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  1. Article ; Online: Neurotoxicity of organic solvents with emphasis on the role of iron.

    Shahy, Eman M / Ibrahim, Khadiga S / Mahdy-Abdallah, Heba / Taha, Mona M / Saad-Hussien, Amal / Hafez, Salwa F

    Journal of complementary & integrative medicine

    2021  Volume 18, Issue 3, Page(s) 527–533

    Abstract: Background: Exposure to organic solvents (OS) adversely affects different body systems, the central and peripheral nervous systems being the most susceptible ones.: Objectives: This study investigated the role of iron in association with some ... ...

    Abstract Background: Exposure to organic solvents (OS) adversely affects different body systems, the central and peripheral nervous systems being the most susceptible ones.
    Objectives: This study investigated the role of iron in association with some neurotransmitters for diagnosis of neurotoxicity of OS.
    Methods: The study included 90 workers, 50 occupationally exposed to OS and 40 representing control group. Blood samples were collected from the included subjects for determination of serum iron, total iron binding capacity (TIBC), serotonin and gamma-aminobutyric acid (GABA).
    Results: Revealed reduction in serotonin level and serum iron. However, the elevation in GABA and TIBC was observed. The duration of exposure was significantly correlated with iron and serotonin while it was positively correlated with GABA and TIBC.
    Conclusions: Elevated GABA and TIBC with decreased serotonin and serum iron can be used as early diagnostic measures to detect the neurotoxic effects of OS.
    MeSH term(s) Humans ; Iron ; Solvents/adverse effects ; Solvents/poisoning
    Chemical Substances Solvents ; Iron (E1UOL152H7)
    Language English
    Publishing date 2021-02-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2197618-1
    ISSN 1553-3840 ; 2194-6329
    ISSN (online) 1553-3840
    ISSN 2194-6329
    DOI 10.1515/jcim-2019-0103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hepatotoxicity of aflatoxin B1 and its oxidative effects in wood dust Egyptian exposed workers.

    Saad-Hussein, Amal / Shahy, Eman M / Shaheen, Weam / Ibrahim, Khadiga S / Mahdy-Abdallah, Heba / Taha, Mona M / Hafez, Salwa F

    Archives of environmental & occupational health

    2020  Volume 76, Issue 8, Page(s) 561–566

    Abstract: The goal of the present study is to estimate the oxidative effects of AFB1 induced hepatotoxicity in furniture wood dust exposed workers. A cross-sectional comparative study was designed for comparing AFB1/albumin (AFB1/alb) levels and liver functions [ ... ...

    Abstract The goal of the present study is to estimate the oxidative effects of AFB1 induced hepatotoxicity in furniture wood dust exposed workers. A cross-sectional comparative study was designed for comparing AFB1/albumin (AFB1/alb) levels and liver functions [alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP)], malondialdehyde (MDA), glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) in 88 furniture workers and 78 controls not occupationally exposed to wood dust. The AFB1/Alb, AST, ALT, MDA, and GPx were significantly higher; while, CAT significantly reduced in workers compared with controls. There was a significant correlation between AFB1/Alb and MDA level with the liver enzymes among both groups. CAT was inversely correlated with AFB1/Alb and the liver enzymes, and GPx was inversely correlated with AST in the workers. It was concluded that wood dust exposure is associated with raised serum levels of AFB1 and oxidative stress.
    MeSH term(s) Adult ; Aflatoxin B1/adverse effects ; Aflatoxin B1/blood ; Antioxidants/metabolism ; Aspergillus/isolation & purification ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/epidemiology ; Chemical and Drug Induced Liver Injury/etiology ; Cross-Sectional Studies ; Dust/analysis ; Egypt/epidemiology ; Humans ; Liver/drug effects ; Liver/enzymology ; Middle Aged ; Occupational Diseases/blood ; Occupational Diseases/epidemiology ; Occupational Diseases/ethnology ; Occupational Exposure/adverse effects ; Occupational Exposure/statistics & numerical data ; Oxidative Stress/drug effects ; Wood/adverse effects ; Wood/microbiology
    Chemical Substances Antioxidants ; Dust ; Aflatoxin B1 (9N2N2Y55MH)
    Language English
    Publishing date 2020-10-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2245323-4
    ISSN 2154-4700 ; 1933-8244 ; 0003-9896
    ISSN (online) 2154-4700
    ISSN 1933-8244 ; 0003-9896
    DOI 10.1080/19338244.2020.1828246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Comparative Hepatotoxicity of Aflatoxin B1 among Workers Exposed to Different Organic Dust with Emphasis on Polymorphism Role of Glutathione S-Transferase Gene.

    Saad-Hussein, Amal / Shahy, Eman M / Shaheen, Weam / Taha, Mona M / Mahdy-Abdallah, Heba / Ibrahim, Khadiga S / Hafez, Salwa F / Fadl, Nevein N / El-Shamy, Karima A

    Open access Macedonian journal of medical sciences

    2016  Volume 4, Issue 2, Page(s) 312–318

    Abstract: Aim: The study aimed to investigate effects of organic dust exposure from different sources on aflatoxin B1-albumin adducts (AFB1/Alb), and role of glutathione S-transferase (GST) gene polymorphism in hepatotoxicity of (AFB1) among exposed workers.: ... ...

    Abstract Aim: The study aimed to investigate effects of organic dust exposure from different sources on aflatoxin B1-albumin adducts (AFB1/Alb), and role of glutathione S-transferase (GST) gene polymorphism in hepatotoxicity of (AFB1) among exposed workers.
    Material and methods: Liver enzymes, AFB1/Alb, and GST polymorphism were estimated in 132 wheat flour dust and 87 woods sawmill workers, and 156 controls.
    Results: Results revealed that AFB1/Alb and liver enzymes were significantly elevated in exposed workers compared to controls, and were significantly higher in sawmill workers compared to flour workers. AFB1/Alb in flour and sawmill workers with GSTT1 and GSTM1&GSTT1 null genotypes were significantly higher than controls, and in sawmill workers with GSTM1&GSTT1 null than flour workers. Liver enzymes (ALT and AST) in sawmill workers were significantly higher than flour workers and controls in all GST polymorphism; except in GSTT1 polymorphism, where these enzymes were significantly higher in the two exposed groups than controls.
    Conclusions: In conclusion, organic dust exposure may cause elevation in AFB1/Alb and liver enzymes of exposed workers, and GST gene polymorphism plays an important role in susceptibility to hepatic parenchymal cell injury; except in workers with GSTT1&GSTM1 null genotype, gene susceptibility seemed to have little role and the main role was for environmental exposures.
    Language English
    Publishing date 2016-04-20
    Publishing country North Macedonia
    Document type Journal Article
    ISSN 1857-9655
    ISSN 1857-9655
    DOI 10.3889/oamjms.2016.051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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