LIVIVO - Search results -

Search results

Result 1 - 10 of total 128

Search options

Article ; Online: A qualitative report on experiences of participants in the young innovative leadership program.

Vaezi, Atefeh / Khoshgoftar, Mohadeseh / Teimouri-Jervekani, Zahra / Haghjooy Javanmard, Shaghayegh

2024 Volume 24, Issue 1, Page(s) 71

Abstract: Background: Leadership in health system is a universal challenge. The Young Innovative Leadership Program (YILP) designed for undergraduate and postgraduate medical sciences students, implemented at the Isfahan University of Medical Sciences, aimed to ... ...

Abstract	Background: Leadership in health system is a universal challenge. The Young Innovative Leadership Program (YILP) designed for undergraduate and postgraduate medical sciences students, implemented at the Isfahan University of Medical Sciences, aimed to cultivate leadership capacities through a 16-week training program. This program comprises ten modules covering innovation, change leadership, and management skills, with mentor-facilitated group discussions. This study aimed to provide a qualitative report of the experiences of participants in the YILP. Methods: A qualitative study was conducted in 2022, three months after the end of the training program, to investigate the participants' perspectives. Data was extracted through in-depth, semi-structured interviews with 14 participants. Results: In this study 14 undergraduate and postgraduate medical sciences students who had participated in the YILP the previous year were included. Four main categories emerged from the interviews: "emergence of new horizons", "values as beacon", "an expanded toolbox", and "program's structure: a learning atmosphere". Conclusions: The results of our study indicated that medical science students would benefit from leadership development programs. In this regard, the framework utilized to implement YILP could serve as a role model.
MeSH term(s)	Humans ; Curriculum ; Leadership ; Qualitative Research ; Learning
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-024-05033-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Mental Health of Healthcare Workers During the Third Wave of the COVID-19 Pandemic: Did We Forget them after the First Wave?

Saeri, Mahdieh / Vaezi, Atefeh / Tavakolifard, Negah / Haghjooy Javanmard, Shaghayegh

Advanced biomedical research

2023 Volume 12, Page(s) 266

Abstract: Background: Since December 2019, countries experienced different numbers of COVID-19 pandemic waves. The COVID-19 pandemic led to adverse psychologic problems in the communities and among healthcare workers (HCWs), but the dynamic of these problems ... ...

Abstract	Background: Since December 2019, countries experienced different numbers of COVID-19 pandemic waves. The COVID-19 pandemic led to adverse psychologic problems in the communities and among healthcare workers (HCWs), but the dynamic of these problems through different waves needs to be established more. Materials and methods: This cross-sectional study was conducted in October 2020, through the third wave of the COVID-19 pandemic, in Isfahan, Iran. We studied HCWs' depression, anxiety, and stress using Depression, Anxiety, Stress Scale-21 (DASS-21) and insomnia using Insomnia Severity Index (ISI) questionnaires. Multiple linear regression was used to evaluate the association of some characteristic factors with different psychologic symptoms. Results: Our results showed that about 80% of HCWs had one or more psychological problems. The prevalence of depression, anxiety, stress, and insomnia was 46.0%, 50.2%, 44.6%, and 66.5%, respectively. Female sex, working in ICU, and having a history of chronic disease were predictors of psychological symptoms in our participants. Conclusion: HCWs' mental health state could be underestimated or neglected. The third pandemic wave negatively affected the mental health of the HCWs. Since mental health problems of HCWs may reduce the quality of care, the potential impact of not addressing this issue should be highlighted.
Language	English
Publishing date	2023-11-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2672524-1
ISSN	2277-9175
ISSN	2277-9175
DOI	10.4103/abr.abr_439_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The dual role of Nrf2 in melanoma: a systematic review.

