Article: Thy-1 as an Integrator of Diverse Extracellular Signals.
Frontiers in cell and developmental biology
2019 Volume 7, Page(s) 26
Abstract: Thy-1 was discovered over 50 years ago, and in that time investigators from a broad variety of fields have described numerous and heterogeneous biological functions of Thy-1 in multiple contexts. As an outwardly facing cell surface molecule, it is well ... ...
| Abstract | Thy-1 was discovered over 50 years ago, and in that time investigators from a broad variety of fields have described numerous and heterogeneous biological functions of Thy-1 in multiple contexts. As an outwardly facing cell surface molecule, it is well positioned to receive extracellular signals; previously reviewed studies have confirmed an important role in cell-cell and cell-matrix adhesion, cell migration, and regulation of outside-in signaling. More recent studies reviewed here expand the repertoire of Thy-1 effects on signaling pathways, and reveal novel roles in mechanotransduction, cellular differentiation, viral entry, and extracellular vesicle binding and internalization. All of these studies contribute to understanding Thy-1 as a context-dependent integrator of a diverse range of extracellular information, and provide impetus for further studies, some of which are suggested here. |
|---|---|
| Language | English |
| Publishing date | 2019-02-25 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2737824-X |
| ISSN | 2296-634X |
| ISSN | 2296-634X |
| DOI | 10.3389/fcell.2019.00026 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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