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  1. AU="Hai-Tao Tang"
  2. AU=Rouse Benjamin AU=Rouse Benjamin
  3. AU="Rabensteiner, Toni"
  4. AU="Chowdhury, Forhad Uddin Hassan" AU="Chowdhury, Forhad Uddin Hassan"
  5. AU=Verdone Loredana AU=Verdone Loredana
  6. AU="Venegas, M"
  7. AU="Burtnick, Mary N"
  8. AU=Frisoni Giovanni B
  9. AU="Dhiraj Kumar"
  10. AU="Isaac S. Lee"
  11. AU="Bals, Julia"
  12. AU="Rovira-Clavé, Xavier"
  13. AU="Den Boer, Monique L"
  14. AU="Potts, T."
  15. AU="Cifuentes-Diaz, Carmen"
  16. AU="Alvim, Ricardo G"
  17. AU="Barron II, Joseph C"
  18. AU="Godin, Shea-Lee"
  19. AU="Leng, Chengcai"
  20. AU="Hyslop, Brian W"
  21. AU="Suzanne Fischer"
  22. AU="Aboelata, Noha"
  23. AU="Chiang, Sarah N"
  24. AU="Wessel, Kristin M"
  25. AU="Wilson, Jenna M"
  26. AU="Goines, Paula"
  27. AU=Ippolito Mariachiara AU=Ippolito Mariachiara
  28. AU="Jose Chauca"
  29. AU="Asih, Puji B S"
  30. AU="Dsane-Selby, Lydia"
  31. AU="Tolossa, Tadesse"
  32. AU="Erdal Bedir"

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  1. Artikel: Palladium-Metalated Porous Organic Polymers as Recyclable Catalysts for the Chemioselective Synthesis of Thiazoles from Thiobenzamides and Isonitriles

    Tong, Wei / Hai-Tao Tang / Heng-Shan Wang / Wen-Hao Li / Yan He / Ying-Ming Pan / Zu-Yu Mo

    Organic letters. 2018 Apr. 05, v. 20, no. 8

    2018  

    Abstract: Two types of thiazole derivatives are synthesized through a multistep cascade sequence with Pd-metalated phosphorus-doped porous organic polymers (POPs) as heterogeneous catalysts. The POPs could be used as both ligands and catalyst supports. No obvious ... ...

    Abstract Two types of thiazole derivatives are synthesized through a multistep cascade sequence with Pd-metalated phosphorus-doped porous organic polymers (POPs) as heterogeneous catalysts. The POPs could be used as both ligands and catalyst supports. No obvious aggregation and loss of any catalytic activity of the catalysts were observed after 10 runs of the reaction. More importantly, imidazo[4,5-d]thiazoles, which are a new class of thiazole derivatives, could be obtained through K2CO3-promoted intramolecular cyclization of the synthesized polysubstituted thiazoles. Furthermore, the in vitro anticancer activity of these new compounds were tested with MTT assay, and compound 4b exhibited good antitumor activity toward T-24 and A549 cells with IC50 values of 10.3 ± 0.8 and 11.8 ± 0.5 μM, respectively. In addition, the action mechanism of 4b on tumor cells was determined.
    Schlagwörter antineoplastic activity ; catalysts ; catalytic activity ; chemical structure ; cyclization reactions ; inhibitory concentration 50 ; ligands ; neoplasm cells ; polymers ; thiazoles
    Sprache Englisch
    Erscheinungsverlauf 2018-0405
    Umfang p. 2494-2498.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.8b00886
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel: Photocatalytic Construction of S–S and C–S Bonds Promoted by Acridinium Salt: An Unexpected Pathway To Synthesize 1,2,4-Dithiazoles

    Huang, Xiao-Ying / Hai-Tao Tang / Heng-Shan Wang / Rui Ding / Yan-Li Xu / Yan-Yan Chen / Ying-Ming Pan / Zu-Yu Mo

    Organic letters. 2018 Aug. 08, v. 20, no. 16

    2018  

    Abstract: An unexpected cyclization of thioamides with p-quinone methides promoted by acridinium salt under the irradiation of visible light furnished 1,2,4-dithiazoles in moderate to good yields. In addition, the reaction of the obtained 1,2,4-dithiazoles with ... ...

