LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Hain, Sofia"
  2. AU="de Kler, R C F"
  3. AU="Veness, R."

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: Meningeal Whole Mounts for Imaging CNS Fungal Infection.

    Hain, Sofia / Drummond, Rebecca A

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2667, Page(s) 113–121

    Abstract: Invasive fungal infections may involve the brain and central nervous system (CNS), leading to often fatal meningitis in immunocompromised individuals. Recent technological advances have allowed us to move beyond studying the brain parenchyma to ... ...

    Abstract Invasive fungal infections may involve the brain and central nervous system (CNS), leading to often fatal meningitis in immunocompromised individuals. Recent technological advances have allowed us to move beyond studying the brain parenchyma to understanding the immune mechanisms of the meninges, the protective layer that surrounds the brain and spinal cord. Specifically, advanced microscopy techniques have enabled researchers to begin to visualize the anatomy of the meninges and the cellular mediators of meningeal inflammation. In this chapter, we describe how to make meningeal tissue mounts for imaging by confocal microscopy.
    MeSH term(s) Humans ; Meninges ; Central Nervous System ; Brain ; Spinal Cord ; Central Nervous System Fungal Infections
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3199-7_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Microglia are not protective against cryptococcal meningitis.

    Mohamed, Sally H / Fu, Man Shun / Hain, Sofia / Alselami, Alanoud / Vanhoffelen, Eliane / Li, Yanjian / Bojang, Ebrima / Lukande, Robert / Ballou, Elizabeth R / May, Robin C / Ding, Chen / Velde, Greetje Vande / Drummond, Rebecca A

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 7202

    Abstract: Microglia provide protection against a range of brain infections including bacteria, viruses and parasites, but how these glial cells respond to fungal brain infections is poorly understood. We investigated the role of microglia in the context of ... ...

    Abstract Microglia provide protection against a range of brain infections including bacteria, viruses and parasites, but how these glial cells respond to fungal brain infections is poorly understood. We investigated the role of microglia in the context of cryptococcal meningitis, the most common cause of fungal meningitis in humans. Using a series of transgenic- and chemical-based microglia depletion methods we found that, contrary to their protective role during other infections, loss of microglia did not affect control of Cryptococcus neoformans brain infection which was replicated with several fungal strains. At early time points post-infection, we found that microglia depletion lowered fungal brain burdens, which was related to intracellular residence of C. neoformans within microglia. Further examination of extracellular and intracellular fungal populations revealed that C. neoformans residing in microglia were protected from copper starvation, whereas extracellular yeast upregulated copper transporter CTR4. However, the degree of copper starvation did not equate to fungal survival or abundance of metals within different intracellular niches. Taken together, these data show how tissue-resident myeloid cells may influence fungal phenotype in the brain but do not provide protection against this infection, and instead may act as an early infection reservoir.
    MeSH term(s) Humans ; Meningitis, Cryptococcal/prevention & control ; Microglia ; Copper ; Cryptococcus neoformans ; Neuroglia ; Cryptococcosis
    Chemical Substances Copper (789U1901C5)
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43061-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The glucocorticoid dexamethasone inhibits HIF-1α stabilization and metabolic reprogramming in lipopolysaccharide-stimulated primary macrophages.

    Clayton, Sally A / Lockwood, Chloe / O'Neil, John D / Daley, Kalbinder K / Hain, Sofia / Abdelmottaleb, Dina / Bolimowska, Oliwia O / Tennant, Daniel A / Clark, Andrew R

    Discovery immunology

    2023  Volume 2, Issue 1, Page(s) kyad027

    Abstract: Synthetic glucocorticoids are used to treat many chronic and acute inflammatory conditions. Frequent adverse effects of prolonged exposure to glucocorticoids include disturbances of glucose homeostasis caused by changes in glucose traffic and metabolism ... ...

    Abstract Synthetic glucocorticoids are used to treat many chronic and acute inflammatory conditions. Frequent adverse effects of prolonged exposure to glucocorticoids include disturbances of glucose homeostasis caused by changes in glucose traffic and metabolism in muscle, liver, and adipose tissues. Macrophages are important targets for the anti-inflammatory actions of glucocorticoids. These cells rely on aerobic glycolysis to support various pro-inflammatory and antimicrobial functions. Employing a potent pro-inflammatory stimulus in two commonly used model systems (mouse bone marrow-derived and human monocyte-derived macrophages), we showed that the synthetic glucocorticoid dexamethasone inhibited lipopolysaccharide-mediated activation of the hypoxia-inducible transcription factor HIF-1α, a critical driver of glycolysis. In both cell types, dexamethasone-mediated inhibition of HIF-1α reduced the expression of the glucose transporter GLUT1, which imports glucose to fuel aerobic glycolysis. Aside from this conserved response, other metabolic effects of lipopolysaccharide and dexamethasone differed between human and mouse macrophages. These findings suggest that glucocorticoids exert anti-inflammatory effects by impairing HIF-1α-dependent glucose uptake in activated macrophages. Furthermore, harmful and beneficial (anti-inflammatory) effects of glucocorticoids may have a shared mechanistic basis, depending on the alteration of glucose utilization.
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article
    ISSN 2754-2483
    ISSN (online) 2754-2483
    DOI 10.1093/discim/kyad027
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity.

    Hewitson, James P / Shah, Kunal M / Brown, Najmeeyah / Grevitt, Paul / Hain, Sofia / Newling, Katherine / Sharp, Tyson V / Kaye, Paul M / Lagos, Dimitris

    EMBO reports

    2019  Volume 20, Issue 4

    Abstract: Determining the mechanisms that distinguish protective immunity from pathological chronic inflammation remains a fundamental challenge. miR-132 has been shown to play largely immunoregulatory roles in immunity; however, its role in ... ...

    Abstract Determining the mechanisms that distinguish protective immunity from pathological chronic inflammation remains a fundamental challenge. miR-132 has been shown to play largely immunoregulatory roles in immunity; however, its role in CD4
    MeSH term(s) Animals ; Binding Sites ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cytokines/biosynthesis ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Lymphocyte Activation/genetics ; Lymphocyte Activation/immunology ; Mice ; Mice, Transgenic ; MicroRNAs/genetics ; Protein Binding ; RNA Interference ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Spleen/immunology ; Spleen/metabolism ; Spleen/microbiology ; Th1 Cells/immunology ; Th1 Cells/metabolism ; Transcription Factor TFIID/metabolism ; p300-CBP Transcription Factors/metabolism
    Chemical Substances Cytokines ; MIRN132 microRNA, mouse ; MicroRNAs ; Ribosomal Proteins ; Transcription Factor TFIID ; p300-CBP Transcription Factors (EC 2.3.1.48)
    Language English
    Publishing date 2019-03-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.201846620
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 41: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top