Article ; Online: Fever, confusion, acute kidney injury: is this atypical neuroleptic malignant syndrome following polypharmacy with clozapine and risperidone?
Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists
2016 Volume 24, Issue 6, Page(s) 602–603
Abstract: Objective: Clozapine is the gold-standard antipsychotic medication for treatment-refractory schizophrenia (TRS). However, one potentially lethal side effect of clozapine, as with other antipsychotics, is neuroleptic malignant syndrome (NMS) which could ... ...
| Abstract | Objective: Clozapine is the gold-standard antipsychotic medication for treatment-refractory schizophrenia (TRS). However, one potentially lethal side effect of clozapine, as with other antipsychotics, is neuroleptic malignant syndrome (NMS) which could present differently in clozapine therapy. 'Atypical NMS' is a recognised variant of NMS with less rigidity and delayed elevation of creatine kinase; this variant is associated with clozapine. Method: A case from the author's clinical practice was reviewed. Results: A 67-year-old man with TRS was treated with clozapine. Unfortunately, his physical condition deteriorated and he presented with atypical NMS, which initially was treated as presumable urinary tract infection. Conclusions: Atypical NMS is associated with clozapine. This case exposes the potential difficulties in diagnosis, and highlights the importance of considering less common diagnoses in acutely unwell psychiatric patients. |
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| Language | English | ||||||||||
| Publishing date | 2016-12 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 2213198-X | ||||||||||
| ISSN | 1440-1665 ; 1039-8562 | ||||||||||
| ISSN (online) | 1440-1665 | ||||||||||
| ISSN | 1039-8562 | ||||||||||
| DOI | 10.1177/1039856216649768 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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