    Abstract An unexpected cyclization of thioamides with p-quinone methides promoted by acridinium salt under the irradiation of visible light furnished 1,2,4-dithiazoles in moderate to good yields. In addition, the reaction of the obtained 1,2,4-dithiazoles with isocyanides offered a new entry for the synthesis of thiazol-5(4H)-imines in moderate yields.
    Schlagwörter chemical bonding ; chemical structure ; irradiation ; photocatalysis ; thioamides
    Sprache Englisch
    Erscheinungsverlauf 2018-0808
    Umfang p. 4819-4823.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.8b01970
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  3. Artikel: Porous Organic Polymer as a Heterogeneous Ligand for Highly Regio- and Stereoselective Nickel-Catalyzed Hydrosilylation of Alkyne

    Zhou, Yun-Bing / Guo-Liang Zhang / Hai-Tao Tang / Jia-Hao Zeng / Li Chen / Ren-Hao Li / Xin-Yang Fan / Ying-Ming Pan / Zhi-Kai Liu / Zhuang-Ping Zhan

    Organic letters. 2018 Nov. 29, v. 20, no. 24

    2018  

    Abstract: A porous organic polymer (POL-Xantphos) was synthesized and employed as a heterogeneous ligand for selective hydrosilylation of alkynes. It exhibits high selectivity and catalytic efficiency toward a broad range of alkynes. Owing to the confinement ... ...

    Abstract A porous organic polymer (POL-Xantphos) was synthesized and employed as a heterogeneous ligand for selective hydrosilylation of alkynes. It exhibits high selectivity and catalytic efficiency toward a broad range of alkynes. Owing to the confinement effect of the micropore structure, POL-Xantphos was far superior to the monomeric Xantphos ligands in controlling the selectivity. By performing hydrosilylation in a flow reactor system, separation and regeneration of the Ni/POL-Xantphos catalyst are easily achieved without any loss in selectivity or activity.
    Schlagwörter alkynes ; catalysts ; catalytic activity ; chemical reactions ; chemical structure ; ligands ; polymers ; stereoselectivity
    Sprache Englisch
    Erscheinungsverlauf 2018-1129
    Umfang p. 7748-7752.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.8b03064
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  4. Artikel: Copper-Catalyzed Decarboxylative/Click Cascade Reaction: Regioselective Assembly of 5-Selenotriazole Anticancer Agents

    Cui, Fei-hu / Hai-tao Tang / Heng-shan Wang / Jing Chen / Shi-xia Su / Xian-li Ma / Yan-li Xu / Yan-yan Chen / Ying-ming Pan / Zu-yu Mo

    Organic letters. 2018 Feb. 16, v. 20, no. 4

    2018  

    Abstract: A simple and efficient Cu-catalyzed decarboxylative/click reaction for the preparation of 1,4-disubstituted 5-arylselanyl-1,2,3-triazoles from propiolic acids, diselenides, and azides has been developed. The mechanistic study revealed that the ... ...

    Abstract A simple and efficient Cu-catalyzed decarboxylative/click reaction for the preparation of 1,4-disubstituted 5-arylselanyl-1,2,3-triazoles from propiolic acids, diselenides, and azides has been developed. The mechanistic study revealed that the intermolecular AAC reaction of an alkynyl selenium intermediate occurred. The resulting multisubstituted 5-seleno-1,2,3-triazoles were tested for in vitro anticancer activity by MTT assay, and compounds 4f, 4h, and 4p showed potent cancer cell-growth inhibition activities.
    Schlagwörter acids ; antineoplastic activity ; antineoplastic agents ; azides ; cell growth ; chemical reactions ; chemical structure ; neoplasms ; regioselectivity ; selenium ; triazoles
    Sprache Englisch
    Erscheinungsverlauf 2018-0216
    Umfang p. 925-929.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.7b03734
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  5. Artikel: Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid

    Mao, Zhi-Min / Hai-Tao Tang / Hao-Li Chen / Jing-Jing Yang / Meng-Meng Huang / Ren-Mao Tang / Shan-Mei Shen / Wei Sun / Wei Wu / Yi-Gang Wan

    Journal of ethnopharmacology. 2015 Sept. 15, v. 173

    2015  

    Abstract: In traditional Chinese medicine (TCM), Abelmoschus manihot (L.) medic (AM) is a natural medicinal plant used for the treatment of inflammatory diseases. Recently, Huangkui capsule (HKC), a Chinese patent medicine extracted from AM, has been widely ... ...

