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Article ; Online: A review of recent advances in the use of complex metal nanostructures for biomedical applications from diagnosis to treatment.

Hajfathalian, Maryam / Mossburg, Katherine J / Radaic, Allan / Woo, Katherine E / Jonnalagadda, Pallavi / Kapila, Yvonne / Bollyky, Paul L / Cormode, David P

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

2024 Volume 16, Issue 3, Page(s) e1959

Abstract: Complex metal nanostructures represent an exceptional category of materials characterized by distinct morphologies and physicochemical properties. Nanostructures with shape anisotropies, such as nanorods, nanostars, nanocages, and nanoprisms, are ... ...

Abstract	Complex metal nanostructures represent an exceptional category of materials characterized by distinct morphologies and physicochemical properties. Nanostructures with shape anisotropies, such as nanorods, nanostars, nanocages, and nanoprisms, are particularly appealing due to their tunable surface plasmon resonances, controllable surface chemistries, and effective targeting capabilities. These complex nanostructures can absorb light in the near-infrared, enabling noteworthy applications in nanomedicine, molecular imaging, and biology. The engineering of targeting abilities through surface modifications involving ligands, antibodies, peptides, and other agents potentiates their effects. Recent years have witnessed the development of innovative structures with diverse compositions, expanding their applications in biomedicine. These applications encompass targeted imaging, surface-enhanced Raman spectroscopy, near-infrared II imaging, catalytic therapy, photothermal therapy, and cancer treatment. This review seeks to provide the nanomedicine community with a thorough and informative overview of the evolving landscape of complex metal nanoparticle research, with a specific emphasis on their roles in imaging, cancer therapy, infectious diseases, and biofilm treatment. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Diagnostic Tools > Diagnostic Nanodevices.
MeSH term(s)	Humans ; Animals ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/therapeutic use ; Nanomedicine ; Neoplasms/diagnostic imaging ; Neoplasms/therapy ; Nanostructures/chemistry ; Mice
Language	English
Publishing date	2024-05-06
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2502698-7
ISSN	1939-0041 ; 1939-5116
ISSN (online)	1939-0041
ISSN	1939-5116
DOI	10.1002/wnan.1959
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Article: Nisin and Nisin Probiotic Disrupt Oral Pathogenic Biofilms and Restore Their Microbiome Composition towards Healthy Control Levels in a Peri-Implantitis Setting

Radaic, Allan / Brody, Hanna / Contreras, Fernando / Hajfathalian, Maryam / Lucido, Luke / Kamarajan, Pachiyappan / Kapila, Yvonne L.

Microorganisms. 2022 July 01, v. 10, no. 7

2022

Abstract: Peri-implantitis is characterized by chronic inflammation of the peri-implant supporting tissues that progressively and irreversibly leads to bone loss and, consequently, implant loss. Similar to periodontal disease, oral dysbiosis is thought to be a ... ...

Abstract	Peri-implantitis is characterized by chronic inflammation of the peri-implant supporting tissues that progressively and irreversibly leads to bone loss and, consequently, implant loss. Similar to periodontal disease, oral dysbiosis is thought to be a driver of peri-implantitis. However, managing peri-implantitis with traditional treatment methods, such as nonsurgical debridement or surgery, is not always successful. Thus, novel strategies have been proposed to address these shortcomings. One strategy is the use of probiotics as antimicrobial agents since they are considered safe for humans and the environment. Specifically, the probiotic Lactococcus lactis produces nisin, which has been used worldwide for food preservation. The objective of this study was to determine whether nisin and the wild-type (WT) nisin-producing L. lactis probiotic can disrupt oral pathogenic biofilms and promote a healthier oral microbiome within these oral biofilms on titanium discs. Using confocal imaging and 16S rRNA sequencing, this study revealed that nisin and WT L. lactis probiotic disrupt oral pathogenic biofilms in a peri-implantitis setting in vitro. More specifically, nisin decreased the viability of the pathogen-spiked biofilms dose-dependently from 62.53 ± 3.69% to 54.26 ± 3.35% and 44.88 ± 2.98%, respectively. Similarly, 10⁵ CFU/mL of WT L. lactis significantly decreased biofilm viability to 52.45 ± 3.41%. Further, both treatments shift the composition, relative abundance, and diversity levels of these biofilms towards healthy control levels. A total of 1 µg/mL of nisin and 10³ CFU/mL of WT L. lactis were able to revert the pathogen-mediated changes in the Proteobacteria (from 80.5 ± 2.9% to 75.6 ± 2.0%, 78.0 ± 2.8%, and 75.1 ± 5.3%, respectively) and Firmicutes (from 11.6 ± 1.6% to 15.4 ± 1.3%, 13.8 ± 1.8%, and 13.7 ± 2.6%, respectively) phyla back towards control levels. Thus, nisin and its nisin-producing L. lactis probiotic may be useful in treating peri-implantitis by promoting healthier oral biofilms, which may be useful for improving patient oral health.
Keywords	Lactococcus lactis ; Proteobacteria ; biofilm ; bone resorption ; debridement ; dysbiosis ; food preservation ; inflammation ; microbiome ; nisin ; oral health ; patients ; periodontal diseases ; probiotics ; surgery ; titanium ; viability
Language	English
Dates of publication	2022-0701
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10071336
Database	NAL-Catalogue (AGRICOLA)

