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Article ; Online: RSV Prevention - Breakthroughs and Challenges.

Halasa, Natasha B

2023 Volume 389, Issue 26, Page(s) 2480–2481

MeSH term(s)	Humans ; Palivizumab/therapeutic use ; Respiratory Syncytial Virus Infections/prevention & control ; Antiviral Agents/therapeutic use
Chemical Substances	Palivizumab (DQ448MW7KS) ; Antiviral Agents
Language	English
Publishing date	2023-12-29
Publishing country	United States
Document type	Editorial
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMe2312934
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Article ; Online: COVID-19 vaccines protect children of all ages.

Amarin, Justin Z / Hayek, Haya / Halasa, Natasha B

The Journal of clinical investigation

2022 Volume 132, Issue 17

MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines ; Child ; Humans ; Vaccination ; Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI164102
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Article ; Online: Diagnostic models predicting paediatric viral acute respiratory infections: a systematic review.

Rankin, Danielle A / Peetluk, Lauren S / Deppen, Stephen / Slaughter, James Christopher / Katz, Sophie / Halasa, Natasha B / Khankari, Nikhil K

BMJ open

2023 Volume 13, Issue 4, Page(s) e067878

Abstract: Objectives: To systematically review and evaluate diagnostic models used to predict viral acute respiratory infections (ARIs) in children.: Design: Systematic review.: Data sources: PubMed and Embase were searched from 1 January 1975 to 3 February ...

Abstract	Objectives: To systematically review and evaluate diagnostic models used to predict viral acute respiratory infections (ARIs) in children. Design: Systematic review. Data sources: PubMed and Embase were searched from 1 January 1975 to 3 February 2022. Eligibility criteria: We included diagnostic models predicting viral ARIs in children (<18 years) who sought medical attention from a healthcare setting and were written in English. Prediction model studies specific to SARS-CoV-2, COVID-19 or multisystem inflammatory syndrome in children were excluded. Data extraction and synthesis: Study screening, data extraction and quality assessment were performed by two independent reviewers. Study characteristics, including population, methods and results, were extracted and evaluated for bias and applicability using the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies and PROBAST (Prediction model Risk Of Bias Assessment Tool). Results: Of 7049 unique studies screened, 196 underwent full text review and 18 were included. The most common outcome was viral-specific influenza (n=7; 58%). Internal validation was performed in 8 studies (44%), 10 studies (56%) reported discrimination measures, 4 studies (22%) reported calibration measures and none performed external validation. According to PROBAST, a high risk of bias was identified in the analytic aspects in all studies. However, the existing studies had minimal bias concerns related to the study populations, inclusion and modelling of predictors, and outcome ascertainment. Conclusions: Diagnostic prediction can aid clinicians in aetiological diagnoses of viral ARIs. External validation should be performed on rigorously internally validated models with populations intended for model application. Prospero registration number: CRD42022308917.
MeSH term(s)	Child ; Humans ; Bias ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Prognosis ; Respiratory Tract Infections/diagnosis ; SARS-CoV-2 ; Virus Diseases/diagnosis
Language	English
Publishing date	2023-04-21
Publishing country	England
Document type	Journal Article ; Systematic Review ; Research Support, N.I.H., Extramural
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-067878
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Article ; Online: Timing isn't everything: Influenza vaccination in cancer patients.

Dulek, Daniel E / Halasa, Natasha B

Cancer

2017 Volume 123, Issue 5, Page(s) 731–733

MeSH term(s)	Humans ; Influenza, Human ; Neoplasms ; Vaccination
Language	English
Publishing date	2017--01
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.30467
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Article ; Online: Provider-ordered viral testing and antibiotic administration practices among children with acute respiratory infections across healthcare settings in Nashville, Tennessee.

Rankin, Danielle A / Katz, Sophie E / Amarin, Justin Z / Hayek, Haya / Stewart, Laura S / Slaughter, James C / Deppen, Stephen / Yanis, Ahmad / Romero, Yesenia Herazo / Chappell, James D / Khankari, Nikhil K / Halasa, Natasha B

Antimicrobial stewardship & healthcare epidemiology : ASHE

2024 Volume 4, Issue 1, Page(s) e29

Abstract: Objective: Evaluate the association between provider-ordered viral testing and antibiotic treatment practices among children discharged from an ED or hospitalized with an acute respiratory infection (ARI).: Design: Active, prospective ARI ... ...

