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  1. Article ; Online: RSV Prevention - Breakthroughs and Challenges.

    Halasa, Natasha B

    The New England journal of medicine

    2023  Volume 389, Issue 26, Page(s) 2480–2481

    MeSH term(s) Humans ; Palivizumab/therapeutic use ; Respiratory Syncytial Virus Infections/prevention & control ; Antiviral Agents/therapeutic use
    Chemical Substances Palivizumab (DQ448MW7KS) ; Antiviral Agents
    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2312934
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    Ua VI Zs.34: Show issues Location:
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  2. Article ; Online: COVID-19 vaccines protect children of all ages.

    Amarin, Justin Z / Hayek, Haya / Halasa, Natasha B

    The Journal of clinical investigation

    2022  Volume 132, Issue 17

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Child ; Humans ; Vaccination ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI164102
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    Ua VI Zs.184: Show issues Location:
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  3. Article ; Online: SARS-CoV-2 Vaccine in Dialysis Patients: Time for a Boost?

    Krueger, Karen M / Halasa, Natasha / Ison, Michael G

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2021  Volume 79, Issue 2, Page(s) 162–163

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Immunogenicity, Vaccine ; Renal Dialysis/adverse effects ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-12-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2021.10.003
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    Zs.A 1669: Show issues Location:
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    Zs.MO 468: Show issues

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  4. Article ; Online: Vaccine protection and how we measure it.

    Ni, Bin / Yanis, Ahmad / Chappell, James / Halasa, Natasha

    Transplant infectious disease : an official journal of the Transplantation Society

    2021  Volume 23, Issue 6, Page(s) e13748

    MeSH term(s) Humans ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2021-11-30
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13748
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    Zs.A 5100: Show issues Location:
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  5. Article ; Online: Preparing for the 2020-2021 influenza season.

    de St Maurice, Annabelle / Martin-Blais, Rachel / Halasa, Natasha

    Pediatric transplantation

    2021  Volume 25, Issue 5, Page(s) e14025

    Abstract: The COVID-19 pandemic has altered health seeking behaviors and has increased attention to non-pharmaceutical interventions that reduce the risk of transmission of respiratory viruses including SARS-CoV-2 and influenza. While the potential impact of the ... ...

    Abstract The COVID-19 pandemic has altered health seeking behaviors and has increased attention to non-pharmaceutical interventions that reduce the risk of transmission of respiratory viruses including SARS-CoV-2 and influenza. While the potential impact of the COVID-19 pandemic on influenza is not fully known, in the Southern hemisphere influenza infection rates appear to be very low. Influenza vaccine efficacy for 2019-2020 season was comparable to prior season and influenza vaccine recommendations for pediatric immunizations remain similar to prior years. Influenza treatments continue to include neuraminidase inhibitors as well as baloxavir for treatment and in some instances prophylaxis.
    MeSH term(s) Adolescent ; Adult ; Aged ; Animals ; Antiviral Agents/pharmacology ; COVID-19/complications ; COVID-19/epidemiology ; Chemoprevention ; Child ; Child, Preschool ; Coinfection ; Communicable Disease Control ; Humans ; Immunization ; Infant ; Influenza Vaccines ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Middle Aged ; Pandemics ; SARS-CoV-2 ; Seasons ; Young Adult ; Zoonoses
    Chemical Substances Antiviral Agents ; Influenza Vaccines
    Language English
    Publishing date 2021-04-27
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14025
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    Zs.A 4947: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Diagnostic models predicting paediatric viral acute respiratory infections: a systematic review.

    Rankin, Danielle A / Peetluk, Lauren S / Deppen, Stephen / Slaughter, James Christopher / Katz, Sophie / Halasa, Natasha B / Khankari, Nikhil K

    BMJ open

    2023  Volume 13, Issue 4, Page(s) e067878

    Abstract: Objectives: To systematically review and evaluate diagnostic models used to predict viral acute respiratory infections (ARIs) in children.: Design: Systematic review.: Data sources: PubMed and Embase were searched from 1 January 1975 to 3 February ...