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Article: Nisin and Nisin Probiotic Disrupt Oral Pathogenic Biofilms and Restore Their Microbiome Composition towards Healthy Control Levels in a Peri-Implantitis Setting.

Radaic, Allan / Brody, Hanna / Contreras, Fernando / Hajfathalian, Maryam / Lucido, Luke / Kamarajan, Pachiyappan / Kapila, Yvonne L

Microorganisms

2022 Volume 10, Issue 7

Abstract	Peri-implantitis is characterized by chronic inflammation of the peri-implant supporting tissues that progressively and irreversibly leads to bone loss and, consequently, implant loss. Similar to periodontal disease, oral dysbiosis is thought to be a driver of peri-implantitis. However, managing peri-implantitis with traditional treatment methods, such as nonsurgical debridement or surgery, is not always successful. Thus, novel strategies have been proposed to address these shortcomings. One strategy is the use of probiotics as antimicrobial agents since they are considered safe for humans and the environment. Specifically, the probiotic
Language	English
Publishing date	2022-07-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10071336
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University.

Würstle, Silvia / Lee, Alina / Kortright, Kaitlyn E / Winzig, Franziska / An, William / Stanley, Gail L / Rajagopalan, Govindarajan / Harris, Zach / Sun, Ying / Hu, Buqu / Blazanin, Michael / Hajfathalian, Maryam / Bollyky, Paul L / Turner, Paul E / Koff, Jonathan L / Chan, Benjamin K

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2657

Abstract: Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked the centennial of Felix d'Hérelle's first publication on the clinical applications of phages. At the Center for ... ...

Abstract	Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked the centennial of Felix d'Hérelle's first publication on the clinical applications of phages. At the Center for Phage Biology & Therapy at Yale University, a preparatory modular approach has been established to offer safe and potent phages for single-patient investigational new drug applications while recognizing the time constraints imposed by infection(s). This study provides a practical walkthrough of the pipeline with an Autographiviridae phage targeting Pseudomonas aeruginosa (phage vB_PaeA_SB, abbreviated to ΦSB). Notably, a thorough phage characterization and the evolutionary selection pressure exerted on bacteria by phages, analogous to antibiotics, are incorporated into the pipeline.
MeSH term(s)	Humans ; Bacteriophages ; Phage Therapy ; Pseudomonas aeruginosa ; Universities ; Pseudomonas Phages/genetics ; Pseudomonas Infections/therapy ; Pseudomonas Infections/microbiology
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52192-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Hydrogels for Local and Sustained Delivery of Bacteriophages to Treat Multidrug-Resistant Wound Infections.

Lin, Yung-Hao / Dharmaraj, Tejas / Chen, Qingquan / Echterhof, Arne / Manasherob, Robert / Zheng, Lucy Jia / de Leeuw, Cas / Peterson, Nana Ansuah / Stannard, Whitney / Li, Zhiwei / Hajfathalian, Maryam / Hargil, Aviv / Martinez, Hunter A / Chang, Tony Hong Wei / Blankenberg, Francis B / Amanatullah, Derek / Chaudhuri, Ovijit / Bollyky, Paul

bioRxiv : the preprint server for biology

2024

Abstract: Bacteriophages (phages), viruses that specifically target and kill bacteria, represent a promising strategy to combat multidrug-resistant (MDR) pathogens such ... ...