Malakoutikhah, Zahra / Mohajeri, Zahra / Dana, Nasim / Haghjooy Javanmard, Shaghayegh

BMC molecular and cell biology

2023 Volume 24, Issue 1, Page(s) 5

Abstract: Melanoma is the most lethal type of skin cancer that originates from the malignant transformation of melanocytes. Although novel treatments have improved patient survival in melanoma, the overall prognosis remains poor. To improve current therapies and ... ...

Abstract	Melanoma is the most lethal type of skin cancer that originates from the malignant transformation of melanocytes. Although novel treatments have improved patient survival in melanoma, the overall prognosis remains poor. To improve current therapies and patients outcome, it is necessary to identify the influential elements in the development and progression of melanoma.Due to UV exposure and melanin synthesis, the melanocytic lineage seems to have a higher rate of ROS (reactive oxygen species) formation. Melanoma has been linked to an increased oxidative state, and all facets of melanoma pathophysiology rely on redox biology. Several redox-modulating pathways have arisen to resist oxidative stress. One of which, the Nrf2 (nuclear factor erythroid 2-related factor 2), has been recognized as a master regulator of cellular response to oxidative or electrophilic challenges. The activation of Nrf2 signaling causes a wide range of antioxidant and detoxification enzyme genes to be expressed. As a result, this transcription factor has lately received a lot of interest as a possible cancer treatment target.On the other hand, Nrf2 has been found to have a variety of activities in addition to its antioxidant abilities, constant Nrf2 activation in malignant cells may accelerate metastasis and chemoresistance. Hence, based on the cell type and context, Nrf2 has different roles in either preventing or promoting cancer. In this study, we aimed to systematically review all the studies discussing the function of Nrf2 in melanoma and the factors determining its alteration.
MeSH term(s)	Humans ; Antioxidants/metabolism ; Melanoma/genetics ; Melanoma/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism
Chemical Substances	Antioxidants ; NF-E2-Related Factor 2 ; Reactive Oxygen Species ; NFE2L2 protein, human
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Systematic Review ; Journal Article
ISSN	2661-8850
ISSN (online)	2661-8850
DOI	10.1186/s12860-023-00466-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The potential interplay between opioid and the toll-like receptor 4 (TLR-4).

Zare, Nasrin / Pourhadi, Marjan / Vaseghi, Golnaz / Haghjooy Javanmard, Shaghayegh

Immunopharmacology and immunotoxicology

2022 Volume 45, Issue 2, Page(s) 240–252

Abstract: Context: Opioids are available for the management of severe and chronic pain. However, long-term use of high-dose opioids could lead to physiologic tolerance, hyperalgesia, gastrointestinal immobility, addiction, respiratory depression, tumor ... ...

Abstract	Context: Opioids are available for the management of severe and chronic pain. However, long-term use of high-dose opioids could lead to physiologic tolerance, hyperalgesia, gastrointestinal immobility, addiction, respiratory depression, tumor progression, and inhibition of the immune system. It seems some of these adverse effects of opioids might be induced by TLR-4 signaling. Objective: The review aims to investigate the potential interplay between opioids and TLR-4 in CNS, gastrointestinal, cancer, and immune system. Methods: The search of PubMed, Embase, Scopus, web of sciences, and Google scholar was performed for all relevant studies published. From a total of 513 papers obtained at the initial database search, publications including Results: A comprehensive review of studies indicated that using opioids for the reduction of pain might induce adverse effects such as analgesic tolerance, hyperalgesia, cancer progression, and suppression of the immune system. Some studies have indicated these effects may be due to a change in the level of expression and signaling pathway of TLR-4. The generalizability of the results was limited due to the inconsistency of findings. Conclusions: More studies are needed to clarify TLR-4-mediated opioid effects on the biology or stages of the disease as well as the role of different types of opioids, appropriate dosage, and exposure in various contexts. Designing the drug candidate and doing many formulation studies for different diseases and various stages of disease could be associated with effective treatment and pain management.
MeSH term(s)	Humans ; Analgesics, Opioid/adverse effects ; Toll-Like Receptor 4 ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Pain/drug therapy ; Neoplasms/drug therapy
Chemical Substances	Analgesics, Opioid ; Toll-Like Receptor 4
Language	English
Publishing date	2022-09-16
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	807033-7
ISSN	1532-2513 ; 0892-3973
ISSN (online)	1532-2513
ISSN	0892-3973
DOI	10.1080/08923973.2022.2122500
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1481: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The Cytotoxicity of 27-Hydroxycholesterol in MCF-7 and MDA-MB-231.