    Abstract Objectives: To systematically review and evaluate diagnostic models used to predict viral acute respiratory infections (ARIs) in children.
    Design: Systematic review.
    Data sources: PubMed and Embase were searched from 1 January 1975 to 3 February 2022.
    Eligibility criteria: We included diagnostic models predicting viral ARIs in children (<18 years) who sought medical attention from a healthcare setting and were written in English. Prediction model studies specific to SARS-CoV-2, COVID-19 or multisystem inflammatory syndrome in children were excluded.
    Data extraction and synthesis: Study screening, data extraction and quality assessment were performed by two independent reviewers. Study characteristics, including population, methods and results, were extracted and evaluated for bias and applicability using the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies and PROBAST (Prediction model Risk Of Bias Assessment Tool).
    Results: Of 7049 unique studies screened, 196 underwent full text review and 18 were included. The most common outcome was viral-specific influenza (n=7; 58%). Internal validation was performed in 8 studies (44%), 10 studies (56%) reported discrimination measures, 4 studies (22%) reported calibration measures and none performed external validation. According to PROBAST, a high risk of bias was identified in the analytic aspects in all studies. However, the existing studies had minimal bias concerns related to the study populations, inclusion and modelling of predictors, and outcome ascertainment.
    Conclusions: Diagnostic prediction can aid clinicians in aetiological diagnoses of viral ARIs. External validation should be performed on rigorously internally validated models with populations intended for model application.
    Prospero registration number: CRD42022308917.
    MeSH term(s) Child ; Humans ; Bias ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Prognosis ; Respiratory Tract Infections/diagnosis ; SARS-CoV-2 ; Virus Diseases/diagnosis
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article ; Systematic Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-067878
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  7. Article ; Online: Timing isn't everything: Influenza vaccination in cancer patients.

    Dulek, Daniel E / Halasa, Natasha B

    Cancer

    2017  Volume 123, Issue 5, Page(s) 731–733

    MeSH term(s) Humans ; Influenza, Human ; Neoplasms ; Vaccination
    Language English
    Publishing date 2017--01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.30467
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    Uh III Zs.146: Show issues Location:
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  8. Article ; Online: Provider-ordered viral testing and antibiotic administration practices among children with acute respiratory infections across healthcare settings in Nashville, Tennessee.

    Rankin, Danielle A / Katz, Sophie E / Amarin, Justin Z / Hayek, Haya / Stewart, Laura S / Slaughter, James C / Deppen, Stephen / Yanis, Ahmad / Romero, Yesenia Herazo / Chappell, James D / Khankari, Nikhil K / Halasa, Natasha B

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2024  Volume 4, Issue 1, Page(s) e29

    Abstract: Objective: Evaluate the association between provider-ordered viral testing and antibiotic treatment practices among children discharged from an ED or hospitalized with an acute respiratory infection (ARI).: Design: Active, prospective ARI ... ...

    Abstract Objective: Evaluate the association between provider-ordered viral testing and antibiotic treatment practices among children discharged from an ED or hospitalized with an acute respiratory infection (ARI).
    Design: Active, prospective ARI surveillance study from November 2017 to February 2020.
    Setting: Pediatric hospital and emergency department in Nashville, Tennessee.
    Participants: Children 30 days to 17 years old seeking medical care for fever and/or respiratory symptoms.
    Methods: Antibiotics prescribed during the child's ED visit or administered during hospitalization were categorized into (1) None administered; (2) Narrow-spectrum; and (3) Broad-spectrum. Setting-specific models were built using unconditional polytomous logistic regression with robust sandwich estimators to estimate the adjusted odds ratios and 95% confidence intervals between provider-ordered viral testing (ie, tested versus not tested) and viral test result (ie, positive test versus not tested and negative test versus not tested) and three-level antibiotic administration.
    Results: 4,107 children were enrolled and tested, of which 2,616 (64%) were seen in the ED and 1,491 (36%) were hospitalized. In the ED, children who received a provider-ordered viral test had 25% decreased odds (aOR: 0.75; 95% CI: 0.54, 0.98) of receiving a narrow-spectrum antibiotic during their visit than those without testing. In the inpatient setting, children with a negative provider-ordered viral test had 57% increased odds (aOR: 1.57; 95% CI: 1.01, 2.44) of being administered a broad-spectrum antibiotic compared to children without testing.
    Conclusions: In our study, the impact of provider-ordered viral testing on antibiotic practices differed by setting. Additional studies evaluating the influence of viral testing on antibiotic stewardship and antibiotic prescribing practices are needed.
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2024.24
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  9. Article ; Online: Preparing for the 2019-2020 influenza season.