Abstract	Bacteriophages (phages), viruses that specifically target and kill bacteria, represent a promising strategy to combat multidrug-resistant (MDR) pathogens such as
Language	English
Publishing date	2024-05-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.05.07.593005
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Article ; Online: A Biodegradable "One-For-All" Nanoparticle for Multimodality Imaging and Enhanced Photothermal Treatment of Breast Cancer.

Hsu, Jessica C / Barragan, Diego / Tward, Alexander E / Hajfathalian, Maryam / Amirshaghaghi, Ahmad / Mossburg, Katherine J / Rosario-Berríos, Derick N / Bouché, Mathilde / Andrianov, Alexander K / Delikatny, Edward J / Cormode, David P

Advanced healthcare materials

2023 Volume 13, Issue 8, Page(s) e2303018

Abstract: Silver sulfide nanoparticles ( ... ...

Abstract	Silver sulfide nanoparticles (Ag
MeSH term(s)	Humans ; Female ; Breast Neoplasms/therapy ; Phototherapy/methods ; Cell Line, Tumor ; Theranostic Nanomedicine/methods ; Nanoparticles ; Polymers
Chemical Substances	Polymers
Language	English
Publishing date	2023-12-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202303018
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Article: A biodegradable "one-for-all" nanoparticle for multimodality imaging and enhanced photothermal treatment of breast cancer.

bioRxiv : the preprint server for biology

2023

Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.11.28.568885
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Article: Theranostic gold in a gold cage nanoparticle for photothermal ablation and photoacoustic imaging of skin and oral infections.

Hajfathalian, Maryam / de Vries, Christiaan R / Hsu, Jessica C / Amirshaghaghi, Ahmad / Dong, Yuxi C / Ren, Zhi / Liu, Yuan / Huang, Yue / Li, Yong / Knight, Simon / Jonnalagadda, Pallavi / Zlitni, Aimen / Grice, Elizabeth / Bollyky, Paul L / Koo, Hyun / Cormode, David P

bioRxiv : the preprint server for biology

2023

Abstract: Biofilms are structured communities of microbial cells embedded in a self-produced matrix of extracellular polymeric substances. Biofilms are associated with many health issues in humans, including chronic wound infections and tooth decay. Current ... ...

Abstract	Biofilms are structured communities of microbial cells embedded in a self-produced matrix of extracellular polymeric substances. Biofilms are associated with many health issues in humans, including chronic wound infections and tooth decay. Current antimicrobials are often incapable of disrupting the polymeric biofilm matrix and reaching the bacteria within. Alternative approaches are needed. Here, we describe a unique structure of dextran coated gold in a gold cage nanoparticle that enables photoacoustic and photothermal properties for biofilm detection and treatment. Activation of these nanoparticles with a near infrared laser can selectively detect and kill biofilm bacteria with precise spatial control and in a short timeframe. We observe a strong biocidal effect against both Streptococcus mutans and Staphylococcus aureus biofilms in mouse models of oral plaque and wound infections respectively. These effects were over 100 times greater than that seen with chlorhexidine, a conventional antimicrobial agent. Moreover, this approach did not adversely affect surrounding tissues. We conclude that photothermal ablation using theranostic nanoparticles is a rapid, precise, and non-toxic method to detect and treat biofilm-associated infections.
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.05.539604
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models.

Hajfathalian, Maryam / de Vries, Christiaan R / Hsu, Jessica C / Amirshaghaghi, Ahmad / Dong, Yuxi C / Ren, Zhi / Liu, Yuan / Huang, Yue / Li, Yong / Knight, Simon Ab / Jonnalagadda, Pallavi / Zlitni, Aimen / Grice, Elizabeth A / Bollyky, Paul L / Koo, Hyun / Cormode, David P