Abstract	Objective: Evaluate the association between provider-ordered viral testing and antibiotic treatment practices among children discharged from an ED or hospitalized with an acute respiratory infection (ARI). Design: Active, prospective ARI surveillance study from November 2017 to February 2020. Setting: Pediatric hospital and emergency department in Nashville, Tennessee. Participants: Children 30 days to 17 years old seeking medical care for fever and/or respiratory symptoms. Methods: Antibiotics prescribed during the child's ED visit or administered during hospitalization were categorized into (1) None administered; (2) Narrow-spectrum; and (3) Broad-spectrum. Setting-specific models were built using unconditional polytomous logistic regression with robust sandwich estimators to estimate the adjusted odds ratios and 95% confidence intervals between provider-ordered viral testing (ie, tested versus not tested) and viral test result (ie, positive test versus not tested and negative test versus not tested) and three-level antibiotic administration. Results: 4,107 children were enrolled and tested, of which 2,616 (64%) were seen in the ED and 1,491 (36%) were hospitalized. In the ED, children who received a provider-ordered viral test had 25% decreased odds (aOR: 0.75; 95% CI: 0.54, 0.98) of receiving a narrow-spectrum antibiotic during their visit than those without testing. In the inpatient setting, children with a negative provider-ordered viral test had 57% increased odds (aOR: 1.57; 95% CI: 1.01, 2.44) of being administered a broad-spectrum antibiotic compared to children without testing. Conclusions: In our study, the impact of provider-ordered viral testing on antibiotic practices differed by setting. Additional studies evaluating the influence of viral testing on antibiotic stewardship and antibiotic prescribing practices are needed.
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ISSN	2732-494X
ISSN (online)	2732-494X
DOI	10.1017/ash.2024.24
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Article ; Online: Epidemiologic trends and characteristics of SARS-CoV-2 infections among children in the United States.

Rankin, Danielle A / Talj, Rana / Howard, Leigh M / Halasa, Natasha B

Current opinion in pediatrics

2020 Volume 33, Issue 1, Page(s) 114–121

Abstract: Purpose of review: To review the epidemiological characteristics and clinical features associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among children in the United States.: Recent findings: In the United States, ...

Abstract	Purpose of review: To review the epidemiological characteristics and clinical features associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among children in the United States. Recent findings: In the United States, the majority of SARS-CoV-2 infections in children have been mild illnesses, with those 5-17 years of age having the highest frequency. Specifically, the incidence of SARS-CoV-2 in children is two times higher in adolescents (12-17 years) than younger school-aged children (5-11 years). Despite the higher case counts in older children, 10% of pediatric hospitalizations have been in infants less than one year. In addition, severe respiratory and renal complications, hospitalization, and even death have been documented in children. Summary: Clinical manifestations of SARS-CoV-2 infection in children range from asymptomatic to severe respiratory distress, with mild nonspecific symptoms being the most commonly reported. The broad clinical presentation and the frequency of asymptomatic or minimally symptomatic infections in children pose challenges for controlling and detecting SARS-CoV-2. However, severe disease has been noted in children with associated medical complications and death. Thus, additional active surveillance and research is needed to understand the burden children contribute to the SARS-CoV-2 pandemic in the United States.
MeSH term(s)	Adolescent ; COVID-19 ; Child ; Child, Preschool ; Hospitalization ; Humans ; Incidence ; Pandemics ; SARS-CoV-2 ; United States/epidemiology
Language	English
Publishing date	2020-12-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1049374-8
ISSN	1531-698X ; 1040-8703
ISSN (online)	1531-698X
ISSN	1040-8703
DOI	10.1097/MOP.0000000000000971
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Article ; Online: Reply to Mejias et al.

Haddadin, Zaid / Spieker, Andrew J / Schaffner, William / Halasa, Natasha B

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 72, Issue 12, Page(s) e1162–e1163

MeSH term(s)	Child ; Child, Preschool ; Communicable Diseases ; Humans ; Respiratory Syncytial Virus Infections ; Respiratory Syncytial Viruses ; Severity of Illness Index
Language	English
Publishing date	2020-11-14
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciaa1753
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Article ; Online: Make new friends, but keep the old: influenza vaccines in children with cancer.

Halasa, Natasha B

The Journal of infectious diseases

2011 Volume 204, Issue 10, Page(s) 1471–1474

MeSH term(s)	Antibodies, Viral/blood ; Female ; Humans ; Immunocompromised Host ; Influenza A virus/immunology ; Influenza B virus/immunology ; Influenza Vaccines/adverse effects ; Influenza Vaccines/immunology ; Male ; Neoplasms/immunology
Chemical Substances	Antibodies, Viral ; Influenza Vaccines
Language	English
Publishing date	2011-11-15
Publishing country	United States
Document type	Comment ; Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jir563
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Article ; Online: Update on the 2009 pandemic influenza A H1N1 in children.

