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  1. Article: Feasibility and accuracy of targeted axillary dissection in breast cancer patients; single center experience.

    Kaya, Cemal / Burcu, Büşra / Çetinoğlu, Işık / Uçak, Ramazan / Çerekçi, Esma / Şahin, Cennet / Demircioğlu, Zeynep Gül / Şener, Aziz / Halil, Süleyman

    Frontiers in surgery

    2024  Volume 10, Page(s) 1332142

    Abstract: Introduction: Axillary complete response (pCR) was observed in approximately half of breast cancer patients who received neoadjuvant chemotherapy (NAC) due to axillary positivity. Preventing axillary morbidity due to unnecessary axillary lymph node ... ...

    Abstract Introduction: Axillary complete response (pCR) was observed in approximately half of breast cancer patients who received neoadjuvant chemotherapy (NAC) due to axillary positivity. Preventing axillary morbidity due to unnecessary axillary lymph node dissection (ALND) is extremely important for patients' quality of life. Targeted axillary dissection (TAD) is a technique developed to improve axillary staging and reduce the false negative rate in sentinel lymph node biopsy.
    Methods: Patients with cN1-N2 (clinically node) breast cancer whose axillary lymph node metastasis was confirmed by biopsy and who received NAC marked with a clip were included in the study. Patients who achieved clinical response after systemic treatment underwent sentinel lymph node biopsy (SLNB) with additional methods such as methylene blue guided dissection, skin marking for clip on lymph node (CLN) localization, and wire guided with imaging excision of the CLN. TAD and ALND pathology results were evaluated and analyzed with patient and tumor characteristics.
    Results: 83 patients who met the eligibility criterias for the study were examined retrospectively. 21 of the patients underwent TAD alone, and 62 patients underwent ALND after TAD. CLN rate was 98.8% in patients underwent only TAD and this rate was increased to 100% in patients underwent ALND after TAD. FNR in SLN, CLN, and TAD were 28.6%, 10.7%, and 3.6%, respectively.
    Conclusion: TAD is a feasible and reliable surgical approach to detect axillary residual disease with a high success rate.
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1332142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Interdisciplinary treatment of multiple maxillary anterior diastemas: case report.

    Terzioglu, Hakan / Akcam, Okan / Yilmaz, Burak / Halil, Suleyman

    General dentistry

    2009  Volume 57, Issue 2, Page(s) e15–9

    Abstract: This article describes an interdisciplinary (orthodontic and prosthodontic) approach for treating a 28-year-old woman who had multiple maxillary anterior diastemas, insufficient lip support, and inadequate anterior guidance. Although the patient also had ...

    Abstract This article describes an interdisciplinary (orthodontic and prosthodontic) approach for treating a 28-year-old woman who had multiple maxillary anterior diastemas, insufficient lip support, and inadequate anterior guidance. Although the patient also had diastemas among her mandibular anterior teeth, she declined orthodontic or restorative treatment for this arch. Initially, ceramic orthodontic brackets and polytetrafluoroethylene-coated arch wires were used. Orthodontic treatment involved leveling and aligning the maxillary dental arch, correcting the incisor angulations, and providing appropriate spaces for prosthetic restoration. After orthodontic treatment, IPS Empress 2 crowns were delivered to the six maxillary anterior teeth. This interdisciplinary approach produced a successful outcome and improved esthetics. The patient remained satisfied at the three-year follow-up examination.
    MeSH term(s) Adult ; Crowns ; Dental Arch ; Diastema/therapy ; Esthetics, Dental ; Female ; Humans ; Malocclusion, Angle Class I/complications ; Malocclusion, Angle Class I/therapy ; Maxilla ; Orthodontics, Corrective/methods ; Treatment Outcome
    Language English
    Publishing date 2009-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 603650-8
    ISSN 0363-6771
    ISSN 0363-6771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2262: Show issues Location:
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  3. Article ; Online: Assessment of survival and prognostic factors in metastatic colorectal cancer patients treated with first-line bevacizumab-based therapy.

    Demircan, Nazim / Dane, Faysal / Ozturk, Mehmet Akif / Babacan, Nalan Akgul / Besiroglu, Mehmet / Kaya, Serap / Ercelep, Ozlem / Tanrikulu, Eda / Halil, Suleyman / Koca, Sinan / Alan, Ozkan / Hasanov, Rahip / Yumuk, Perran Fulden

    Journal of B.U.ON. : official journal of the Balkan Union of Oncology

    2019  Volume 24, Issue 4, Page(s) 1494–1500

    Abstract: Purpose: Colorectal cancer (CRC) is a significant cause of cancer mortality worldwide. Survival has improved with bevacizumab in metastatic CRC treatment. Our purpose was to analyse survival and prognostic factors in metastatic CRC patients treated with ...

