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  1. Article ; Online: Starving lethal prostate cancer by targeting heat shock proteins and glycolytic enzymes.

    Plymate, Stephen R / Sprenger, Cynthia / Haffner, Michael C

    Cell reports. Medicine

    2022  Volume 3, Issue 2, Page(s) 100493

    Abstract: Metastatic prostate cancer remains uncurable. In this issue ... ...

    Abstract Metastatic prostate cancer remains uncurable. In this issue of
    MeSH term(s) Glycolysis ; HSP90 Heat-Shock Proteins ; Heat-Shock Proteins ; Humans ; Inhibition, Psychological ; Male ; Prostatic Neoplasms/drug therapy
    Chemical Substances HSP90 Heat-Shock Proteins ; Heat-Shock Proteins
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type News ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2021.100493
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  2. Article ; Online: Outcome Analysis of a Series of Mixed-Grade, Non-muscle Invasive, Papillary Carcinomas of the Bladder.

    Chambers, Meagan / Andre, Alexa T / Wright, Jonathan L / Vakar-Lopez, Funda / Tretiakova, Maria / Reder, Nicholas P / Haffner, Michael C / True, Lawrence D

    International journal of surgical pathology

    2024  , Page(s) 10668969241246492

    Abstract: Introduction. ...

    Abstract Introduction.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969241246492
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  3. Article ; Online: Molecular Pathology of Prostate Cancer.

    Kulac, Ibrahim / Roudier, Martine P / Haffner, Michael C

    Surgical pathology clinics

    2021  Volume 14, Issue 3, Page(s) 387–401

    Abstract: Molecular profiling studies have shed new light on the complex biology of prostate cancer. Genomic studies have highlighted that structural rearrangements are among the most common recurrent alterations. In addition, both germline and somatic mutations ... ...

    Abstract Molecular profiling studies have shed new light on the complex biology of prostate cancer. Genomic studies have highlighted that structural rearrangements are among the most common recurrent alterations. In addition, both germline and somatic mutations in DNA repair genes are enriched in patients with advanced disease. Primary prostate cancer has long been known to be multifocal, but recent studies demonstrate that a large fraction of prostate cancer shows evidence of multiclonality, suggesting that genetically distinct, independently arising tumor clones coexist. Metastatic prostate cancer shows a high level of morphologic and molecular diversity, which is associated with resistance to systemic therapies. The resulting high level of intratumoral heterogeneity has important implications for diagnosis and poses major challenges for the implementation of molecular studies. Here we provide a concise review of the molecular pathology of prostate cancer, highlight clinically relevant alterations, and discuss opportunities for molecular testing.
    MeSH term(s) Genomics ; Humans ; Male ; Pathology, Molecular ; Prostatic Neoplasms/genetics
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2021.05.004
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  4. Article ; Online: Divining Harm-Benefit Tradeoffs of Magnetic Resonance Imaging-targeted Biopsy.

    Etzioni, Ruth / Haffner, Michael C / Gulati, Roman

    European urology

    2021  Volume 80, Issue 5, Page(s) 573–574

    MeSH term(s) Biopsy ; Humans ; Magnetic Resonance Imaging ; Male ; Prostate
    Language English
    Publishing date 2021-09-01
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2021.08.009
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    Zs.MO 294: Show issues

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  5. Article ; Online: Whole Genome Sequencing Reveals Independent Clonal Origin of Bilateral Testicular Germ Cell Tumors in 2 Patients with Pure Seminoma.

    Biles, Michael J / Haffner, Michael C / Hanratty, Brian / Pierorazio, Phillip M

    Urology

    2022  Volume 165, Page(s) 184–186

    Abstract: The pathophysiology of bilateral testicular germ cell tumors (TGCT) is poorly understood. It is unclear if they develop independently, arise from common germline genetic changes, or metastasize from one gonad to the other. We determined the underlying ... ...

    Abstract The pathophysiology of bilateral testicular germ cell tumors (TGCT) is poorly understood. It is unclear if they develop independently, arise from common germline genetic changes, or metastasize from one gonad to the other. We determined the underlying genomic alterations in two cases of bilateral TGCTs with pure seminoma using whole genome sequencing. Large chromosomal aberrations and KIT amplification were identified, but there were no shared single nucleotide variants or structural chromosomal rearrangements in paired TGCTs, suggesting they develop independently. The biological behavior of bilateral TGCTs may be distinct and the staging and prognostic evaluation of each tumor should be performed independently.
    MeSH term(s) Humans ; Male ; Neoplasms, Germ Cell and Embryonal/genetics ; Seminoma/genetics ; Seminoma/pathology ; Testicular Neoplasms/genetics ; Testicular Neoplasms/pathology ; Whole Genome Sequencing
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2022.01.025
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  6. Article: Prostate multi-parametric magnetic resonance imaging appearance of diffuse adenosis of the peripheral zone (DAPZ).

    Lowe, Avanka W / Macura, Katarzyna J / Kates, Max / Lotan, Tamara / Haffner, Michael C / Rowe, Steven P

    Urology case reports

    2022  Volume 45, Page(s) 102178

    Abstract: Imaging specialists must recognize potential mimics of prostate cancer (PCa) on multi-parametric magnetic resonance imaging (mpMRI). We describe the appearance of diffuse adenosis of the peripheral zone (DAPZ) on mpMRI. The features of DAPZ parallel ... ...

