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  1. AU="Hakimi, Mathew"
  2. AU="Voigt, C"
  3. AU="Harenberg, Job"
  4. AU="Bradfield, Owen"
  5. AU=Parmegiani Lodovico
  6. AU=Nasmyth Kim AU=Nasmyth Kim
  7. AU=Krumm Brian AU=Krumm Brian
  8. AU="Isojima, Tsuyoshi"
  9. AU="Rioufol, Gilles"
  10. AU="Hiesmayr, B. C."
  11. AU="Qudrat-Ullah, Hassan"
  12. AU=Kim Ginah Lee
  13. AU="Jeannin, Anne-Caroline"

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  1. Artikel ; Online: Tic Disorders, Anti-Tic Medications, and Risk of Atopy.

    Hakimi, Mathew / Skinner, Sandra / Maurer, Carine W

    Movement disorders clinical practice

    2022  Band 9, Heft 7, Seite(n) 879–885

    Abstract: Objective: To clarify patterns of comorbid atopic disorders in children with tic disorders compared to controls, and to evaluate whether medications commonly used for treatment of tics and attention deficit hyperactivity disorder (ADHD) are associated ... ...

    Abstract Objective: To clarify patterns of comorbid atopic disorders in children with tic disorders compared to controls, and to evaluate whether medications commonly used for treatment of tics and attention deficit hyperactivity disorder (ADHD) are associated with differing risks of atopy.
    Background: Inflammatory mechanisms are increasingly recognized as playing a role in a range of neuropsychiatric disorders. The association between tic disorders, ADHD, obsessive-compulsive disorder (OCD) and atopic disorders is uncertain.
    Methods: We performed a retrospective cohort study using the global electronic health records database TriNetX. Using odds ratios, we compared the risk of atopy in children with tic disorder (n = 4508), ADHD (n = 83,569), and/or OCD (n = 1555) to controls (n = 758 290). To analyze the risk of developing atopy with use of different medications commonly prescribed to treat tics and ADHD, we performed a separate analysis including children with tic disorder, ADHD, and/or OCD who had initiated treatment with one of these medications. Binary logistic regression controlling for age and sex was used to calculate odds ratios.
    Results: Children with tic disorder, ADHD, or OCD were more likely than controls to have comorbid atopy. Children who had taken clonidine, guanfacine, methylphenidate, or dexmethylphenidate were more likely to develop an atopic disorder than controls.
    Conclusions: Our study suggests a link between atopic disorders and tic disorders, ADHD, and OCD. Although the underlying mechanism for this association remains unclear, medication use may play a role.
    Sprache Englisch
    Erscheinungsdatum 2022-07-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13506
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Pseudobulbar Affect in Parkinsonian Disorders: A Review.

    Hakimi, Mathew / Maurer, Carine W

    Journal of movement disorders

    2019  Band 12, Heft 1, Seite(n) 14–21

    Abstract: Pseudobulbar affect (PBA) is a neurological symptom of inappropriate and uncontrollable laughter or crying that occurs secondary to a variety of neurological conditions, including parkinsonian disorders. PBA is a socially and emotionally debilitating ... ...

    Abstract Pseudobulbar affect (PBA) is a neurological symptom of inappropriate and uncontrollable laughter or crying that occurs secondary to a variety of neurological conditions, including parkinsonian disorders. PBA is a socially and emotionally debilitating symptom that has been estimated to affect 3.6% to 42.5% of the population with Parkinson's disease. While indexing measures and treatment options for PBA have been extensively studied in neurological conditions such as amyotrophic lateral sclerosis and multiple sclerosis, there has been considerably less attention given in the literature to PBA in parkinsonian disorders. The purpose of this review is to discuss the pathophysiology of PBA, its prevalence and impact on quality of life in parkinsonian disorders, and the treatment options currently available. Areas requiring further study, including the development of standardized, cross-culturally validated methods of symptom assessment, and evidence-based studies exploring the efficacy of current treatment options in parkinsonian disorders, are also highlighted.
    Sprache Englisch
    Erscheinungsdatum 2019-01-30
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 3021788-X
    ISSN 2093-4939 ; 2005-940X
    ISSN (online) 2093-4939
    ISSN 2005-940X
    DOI 10.14802/jmd.18051
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Learning the Language of Medical Device Innovation: A Longitudinal Interdisciplinary Elective for Medical Students.

    Maloney, Lauren M / Hakimi, Mathew / Hays, Thomas / Adachi, Joseph / Chau, Annie / Esper, Brecken S / Koulouris, Vasilios / Kung, Preston / Meier, Karl R / Schum, Ryan S / Sha, Sha / Wong, Ada / Wu, Ariel / Yin, Wei / Page, Christopher R

    Academic medicine : journal of the Association of American Medical Colleges

    2022  Band 97, Heft 9, Seite(n) 1341–1345

    Abstract: Problem: Physicians are playing a growing role as clinician-innovators. Academic physicians are well positioned to contribute to the medical device innovation process, yet few medical school curricula provide students opportunities to learn the ... ...

