Artikel ; Online: Comparing reactivation and retreatment for three doses of bevacizumab in type 1 retinopathy of prematurity.
2024 Band 28, Heft 2, Seite(n) 103866
Abstract: Purpose: To determine timing and rates of reactivation and retreatment of type 1 retinopathy of prematurity (ROP) after treatment with either 0.125 mg, 0.250 mg, or 0.500 mg of intravitreal bevacizumab (IVB).: Methods: Retrospective data, including ... ...
Abstract | Purpose: To determine timing and rates of reactivation and retreatment of type 1 retinopathy of prematurity (ROP) after treatment with either 0.125 mg, 0.250 mg, or 0.500 mg of intravitreal bevacizumab (IVB). Methods: Retrospective data, including demographic information, past medical history, and ROP characteristics were analyzed for babies with type 1 ROP treated with IVB at Riley Hospital for Children for the perioed 2014-2021. Results: A total of 84 patients met inclusion criteria: 29 patients received 0.125 mg of IVB; 39, 0.250 mg; and 16, 0.500 mg. Of the 84, 67 (80%) had additional laser treatment because of late reactivation (n = 52) or persistent avascular retina (PAR) (n = 15). Subsequent laser treatment was more common with lower doses: 0.125 mg (n = 27 [93%]); 0.250 mg (n = 31 [80%]); 0.500 mg (n = 9 [57%]) (P = 0.012). There was no difference between groups with regard to reason for subsequent laser treatment (reactivation vs PAR). The 0.125 mg group required retreatment because of reactivation 3.8 weeks sooner than the other dosing groups (P = 0.047). Conclusions: The outcomes comparing three doses of IVB for severe ROP showed a difference in the timing of secondary treatment, with the lower dosing group requiring laser for reactivation earlier. |
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Mesh-Begriff(e) | Infant, Newborn ; Infant ; Child ; Humans ; Bevacizumab/therapeutic use ; Angiogenesis Inhibitors/therapeutic use ; Retinopathy of Prematurity/surgery ; Retrospective Studies ; Laser Coagulation ; Intravitreal Injections ; Retreatment ; Gestational Age |
Chemische Substanzen | Bevacizumab (2S9ZZM9Q9V) ; Angiogenesis Inhibitors |
Sprache | Englisch |
Erscheinungsdatum | 2024-03-06 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
ZDB-ID | 1412476-2 |
ISSN | 1528-3933 ; 1091-8531 |
ISSN (online) | 1528-3933 |
ISSN | 1091-8531 |
DOI | 10.1016/j.jaapos.2024.103866 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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