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  1. AU="Haixiang Zhou"
  2. AU="Choi, Jinyong"
  3. AU="González-Mansilla, Ana"
  4. AU="Cho Kilwon"
  5. AU="Rachide Onadja, Palamanga Abdoul"
  6. AU="Bertacca, Sofia"
  7. AU="Bansal, Ayush"
  8. AU="Liao, Naikai"
  9. AU="Gomes, Lux Attiê Santos"
  10. AU="İdil Su Canıtez"
  11. AU="Baptiste Duceau"
  12. AU="Pedro Seoane-Zonjic"
  13. AU="Guthridge, Carla J"
  14. AU=Meena Netra P.
  15. AU="Boustany, Tara"

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  1. Artikel ; Online: N6-methyladenosine methylation in ophthalmic diseases

    Bingyan Li / Zicong Wang / Haixiang Zhou / Jingling Zou / Shigeo Yoshida / Yedi Zhou

    Heliyon, Vol 10, Iss 1, Pp e23668- (2024)

    From mechanisms to potential applications

    1481  

    Abstract: N6-methyladenosine (m6A) modification, as the most common modification method in eukaryotes, is widely involved in numerous physiological and pathological processes, such as embryonic development, malignancy, immune regulation, and premature aging. Under ...

    Abstract N6-methyladenosine (m6A) modification, as the most common modification method in eukaryotes, is widely involved in numerous physiological and pathological processes, such as embryonic development, malignancy, immune regulation, and premature aging. Under pathological conditions of ocular diseases, changes in m6A modification and its metabolism can be detected in aqueous and vitreous humor. At the same time, an increasing number of studies showed that m6A modification is involved in the normal development of eye structures and the occurrence and progress of many ophthalmic diseases, especially ocular neovascular diseases, such as diabetic retinopathy, age-related macular degeneration, and melanoma. In this review, we summarized the latest progress regarding m6A modification in ophthalmic diseases, changes in m6A modification-related enzymes in various pathological states and their upstream and downstream regulatory networks, provided new prospects for m6A modification in ophthalmic diseases and new ideas for clinical diagnosis and treatment.
    Schlagwörter m6A modification ; Ophthalmic diseases ; m6A modification-related enzymes ; Diabetic retinopathy ; Melanoma ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Transcriptomic–Proteomic Analysis Revealed the Regulatory Mechanism of Peanut in Response to Fusarium oxysporum

    Mian Wang / Lifei Zhu / Chushu Zhang / Haixiang Zhou / Yueyi Tang / Shining Cao / Jing Chen / Jiancheng Zhang

    International Journal of Molecular Sciences, Vol 25, Iss 1, p

    2024  Band 619

    Abstract: Peanut Fusarium rot, which is widely observed in the main peanut-producing areas in China, has become a significant factor that has limited the yield and quality in recent years. It is highly urgent and significant to clarify the regulatory mechanism of ... ...

    Abstract Peanut Fusarium rot, which is widely observed in the main peanut-producing areas in China, has become a significant factor that has limited the yield and quality in recent years. It is highly urgent and significant to clarify the regulatory mechanism of peanuts in response to Fusarium oxysporum . In this study, transcriptome and proteome profiling were combined to provide new insights into the molecular mechanisms of peanut stems after F. oxysporums infection. A total of 3746 differentially expressed genes (DEGs) and 305 differentially expressed proteins (DEPs) were screened. The upregulated DEGs and DEPs were primarily enriched in flavonoid biosynthesis, circadian rhythm-plant, and plant–pathogen interaction pathways. Then, qRT-PCR analysis revealed that the expression levels of phenylalanine ammonia-lyase (PAL), chalcone isomerase (CHI), and cinnamic acid-4-hydroxylase (C4H) genes increased after F. oxysporums infection. Moreover, the expressions of these genes varied in different peanut tissues. All the results revealed that many metabolic pathways in peanut were activated by improving key gene expressions and the contents of key enzymes, which play critical roles in preventing fungi infection. Importantly, this research provides the foundation of biological and chemical analysis for peanut disease resistance mechanisms.
    Schlagwörter peanut rot ; Fusarium oxysporum ; transcriptome analysis ; proteomic profiling ; regulatory mechanism ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Progress and prospects of gene therapy in ophthalmology from 2000 to 2022

    Bingyan Li / Wei Tan / Zicong Wang / Haixiang Zhou / Jingling Zou / Yun Li / Shigeo Yoshida / Yedi Zhou

    Heliyon, Vol 9, Iss 7, Pp e18228- (2023)

    A bibliometric analysis

    2023  

    Abstract: Background: Gene therapy is a treatment approach at the genetic level, which brings great advances in many diseases and develops rapidly in recent years. Currently, its mechanism of action is mainly through the replacement of missing or defective genes, ... ...

