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  1. Article ; Online: Superconductivity in nickel-based 112 systems

    Qiangqiang Gu / Hai-Hu Wen

    The Innovation, Vol 3, Iss 1, Pp 100202- (2022)

    2022  

    Abstract: Superconductivity has been discovered recently in infinite-layer nickel-based 112 thin films R1−xAxNiO2 (R = La, Nd, Pr and A = Sr, Ca). They are isostructural to the infinite-layer cuprate (Ca,Sr)CuO2 and are supposed to have a formal Ni 3d9 valence, ... ...

    Abstract Superconductivity has been discovered recently in infinite-layer nickel-based 112 thin films R1−xAxNiO2 (R = La, Nd, Pr and A = Sr, Ca). They are isostructural to the infinite-layer cuprate (Ca,Sr)CuO2 and are supposed to have a formal Ni 3d9 valence, thus providing a new platform to study the unconventional pairing mechanism of high-temperature superconductors. This important discovery immediately triggers a huge amount of innovative scientific curiosity in the field. In this paper, we try to give an overview of the recent research progress on the newly found superconducting nickelate systems, both from experimental and theoretical aspects. We mainly focus on the electronic structures, magnetic excitations, phase diagrams and superconducting gaps, and finally make some open discussions for possible pairing symmetries in Ni-based 112 systems. Public summary: • The infinite-layer nickel-based 112 thin films R1−xAxNiO2 can host superconductivity up to 15 K • R1−xAxNiO2 is a multiband system, in which the short-range antiferromagnetic fluctuations can be detected • R1−xAxNiO2 has an unconventional superconducting pairing sate with a robust d-wave gap and a full gap without unified understanding • The nickelate system provides a new platform for researching unconventional superconductivity
    Keywords Science (General) ; Q1-390
    Subject code 530
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The Roles of 2-Hydroxyglutarate

    Xin Du / Hai Hu

    Frontiers in Cell and Developmental Biology, Vol

    2021  Volume 9

    Abstract: 2-Hydroxyglutarate (2-HG) is structurally similar to α-ketoglutarate (α-KG), which is an intermediate product of the tricarboxylic acid (TCA) cycle; it can be generated by reducing the ketone group of α-KG to a hydroxyl group. The significant role that 2- ...

    Abstract 2-Hydroxyglutarate (2-HG) is structurally similar to α-ketoglutarate (α-KG), which is an intermediate product of the tricarboxylic acid (TCA) cycle; it can be generated by reducing the ketone group of α-KG to a hydroxyl group. The significant role that 2-HG plays has been certified in the pathophysiology of 2-hydroxyglutaric aciduria (2HGA), tumors harboring mutant isocitrate dehydrogenase 1/2 (IDH1/2mt), and in clear cell renal cell carcinoma (ccRCC). It is taken as an oncometabolite, raising much attention on its oncogenic mechanism. In recent years, 2-HG has been verified to accumulate in the context of hypoxia or acidic pH, and there are also researches confirming the vital role that 2-HG plays in the fate decision of immune cells. Therefore, 2-HG not only participates in tumorigenesis. This text will also summarize 2-HG’s identities besides being an oncometabolite and will discuss their enlightenment for future research and clinical treatment.
    Keywords 2-Hydroxyglutarate ; epigenetics ; metabolism ; immunology ; isocitrate dehydrogenase ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  3. Article ; Online: Assessment of earthquake casualties and comparison of accuracy of five injury triage methods

    Yang Peng / Hai Hu

    BMJ Open, Vol 11, Iss

    evidence from a retrospective study

    2021  Volume 10

    Keywords Medicine ; R
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
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  4. Article ; Online: A flexible and accurate method for electroencephalography rhythms extraction based on circulant singular spectrum analysis

    Hai Hu / Zihang Pu / Peng Wang

    PeerJ, Vol 10, p e

    2022  Volume 13096

    Abstract: Rhythms extraction from electroencephalography (EEG) signals can be used to monitor the physiological and pathological states of the brain and has attracted much attention in recent studies. A flexible and accurate method for EEG rhythms extraction was ... ...

    Abstract Rhythms extraction from electroencephalography (EEG) signals can be used to monitor the physiological and pathological states of the brain and has attracted much attention in recent studies. A flexible and accurate method for EEG rhythms extraction was proposed by incorporating a novel circulant singular spectrum analysis (CiSSA). The EEG signals are decomposed into the sum of a set of orthogonal reconstructed components (RCs) at known frequencies. The frequency bandwidth of each RC is limited to a particular brain rhythm band, with no frequency mixing between different RCs. The RCs are then grouped flexibly to extract the desired EEG rhythms based on the known frequencies. The extracted brain rhythms are accurate and no mixed components of other rhythms or artifacts are included. Simulated EEG data based on the Markov Process Amplitude EEG model and experimental EEG data in the eyes-open and eyes-closed states were used to verify the CiSSA-based method. The results showed that the CiSSA-based method is flexible in alpha rhythms extraction and has a higher accuracy in distinguishing between the eyes-open and eyes-closed states, compared with the basic SSA method, the wavelet decomposition method, and the finite impulse response filtering method.
    Keywords Rhythms extraction ; Electroencephalography ; Circulant singular spectrum analysis ; Eyes-open and eyes-closed condition ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 518
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Superconductivity in nickel-based 112 systems.

