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Article ; Online: Peri-operative ovarian cancer guidelines: major intra-operative and post-operative bleeding and thromboembolic events.

Fotopoulou, Christina / Haidopoulos, Dimitrios / Trappe, Ralf Ulrich

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2022 Volume 32, Issue 12, Page(s) 1621–1622

MeSH term(s)	Humans ; Female ; Thromboembolism/etiology ; Thromboembolism/prevention & control ; Anticoagulants ; Ovarian Neoplasms/surgery
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2022-003818
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Zs.A 3198: Show issues

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Article ; Online: Extraperitoneal en bloc intestinal resection as palliative surgery for treatment refractory bowel obstruction in ovarian cancer relapse.

Fotopoulou, Christina / Haidopoulos, Dimitrios

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2020 Volume 30, Issue 5, Page(s) 711

MeSH term(s)	Adult ; Female ; Humans ; Intestinal Obstruction/pathology ; Intestinal Obstruction/surgery ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/surgery ; Palliative Care
Language	English
Publishing date	2020-01-27
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2019-001058
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Zs.A 3198: Show issues

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Article: Ocular metastasis of primary gynecological malignancies, a rare but not insignificant entity: A systematic review.

Vlachos, D E / Thomakos, N / Haidopoulos, D / Pergialiotis, V / Theodoulidis, V / Protopapas, A / Rodolakis, A

Nigerian journal of clinical practice

2022 Volume 25, Issue 6, Page(s) 739–746

Abstract: The genital system remains one of the most common sites of carcinogenesis in women. Advances in surgery, radiation treatment, and chemotherapy have increased their efficacy and many patients survive for many years after their initial diagnosis. The eye ... ...

Abstract	The genital system remains one of the most common sites of carcinogenesis in women. Advances in surgery, radiation treatment, and chemotherapy have increased their efficacy and many patients survive for many years after their initial diagnosis. The eye is a rare site of metastasis from gynecological cancer due to its distant location from the genitalia. In this systematic review, we retrieved all case reports of patients with ocular metastasis from gynecological neoplasms. The demographic, clinical, and treatment characteristics were retrieved and analyzed. A total of 70 case reports were included. Forty-eight of these reports concerned patients with a known malignancy that recurred in the eye and in 22 patients' ocular symptomatology accompanied the initial diagnosis of the gynecologic malignancy. 73.9% of these patients exhibited concomitant metastasis to other organs. The mean disease-free interval was found at 25.7 months and mean survival time after the eye metastasis was 13.5 months. Refractory disease was identified as the most important risk factor associated with mortality. Because eye metastasis has such a dismal prognosis, all gynecologists who treat oncological patients should be highly suspicious for reported eye complaints.
MeSH term(s)	Disease-Free Survival ; Eye Neoplasms/therapy ; Female ; Genital Neoplasms, Female/pathology ; Genital Neoplasms, Female/surgery ; Humans ; Neoplasm Recurrence, Local ; Prognosis
Language	English
Publishing date	2022-06-16
Publishing country	India
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1458330-6
ISSN	1119-3077
ISSN	1119-3077
DOI	10.4103/njcp.njcp_1763_21
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Zs.A 4975: Show issues

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Article ; Online: Survival Outcomes of Epithelial Ovarian Cancer Patients Following Dose-dense Versus 3-Weekly Platinum-Paclitaxel Chemotherapy: A Meta-Analysis.

Pergialiotis, V / Liatsou, E / Thomakos, N / Liontos, M / Frountzas, M / Papapanagiotou, A / Rodolakis, A / Haidopoulos, D

Clinical oncology (Royal College of Radiologists (Great Britain))

2022 Volume 35, Issue 2, Page(s) e189–e198

Abstract: Aims: Dose-dense chemotherapy has proven its value in several cancer fields. The purpose of the present systematic review is to evaluate the impact of dose-dense chemotherapy on survival outcomes of epithelial ovarian cancer patients.: Materials and ... ...

