Article ; Online: Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
Cell. 2021 Jan. 07, v. 184, no. 1 p.64-75.e11
2021
Abstract: Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the ... ...
Institution | COG-UK Consortium | ||||||||||
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Abstract | Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant. |
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Keywords | COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; data collection ; founder effect ; genetic analysis ; genome ; mortality ; mutation ; pathogenicity ; phylogeny ; viral load ; United Kingdom ; COVID-19 ; SARS-CoV-2 ; evolution ; epidemiology ; spike | ||||||||||
Language | English | ||||||||||
Dates of publication | 2021-0107 | ||||||||||
Size | p. 64-75.e11. | ||||||||||
Publishing place | Elsevier Inc. | ||||||||||
Document type | Article ; Online | ||||||||||
Note | NAL-AP-2-clean | ||||||||||
ZDB-ID | 187009-9 | ||||||||||
ISSN | 1097-4172 ; 0092-8674 | ||||||||||
ISSN (online) | 1097-4172 | ||||||||||
ISSN | 0092-8674 | ||||||||||
DOI | 10.1016/j.cell.2020.11.020 | ||||||||||
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Database | NAL-Catalogue (AGRICOLA) |
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