    Gu, Qiangqiang / Wen, Hai-Hu

    Innovation (Cambridge (Mass.))

    2021  Volume 3, Issue 1, Page(s) 100202

    Abstract: Superconductivity has been discovered recently in infinite-layer nickel-based 112 thin ... ...

    Abstract Superconductivity has been discovered recently in infinite-layer nickel-based 112 thin films
    Language English
    Publishing date 2021-12-24
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-6758
    ISSN (online) 2666-6758
    DOI 10.1016/j.xinn.2021.100202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats.

    Jing, Shao-Ze / Yang, Shu-Han / Qu, Yun-Kun / Hao, Hai-Hu / Wu, Hua

    Current medical science

    2024  Volume 44, Issue 2, Page(s) 355–368

    Abstract: Objective: Osteoarthritis (OA) is a degenerative joint disorder characterized by the gradual degradation of joint cartilage and local inflammation. This study aimed to investigate the anti-OA effect of scutellarein (SCU), a single-unit flavonoid ... ...

    Abstract Objective: Osteoarthritis (OA) is a degenerative joint disorder characterized by the gradual degradation of joint cartilage and local inflammation. This study aimed to investigate the anti-OA effect of scutellarein (SCU), a single-unit flavonoid compound obtained from Scutellaria barbata D. Don, in rats.
    Methods: The extracted rat chondrocytes were treated with SCU and IL-1β. The chondrocytes were divided into control group, IL-1β group, IL-1β+SCU 50 µmol/L group, and IL-1β+SCU 100 µmol/L group. Morphology of rat chondrocytes was observed by toluidine blue and safranin O staining. CCK-8 method was used to detect the cytotoxicity of SCU. ELISA, qRT-PCR, Western blotting, immunofluorescence, SAβ-gal staining, flow cytometry, and bioinformatics analysis were applied to evaluate the effect of SCU on rat chondrocytes under IL-1β intervention. Additionally, anterior cruciate ligament transection (ACL-T) was used to establish a rat OA model. Histological changes were detected by safranin O/fast green, hematoxylin-eosin (HE) staining, and immunohistochemistry.
    Results: SCU protected cartilage and exhibited anti-inflammatory effects via multiple mechanisms. Specifically, it could enhance the synthesis of extracellular matrix in cartilage cells and inhibit its degradation. In addition, SCU partially inhibited the nuclear factor kappa-B/mitogen-activated protein kinase (NF-κB/MAPK) pathway, thereby reducing inflammatory cytokine production in the joint cartilage. Furthermore, SCU significantly reduced IL-1β-induced apoptosis and senescence in rat chondrocytes, further highlighting its potential role in OA treatment. In vivo experiments revealed that SCU (at a dose of 50 mg/kg) administered for 2 months could significantly delay the progression of cartilage damage, which was reflected in a lower Osteoarthritis Research Society International (OARSI) score, and reduced expression of matrix metalloproteinase 13 (MMP13) in cartilage.
    Conclusion: SCU is effective in the therapeutic management of OA and could serve as a potential candidate for future clinical drug therapy for OA.
    MeSH term(s) Rats ; Animals ; Chondrocytes ; Osteoarthritis/drug therapy ; Osteoarthritis/metabolism ; Inflammation/pathology ; Cartilage ; Apigenin
    Chemical Substances scutellarein (P460GTI853) ; Apigenin (7V515PI7F6)
    Language English
    Publishing date 2024-04-04
    Publishing country China
    Document type Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-024-2854-6
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  7. Article ; Online: Development of a Nomogram Model to Identify Appropriate Candidates from Cytoreductive Nephrectomy in Metastatic Renal Cell Carcinoma Based on the Surveillance, Epidemiology and End Results Database.

    Ren, Kong / Ning, Hao / Wu, Hai-Hu / Wu, Fei / Lyu, Jia-Ju

    Clinical genitourinary cancer

    2024  , Page(s) 102062

    Abstract: Background: Although a survival benefit was observed in patients with metastatic renal cell carcinoma (mRCC) who underwent cytoreductive nephrectomy (CN), there is a lack of effective tools for predicting which individuals are likely to benefit from ... ...