Abstract	Aims: Dose-dense chemotherapy has proven its value in several cancer fields. The purpose of the present systematic review is to evaluate the impact of dose-dense chemotherapy on survival outcomes of epithelial ovarian cancer patients. Materials and methods: Medline, Scopus, the Cochrane Central Register of Controlled Trials CENTRAL, Google Scholar and Clinicaltrials.gov databases were searched for relevant articles. Effect sizes were calculated in Rstudio using the meta and metafor functions. A sensitivity analysis was carried out to evaluate the possibility of small study effects and P-hacking. The methodological quality of the included studies was assessed using Risk of Bias 2 (RoB2) and Risk of Bias in non-Randomized Trials (RoBINS) tools. Results: Overall, 12 studies were included in the present systematic review, involving 4979 epithelial ovarian cancer patients. The risk of recurrence was substantially improved in patients receiving dose-dense chemotherapy (hazard ratio 0.82, 95% confidence interval 0.70, 0.96); however, the result of the meta-analysis may be attributed to the effect size of smaller studies as following adjustment for small study effects the outcome becomes non-significant (hazard ratio 0.91, 95% confidence interval 0.81, 1.02, P = 0.123). Overall survival rates were not improved by dose-dense chemotherapy (hazard ratio 0.79, 95% confidence interval 0.60, 1.04). Thirty-five types of adverse effect were identified following retrieval of data from the original studies. Dose-dense chemotherapy did not increase significantly the rates of severe adverse effects, although thrombosis, severe diarrhoea and severe nausea were more prevalent in this group of patients. Conclusion: Dose-dense chemotherapy is associated with comparable side-effects to those of standard chemotherapy; however, data related to survival outcomes are not positive; hence, its use outside the setting of clinical trials should be discouraged.
MeSH term(s)	Female ; Humans ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Carcinoma, Ovarian Epithelial/drug therapy ; Ovarian Neoplasms/drug therapy ; Paclitaxel/therapeutic use ; Platinum/therapeutic use ; Proportional Hazards Models
Chemical Substances	Paclitaxel (P88XT4IS4D) ; Platinum (49DFR088MY)
Language	English
Publishing date	2022-11-07
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1036844-9
ISSN	1433-2981 ; 0936-6555
ISSN (online)	1433-2981
ISSN	0936-6555
DOI	10.1016/j.clon.2022.10.015
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Zs.A 2774: Show issues

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Article: Splenectomy as Part of Maximal-Effort Cytoreductive Surgery in Advanced Epithelial Ovarian Cancer.

Pergialiotis, Vasilios / Zachariou, Eleftherios / Lygizos, Vasilios / Vlachos, Dimitrios Efthymios / Stamatakis, Emmanouil / Angelou, Kyveli / Daskalakis, Georgios / Thomakos, Nikolaos / Haidopoulos, Dimitrios

Cancers

2024 Volume 16, Issue 4

Abstract: Introduction: A splenectomy is frequently performed during debulking surgery for advanced ovarian cancer. Its impact on perioperative and survival outcomes remains questionable as current evidence is conflicting. In the present study, we sought to ... ...

Abstract	Introduction: A splenectomy is frequently performed during debulking surgery for advanced ovarian cancer. Its impact on perioperative and survival outcomes remains questionable as current evidence is conflicting. In the present study, we sought to determine the factors that affect survival rates in ovarian cancer patients that undergo a splenectomy as part of maximal-effort cytoreduction. Patients and methods: A retrospective chart review was conducted that included all epithelial ovarian cancer patients that had surgical cytoreduction for advanced epithelial ovarian cancer. Differences among splenectomized and non splenectomized patients were evaluated as well as the impact of known risk factors on survival outcomes of splenectomized patients. Results: Overall, 245 patients were identified and 223 were included in the present series, of whom 91 had a splenectomy. Recurrence rates as well as death rates were comparable among splenectomized and non-splenectomized patients; however, both the disease-free survival ( Discussion: The findings of our study support the feasibility of splenectomy in advanced epithelial ovarian cancer; however, its impact on patients' survival is considerable. Therefore, every effort should be made to avoid splenic injury which will result in unintended splenectomy for non-oncological reasons.
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16040790
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Article ; Online: Prognostic Nutritional Index as a Predictive Biomarker of Post-Operative Infectious Morbidity in Gynecological Cancer Patients: A Prospective Cohort Study.

