors of adverse outcomes are incompletely understood. Thus, we studied various patient-related factors during vaECMO removal to determine their association with outcomes. Methods: A total of 58 patients from a university hospital were included retrospectively. Demographic, clinical, and echocardiographic parameters were recorded while under vaECMO support, as well as the need for inotropic and vasoactive-inotropic scores (VIS). Successful weaning was defined as 28-day survival without reinitiation of vaECMO. Results: Patient age differed significantly between patients with a successful and a failed vaECMO weaning (54 ± 14 vs. 62 ± 12 years, Conclusions: In this cohort, age and the extent of vasoactive-inotropic agents were associated with adverse outcomes following vaECMO, whereas echocardiographic biventricular function during vaECMO support was not.
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12237406
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Early vvECMO implantation may be associated with lower mortality in ARDS.

Rosenberger, Peter / Korell, Lisa / Haeberle, Helene A / Mirakaj, Valbona / Bernard, Alice / Tang, Linyan / Körner, Andreas / Martus, Peter / Koeppen, Michael

Respiratory research

2023 Volume 24, Issue 1, Page(s) 230

Abstract: Background: Venovenous extracorporeal membrane oxygenation (vvECMO) is used to treat hypoxia in patients with severe acute respiratory distress syndrome (ARDS). Nevertheless, uncertainty exists regarding the optimal timing of initiation of vvECMO ... ...

Abstract	Background: Venovenous extracorporeal membrane oxygenation (vvECMO) is used to treat hypoxia in patients with severe acute respiratory distress syndrome (ARDS). Nevertheless, uncertainty exists regarding the optimal timing of initiation of vvECMO therapy. We aimed to investigate the association between number of days of invasive mechanical ventilation (IMV) prior to vvECMO implantation and mortality. Methods: In this retrospective observational study, we included patients treated at an academic intensive care unit with vvECMO for severe ARDS. The primary outcome was all-cause 28-day mortality. We conducted a multivariate logistic regression analysis to estimate the association between number of days of IMV prior to vvECMO implantation and mortality after adjustment for confounders. Results: Out of 274 patients who underwent ECMO for severe ARDS, 158 patients (median age: 58 years) with relevant data were included in the analysis. The mean duration of IMV prior to vvECMO was significantly shorter in survivors than in nonsurvivors [survivors median: 1; interquartile range: 1-3; non-survivors median 4; interquartile range: 1-5.75; p = 0.0001). Logistic regression showed an association between the duration of ventilation prior to vvECMO and patient mortality. The odds ratio for the all-cause 28-day mortality and in-hospital mortality was significantly reduced in patients who received vvECMO within the first 5 days of IMV. Conclusions: Early vvECMO implantation may be associated with lower mortality in ARDS.
MeSH term(s)	Humans ; Middle Aged ; Extracorporeal Membrane Oxygenation ; Hospital Mortality ; Respiration, Artificial ; Retrospective Studies ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/etiology
Language	English
Publishing date	2023-09-26
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-023-02541-z
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Article ; Online: Anästhesie und Outcome: Einfluss der perioperativen Prozesse.

Zieger, Jörg / Häberle, Helene A

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

2017 Volume 52, Issue 7-08, Page(s) 525–541

Abstract: In recent years, the role of the anesthesiologist has turned tremendously from the "anaesthesia doctor" into a perioperative physician and risk specialist. Patients are older, multimorbid, and are called up for more and more extensive surgery and ... ...

Title translation	Anesthesiology and Outcome - Impact of the Perioperative Process.
Abstract	In recent years, the role of the anesthesiologist has turned tremendously from the "anaesthesia doctor" into a perioperative physician and risk specialist. Patients are older, multimorbid, and are called up for more and more extensive surgery and interventions. Socioeconomic aspects have grown in importance. The anesthesiologist, paving the way for a good outcome, is involved in nearly all perioperative processes: preoperative evaluation, definition and optimization of preoperative and intraoperative conditions, management of modern intraoperative anesthesia as well as postoperative medically indicated, effective and efficient treatment of partially highly complex patients. The individual perioperative process steps in this way are examined in accordance with established guidelines and the increase in current requirements. Finally, a special emphasis is placed on the perception that the perioperative process has not been completed with the end of surgery - postoperative outcome is not least adversely affected by postoperative complications on the normal ward. The risk of death after complications, "failure to rescue", should be identified early and treated promptly.
Language	German
Publishing date	2017-07
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/s-0042-118828
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Article ; Online: Angiotensin II for the Treatment of Vasodilatory Shock.

Haeberle, Helene A / Rosenberger, Peter

The New England journal of medicine

2017 Volume 377, Issue 26, Page(s) 2602

MeSH term(s)	Angiotensin II ; Humans ; Shock ; Vasoconstrictor Agents
Chemical Substances	Vasoconstrictor Agents ; Angiotensin II (11128-99-7)
Language	English
Publishing date	2017--28
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc1714511
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Article ; Online: Inhaled Prostacyclin Improves Oxygenation in Patients with COVID-19-induced Acute Respiratory Distress Syndrome

Haeberle, Helene / Rosenberger, Peter / Martus, Peter

medRxiv

Abstract: Background. Acute Respiratory Distress Syndrome (ARDS) results in significant hypoxia, and ARDS is the central pathology of COVID-19. Inhaled prostacyclin has been proposed as a therapy for ARDS, but data regarding its role in this syndrome are ... ...

Abstract	Background. Acute Respiratory Distress Syndrome (ARDS) results in significant hypoxia, and ARDS is the central pathology of COVID-19. Inhaled prostacyclin has been proposed as a therapy for ARDS, but data regarding its role in this syndrome are unavailable. Therefore, we investigated whether inhaled prostacyclin would affect the oxygenation and survival of patients suffering from ARDS. Methods. We performed a prospective randomized controlled single-blind multicenter trial across Germany. The trial was conducted from March 2019 with final follow-up on 12 th of August 2021. Patients with moderate to severe ARDS were included and randomized to receive either inhaled prostacyclin (3 times/day for 5 days) or sodium chloride. The primary outcome was the oxygenation index in the intervention and control groups on Day 5 of therapy. Secondary outcomes were mortality, secondary organ failure, disease severity and adverse events. Findings. Of 707 patients approached 150 patients were randomized to receive inhaled prostacyclin (n=73) or sodium chloride (n=77). Data from 144 patients were analyzed. The baseline oxygenation index did not differ between groups. The primary analysis of the study was negative, and prostacyclin improved oxygenation by 20 mmHg more than NaCl (p=0.17). Oxygenation was significantly improved in patients with ARDS who were COVID-19-positive (34 mmHg, p=0.04). Mortality did not differ between groups. Secondary organ failure and adverse events were similar in the intervention and control groups. Interpretation. Although the primary result of our study was negative, our data suggest that inhaled prostacyclin might be a more beneficial treatment than standard care for patients with ARDS.
Keywords	covid19
Language	English
Publishing date	2021-11-16
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.11.15.21266343
Database	COVID19

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