    de St Maurice, Annabelle / Halasa, Natasha

    Pediatric transplantation

    2019  Volume 24, Issue 1, Page(s) e13645

    Abstract: Although the 2017-2018 influenza season had very high rates of influenza-associated illness, the 2018-2019 influenza season was comparable to previous seasons. Influenza A was the most commonly identified type worldwide, although variations in influenza ... ...

    Abstract Although the 2017-2018 influenza season had very high rates of influenza-associated illness, the 2018-2019 influenza season was comparable to previous seasons. Influenza A was the most commonly identified type worldwide, although variations in influenza A subtype prevalence existed. Influenza vaccination remains the single most effective way to prevent influenza-associated illness. A novel influenza antiviral, baloxavir, has demonstrated promising results; however, concerns about development of resistance exist.
    MeSH term(s) Antiviral Agents/therapeutic use ; Dibenzothiepins/therapeutic use ; Global Health ; Humans ; Influenza Vaccines ; Influenza, Human/drug therapy ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Morpholines/therapeutic use ; Pyridones/therapeutic use ; Seasons ; Triazines/therapeutic use
    Chemical Substances Antiviral Agents ; Dibenzothiepins ; Influenza Vaccines ; Morpholines ; Pyridones ; Triazines ; baloxavir (4G86Y4JT3F)
    Language English
    Publishing date 2019-12-29
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.13645
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    Zs.A 4947: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Evaluating Acute Viral Gastroenteritis Severity: Modified Vesikari and Clark Scoring Systems.

    Plancarte, Carlos / Stopczynski, Tess / Hamdan, Lubna / Stewart, Laura S / Rahman, Herdi / Amarin, Justin Z / Chappell, James / Wikswo, Mary E / Dunn, John R / Payne, Daniel C / Hall, Aron J / Spieker, Andrew J / Halasa, Natasha

    Hospital pediatrics

    2024  

    Abstract: Objective: Acute gastroenteritis (AGE) is the second leading cause of death in children worldwide. Objectively evaluating disease severity is critical for assessing future interventions. We used data from a large, prospective surveillance study to ... ...

    Abstract Objective: Acute gastroenteritis (AGE) is the second leading cause of death in children worldwide. Objectively evaluating disease severity is critical for assessing future interventions. We used data from a large, prospective surveillance study to assess risk factors associated with severe presentation using modified Vesikari score (MVS) and Clark score (CS) of severity.
    Methods: From December 1, 2012 to June 30, 2016, AGE surveillance was performed for children between 15 days and 17 years old in the emergency, inpatient, and outpatient settings at Vanderbilt's Monroe Carell Jr. Children's Hospital in Nashville, TN. Stool specimens were tested for norovirus, sapovirus, rotavirus, and astrovirus. We compared demographic and clinical characteristics, along with the MVS and CS, by viral detection status and by setting.
    Results: Of the 6309 eligible children, 4216 (67%) were enrolled, with 3256 (77%) providing a stool specimen. The median age was 1.9 years, 52% were male, and 1387 (43%) of the stool samples were virus positive. Younger age, male sex, hospitalization, and rotavirus detection were significantly associated with higher mean MVS and CS. Non-Hispanic Black race and ethnicity was associated with a lower mean MVS and CS as compared with non-Hispanic white race and ethnicity. Prematurity and enrollment in the ED were associated with higher mean CS. The 2 scoring systems were highly correlated.
    Conclusions: Rotavirus continues to be associated with more severe pediatric illness compared with other viral causes of AGE. MVS and CS systems yielded comparable results and can be useful tools to assess AGE severity.
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ISSN 2154-1671
    ISSN (online) 2154-1671
    DOI 10.1542/hpeds.2023-007357
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