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  1. Article ; Online: Glioma dataset from Rabat: Clinicopathological, immunohistochemical and disease progression features of 32 Moroccan patients with diffuse Glioma.

    Sfifou, Fatima / Ouzir, Mounir / Hakkou, El Mehdi / Obtel, Majdouline / Errihani, Hassan / Bouzidi, Abderrahmane Al / Abouqal, Redouane / Ouahabi, Abdessamad El / Cherradi, Nadia

    Data in brief

    2022  Volume 42, Page(s) 108265

    Abstract: The Moroccan Glioma Dataset contains the clinical data of 32 patients with glioma. The clinical data including demographic data (age, sex), tumor characteristics (tumor location, Glioma type, Karnofsky performance score, mitotic activity, cell density, ... ...

    Abstract The Moroccan Glioma Dataset contains the clinical data of 32 patients with glioma. The clinical data including demographic data (age, sex), tumor characteristics (tumor location, Glioma type, Karnofsky performance score, mitotic activity, cell density, necrosis, endotheliocapillary vascular proliferation, MRI contrast pick-up, corpus collosum infiltration and Oedema), treatment strategy (subtotal resection, gross resection, biopsy, radiotherapy, chemotherapy), expression pattern of tumor biomarkers (IDH1, HIF-1alpha, P53, Ki-67), and survival data (Kaplan-Meier curves for disease progression). The dataset can be used to relate tumor characteristics to tumor biomarkers and to predict disease progression for a better treatment management. The data were presented, analyzed, and described in the article "Immunohistochemical expression of HIF-1α, IDH1 and TP53: prognostic profile of Moroccan patients with diffuse glioma" published in Journal of Chemical Neuroanatomy [1].
    Language English
    Publishing date 2022-05-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2022.108265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Glioma dataset from Rabat: Clinicopathological, immunohistochemical and disease progression features of 32 Moroccan patients with diffuse Glioma

    Sfifou, Fatima / Ouzir, Mounir / Hakkou, El Mehdi / Obtel, Majdouline / Errihani, Hassan / Bouzidi, Abderrahmane Al / Abouqal, Redouane / Ouahabi, Abdessamad El / Cherradi, Nadia

    Data in Brief. 2022 June, v. 42

    2022  

    Abstract: The Moroccan Glioma Dataset contains the clinical data of 32 patients with glioma. The clinical data including demographic data (age, sex), tumor characteristics (tumor location, Glioma type, Karnofsky performance score, mitotic activity, cell density, ... ...

    Abstract The Moroccan Glioma Dataset contains the clinical data of 32 patients with glioma. The clinical data including demographic data (age, sex), tumor characteristics (tumor location, Glioma type, Karnofsky performance score, mitotic activity, cell density, necrosis, endotheliocapillary vascular proliferation, MRI contrast pick-up, corpus collosum infiltration and Oedema), treatment strategy (subtotal resection, gross resection, biopsy, radiotherapy, chemotherapy), expression pattern of tumor biomarkers (IDH1, HIF-1alpha, P53, Ki-67), and survival data (Kaplan-Meier curves for disease progression). The dataset can be used to relate tumor characteristics to tumor biomarkers and to predict disease progression for a better treatment management. The data were presented, analyzed, and described in the article “Immunohistochemical expression of HIF-1α, IDH1 and TP53: prognostic profile of Moroccan patients with diffuse glioma” published in Journal of Chemical Neuroanatomy [1].
    Keywords biomarkers ; biopsy ; data collection ; disease progression ; drug therapy ; edema ; glioma ; immunohistochemistry ; mitosis ; necrosis ; radiotherapy ; resection
    Language English
    Dates of publication 2022-06
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 2786545-9
    ISSN 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2022.108265
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Letter: Neurosurgical Patients' Management During the COVID-19 Pandemic-An Institutional Report From an African Neurosurgical Center.

    Oudrhiri, Mohammed Yassaad / Bechri, Hajar / Hakkou, El Mehdi / Melhaoui, Adyl / Arkha, Yasser / El Ouahabi, Abdessamad

    Neurosurgery

    2020  Volume 87, Issue 2, Page(s) E230–E231

    Keywords covid19
    Language English
    Publishing date 2020-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyaa182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1424: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 539: Show issues

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  4. Article ; Online: Letter to the Editor: How the Pandemic Is Changing Neurosurgical Education in Morocco.

    Oudrhiri, Mohammed Yassaad / Bechri, Hajar / Hakkou, El Mehdi / Arkha, Yasser / El Ouahabi, Abdessamad

    World neurosurgery

    2020  Volume 140, Page(s) 474–475

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Morocco/epidemiology ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.05.281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1159: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Immunohistochemical expression of HIF-1α, IDH1 and TP53: Prognostic profile of Moroccan patients with diffuse glioma.

    Sfifou, Fatima / Ouzir, Mounir / Hakkou, El Mehdi / Obtel, Majdouline / Errihani, Hassan / Bouzidi, Abderrahmane Al / Abouqal, Redouane / El Ouahabi, Abdessamad / Cherradi, Nadia

    Journal of chemical neuroanatomy

    2021  Volume 119, Page(s) 102056

    Abstract: Diffuse gliomas are growing brain tumors that occur in adult life. This study was designed to determine whether the immunohistochemical analysis of IDH1, HIF-1alpha, or TP53 can provide useful biomarkers of clinical severity and progression of diffuse ... ...

