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  1. Article ; Online: Immature neutrophils and myeloid-derived suppressor cells in sepsis: differences in occurrence kinetics.

    Coudereau, Rémy / Haem Rahimi, Muzhda / Lukaszewicz, Anne-Claire / Cour, Martin / Bidar, Frank / Argaud, Laurent / Venet, Fabienne / Monneret, Guillaume

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 7

    MeSH term(s) Humans ; Neutrophils ; Myeloid-Derived Suppressor Cells ; Sepsis
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04781-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Association of pronounced elevation of NET formation and nucleosome biomarkers with mortality in patients with septic shock.

    Haem Rahimi, Muzhda / Bidar, Frank / Lukaszewicz, Anne-Claire / Garnier, Lorna / Payen-Gay, Léa / Venet, Fabienne / Monneret, Guillaume

    Annals of intensive care

    2023  Volume 13, Issue 1, Page(s) 102

    Abstract: Background: Understanding the mechanisms underlying immune dysregulation in sepsis is a major challenge in developing more individualized therapy, as early and persistent inflammation, as well as immunosuppression, play a significant role in ... ...

    Abstract Background: Understanding the mechanisms underlying immune dysregulation in sepsis is a major challenge in developing more individualized therapy, as early and persistent inflammation, as well as immunosuppression, play a significant role in pathophysiology. As part of the antimicrobial response, neutrophils can release extracellular traps (NETs) which neutralize and kill microorganisms. However, excessive NETs formation may also contribute to pathogenesis, tissue damage and organ dysfunction. Recently, a novel automated assay has been proposed for the routine measurement of nucleosomes H3.1 (fundamental units of chromatin) that are released during NETs formation. The aim of the present study was to measure nucleosome levels in 151 septic shock patients (according to sepsis-3 definition) and to determine association with mortality.
    Results: The nucleosome H3.1 levels (as determined by a chemiluminescence immunoassay performed on an automated immunoanalyzer system) were markedly and significantly elevated at all-time points in septic shock patients compared to the control group. Immunological parameters indicated tremendous early inflammation (IL-6 = 1335 pg/mL at day 1-2) along with marked immunosuppression (e.g., mHLA-DR = 3853 AB/C and CD4 = 338 cell /µL at day 3-4). We found significantly positive correlation between nucleosome levels and organ failure and severity scores, IL-6 concentrations and neutrophil count. Significantly higher values (day 1-2 and 3-4) were measured in non-survivor patients (28-day mortality). This association was still significant after multivariate analysis and was more pronounced with highest concentration. Early (day 1-2) increased nucleosome levels were also independently associated with 5-day mortality. At day 6-8, persistent elevated nucleosome levels were negatively correlated to mHLA-DR values.
    Conclusions: This study reports a significant elevation of nucleosome in patients during a one-week follow-up. The nucleosome levels showed correlation with neutrophil count, IL-6 and were found to be independently associated with mortality assessed at day 5 or 28. Therefore, nucleosome concentration seems to be a promising biomarker for detecting hyper-inflammatory phenotype upon a patient's admission. Additional investigations are required to evaluate the potential association between sustained elevation of nucleosome and sepsis-induced immunosuppression.
    Language English
    Publishing date 2023-10-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-023-01204-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interferon-Gamma-Release assay and absolute CD8 lymphocyte count for acquired immunosuppression monitoring in critically ill patients.

    Haem Rahimi, Muzhda / Venet, Fabienne / Lukaszewicz, Anne-Claire / Peronnet, Estelle / Cerrato, Elisabeth / Rimmelé, Thomas / Monneret, Guillaume

    Cytokine

    2023  Volume 174, Page(s) 156474

    Abstract: Guided biomarker-personalized immunotherapy is advancing rapidly as a means to rejuvenate immune function in injured patients who are the most immunosuppressed. A recent study introduced a fully automated interferon-γ release assay (IGRA) for monitoring ... ...