The Journal of clinical investigation

2023 Volume 133, Issue 21

Abstract	Biofilms are structured communities of microbial cells embedded in a self-produced matrix of extracellular polymeric substances. Biofilms are associated with many health issues in humans, including chronic wound infections and tooth decay. Current antimicrobials are often incapable of disrupting the polymeric biofilm matrix and reaching the bacteria within. Alternative approaches are needed. Here, we described a complex structure of a dextran-coated gold-in-gold cage nanoparticle that enabled photoacoustic and photothermal properties for biofilm detection and treatment. Activation of these nanoparticles with a near infrared laser could selectively detect and kill biofilm bacteria with precise spatial control and in a short timeframe. We observed a strong biocidal effect against both Streptococcus mutans and Staphylococcus aureus biofilms in mouse models of oral plaque and wound infections, respectively. These effects were over 100 times greater than those seen with chlorhexidine, a conventional antimicrobial agent. Moreover, this approach did not adversely affect surrounding tissues. We concluded that photothermal ablation using theranostic nanoparticles is a rapid, precise, and nontoxic method to detect and treat biofilm-associated infections.
MeSH term(s)	Animals ; Mice ; Anti-Bacterial Agents ; Biofilms ; Gold/pharmacology ; Gold/chemistry ; Nanoparticles/chemistry ; Photoacoustic Techniques ; Precision Medicine ; Wound Infection
Chemical Substances	Anti-Bacterial Agents ; Gold (7440-57-5)
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI168485
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Article ; Online: Noble Metal Nanostructure Synthesis at the Liquid-Substrate Interface: New Structures, New Insights, and New Possibilities.

Neretina, Svetlana / Hughes, Robert A / Gilroy, Kyle D / Hajfathalian, Maryam

Accounts of chemical research

2016 Volume 49, Issue 10, Page(s) 2243–2250

Abstract: Modern technologically driven societies could not exist in their current form if it were not for a great many synthetic achievements reliant on solution-based chemistry and substrate-based processing techniques. It is, hence, not surprising that these ... ...

Abstract	Modern technologically driven societies could not exist in their current form if it were not for a great many synthetic achievements reliant on solution-based chemistry and substrate-based processing techniques. It is, hence, not surprising that these same materials preparation techniques have given rise to an impressive list of functional nanomaterials including those derived from noble metals, a class of materials renowned for their extraordinary optical and catalytic properties. Acting as the foundation for substrate-based processing is a collection of techniques such as physical and chemical vapor deposition, epitaxy, self- and directed assembly, and a host of lithographic methods. These techniques allow for precise control over nanostructure placement, but where the fabrication of sophisticated architectures and sub-50 nm feature sizes are often unattainable or reliant on the use of technically demanding cost-prohibitive routes. In contrast, solution-based chemistry allows for the formation of complex nanostructures while maintaining synthetic ease, cost-effectiveness, and exacting control over monodispersity, size, shape, composition, and crystallinity. While many methods exist for the dispersal of colloids onto substrates, few are capable of achieving nanostructure ensembles where nanostructure placement allows for true long-range order as well as control over the crystallographic alignment of the nanostructures relative to each other and the underlying substrate. A more exhaustive comparison of these two approaches reveals that, more often than not, a weakness of substrate-based processing is a strength of colloidal synthesis and vice versa. In this Account, we describe a synthetic strategy devised and validated by the Neretina laboratory that integrates the competencies of substrate-based techniques with colloidal chemistry and, in doing so, brings this rich and exciting chemistry and its associated functionalities to the substrate surface. The strategy takes advantage of an impressive collection of seed-mediated solution-based protocols in which dispersed seeds direct noble metal nanostructure formation along orderly reaction pathways. It, however, replaces the seed colloid with substrate-immobilized templates formed in periodic arrays where the crystallographic orientation of the templates is defined by an epitaxial relationship with the substrate. Demonstrated are syntheses at the liquid-substrate interface in which organized surfaces of crystalline templates formed through templated dewetting are subjected to galvanic replacement, preferential etching, and/or heterogeneous deposition facilitated by redox reactions in both the presence and absence of capping agents. While the protocols utilized are adapted from some of the most well-studied colloidal syntheses, in no case do they yield reaction products that are identical since the substrate inflicts asymmetries onto the growth mode. We believe that the strategy described herein not only demonstrates a family of nanostructures unobtainable through other means but also establishes a synthetic foundation that offers unprecedented flexibility, expands the palette of accessible template materials, provides a new vantage point from which complex reactions occurring in liquid media can be examined, and has the potential to underpin photovoltaic, catalytic, and sensing applications reliant on substrate-based noble metal nanostructures.
Language	English
Publishing date	2016--18
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1483291-4
ISSN	1520-4898 ; 0001-4842
ISSN (online)	1520-4898
ISSN	0001-4842
DOI	10.1021/acs.accounts.6b00393
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