    Abstract Background: Although a survival benefit was observed in patients with metastatic renal cell carcinoma (mRCC) who underwent cytoreductive nephrectomy (CN), there is a lack of effective tools for predicting which individuals are likely to benefit from surgical intervention. Herein, we developed a predictive model using data from the Surveillance, Epidemiology, and End Results (SEER) database.
    Materials and methods: Patients diagnosed with mRCC were screened from the SEER database (2010-2020), supplemented by patients from East Asia. Patients were categorized into surgical and non-surgical groups, with propensity score matching conducted to balance baseline characteristics. Logistic regression analysis was performed to identify independent factors associated with benefits and a nomogram was constructed based on these factors.
    Results: This study included 11,044 cases from the SEER database and 50 cases from an external validation cohort. CN was identified as an independent protective factor for OS. A nomogram was established, and it performed well in the training and validation sets. The calibration curves and DCA confirmed that the nomogram model could precisely predict the probability of surgical benefit. We used the nomogram to classify surgical patients into benefit and non-benefit groups. Then, we found that OS was significantly higher in the benefit group than in the non-benefit group. The external validation cohort observed the same result (P=0.035).
    Conclusion: While CN offers potential benefits for patients with mRCC, its applicability varies across the patient population. Our study constructed a nomogram that quantitatively assesses the likelihood of surgical benefit in mRCC patients, facilitating more tailored therapeutic decision-making.
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2225121-2
    ISSN 1938-0682 ; 1558-7673
    ISSN (online) 1938-0682
    ISSN 1558-7673
    DOI 10.1016/j.clgc.2024.02.013
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  8. Article ; Online: N6-methylandenosine-related lncRNAs play an important role in the prognosis and immune microenvironment of pancreatic ductal adenocarcinoma

    YuHai Hu / YiPing Chen

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 14

    Abstract: Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive, fatal tumor. N6-methylandenosine (m6A) methylation is the major epigenetic modification of RNA including lncRNAs. The roles of m6A-related lncRNAs in PDAC have not been fully ... ...

    Abstract Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive, fatal tumor. N6-methylandenosine (m6A) methylation is the major epigenetic modification of RNA including lncRNAs. The roles of m6A-related lncRNAs in PDAC have not been fully clarified. This study aims to assess gene signatures and prognostic value of m6A-related lncRNAs in PDAC. The Cancer Genome Atlas (TCGA) dataset and the International Cancer Genome Consortium (ICGC) dataset were explored to identify m6A-related lncRNAs. Univariate, least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression were performed to construct the m6A-related lncRNAs prognostic riskscore (m6A-LPR) model to predict the overall survival (OS) in the TCGA training cohort. Kaplan–Meier curve with log-rank test and receiver operating characteristic (ROC) curve were used to evaluate the prognostic value of the m6A-LPR. Furthermore, the robustness of the m6A-LPR was further validated in the ICGC cohort. Tumor immunity was evaluated using ESTIMATE and CIBERSORT algorithms. A total of 262 m6A-related lncRNAs were identified in two datasets. In the TCGA training cohort, 28 prognostic m6A-related lncRNAs were identified and the m6A-LPR including four m6A-related lncRNAs was constructed. The m6A-LPR was able to identify high-risk patients with significantly poorer OS and accurately predict OS in both the TCGA training cohort and the ICGC validation cohort. Analysis of tumor immunity revealed that high-risk groups had remarkably lower stromal, immune, and ESTIMATE scores. Moreover, high-risk groups were associated with significantly higher levels of plasma B cells and resting NK cells infiltration, and lower levels of infiltrating resting memory CD4 T cells, monocytes, and resting mast cells. Our study proposed a robust m6A-related prognostic signature of lncRNAs for predicting OS in PDAC, which provides some clues for further studies focusing on the mechanism process underlying m6A modification of lncRNAs.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Antiferromagnetism, charge ordering and stretched Ni-O bond in Ln

    Fan, Xinwei / Wen, Hai-Hu

    Journal of physics. Condensed matter : an Institute of Physics journal

    2020  Volume 33, Issue 7, Page(s) 75503

    Abstract: Superconductivity was recently observed in Sr-doped ... ...

    Abstract Superconductivity was recently observed in Sr-doped NdNiO
    Language English
    Publishing date 2020-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472968-4
    ISSN 1361-648X ; 0953-8984
    ISSN (online) 1361-648X
    ISSN 0953-8984
    DOI 10.1088/1361-648X/abc6c4
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  10. Article ; Online: Research on Public Participation in Sustainable Urbanization Process

    Hai Hu

    Journal of Politics and Law, Vol 5, Iss

    2012  Volume 2

    Abstract: This paper argues that the problems emerging in the process of current Government-led urbanization are caused by the unbalanced game mechanism between state forces and social forces in nature. In future, the key for achieving the sustainability of ... ...

    Abstract This paper argues that the problems emerging in the process of current Government-led urbanization are caused by the unbalanced game mechanism between state forces and social forces in nature. In future, the key for achieving the sustainability of Chinese urbanization process is to seek for the institutional balance between the state and the society. Therefore, it is necessary to include the public interests demands into the process of urban development to achieve the benign interaction between the state and the society, jointly promoting the sustainable urban development.
    Keywords Political science (General) ; JA1-92 ; Political science ; J ; Law in general. Comparative and uniform law. Jurisprudence ; K1-7720 ; Law ; K
    Language English
    Publishing date 2012-04-01T00:00:00Z
    Publisher Canadian Center of Science and Education
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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