Pergialiotis, Vasilios / Thomakos, Nikolaos / Papalios, Theodoros / Lygizos, Vasilios / Vlachos, Dimitrios Efthimios / Rodolakis, Alexandros / Haidopoulos, Dimitrios

Nutrition and cancer

2024 Volume 76, Issue 4, Page(s) 364–371

Abstract: Malnutrition significantly impacts the post-operative process of gynecological cancer patients. A prominent variable for determining perioperative morbidity is the Prognostic Nutritional Index (PNI). To investigate PNI's predictive value on the risk of ... ...

Abstract	Malnutrition significantly impacts the post-operative process of gynecological cancer patients. A prominent variable for determining perioperative morbidity is the Prognostic Nutritional Index (PNI). To investigate PNI's predictive value on the risk of post-operative infections, we conducted a prospective cohort study involving women who underwent surgery for gynecological malignancies. Out of the 208 patients enrolled, 28 (13.5%) were malnourished and post-operative infections occurred in 43 patients. Notably, there was a significant difference in PNI between patients who developed infections and those who did not (
MeSH term(s)	Humans ; Female ; Nutrition Assessment ; Genital Neoplasms, Female/complications ; Genital Neoplasms, Female/surgery ; Prognosis ; Prospective Studies ; Biomarkers ; Malnutrition ; Morbidity ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581.2024.2318827
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Zs.A 1496: Show issues

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Article ; Online: Awareness, knowledge and attitudes of human papillomavirus infection, screening and vaccination: a survey study in Greece.

Pergialiotis, Vasilios / Papageorgiou, Dimitrios / Douligeris, Athanasios / Mortaki, Anastasia / Vlachos, Dimitrios Efthymios / Thomakos, Nikolaos / Rodolakis, Alexandros / Haidopoulos, Dimitrios

Archives of gynecology and obstetrics

2024 Volume 309, Issue 5, Page(s) 2031–2040

Abstract: Purpose: To evaluate the awareness and existing knowledge of a portion of the Greek population about prevention, screening, and HPV vaccination.: Methods: A questionnaire designed in Google forms has been distributed through social media between June ...

Abstract	Purpose: To evaluate the awareness and existing knowledge of a portion of the Greek population about prevention, screening, and HPV vaccination. Methods: A questionnaire designed in Google forms has been distributed through social media between June 2021 and December 2021 in men and women aged > 16 years old. Statistical analysis was performed using the SPSS 20.0 program. Inferential analysis was performed to evaluate differences in responses among men and women. Results: We enrolled 2685 participants. Of those, 2285 were women, 386 were men, while 14 respondents chose not to respond to this question. Various age groups were detected with those aged between 26 and 30 years old being the predominant one. Participants with a higher education constituted 36.5% of the population. Most respondents were married (59.8%). In socioeconomic terms 75.5% of participants were employed whereas, monthly income ranged between 1000 and 1500 euros in the predominant group (36.8%). Only 40% of females and 3.9% of males were vaccinated against HPV. Adolescent immunization, acceptability rates reached 92.7% among female and 82.1% among male responders. Although, only a small proportion of the participants were not aware of the existence of HPV, 24.1% of males and 23.4% of females had the impression that condom use may provide absolute immunity to HPV and only 51.6% of males and 60.4% of females were aware about the high prevalence of HPV in the general population. Logistic regression analysis indicated that male participants as well as those aged > 50 years and those choosing to reject vaccination had decreased knowledge of the basic pathophysiology of HPV infection, as well as knowledge related to the existence and use of HPV DNA as a screening tool and the existence and efficacy of HPV vaccination. Conclusion: Our results indicate that although awareness of the existence of HPV infection is high in Greek general population, the actual perception of the pathophysiology of transmission and importance of HPV testing and vaccination is low. Targeting specific population groups is essential to help increase HPV coverage and screening.
MeSH term(s)	Adolescent ; Humans ; Male ; Female ; Adult ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/prevention & control ; Greece/epidemiology ; Health Knowledge, Attitudes, Practice ; Surveys and Questionnaires ; Vaccination ; Papillomavirus Vaccines ; Uterine Cervical Neoplasms
Chemical Substances	Papillomavirus Vaccines
Language	English
Publishing date	2024-03-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-024-07398-1
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Um I Zs.55: Show issues

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Article: Maximal Effort Cytoreduction in Epithelial Ovarian Cancer: Perioperative Complications and Survival Outcomes from a Retrospective Cohort.