    Abstract Guided biomarker-personalized immunotherapy is advancing rapidly as a means to rejuvenate immune function in injured patients who are the most immunosuppressed. A recent study introduced a fully automated interferon-γ release assay (IGRA) for monitoring the functionality of T lymphocytes in patients with septic shock. While a significant decrease in IFN-γ release capacity was observed, a significant correlation with CD8 lymphocyte absolute count was also reported, raising the question of whether ex-vivo IFN-γ production would be only a surrogate marker for lymphocyte count or if these two parameters conveyed distinct and complementary information. In a large cohort of more than 353 critically ill patients following various injuries (sepsis, trauma, major surgery), the primary objective of the present study was to simultaneously evaluate the association between ex vivo IFN-γ release and CD8 cell count with regard to adverse outcome. Our findings provide a clear-cut result, as they distinctly demonstrate that IGRA offers higher-quality information than CD8 count in terms of an independent association with the occurrence of an adverse outcome. These results strengthen the case for incorporating IGRA into the array of biomarkers of interest for defining endotypes in sepsis. This holds especially true given that fully automated tests are now readily available and could be used in routine clinical practice.
    MeSH term(s) Humans ; Interferon-gamma Release Tests/methods ; Interferon-gamma ; Critical Illness ; Immunosuppression Therapy ; Lymphocyte Count ; CD8-Positive T-Lymphocytes ; Biomarkers ; Sepsis
    Chemical Substances Interferon-gamma (82115-62-6) ; Biomarkers
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2023.156474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2840: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Monocyte HLA-DR expression as an enrollment biomarker in sepsis clinical trials: Evaluation of two sampling tubes and definition of respective clinical thresholds.

    Haem Rahimi, Muzhda / Conti, Filippo / Llitjos, Jean-Francois / Fleurie, Aurore / Cerro, Valérie / Venet, Fabienne / Lukaszewicz, Anne-Claire / Monneret, Guillaume

    Cytometry. Part B, Clinical cytometry

    2023  Volume 104, Issue 6, Page(s) 468–470

    MeSH term(s) Humans ; Monocytes/metabolism ; Flow Cytometry ; HLA-DR Antigens ; Sepsis/diagnosis ; Biomarkers/metabolism
    Chemical Substances HLA-DR Antigens ; Biomarkers
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Intramural
    ZDB-ID 2099657-3
    ISSN 1552-4957 ; 1552-4949 ; 0196-4763
    ISSN (online) 1552-4957
    ISSN 1552-4949 ; 0196-4763
    DOI 10.1002/cyto.b.22133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1688: Show issues Location:
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  5. Article: Assessment of neutrophil subsets and immune checkpoint inhibitor expressions on T lymphocytes in liver transplantation: A preliminary study beyond the neutrophil-lymphocyte ratio.

    Riff, Arnaud / Haem Rahimi, Muzhda / Delignette, Marie-Charlotte / Gossez, Morgane / Coudereau, Rémy / Pantel, Solène / Antonini, Teresa / Villeret, François / Zoulim, Fabien / Mabrut, Jean-Yves / Dumortier, Jérome / Venet, Fabienne / Lebossé, Fanny / Monneret, Guillaume

    Frontiers in physiology

    2023  Volume 14, Page(s) 1095723

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1095723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fully automated interferon-γ release assay to monitor antigen-independent T cell functionality: A proof of concept study in septic shock.

    Haem Rahimi, Muzhda / Daniel, Soizic / Venet, Fabienne / Bidar, Frank / Cour, Martin / Ducrot, Sandrine / Argaud, Laurent / Lukaszewicz, Anne-Claire / Berthier, Franck / Monneret, Guillaume

    Cytokine

    2023  Volume 169, Page(s) 156263

    Abstract: In sepsis, personalized immunotherapy is being evaluated as a means of restoring immune function in the most severely affected patients. Biomarkers play a crucial role in this process, as there are no clear clinical indicators of immune dysfunction. ... ...

    Abstract In sepsis, personalized immunotherapy is being evaluated as a means of restoring immune function in the most severely affected patients. Biomarkers play a crucial role in this process, as there are no clear clinical indicators of immune dysfunction. Functional testing is considered a gold standard for assessing immune function, but this approach faces analytical challenges in terms of clinical implementation. The use of technician-dependent, time-consuming, home-made protocols often leads to poor standardization. This study represents the first beta testing of a fully automated interferon-γ release assay (IGRA) for monitoring the functionality of antigen-independent T lymphocytes. We observed a significant decrease in IFN-γ release capacity, which was associated with typical alterations in immunological cellular parameters (such as low mHLA-DR expression and decreased CD8 T lymphocyte count), in 22 patients with septic shock. Since the test is performed using whole blood and requires no technician intervention, with results available within 4 h, it may offer new possibilities for monitoring patients with immune alterations in routine clinical conditions. Further investigations in larger cohorts of patients are now needed to validate its clinical potential.
    MeSH term(s) Humans ; Shock, Septic ; Interferon-gamma Release Tests ; Proof of Concept Study ; Sepsis/metabolism ; CD8-Positive T-Lymphocytes/metabolism
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2023.156263
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2840: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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