    Abstract Diffuse gliomas are growing brain tumors that occur in adult life. This study was designed to determine whether the immunohistochemical analysis of IDH1, HIF-1alpha, or TP53 can provide useful biomarkers of clinical severity and progression of diffuse gliomas. Also, it is hypothesized that the expression of IDH1 mutant induces HIF-1alpha. Immunohistochemical staining for HIF-1alpha, IDH1, and TP 53 was performed in biopsy or resection (sub-total or gross-total) tissue from diffuse gliomas in a clinical series of 32 patients. Associations of the HIF-1alpha, IDH1, and TP53 with clinical characteristics were evaluated and the co-expression of two biomarkers (HIF-1alpha and IDH1) was tested. Our data revealed that each biomarker is expressed in a subset of gliomas (IDH1 was positive in 56% cases, HIF-1alpha was positive in 50% cases and TP53 was positive in 44% cases). While no associations were found between clinical characteristics and the expression of HIF-1alpha, and TP53, IDH1 expression was associated with less severe clinical presentation (Karnofsky Performance Status) and disease progression and was more often expressed in females than males. In addition, there was no clear association between IDH1 and HIF-1alpha expression (21.9% of patients co-expressed IDH1 and HIF-1alpha). The current series provides clinical and immunohistochemical findings that can be useful for the clinical management of patients with diffused gliomas.
    MeSH term(s) Adult ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Female ; Glioma/diagnosis ; Glioma/metabolism ; Glioma/pathology ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; Male ; Morocco ; Prognosis ; Tumor Suppressor Protein p53/metabolism
    Chemical Substances HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; TP53 protein, human ; Tumor Suppressor Protein p53 ; Isocitrate Dehydrogenase (EC 1.1.1.41) ; IDH1 protein, human (EC 1.1.1.42.)
    Language English
    Publishing date 2021-12-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639443-7
    ISSN 1873-6300 ; 0891-0618
    ISSN (online) 1873-6300
    ISSN 0891-0618
    DOI 10.1016/j.jchemneu.2021.102056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2363: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Letter to the Editor regarding "COVID-19 and Neurosurgical Education in Africa"; How the pandemic is changing neurosurgical education in Morocco

    Oudrhiri, Mohammed Yassaad / Bechri, Hajar / Hakkou, El Mehdi / Arkha, Yasser / El Ouahabi, Abdessamad

    World neurosurgery (Online)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #548028
    Database COVID19

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  7. Article: Letter: Neurosurgical Patients' Management During the COVID-19 Pandemic-An Institutional Report From an African Neurosurgical Center

    Oudrhiri, Mohammed Yassaad / Bechri, Hajar / Hakkou, El Mehdi / Melhaoui, Adyl / Arkha, Yasser / El Ouahabi, Abdessamad

    Neurosurgery

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #155201
    Database COVID19

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  8. Article: Letter to the Editor: How the Pandemic Is Changing Neurosurgical Education in Morocco

    Oudrhiri, Mohammed Yassaad / Bechri, Hajar / Hakkou, El Mehdi / Arkha, Yasser / El Ouahabi, Abdessamad

    World Neurosurg

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #548028
    Database COVID19

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  9. Article ; Online: Letter

    Oudrhiri, Mohammed Yassaad / Bechri, Hajar / Hakkou, El Mehdi / Melhaoui, Adyl / Arkha, Yasser / El Ouahabi, Abdessamad

    Neurosurgery

    Neurosurgical Patients’ Management During the COVID-19 Pandemic—An Institutional Report From an African Neurosurgical Center

    2020  Volume 87, Issue 2, Page(s) E230–E231

    Keywords Surgery ; Clinical Neurology ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyaa182
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Zs.MO 539: Show issues

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  10. Article: Correlation of immunohistochemical expression of HIF-1alpha and IDH1 with clinicopathological and therapeutic data of moroccan glioblastoma and survival analysis.

    Sfifou, Fatima / Hakkou, El Mehdi / Bouaiti, El Arbi / Slaoui, Meriem / Errihani, Hassan / Al Bouzidi, Abderrahmane / Abouqal, Redouane / El Ouahabi, Abdessamad / Cherradi, Nadia

    Annals of medicine and surgery (2012)

    2021  Volume 69, Page(s) 102731

    Abstract: Introduction: Glioblastomas are aggressive primary intracranial tumours of the central nervous system causing significant mortality and morbidity worldwide.: Objective: This study aims to evaluate the prognostic value of tissue expression by ... ...

    Abstract Introduction: Glioblastomas are aggressive primary intracranial tumours of the central nervous system causing significant mortality and morbidity worldwide.
    Objective: This study aims to evaluate the prognostic value of tissue expression by immunostaining of hypoxia-inducible factor (HIF-1α), isocitrate dehydrogenase 1 (IDH1), and tumour protein p53 in glioblastoma in Moroccan patients. The association of HIF-1α, IDH1, and p53 expression with the clinicopathological data and overall patient survival (OS) was also evaluated.
    Materials and methods: Confirmed glioblastomas were included in this study. Twenty-two tissue samples were obtained by neurosurgical intervention resulting from total resection, and subtotal resection or biopsy. Karnofsky index, histological type of tumour, and the status of IDH1, p53 protein, and HIF-1α expression by immunostaining were reported.
    Results: The majority of the patients were males (64%) with a sex ratio of 1.75. The average age was 54 ± 13. Median follow-up was 10.10 months and median overall survival was 10 months. The expression of HIF-1α was high in 10 samples (45%) and low in 12 (55%). There was a statistically significant difference in OS of 85% at 12 months for the subgroup of patients "HIF-1α negative IDH1 positive" p = 0.038, the unadjusted analysis showed that the group "HIF-1α positive, IDH1 positive" was a poor prognostic factor, the HR was 0.08 (95% CI: 0.009-0.756, p = 0.027).
    Conclusion: Patients with negative HIF-1α expression and positive IDH1 expression have a better prognosis, suggesting that these two biomarkers may be useful in the search for new approaches for targeted therapy in glioblastoma.
    Language English
    Publishing date 2021-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2021.102731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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