    Abstract Purpose: Colorectal cancer (CRC) is a significant cause of cancer mortality worldwide. Survival has improved with bevacizumab in metastatic CRC treatment. Our purpose was to analyse survival and prognostic factors in metastatic CRC patients treated with first-line bevacizumab-based treatment.
    Methods: Files of CRC patients were examined retrospectively and 360 patients treated with first-line bevacizumab were included. Objective response rates (ORRs), median progression-free and overall survival (PFS and OS) of the patients were calculated. Survival was analyzed with the Kaplan-Meier method. Log-rank test and Cox regression model were used for univariate and multivariate analyses, respectively.
    Results: Median age at diagnosis was 59.5 years. Of the patients 74.4% had initially stage IV disease. Median PFS was 8.5 months, median OS 25.3 months and ORR was 51.4%. ORRs, median PFS and OS of KRAS mutant and wild-type or unknown patients were statistically similar. In left-sided disease, median PFS and OS (9.6 and 27.1 months) were superior compared to right-sided disease (7.3 and 19.4 months) (p=0.005 and 0.02, respectively). Primary disease location, histopathologic grade, primary surgery and metastasectomy affected OS significantly. Histopathologic grade (hazard ratio=1.77, p=0.002) and metastasectomy (hazard ratio=0.48, p=0.001) were independent prognostic factors.
    Conclusions: Our study confirmed that after bevacizumab-based treatment, KRAS status might not be a prognostic factor. We have also shown that left CRC have more favorable outcomes than right CRC in bevacizumab therapy. Additionally, even in metastatic setting histopathologic grade of the primary CRC together with metastasectomy are independent prognostic factors.
    MeSH term(s) Aged ; Bevacizumab/administration & dosage ; Cell Survival/drug effects ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Progression-Free Survival ; Proto-Oncogene Proteins p21(ras)/genetics ; Retrospective Studies
    Chemical Substances KRAS protein, human ; Bevacizumab (2S9ZZM9Q9V) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2019-10-24
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2040386-0
    ISSN 2241-6293 ; 1107-0625
    ISSN (online) 2241-6293
    ISSN 1107-0625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5438: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: Changes in 18F-FDG-PET/CT tumor metabolism are not consistent with pathologic complete response in hormone-positive breast cancer.

    Kaya, Serap / Aktas, Bilge / Tanrikulu Sismek, Eda / Akif Ozturk, Mehmet / Dede, Fuat / Kaya, Handan / Ugurlu, Umit / Ozgen, Zerrin / Koca, Sinan / Halil, Suleyman / Hasanov, Rahib / Alan, Ozkan / Akgul Babacan, Nalan / Ercelep, Ozlem / Dane, Faysal / Gumus, Mahmut / Yumuk, Fulden

    Journal of B.U.ON. : official journal of the Balkan Union of Oncology

    2017  Volume 22, Issue 5, Page(s) 1191–1198

    Abstract: Purpose: Current evaluation of response to neoadjuvant chemotherapy (NAC) shows that it could achieve pathological complete response (pCR). The purpose of this study was to assess the consistency of maximum uptake values (SUVmax) changes and pCR in ... ...

    Abstract Purpose: Current evaluation of response to neoadjuvant chemotherapy (NAC) shows that it could achieve pathological complete response (pCR). The purpose of this study was to assess the consistency of maximum uptake values (SUVmax) changes and pCR in hormone-positive locally advanced breast cancer (LABC).
    Methods: Ninety hormone-positive LABC patients treated at Marmara University Medical Oncology Clinic, Istanbul, Turkey, between 2009 and 2015 were retrospectively studied. All eligible patients (n=5) received NAC (4-8 cycles) and were evaluated for pCR. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18FFDG- PET/CT) scan was performed before and after the completion of NAC. The relative changes of SUVmax both in the primary tumor and the axilla were assessed for consistency with pCR.
    Results: The patient median age was 46 years (range 26- 76). The patients 13.7% achieved pCR. Values of >50% (n=40) and <50% (n=11) SUVmax changes were not associated with pCR (15% and 18% respectively) (p=1.00). Patients with >75% SUVmax changes could achieve pCR of 20%. Interestingly, most patients with complete metabolic response did not achieve pCR (81%). The difference of the Ki67 levels before and after NAC, tumor localization, HER- 2 positivity, menopausal status, grade of differentiation, lymphovascular and perineural invasion were not associated with pCR.
    Conclusion: SUVmax changes in later cycles of NAC as commonly practised in oncology clinics were not consistent with pCR (p=1.0). Complete metabolic response may not be associated with pCR in hormone-positive LABC. However, almost 80% of patients had >50% decrease in SUVmax and may still have a chance for conservative surgery and less postoperative morbidity. Therefore, 18F-FDG-PET/CT may still have a role to evaluate the tumor response with a need of larger studies and analysis for cost-effectiveness.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Female ; Fluorodeoxyglucose F18/therapeutic use ; Humans ; Middle Aged ; Positron Emission Tomography Computed Tomography/methods ; Retrospective Studies
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2017-11-11
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2040386-0
    ISSN 2241-6293 ; 1107-0625
    ISSN (online) 2241-6293
    ISSN 1107-0625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5438: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Hemisection of a fused tooth.