    Abstract Problem: Physicians are playing a growing role as clinician-innovators. Academic physicians are well positioned to contribute to the medical device innovation process, yet few medical school curricula provide students opportunities to learn the conceptual framework for clinical needs finding, needs screening, concept generation and iterative prototyping, and intellectual property management. This framework supports innovation and encourages the development of valuable interdisciplinary communication skills and collaborative learning strategies.
    Approach: Our university offers a novel 3-year-long medical student Longitudinal Interdisciplinary Elective in Biodesign (MSLIEB) that teaches medical device innovation in 4 stages: (1) seminars and small-group work, (2) shared clinical experiences for needs finding, (3) concept generation and product development by serving as consultants for biomedical engineering capstone projects, and (4) reflection and mentorship. The MSLIEB objectives are to: create a longitudinal interdisciplinary peer mentorship relationship between undergraduate biomedical engineering students and medical students, and encourage codevelopment of professional identities in relation to medical device innovation.
    Outcomes: The MSLIEB enrolled 5 entering cohorts from 2017 to 2021 with a total of 37 medical student participants. The first full entering cohort of 12 medical students produced 8 mentored biomedical engineering capstone projects, 7 of which were based on clinical needs statements derived from earlier in the elective. Medical student participants have coauthored poster and oral presentations; contributed to projects that won WolfieTank, a university-wide competition modeled after the television show Shark Tank; and participated in the filing of provisional patents. Students reflecting on the course reported a change in their attitude towards existing medical problems, felt better-equipped to collaboratively design solutions for clinical needs, and considered a potential career path in device design.
    Next steps: The MSLIEB will be scaled up by recruiting additional faculty, broadening clinical opportunities to include the outpatient setting, and increasing medical student access to rapid prototyping equipment.
    Mesh-Begriff(e) Curriculum ; Education, Medical, Undergraduate ; Humans ; Learning ; Schools, Medical ; Students, Medical
    Sprache Englisch
    Erscheinungsdatum 2022-05-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000004723
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 112: Hefte anzeigen Standort:
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  4. Artikel ; Online: Patients with dorsolateral prefrontal cortex lesions are capable of discriminatory threat learning but appear impaired in cognitive regulation of subjective fear.

    Kroes, Marijn C W / Dunsmoor, Joseph E / Hakimi, Mathew / Oosterwaal, Sofie / Meager, Michael R / Phelps, Elizabeth A

    Social cognitive and affective neuroscience

    2019  Band 14, Heft 6, Seite(n) 601–612

    Abstract: Humans are able to cognitively regulate emotions by changing their thoughts. Neuroimaging studies show correlations between dorsolateral prefrontal cortex (dlPFC) activity and cognitive regulation of emotions. Here our objective was to investigate ... ...

    Abstract Humans are able to cognitively regulate emotions by changing their thoughts. Neuroimaging studies show correlations between dorsolateral prefrontal cortex (dlPFC) activity and cognitive regulation of emotions. Here our objective was to investigate whether dlPFC damage is associated with impaired cognitive regulation of emotion. We therefore tested the ability of patients with dlPFC lesions (N = 6) and matched control participants (N = 19) to utilize a laboratory version of cognitive regulation training (CRT) to regulate subjective fear and autonomic threat responses following Pavlovian threat conditioning. We found that patients with dlPFC lesions were able to acquire conditioned threat but seemed impaired in their ability to utilize CRT to cognitively regulate subjective fear to a threatening stimulus. Despite inclusion of a limited number of lesion patients, our results suggest that the dlPFC is important for the cognitive regulation of subjective fear.
    Mesh-Begriff(e) Adult ; Aged ; Cognition/physiology ; Conditioning, Classical/physiology ; Discrimination Learning/physiology ; Fear/physiology ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Prefrontal Cortex/physiopathology
    Sprache Englisch
    Erscheinungsdatum 2019-02-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2236933-8
    ISSN 1749-5024 ; 1749-5016
    ISSN (online) 1749-5024
    ISSN 1749-5016
    DOI 10.1093/scan/nsz039
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Hippocampal volumetric integrity in mesial temporal lobe epilepsy: A fast novel method for analysis of structural MRI.

    Hakimi, Mathew / Ardekani, Babak A / Pressl, Christina / Blackmon, Karen / Thesen, Thomas / Devinsky, Orrin / Kuzniecky, Ruben I / Pardoe, Heath R

    Epilepsy research

    2019  Band 154, Seite(n) 157–162

    Abstract: Objective: We investigate whether a rapid and novel automated MRI processing technique for assessing hippocampal volumetric integrity (HVI) can be used to identify hippocampal sclerosis (HS) in patients with mesial temporal lobe epilepsy (mTLE) and ... ...

    Abstract Objective: We investigate whether a rapid and novel automated MRI processing technique for assessing hippocampal volumetric integrity (HVI) can be used to identify hippocampal sclerosis (HS) in patients with mesial temporal lobe epilepsy (mTLE) and determine its performance relative to hippocampal volumetry (HV) and visual inspection.
    Methods: We applied the HVI technique to T1-weighted brain images from healthy control (n = 35), mTLE (n = 29), non-HS temporal lobe epilepsy (TLE, n = 44), and extratemporal focal epilepsy (EXTLE, n = 25) subjects imaged using a standardized epilepsy research imaging protocol and on non-standardized clinically acquired images from mTLE subjects (n = 40) to investigate if the technique is translatable to clinical practice. Performance of HVI, HV, and visual inspection was assessed using receiver operating characteristic (ROC) analysis.
    Results: mTLE patients from both research and clinical groups had significantly reduced ipsilateral HVI relative to controls (effect size: -0.053, 5.62%, p =  0.002 using a standardized research imaging protocol). For lateralizing mTLE, HVI had a sensitivity of 88% compared with a HV sensitivity of 92% when using specificity equal to 70%.
    Conclusions: The novel HVI approach can effectively detect HS in clinical populations, with an average image processing time of less than a minute. The fast processing speed suggests this technique could have utility as a quantitative tool to assist with imaging-based diagnosis and lateralization of HS in a clinical setting.
    Mesh-Begriff(e) Adult ; Epilepsy, Temporal Lobe/diagnostic imaging ; Female ; Hippocampus/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2019-05-24
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2019.05.014
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2193: Hefte anzeigen Standort:
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