Haidopoulos, Dimitrios / Pergialiotis, Vasilios / Zachariou, Eleftherios / Sapantzoglou, Ioakim / Thomakos, Nikolaos / Stamatakis, Emmanouil / Alexakis, Nikolaos

Journal of clinical medicine

2023 Volume 12, Issue 2

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12020622
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Article ; Online: Pre-Operative Neutrophil-to-Lymphocyte Ratio as a Predictor of Post-Operative Infectious Morbidity in Gynecologic Oncology Patients.

Pergialiotis, Vasilios / Papalios, Theodoros / Haidopoulos, Dimitrios / Papapanagiotou, Angeliki / Vlachos, Athanasios / Rodolakis, Alexandros / Thomakos, Nikolaos

Surgical infections

2023 Volume 24, Issue 4, Page(s) 390–396

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Female ; Humans ; Biomarkers ; Blood Platelets ; Genital Neoplasms, Female ; Lymphocytes ; Neutrophils ; Postoperative Complications ; Prognosis ; Prospective Studies ; Retrospective Studies ; Pelvic Infection
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440120-4
ISSN	1557-8674 ; 1096-2964
ISSN (online)	1557-8674
ISSN	1096-2964
DOI	10.1089/sur.2022.381
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Zs.A 5617: Show issues

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Article ; Online: Is there a correlation of positive peritoneal washing cytology during interval debulking surgery on the survival outcomes of ovarian cancer patients? A systematic review and meta-analysis of the literature.

Douligeris, Athanasios / Pergialiotis, Vasilios / Fasoulakis, Zacharias / Rodolakis, Alexandros / Haidopoulos, Dimitrios

Journal of gynecology obstetrics and human reproduction

2021 Volume 51, Issue 1, Page(s) 102256

Abstract: Objective: The aim of the present study was to evaluate the prognostic impact of peritoneal washing cytology (PWC) on progression-free (PFS) and overall survival (OS) of patients undergoing interval debulking surgery (IDS) after neoadjuvant chemotherapy ...

Abstract	Objective: The aim of the present study was to evaluate the prognostic impact of peritoneal washing cytology (PWC) on progression-free (PFS) and overall survival (OS) of patients undergoing interval debulking surgery (IDS) after neoadjuvant chemotherapy (NACT) for ovarian cancer (OC). Methods: We systematically searched Medline (1966-2020), Scopus (2004-2020), EMBASE (1980-2020), Cochrane Central Register of Controlled Trials CENTRAL (1999-2020), Clinicaltrials.gov (2008-2020) and Google Scholar (2004-2020). All the studies that investigated the correlation of peritoneal washing cytology with survival outcomes of patients undergoing interval debulking for ovarian cancer, were finally included in the present meta-analysis. Results: A total of 7 retrospective studies were included, comprising 907 patients, of whom 535 had positive peritoneal washing cytology on interval debulking surgery. The methodological quality of the included studies was assessed as moderate, primarily due to the lack of data referring to the adequacy of the follow-up of patients and secondarily due the lack of comparability of patients. Progression - free survival was significantly better in the negative peritoneal cytology group (HR 2.07, 95% CI 1.73, 2.48 respectively), however, overall survival did not reach a significant difference among the two groups (HR 1.90, 95% CI 0.99, 3,65, p = 0.052). Conclusions: Our data support a negative correlation between positive peritoneal washing cytology at interval debulking surgery and the survival of ovarian cancer patients.
MeSH term(s)	Adult ; Cytoreduction Surgical Procedures/methods ; Cytoreduction Surgical Procedures/standards ; Female ; Humans ; Middle Aged ; Neoadjuvant Therapy/methods ; Ovarian Neoplasms/surgery ; Peritoneal Lavage/methods ; Peritoneal Lavage/standards ; Prognosis ; Retrospective Studies
Language	English
Publishing date	2021-10-20
Publishing country	France
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	2468-7847
ISSN (online)	2468-7847
DOI	10.1016/j.jogoh.2021.102256
Database	MEDical Literature Analysis and Retrieval System OnLINE

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