Rashidi Alavijeh, Mehran / Etesami, Hossein / Dehghan, Amin / Babajani, Amirhesam / Haghjooy Javanmard, Shaghayegh

Advanced biomedical research

2023 Volume 12, Page(s) 246

Abstract: Background: Although several roles of 27-hydroxycholesterol (27-HC), the most abundant oxysterol in blood circulation, in cancers have been elucidated, its impact on breast cancer proliferation and its pathway remain unknown.: Materials and methods: ... ...

Abstract	Background: Although several roles of 27-hydroxycholesterol (27-HC), the most abundant oxysterol in blood circulation, in cancers have been elucidated, its impact on breast cancer proliferation and its pathway remain unknown. Materials and methods: The effect of 27-HC on breast cancer cell proliferation and its pathway was evaluated using Michigan Cancer Foundation - 7 (MCF-7) and M.D. Anderson - Metastatic Breast 231 (MDA-MB-231) cell lines. The MTT assay was applied after 24- and 48-hour incubation to distinguish cell proliferation. To determine the cause of different viability results from the MTT assay, the Annexin-FITC/PI test was used at concentrations of 0.1, 1, and 10 μM after 24- and 48-hour incubation. Results: 27-HC in concentrations of 5, 10, and 20 μM induced cell cytotoxicity compared with control. Also, the annexin V conjugated with fluorescein isothiocyanate/propidium iodide (Annexin-FITC/PI) test revealed an increase in total apoptotic cells treated with 0.1, 1, and 10 μM of 27-HC after 48 hours ( Conclusion: The identification of 27-HC's cytotoxic effects on both estrogen receptor (ER)-negative and ER-positive breast cancer cell lines is a novel discovery that may be linked to LXRβ.
Language	English
Publishing date	2023-10-28
Publishing country	India
Document type	Journal Article
ZDB-ID	2672524-1
ISSN	2277-9175
ISSN	2277-9175
DOI	10.4103/abr.abr_13_23
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: The Effects of 4-Week Aerobic Exercise on the Levels of CCl2, CCl5, and their Respective Receptors in Female BALB/C Mice Suffering from Breast Cancer.

Esmailiyan, Mehrnoosh / Kargarfard, Mehdi / Esfarjani, Fahimeh / Vaseghi, Golnaz / Haghjooy Javanmard, Shaghayegh / Amerizadeh, Atefeh

Advanced biomedical research

2023 Volume 12, Page(s) 28

Abstract: Background: The studies reported that chemokines Chemokine (C-C motif) ligand 2 (CCL2) and Chemokine (C-C motif) ligand 5 (CCL5) have tumor-promoting roles in breast cancer (BC). The aim of the present study was to evaluate the effect of 4 weeks of ... ...