    Cetinbas, Tugba / Halil, Suleyman / Akcam, Mehmet Okan / Sari, Saziye / Cetiner, Serap

    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics

    2007  Volume 104, Issue 4, Page(s) e120–4

    Abstract: Fusion is a developmental anomaly which occurs due to a union of 1 or more adjacent teeth during morphodifferentiation of the dental germs. The present case report presents the hemisection of a maxillary central incisor fused with a supernumerary tooth. ... ...

    Abstract Fusion is a developmental anomaly which occurs due to a union of 1 or more adjacent teeth during morphodifferentiation of the dental germs. The present case report presents the hemisection of a maxillary central incisor fused with a supernumerary tooth. A 10-year-old boy was referred to clinic with the chief complaint of the presence of a large anterior tooth. Intraoral and radiographic investigations indicated fusion between the left central incisor and a supernumerary tooth. The fused tooth was separated with a diamond bur, and the supernumerary tooth was extracted. The left central incisor was restored with composite resin and the diastema between the maxillary central incisors was closed with orthodontic treatment. The left central incisor was still healthy after a follow-up examination period of 24 months. An ideal overjet and overbite relation was achieved at the end of the orthodontic treatment. Hemisection can be considered as an appropriate treatment alternative for a permanent tooth fused with a supernumerary tooth.
    MeSH term(s) Child ; Fused Teeth/surgery ; Humans ; Incisor/abnormalities ; Incisor/surgery ; Male ; Maxilla ; Orthodontic Space Closure ; Tooth Extraction ; Tooth, Supernumerary/surgery
    Language English
    Publishing date 2007-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 202468-8
    ISSN 1528-395X ; 0030-4220 ; 1079-2104
    ISSN (online) 1528-395X
    ISSN 0030-4220 ; 1079-2104
    DOI 10.1016/j.tripleo.2007.03.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul III Zs.121: Show issues Location:
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  6. Article: Rezene Üretiminin Pazarlama Yapısı ve Sorunlarının Analizi: Burdur İli Örneği

    Parlak, Halil / Süleyman Demirel Üniversitesi / Öktem, Huriye / Süleyman Demirel Üniversitesi / Gül, Mevlüt

    Mustafa Kemal Üniversitesi Ziraat Fakültesi Dergisi; Cilt 20, Sayı 2 (2015)

    Abstract: Bu çalışmada, Burdur ilinde rezene üretimi yapan işletmelerin pazarlama yapısı ve sorunları ortaya koyulması amaçlanmıştır. Bu çerçevede Burdur ilinde rezene yetiştiriciliğinin yoğun olarak yapıldığı Burdur iline ait Tefenni, Çavdır, Gölhisar, Karamanlı ... ...

    Abstract Bu çalışmada, Burdur ilinde rezene üretimi yapan işletmelerin pazarlama yapısı ve sorunları ortaya koyulması amaçlanmıştır. Bu çerçevede Burdur ilinde rezene yetiştiriciliğinin yoğun olarak yapıldığı Burdur iline ait Tefenni, Çavdır, Gölhisar, Karamanlı ilçelerinde yürütülmüştür. Tabakalı Örnekleme Neyman yöntemi uygulanarak, 81 adet rezene üretici işletmesinden anket yöntemi ile konu ile ilgili hazırlanan formlar uygulanarak veriler temin edilmiştir. Ayrıca 2 adet aracı ve 1 adet rezene işleyicisi ile görüşülmüştür. Rezene yetiştiricisi işletmelerden elde edilen veriler 2013 üretim sezonunu kapsamaktadır. Rezene ekiliş alanına bağlı olarak satış miktarı değişiklik göstermektedir. İşletmeler ortalamasında rezene satış fiyatının 1.47 $/kg ve hektara rezene veriminin 2854 kg olduğu saptanmıştır. Rezene tarımının tercihinde en önemli kriter, verimliliğin yüksek olmasıdır. Rezene satışı çoğunlukla eylül ayında gerçekleştirmektedir. Rezene fiyatını büyük ölçüde firmalar belirlemektedir. İşletme gruplarının rezene pazarlama kanalları irdelendiğinde; işletmeler ürünlerini çoğunlukla toptancı-tüccara pazarlamaktadır. İklim koşullarının uygunluğu, arz yetersizliği, işgücü maliyetlerinin düşüklüğü gibi faktörler sayesinde rezene tarımının bölgede gelişimini sürdüreceği söylenebilir. Ancak pazarın darlığı tehdit olarak algılanmaktadır. Bölgedeki rezene yetiştiricilerinde örgütlülük bilincinin geliştirilmesi ile üreticinin piyasada daha etkili bir konuma gelebileceği ifade edilebilir.
    Language Turkish
    Document type Article
    ISSN 1300-9362
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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