Halasa, Natasha B

Current opinion in pediatrics

2010 Volume 22, Issue 1, Page(s) 83–87

Abstract: Purpose of review: To provide an updated review of the epidemiology, clinical presentations, and outcomes of the 2009 pandemic influenza A H1N1 in children.: Recent findings: The majority of cases of 2009 pandemic influenza A H1N1 in children have ... ...

Abstract	Purpose of review: To provide an updated review of the epidemiology, clinical presentations, and outcomes of the 2009 pandemic influenza A H1N1 in children. Recent findings: The majority of cases of 2009 pandemic influenza A H1N1 in children have been mild. However, neurological complications, hospitalization, and even deaths have been reported in children. Death and severe illnesses have mostly occurred in children below 5 years of age and children with high-risk conditions. Coinfections with bacteria have also been reported. Most strains are sensitive to oseltamivir and all to zanamivir. Summary: Even though the majority of cases of 2009 pandemic influenza A H1N1 are mild, severe disease does occur in children. In addition, neurological complications and coinfection with bacteria exist. Treatment with antiviral medications should be initiated within 48 h to be most effective. When pandemic H1N1 vaccines become available, the safety and efficacy of these vaccines in this vulnerable population will be important to document.
MeSH term(s)	Antiviral Agents/therapeutic use ; Child ; Disease Outbreaks ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza Vaccines ; Influenza, Human/diagnosis ; Influenza, Human/epidemiology ; Influenza, Human/therapy
Chemical Substances	Antiviral Agents ; Influenza Vaccines
Language	English
Publishing date	2010-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1049374-8
ISSN	1531-698X ; 1040-8703
ISSN (online)	1531-698X
ISSN	1040-8703
DOI	10.1097/MOP.0b013e3283350317
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Article ; Online: Principal Component Patterns of Pediatric Respiratory Viral Testing Across Health Care Settings.

Rankin, Danielle A / Stewart, Laura S / Slaughter, James C / Deppen, Stephen / Katz, Sophie E / Stahl, Anna L / Stopczynski, Tess / Yanis, Ahmad / McHenry, Rendie / Guevara Pulido, Claudia / Herazo Romero, Yesenia / Chappell, James D / Halasa, Natasha B / Khankari, Nikhil K

Hospital pediatrics

2024 Volume 14, Issue 2, Page(s) 126–136

Abstract: Background and objectives: Factors prompting clinicians to request viral testing in children are unclear. We assessed patterns prompting clinicians to perform viral testing in children discharged from an emergency department (ED) or hospitalized with an ...

Abstract	Background and objectives: Factors prompting clinicians to request viral testing in children are unclear. We assessed patterns prompting clinicians to perform viral testing in children discharged from an emergency department (ED) or hospitalized with an acute respiratory infection (ARI). Methods: Using active ARI surveillance data collected from November 2017 through February 2020, children aged between 30 days and 17 years with fever or respiratory symptoms who had a research respiratory specimen tested were included. Children's presentation patterns from their initial evaluation at each health care setting were analyzed using principal components (PCs) analysis. PC-specific models using logistic regression with robust sandwich estimators were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) between PCs and provider-ordered viral testing. PCs were assigned respiratory virus/viruses names a priori based on the patterns represented. Results: In total, 4107 children were enrolled and tested, with 2616 (64%) discharged from the ED and 1491 (36%) hospitalized. In the ED, children with a coviral presentation pattern had a 1.44-fold (95% CI, 1.24-1.68) increased odds of receiving a provider-ordered viral test than children showing clinical symptoms less representative of coviral-like infection. Whereas children in the ED and hospitalized with rhinovirus-like symptoms had 71% (OR, 0.29; 95% CI, 0.24-0.34) and 39% (OR, 0.61; 95% CI, 0.49-0.76) decreased odds, respectively, of receiving a provider-ordered viral test during their medical encounter. Conclusions: Viral tests are frequently ordered by clinicians, but presentation patterns vary by setting and influence the initiation of testing. Additional assessments of factors affecting provider decisions to use viral testing in pediatric ARI management are needed to maximize patient benefits of testing.
MeSH term(s)	Child ; Humans ; Infant ; Viruses ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Enterovirus Infections ; Emergency Service, Hospital ; Delivery of Health Care
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article
ISSN	2154-1671
ISSN (online)	2154-1671
DOI	10.1542/hpeds.2023-007389
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