    Abstract Imaging specialists must recognize potential mimics of prostate cancer (PCa) on multi-parametric magnetic resonance imaging (mpMRI). We describe the appearance of diffuse adenosis of the peripheral zone (DAPZ) on mpMRI. The features of DAPZ parallel those of diffuse PCa, with low signal on T2-weighted images, rapid enhancement on dynamic contrast-enhanced sequences, and restricted diffusion. DAPZ is typically encountered in younger men with elevated prostate specific antigen (PSA) levels and portends an increased risk of the development of PCa. Recognition of the imaging appearance of DAPZ may reassure patients with concordant pathologic findings and may aid in selecting patients for follow-up.
    Language English
    Publishing date 2022-08-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2022.102178
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  7. Article ; Online: Re: Heng Li, Yucong Zhang, Dong Li, et al. Androgen Receptor Splice Variant 7 Predicts Shorter Response in Patients with Metastatic Hormone-sensitive Prostate Cancer Receiving Androgen Deprivation Therapy. Eur Urol 2021;79:879-86 AR-V7 is Rare in Hormone-sensitive Prostate Cancer: AR-V7 is Rare in Hormone-sensitive Prostate Cancer.

    Sowalsky, Adam G / Plymate, Stephen R / Haffner, Michael C / de Bono, Johann S / Sharp, Adam

    European urology

    2022  Volume 82, Issue 5, Page(s) e135–e136

    MeSH term(s) Androgen Antagonists/therapeutic use ; Androgens ; Humans ; Male ; Phenylthiohydantoin ; Prostatic Neoplasms, Castration-Resistant/pathology ; Protein Isoforms ; Receptors, Androgen/genetics
    Chemical Substances Androgen Antagonists ; Androgens ; Protein Isoforms ; Receptors, Androgen ; Phenylthiohydantoin (2010-15-3)
    Language English
    Publishing date 2022-08-26
    Publishing country Switzerland
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.06.028
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    Zs.A 1247: Show issues Location:
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  8. Article ; Online: A combinatorial genetic strategy for exploring complex genotype-phenotype associations in cancer.

    Li, Shan / Wong, Alicia / Sun, Huiyun / Bhatia, Vipul / Javier, Gerardo / Jana, Sujata / Wu, Qian / Montgomery, Robert B / Wright, Jonathan L / Lam, Hung-Ming / Hsieh, Andrew C / Faltas, Bishoy M / Haffner, Michael C / Lee, John K

    Nature genetics

    2024  Volume 56, Issue 3, Page(s) 371–376

    Abstract: Available genetically defined cancer models are limited in genotypic and phenotypic complexity and underrepresent the heterogeneity of human cancer. Here, we describe a combinatorial genetic strategy applied to an organoid transformation assay to rapidly ...

    Abstract Available genetically defined cancer models are limited in genotypic and phenotypic complexity and underrepresent the heterogeneity of human cancer. Here, we describe a combinatorial genetic strategy applied to an organoid transformation assay to rapidly generate diverse, clinically relevant bladder and prostate cancer models. Importantly, the clonal architecture of the resultant tumors can be resolved using single-cell or spatially resolved next-generation sequencing to uncover polygenic drivers of cancer phenotypes.
    MeSH term(s) Male ; Humans ; Genotype ; Phenotype ; Neoplasms/genetics ; Genetic Association Studies
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-024-01674-1
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    Zs.A 3613: Show issues Location:
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    Zs.MG 46: Show issues

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  9. Article ; Online: Gleason pattern 4 with cribriform morphology on biopsy is associated with adverse clinicopathological findings in a prospective radical prostatectomy cohort.

    Haffner, Michael C / Salles, Daniela C / Gao, Guofeng / Epstein, Jonathan I

    Human pathology

    2020  Volume 98, Page(s) 74–80

    Abstract: The prognostic significance of the Gleason grading system has been well established. However, individual Gleason patterns comprise heterogeneous morphologies which might add additional prognostic information. Recent evidence suggests that Gleason pattern ...

    Abstract The prognostic significance of the Gleason grading system has been well established. However, individual Gleason patterns comprise heterogeneous morphologies which might add additional prognostic information. Recent evidence suggests that Gleason pattern 4 with cribriform growth pattern is associated with an adverse prognosis. To determine the association between cribriform pattern on biopsies and pathological findings on subsequent prostatectomies, we evaluated the presence of cribriform architecture in a prospective cohort of 367 men from 2014 to 2018 treated at a single institution. Cribriform architecture was present in 63.5% of all biopsies and was correlated with the overall extent of Gleason pattern 4. In addition, cribriform morphology on biopsy showed a statistically significant association with higher Gleason grade and increased pathological stage and nodal metastasis. In a subset analysis of cases with Grade Group 2 (Gleason score 3 + 4, n = 208), these associations did not reach statistical significance, but the presence of cribriform growth in this subgroup showed a trend toward increased upgrading to Grade Group 5 (Gleason score 9/10) (1 [0.5%] vs. 5 [2.4%], P = 0.06). This large prospective study comparing biopsy and prostatectomy finding of cribriform architecture demonstrates that cribriform pattern 4 is associated with adverse prognostic features and highlights the relevance for recognizing specific morphologies with distinct biological and clinical features.
    MeSH term(s) Biopsy ; Humans ; Lymphatic Metastasis ; Male ; Neoplasm Grading ; Neoplasm Staging ; Predictive Value of Tests ; Prospective Studies ; Prostatectomy ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2020-02-28
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 207657-3
    ISSN 1532-8392 ; 0046-8177
    ISSN (online) 1532-8392
    ISSN 0046-8177
    DOI 10.1016/j.humpath.2020.02.004
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  10. Article ; Online: Shifting Paradigms for High-grade Prostatic Intraepithelial Neoplasia.

    Haffner, Michael C / Barbieri, Christopher E

    European urology

    2016  Volume 69, Issue 5, Page(s) 831–833

    Language English
    Publishing date 2016-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2015.11.020
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