Abstract	Background: The studies reported that chemokines Chemokine (C-C motif) ligand 2 (CCL2) and Chemokine (C-C motif) ligand 5 (CCL5) have tumor-promoting roles in breast cancer (BC). The aim of the present study was to evaluate the effect of 4 weeks of continuous aerobic exercise (AE) on chemokines CCL2 and CCL5 and their relative receptors in animal model of human BC. Materials and methods: BALB/c mice were divided randomly into four groups included cancer control (CC) and three other groups. The total duration of the experiment was 14 weeks, including 2 weeks of familiarization of mice with treadmills and three of 4-week periods of experiment. Tumor inoculation and formation were performed in the second 4-week period. Group 1 received AE in the first 4-week, Group 2 received AE in the second 4-week and Group 3 in the third 4-week. Results: The CCL2 was reduced significantly in Groups 1, 2, and 3 compared to control (F Conclusion: It can be concluded that 4-week AE significantly reduces the chemokines CCL2 and CCL5 and their respective receptors levels CCR5 and CCR2 in different stages, and it may have an inhibitory effect on tumor growth.
Language	English
Publishing date	2023-02-25
Publishing country	India
Document type	Journal Article
ZDB-ID	2672524-1
ISSN	2277-9175
ISSN	2277-9175
DOI	10.4103/abr.abr_288_21
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Does COVID-19 Escalate Aging Process? A Possible Concern.

Tayeri, Katayoun / Asadollahi, Kiarash / Madani, Navid / Haghjooy Javanmard, Shaghayegh

Advanced biomedical research

2022 Volume 11, Page(s) 106

Abstract: A key challenge after the COVID-19 pandemic will be managing the long-term sequelae for the millions of individuals who recover from the disease. Based on the available evidence, our hypothesis is that the SARS-CoV-2 pandemic and its long-term ... ...

Abstract	A key challenge after the COVID-19 pandemic will be managing the long-term sequelae for the millions of individuals who recover from the disease. Based on the available evidence, our hypothesis is that the SARS-CoV-2 pandemic and its long-term complications will lead to premature aging (in terms of health) of many people in the world. Obviously, to maintain appropriate public health and prevent poor health-care services, countries should think and plan about the health problems and the long-term consequences of SARS-CoV-2 after controlling the COVID-19 pandemic.
Language	English
Publishing date	2022-11-28
Publishing country	India
Document type	Journal Article
ZDB-ID	2672524-1
ISSN	2277-9175
ISSN	2277-9175
DOI	10.4103/abr.abr_350_21
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Remdesivir Prescription in Pregnant Women Infected with COVID-19: A Report of Compassionate Use.

Zafarbakhsh, Azam / Vaezi, Atefeh / Haghjooy Javanmard, Shaghayegh / Sabet, Fahimeh / Dehghan, Maryam

Advanced biomedical research

2023 Volume 12, Page(s) 163

Abstract: Background: Coronavirus disease 2019 (COVID-19) is an infectious disease that the physiological changes in pregnancy can make pregnant patients more susceptible to more severe forms of this infection. Hence, the treatment of COVID-19 in pregnant women ... ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) is an infectious disease that the physiological changes in pregnancy can make pregnant patients more susceptible to more severe forms of this infection. Hence, the treatment of COVID-19 in pregnant women can be challenging. This study was designed to evaluate the safety and efficacy of Remdesivir in pregnant women with COVID-19. Materials and methods: This study was conducted on 150 pregnant women with moderate to severe COVID-19 infection. Remdesivir was prescribed and continued for 5 or 10 days according to the patient's condition. Maternal and pregnancy outcomes and also recovery rates were evaluated. Moreover, additional variables were examined: age, gestational age, symptoms, O2 saturation and laboratory tests at admission, the interval between symptom initiation and admission to hospital and Remdesivir prescription, hospitalization days, and ICU admission. Results: The mean age was 32.37 years. Cough and dyspnea were the most prevalent symptoms (74% and 68.7%, respectively). At the time of admission, 79 (52.7%) women needed low-flow oxygen support, 67 (44.7%) needed high-flow oxygen support, and 4 (2.7%) were intubated. Fifty-four (36%) patients required ICU care. In patients who died (12 women), Remdesivir was prescribed later than those discharged ( Conclusion: The results suggest that the early prescription of Remdesivir in pregnant women with moderate COVID-19 can improve the outcomes.
Language	English
Publishing date	2023-06-30
Publishing country	India
Document type	Journal Article
ZDB-ID	2672524-1
ISSN	2277-9175
ISSN	2277-9175
DOI	10.4103/abr.abr_142_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Steroid in the Treatment of Outpatient COVID-19: A Multicenter Randomized Controlled Trial.

