Article ; Online: Testing the test strips: laboratory performance of fentanyl test strips.
2024 Volume 21, Issue 1, Page(s) 14
Abstract: Background: The overdose crisis driven by synthetic opioids continues to escalate in the USA. We evaluated the efficacy of multiple manufacturing lots of a fentanyl test strip (FTS) to detect fentanyl and fentanyl analogs and assessed cross-reactivity ... ...
| Abstract | Background: The overdose crisis driven by synthetic opioids continues to escalate in the USA. We evaluated the efficacy of multiple manufacturing lots of a fentanyl test strip (FTS) to detect fentanyl and fentanyl analogs and assessed cross-reactivity with possible interferences. Methods: Drug standards were dissolved in water in a laboratory setting and serially diluted. Drug dilutions were tested using five different manufacturing lots of BTNX Rapid Response (20 ng/mL cutoff) lateral flow chromatographic immunoassay strips to assess lot-to-lot variability for FTS sensitivity and cross-reactivity for the analytes of interest. Results: All five manufacturing lots cross-reacted with fentanyl and eleven fentanyl analogs. Diphenhydramine, lidocaine, MDMA, and methamphetamine were found to cause false positives with the strips. There was notable lot-to-lot variability in the sensitivity of the strips for fentanyl, fentanyl analogs, and known interferences. Discussion: FTS remains an important overdose prevention tool, but lot-to-lot variability in performance complicates robust instructions that balance the prevention of false positives and false negatives. Continued lot-to-lot performance assessment is recommended to ensure health education for FTS remains accurate. More sophisticated drug checking technologies and services are needed in the community landscape to augment personal FTS use to facilitate informed consumption and overdose risk mitigation. |
|---|---|
| MeSH term(s) | Humans ; Fentanyl/analysis ; Analgesics, Opioid/analysis ; Drug Overdose/prevention & control |
| Chemical Substances | Fentanyl (UF599785JZ) ; Analgesics, Opioid |
| Language | English |
| Publishing date | 2024-01-18 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2146691-9 |
| ISSN | 1477-7517 ; 1477-7517 |
| ISSN (online) | 1477-7517 |
| ISSN | 1477-7517 |
| DOI | 10.1186/s12954-023-00921-8 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.