    Abstract In traditional Chinese medicine (TCM), Abelmoschus manihot (L.) medic (AM) is a natural medicinal plant used for the treatment of inflammatory diseases. Recently, Huangkui capsule (HKC), a Chinese patent medicine extracted from AM, has been widely applied to the clinical therapy of renal fibrosis in patients with early diabetic nephropathy (DN). However, the therapeutic mechanisms involved in vivo remain ambiguous. The goal of this study is to expound the mechanism in vivo of HKC in order to deepen the understanding of its clinical effects, by using the approaches of contrasting the dose-effects of HKC on oxidative stress (OS) in the kidney compared to α-lipoic acid (LA), and then demonstrating whether and how anti-oxidative properties of HKC or LA might be beneficial for the treatment of renal fibrosis in vivo.Thirty-three rats were divided into 5 groups, a Sham group, a Vehicle group, a L-HKC group, a H-HKC group and a LA group. The different doses of HKC, LA and distilled water were daily administrated for 8 weeks after the induction of DN by the unilateral nephrectomy combined with streptozotocin (STZ) intraperitoneal injections. Rat's general status, biochemical parameters, renal histological changes and OS indicators, as well as the key protein expressions in p38 mitogen-activated protein kinase (p38MAPK)/serine-threonine kinase (Akt) signaling pathways and downstream cytokines including transforming growth factor (TGF)-β1 and tumor necrosis factor (TNF)-α were examined, respectively.HKC and LA ameliorated body weight, kidney weight, urinary albumin and renal function including blood urea nitrogen and serum uric acid, attenuated renal fibrosis including the cell numbers and extracellular matrix rate in glomerulus, and controlled OS indicators including malondialdehyde, total superoxide dismutase, 8-hydroxy-2′-deoxyguanosine and nicotinamide adenine dinucleotide phosphate oxidase 4, but did not lower blood glucose in DN model rats. Among them, the anti-renal fibrosis effect of H-HKC was better than that of LA. In addition, HKC simultaneously down-regulated the protein expressions of phosphorylated p38MAPK, phosphorylated Akt (p-Akt), TGF-β1 and TNF-α in the kidney of DN model rats, unlike HKC, LA only down-regulated p-Akt and TNF-α protein expressions.We have demonstrated that HKC, similar to LA, is renoprotective via attenuating OS and renal fibrosis in the DN rat model. The potential mechanisms by which HKC and LA exert their therapeutic effects in vivo are respectively through down-regulating the activation of p38MAPK and/or Akt pathways as well as the expressions of TGF-β1 and/or TNF-α in the kidney. Our findings thus provide the useful information about a clinical combination of HKC and LA in early DN patients.
    Schlagwörter Abelmoschus manihot ; albumins ; animal models ; blood serum ; body weight ; diabetic nephropathy ; extracellular matrix ; fibrosis ; histology ; kidneys ; lipoic acid ; malondialdehyde ; medicinal plants ; mitogen-activated protein kinase ; NADP (coenzyme) ; Oriental traditional medicine ; oxidative stress ; patients ; rats ; renal function ; signal transduction ; streptozotocin ; superoxide dismutase ; therapeutics ; transforming growth factor beta 1 ; tumor necrosis factor-alpha ; urea nitrogen ; uric acid
    Sprache Englisch
    Erscheinungsverlauf 2015-0915
    Umfang p. 256-265.
    Erscheinungsort Elsevier Ireland Ltd
    Dokumenttyp Artikel
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2015.07.036
    Datenquelle NAL Katalog (AGRICOLA)

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