Amra, Babak / Vaezi, Atefeh / Soltaninejad, Forogh / Salahi, Mehrdad / Salmasi, Mehrzad / Haghjooy Javanmard, Shaghayegh

Advanced biomedical research

2023 Volume 12, Page(s) 122

Abstract: Background: Early treatment of COVID-19 patients could reduce hospitalization and death. The effect of corticosteroids in the outpatient setting is still unknown. This study aimed to determine the effect of corticosteroids in the prevention of ... ...

Abstract	Background: Early treatment of COVID-19 patients could reduce hospitalization and death. The effect of corticosteroids in the outpatient setting is still unknown. This study aimed to determine the effect of corticosteroids in the prevention of hospitalization of nonsevere cases. Materials and methods: This study is a multicenter randomized controlled trial. Seventy five nonsevere COVID-19 patients presented between days 7 and 14 of their symptoms received either prednisolone or placebo. The primary outcome was hospitalization. The study protocol was registered in the Iranian Registry of Clinical Trials on December 2, 2020 (IRCT20171219037964N2). Results: Although the rate of hospitalization in the prednisolone group was higher than the placebo group (10.8% vs. 7.9%, respectively), it was not statistically significant ( Conclusion: Considering the null effect of corticosteroids in the prevention of hospitalization in outpatient settings, it is suggested not to consider corticosteroids for outpatient treatment.
Language	English
Publishing date	2023-05-15
Publishing country	India
Document type	Journal Article
ZDB-ID	2672524-1
ISSN	2277-9175
ISSN	2277-9175
DOI	10.4103/abr.abr_72_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: The Effect of Eight Weeks of Aquatic Exercises on Muscle Strength in Children with Cerebral Palsy: A Case Study.

Esmailiyan, Mehrnoosh / Marandi, Seyed Mohamad / Darvishi, Maryam / Haghjooy Javanmard, Shaghayegh / Amerizadeh, Atefeh

Advanced biomedical research

2023 Volume 12, Page(s) 87

Abstract: Background: Cerebral palsy in children is considered a non-progressive brain injury due to abnormal brain development. The aim of this study was to investigate the effect of eight weeks of aquatic exercises on muscle strength in children with cerebral ... ...

Abstract	Background: Cerebral palsy in children is considered a non-progressive brain injury due to abnormal brain development. The aim of this study was to investigate the effect of eight weeks of aquatic exercises on muscle strength in children with cerebral palsy. Materials and methods: This study was performed on three boys with cerebral palsy with a mean age of 6.5 years. In this research, a single case study method with A1-B-A2 design has been used. After determining the position of the baseline, the intervention began and during 24 sessions of individual intervention, aquatic exercises were presented to the subjects and all three subjects were followed up for 2 consecutive weeks and one month after the end of the intervention. The strength of the flexor muscles of the arms and legs was measured by a power track dynamometer made by JTECK with a threshold of 4.4 N. Results: Based on the indicators of descriptive statistics and visual analysis, the intervention was effective for all three participants in muscle strength, and the strength of individuals after the intervention has improved compared to the baseline stage (percentage). Information overlap for the first and second participant in the strength of right thigh flexors was 75% and for the third participant was 100%. The strength of the upper and lower torso muscles improved after the end of the training compared to the basic stage. Conclusion: Aquatic exercises can increase the strength of children with cerebral palsy and provide a favorable environment for children with cerebral palsy.
Language	English
Publishing date	2023-04-25
Publishing country	India
Document type	Journal Article
ZDB-ID	2672524-1
ISSN	2277-9175
ISSN	2277-9175
DOI	10.4103/abr.abr_363_21
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito