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  1. Article ; Online: Acute adrenal crisis and mortality in adrenal insufficiency: Still a concern in 2018!

    Hahner, Stefanie

    Annales d'endocrinologie

    2018  Volume 79, Issue 3, Page(s) 164–166

    Abstract: Despite established replacement therapy, mortality in patients suffering from chronic adrenal insufficiency is increasing. This may be partly explained by the fact that lack of adrenal stress hormones impairs the body's capacity to deal adequately with ... ...

    Abstract Despite established replacement therapy, mortality in patients suffering from chronic adrenal insufficiency is increasing. This may be partly explained by the fact that lack of adrenal stress hormones impairs the body's capacity to deal adequately with stress situations, resulting in life-threatening adrenal crises. Since many such situations are of rapid onset, concepts that allow for quick response to emergencies are particularly important. Optimal education for patients and relatives, improved awareness on the part of health professionals and the development of new easy-to-use drugs for acute therapy are of prime importance.
    MeSH term(s) Acute Disease ; Addison Disease/epidemiology ; Addison Disease/mortality ; Addison Disease/therapy ; Adrenal Insufficiency/epidemiology ; Adrenal Insufficiency/mortality ; Adrenal Insufficiency/therapy ; Consensus ; Endocrinology/standards ; Endocrinology/trends ; Glucocorticoids/therapeutic use ; Hormone Replacement Therapy/methods ; Humans
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2018-04-30
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2018.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nebennieren-Erkrankungen: Morbus Addison.

    Chifu, Irina / Hahner, Stefanie

    Deutsche medizinische Wochenschrift (1946)

    2022  Volume 147, Issue 3, Page(s) 98–106

    Abstract: Addison's disease typically results from the autoimmune destruction of the adrenal cortex and requires lifelong replacement with glucocorticoids and mineralocorticoids. Main symptoms are non-specific and, therefore, often overlooked or misleading. ... ...

    Title translation Adrenal gland diseases: Addison's Disease.
    Abstract Addison's disease typically results from the autoimmune destruction of the adrenal cortex and requires lifelong replacement with glucocorticoids and mineralocorticoids. Main symptoms are non-specific and, therefore, often overlooked or misleading. Patients are frequently not diagnosed until experiencing a life-threatening adrenal crisis. This article highlights the essential clinical characteristics, diagnostic aspects and principles of management of adrenal insufficiency.
    MeSH term(s) Addison Disease/diagnosis ; Addison Disease/therapy ; Adrenal Cortex ; Adrenal Gland Diseases/diagnosis ; Adrenal Gland Diseases/therapy ; Adrenal Insufficiency/diagnosis ; Glucocorticoids/therapeutic use ; Humans
    Chemical Substances Glucocorticoids
    Language German
    Publishing date 2022-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1370-5874
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  3. Article: Nebennieren-Erkrankungen: Morbus Addison

    Chifu, Irina / Hahner, Stefanie

    DMW - Deutsche Medizinische Wochenschrift

    2022  Volume 147, Issue 03, Page(s) 98–106

    Keywords Nebenniereninsuffizienz ; Autoimmun ; Nebennierenkrise ; Schulung ; adrenal insufficiency ; autoimmune ; adrenal crisis ; patient education
    Language German
    Publishing date 2022-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1370-5874
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  4. Article ; Online: Adrenal functional imaging - which marker for which indication?

    Werner, Rudolf A / Hartrampf, Philipp E / Schirbel, Andreas / Hahner, Stefanie

    Current opinion in urology

    2022  Volume 32, Issue 6, Page(s) 585–593

    Abstract: Purpose of review: In recent years, a broad spectrum of molecular image biomarkers for assessment of adrenal functional imaging have penetrated the clinical arena. Those include positron emission tomography and single photon emission computed tomography ...

    Abstract Purpose of review: In recent years, a broad spectrum of molecular image biomarkers for assessment of adrenal functional imaging have penetrated the clinical arena. Those include positron emission tomography and single photon emission computed tomography radiotracers, which either target glucose transporter, CYP11B enzymes, C-X-C motif chemokine receptor 4, norepinephrine transporter or somatostatin receptors. We will provide an overview of key radiopharmaceuticals and determine their most relevant clinical applications, thereby providing a roadmap for the right image biomarker at the right time for the right patient.
    Recent findings: Numerous radiotracers for assessment of adrenal incidentalomas ([ 18 F]FDG; [ 123 I]IMTO/IMAZA), ACC ([ 123 I]IMTO/IMAZA; [ 18 F]FDG; [ 68 Ga]PentixaFor), pheochromocytomas and paragangliomas ([ 123 I]mIBG; [ 18 F]flubrobenguane; [ 18 F]AF78; [ 68 Ga]DOTATOC/-TATE), or primary aldosteronism ([ 11 C]MTO, [ 68 Ga]PentixaFor) are currently available and have been extensively investigated in recent years. In addition, the field is currently evolving from adrenal functional imaging to a patient-centered adrenal theranostics approach, as some of those radiotracers can also be labeled with ß-emitters for therapeutic purposes.
    Summary: The herein reviewed functional image biomarkers may not only allow to increase diagnostic accuracy for adrenal gland diseases but may also enable for achieving substantial antitumor effects in patients with adrenocortical carcinoma, pheochromocytoma or paraganglioma.
    MeSH term(s) 3-Iodobenzylguanidine ; Adrenal Cortex Neoplasms ; Adrenal Gland Neoplasms/diagnostic imaging ; Adrenal Gland Neoplasms/pathology ; Biomarkers ; Fluorodeoxyglucose F18 ; Glucose Transport Proteins, Facilitative ; Humans ; Norepinephrine Plasma Membrane Transport Proteins ; Paraganglioma/pathology ; Pheochromocytoma ; Positron-Emission Tomography ; Radiopharmaceuticals ; Receptors, Chemokine ; Receptors, Somatostatin
    Chemical Substances Biomarkers ; Glucose Transport Proteins, Facilitative ; Norepinephrine Plasma Membrane Transport Proteins ; Radiopharmaceuticals ; Receptors, Chemokine ; Receptors, Somatostatin ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; 3-Iodobenzylguanidine (35MRW7B4AD)
    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1091792-5
    ISSN 1473-6586 ; 0963-0643
    ISSN (online) 1473-6586
    ISSN 0963-0643
    DOI 10.1097/MOU.0000000000001040
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  5. Article ; Online: Fluorinated aldosterone synthase (CYP11B2)-inhibitors for differential diagnosis between bilateral and unilateral conditions of primary aldosteronism.

    Maier, Philipp / Heinze, Britta / Gabor, Sabine / Reese, Samario / Hahner, Stefanie / Schirbel, Andreas

    Bioorganic & medicinal chemistry letters

    2023  Volume 96, Page(s) 129501

    Abstract: The enzyme aldosterone synthase (CYP11B2) is specifically expressed in aldosterone-producing tissue of the adrenal cortex and is overexpressed in aldosterone-producing adenomas (APA). It therefore represents an ideal target for molecular imaging, ... ...

    Abstract The enzyme aldosterone synthase (CYP11B2) is specifically expressed in aldosterone-producing tissue of the adrenal cortex and is overexpressed in aldosterone-producing adenomas (APA). It therefore represents an ideal target for molecular imaging, particularly for the differential diagnosis between bilateral hyperplasia and unilateral APA in primary aldosteronism. However, the presence of the cortisol-producing enzyme 11β-hydroxylase (CYP11B1) in the adrenal cortex remains very challenging owing to its high homology to CYP11B2. Within this study, we efficiently synthesized a variety of disubstituted fluorinated pyridines and pyrazines by Suzuki coupling reactions. These compounds were evaluated for their ability to inhibit CYP11B1 and CYP11B2 in transfected Y1 cells and in NCI-h295 cells. Several compounds were found to exhibit excellent affinity (IC
    MeSH term(s) Humans ; Cytochrome P-450 CYP11B2 ; Steroid 11-beta-Hydroxylase ; Aldosterone ; Hyperaldosteronism/diagnosis ; Diagnosis, Differential ; Adenoma
    Chemical Substances Cytochrome P-450 CYP11B2 (EC 1.14.15.4) ; Steroid 11-beta-Hydroxylase (EC 1.14.15.4) ; Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2023.129501
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  6. Book ; Online ; Thesis: Krankheitslast und Auftreten erkrankungsassoziierter Komplikationen bei Patienten mit chronischem Hypoparathyreoidismus - Patienten-Survey

    Engbers, Sarah [Verfasser] / Hahner, Stefanie [Gutachter] / Schlegel, Nicolas [Gutachter]

    2022  

    Author's details Sarah Engbers ; Gutachter: Stefanie Hahner, Nicolas Schlegel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität Würzburg
    Publishing place Würzburg
    Document type Book ; Online ; Thesis
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  7. Article ; Online: Das Conn-Syndrom – häufig, und immer noch zu selten diagnostiziert.

    Fuss, Carmina T / Hahner, Stefanie / Heinrich, Daniel A / Adolf, Christian

    Der Internist

    2021  Volume 63, Issue 1, Page(s) 25–33

    Abstract: Conn's syndrome represents the most common cause of endocrine hypertension and is associated with an increased cardiovascular risk, a series of comorbidities (including type 2 diabetes mellitus) and with their frequent occurrence. Therefore, a correct ... ...

    Title translation Conn's syndrome-Frequent and still too rarely diagnosed to underdiagnosed.
    Abstract Conn's syndrome represents the most common cause of endocrine hypertension and is associated with an increased cardiovascular risk, a series of comorbidities (including type 2 diabetes mellitus) and with their frequent occurrence. Therefore, a correct and rapid diagnosis is of essential importance. Measurement of the aldosterone-renin ratio is used as a first screening test for primary aldosteronism. This should ideally be evaluated under optimized conditions (e.g. at rest), after adjustment of the blood pressure medication and with an equilibrated potassium balance. In cases of elevated aldosterone to renin ratio, further confirmatory testing as well as imaging of the adrenal glands is needed. After confirmation of Conn's syndrome a differentiation between a unilateral and bilateral adrenal disease is necessary for further treatment planning. The current gold standard is still selective adrenal vein catheterization. Promising alternatives to an adrenal vein catheter, such as functional imaging techniques and measurement of steroid profiles are currently being investigated in clinical trials. In cases of lateralization of aldosterone production, unilateral laparoscopic adrenalectomy of the affected side is the treatment of choice. In contrast, patients with bilateral disease or patients with contraindications for adrenalectomy should receive life-long treatment with mineralocorticoid receptor antagonists.
    MeSH term(s) Adrenalectomy ; Aldosterone ; Diabetes Mellitus, Type 2 ; Humans ; Hyperaldosteronism/surgery ; Hyperaldosteronism/therapy ; Hypertension ; Renin
    Chemical Substances Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15)
    Language German
    Publishing date 2021-11-30
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-021-01208-5
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  8. Article ; Online: Hormone und Herz – spannende Fälle aus dem klinischen Alltag.

    Fuss, Carmina Teresa / Kroiss, Matthias / Hahner, Stefanie / Fassnacht, Martin

    Deutsche medizinische Wochenschrift (1946)

    2021  Volume 146, Issue 5, Page(s) 323–329

    Abstract: The heart is closely connected with the endocrine system. On the one hand, the heart is an endocrine organ itself and produces several hormones like atrial and brain natriuretic peptides. On the other hand, cardiac structures are targets of many hormones ...

    Title translation Hormones and The Heart - Clinical Cases.
    Abstract The heart is closely connected with the endocrine system. On the one hand, the heart is an endocrine organ itself and produces several hormones like atrial and brain natriuretic peptides. On the other hand, cardiac structures are targets of many hormones like catecholamines, thyroid hormones, and corticosteroids. Therefore, many endocrine diseases come with cardiac symptoms. In this article, we describe three instructive clinical cases of patients with hormonal disorders that mimicked cardiovascular disease. Furthermore, we shortly discuss useful diagnostic and treatment algorithms. All cases emphasize the value of interdisciplinary management of patients with cardiac symptoms.
    MeSH term(s) Cardiovascular Diseases ; Catecholamines/metabolism ; Endocrine System/physiology ; Endocrine System Diseases ; Heart/physiology ; Hormones/metabolism ; Hormones/physiology ; Humans ; Natriuretic Peptide, Brain/metabolism
    Chemical Substances Catecholamines ; Hormones ; Natriuretic Peptide, Brain (114471-18-0)
    Language German
    Publishing date 2021-03-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1235-0583
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  9. Book ; Online ; Thesis: Sekundärneoplasien bei Patienten mit primärem Hyperaldosteronismus

    Köchel, Katrin [Verfasser] / Hahner, Stefanie [Gutachter]

    2020  

    Author's details Katrin Köchel ; Gutachter: Stefanie Hahner
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität Würzburg
    Publishing place Würzburg
    Document type Book ; Online ; Thesis
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  10. Article ; Online: Adrenal functional imaging.

    Werner, Rudolf A / Schirbel, Andreas / Buck, Andreas K / Fassnacht, Martin / Hahner, Stefanie

    Presse medicale (Paris, France : 1983)

    2022  Volume 51, Issue 2, Page(s) 104114

    Abstract: Given the more widespread use of conventional imaging techniques such as magnetic resonance imaging or computed tomography, recent years have witnessed an increased rate of incidental findings in the adrenal gland and those adrenal masses can be either ... ...

    Abstract Given the more widespread use of conventional imaging techniques such as magnetic resonance imaging or computed tomography, recent years have witnessed an increased rate of incidental findings in the adrenal gland and those adrenal masses can be either of benign or malignant origin. In this regard, routinely conducted morphological imaging cannot always reliably distinguish between cancerous and noncancerous lesions. As such, those incidental adrenal masses trigger further diagnostic work-up, including molecular functional imaging providing a non-invasive read-out on a sub-cellular level. For instance, [
    Language English
    Publishing date 2022-02-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2022.104114
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