    Abstract Background: Gene therapy is a treatment approach at the genetic level, which brings great advances in many diseases and develops rapidly in recent years. Currently, its mechanism of action is mainly through the replacement of missing or defective genes, or the reduction of harmful gene products. However, the application of gene therapy in ophthalmology remains limited. Methods: A total of 1143 articles and reviews published in the field of ocular gene therapies were found in the Web of Science Core Collection database and used for the bibliometric analysis. CiteSpace was mainly applied to the network analysis of countries, institutions, keywords, and dual-map overlay of journals. The visual analysis of authors, journals, and references was used by VOSviewer. The geographical distribution of publications was conducted by R language. Results: The annual publications are increasing in general. Currently, the USA and the UK are two main sources of publications in this field. Switzerland, Denmark, and Finland are the top 3 countries that establish the most cooperation and exchanges with other countries or regions. The most cited and co-cited journal in this field is Investigative Ophthalmology & Visual Science. Gene therapy studies for eye diseases are mainly focused on retinal dysfunctions by the analysis of references, keywords, and counting of original research, including Leber's congenital amaurosis and retinitis pigmentosa. Conclusion: This study used bibliometrics to analyze overall characteristics and put forward prospects for the future in the field of gene therapy in ophthalmology. Ocular diseases, especially hereditary retinal diseases, will be the major focus of gene therapy in the future.
    Schlagwörter Gene therapy ; Ophthalmology ; Bibliometric analysis ; CiteSpace ; VOSviewer ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Thema/Rubrik (Code) 001
    Sprache Englisch
    Erscheinungsdatum 2023-07-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Purification and Characterization of a Secretory Alkaline Metalloprotease with Highly Potent Antiviral Activity from Serratia marcescens Strain S3

    Qin, Yuanxia / Jie Wang / Fenglong Wang / Lili Shen / Haixiang Zhou / Hangjun Sun / Kaiqiang Hao / Liyun Song / Zhicheng Zhou / Chaoqun Zhang / Yuanhua Wu / Jinguang Yang

    Journal of agricultural and food chemistry. 2019 Feb. 25, v. 67, no. 11

    2019  

    Abstract: In this study we report a secretory protein that was purified from Serratia marcescens strain S3 isolated from soil from the tobacco rhizosphere. Subsequent mass spectrometry and annotation characterized the protein as secretory alkaline metalloprotease ( ...

    Abstract In this study we report a secretory protein that was purified from Serratia marcescens strain S3 isolated from soil from the tobacco rhizosphere. Subsequent mass spectrometry and annotation characterized the protein as secretory alkaline metalloprotease (SAMP). SAMP plays a crucial role in inhibiting Tobacco mosaic virus (TMV). Transmission electron microscopy (TEM), dynamic light scattering (DLS), confocal microscopy, and microscale thermophoresis (MST) were employed to investigate the anti-TMV mechanism of SAMP. Our results demonstrated that SAMP, as a hydrolytic metal protease, combined and hydrolyzed TMV coat proteins to destroy the virus particles. This study is the first to investigate the antiviral effects of a S. marcescens metalloprotease, and our finding suggests that S. marcescens-S3 may be agronomically useful as a disease-controlling factor active against Tobacco mosaic virus.
    Schlagwörter Serratia marcescens ; Tobacco mosaic virus ; antiviral properties ; coat proteins ; confocal microscopy ; light scattering ; mass spectrometry ; metalloproteinases ; rhizosphere ; soil ; tobacco ; transmission electron microscopy ; virion
    Sprache Englisch
    Erscheinungsverlauf 2019-0225
    Umfang p. 3168-3178.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.8b06909
    Datenquelle NAL Katalog (AGRICOLA)

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