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  1. Article ; Online: Prevalence of hypothyroidism in patients undergoing hemodialysis at a general hospital in Ahvaz.

    Shayanpour, Shokooh / Hoseinynejad, Khojasteh / Halili, Shahla Ahmadi / Amiri, Fatemeh / Mirsalari, Samaneh / Seyedtabib, Maryam

    Recenti progressi in medicina

    2022  Volume 113, Issue 5, Page(s) 324–328

    Abstract: Riassunto. Obiettivo. Lo scopo di questo studio trasversale è determinare la prevalenza dell'ipotiroidismo tra i pazienti in emodialisi (ED) e i suoi potenziali fattori di rischio. Metodi. Sono stati raccolti dati demografici e di laboratorio [vale a ... ...

    Title translation Prevalenza di ipotiroidismo nei pazienti sottoposti a emodialisi presso un ospedale generale di Ahvaz.
    Abstract Riassunto. Obiettivo. Lo scopo di questo studio trasversale è determinare la prevalenza dell'ipotiroidismo tra i pazienti in emodialisi (ED) e i suoi potenziali fattori di rischio. Metodi. Sono stati raccolti dati demografici e di laboratorio [vale a dire, livelli sierici di tireotropina (TSH), anticorpi anti-perossidasi tiroidea (anti-TPO)] di 117 pazienti con MH. I dati sono stati analizzati da SPSS.V 26, quando necessario. Risultati. I pazienti avevano un'età media (DS) di 59,47±15,08 anni e il 66,7% (n=78) era di genere maschile. I livelli medi (DS) di TSH erano 2,56 (4,01) μIU/mL. L'ipotiroidismo subclinico (SCH) è stato definito come un livello di TSH >4,2 μIU/mL e FT4 normale. Quindici pazienti (12,80%) avevano SCH. Non c'era correlazione significativa tra ipotiroidismo ed età, genere e/o malattie sottostanti (p>0,05). Inoltre, tra i 15 pazienti con SCH, 1 paziente (6,7%) ha mostrato un risultato anti-TPO positivo mentre 14 pazienti (93,3%) hanno avuto un risultato anti-TPO negativo. Conclusione. Data la notevole prevalenza dell'ipotiroidismo nei pazienti con ED, lo screening di routine della funzione tiroidea in questa popolazione di pazienti può aiutare a ridurre i tassi di complicanze e mortalità attraverso una diagnosi precoce e un intervento tempestivo.
    MeSH term(s) Humans ; Thyrotropin
    Chemical Substances Thyrotropin (9002-71-5)
    Language Italian
    Publishing date 2022-05-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/3803.37894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The functions of long non-coding RNA (lncRNA)-MALAT-1 in the pathogenesis of renal cell carcinoma.

    Anbiyaee, Omid / Moalemnia, Arash / Ghaedrahmati, Farhoodeh / Shooshtari, Maryam Khombi / Khoshnam, Seyed Esmaeil / Kempisty, Bartosz / Halili, Shahla Ahmadi / Farzaneh, Maryam / Morenikeji, Olanrewaju B

    BMC nephrology

    2023  Volume 24, Issue 1, Page(s) 380

    Abstract: Renal cell carcinoma (RCC), a prevalent form of renal malignancy, is distinguished by its proclivity for robust tumor proliferation and metastatic dissemination. Long non-coding RNAs (lncRNAs) have emerged as pivotal modulators of gene expression, ... ...

    Abstract Renal cell carcinoma (RCC), a prevalent form of renal malignancy, is distinguished by its proclivity for robust tumor proliferation and metastatic dissemination. Long non-coding RNAs (lncRNAs) have emerged as pivotal modulators of gene expression, exerting substantial influence over diverse biological processes, encompassing the intricate landscape of cancer development. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), an exemplar among lncRNAs, has been discovered to assume functional responsibilities within the context of RCC. The conspicuous expression of MALAT-1 in RCC cells has been closely linked to the advancement of tumors and an unfavorable prognosis. Experimental evidence has demonstrated the pronounced ability of MALAT-1 to stimulate RCC cell proliferation, migration, and invasion, thereby underscoring its active participation in facilitating the metastatic cascade. Furthermore, MALAT-1 has been implicated in orchestrating angiogenesis, an indispensable process for tumor expansion and metastatic dissemination, through its regulatory influence on pro-angiogenic factor expression. MALAT-1 has also been linked to the evasion of immune surveillance in RCC, as it can regulate the expression of immune checkpoint molecules and modulate the tumor microenvironment. Hence, the potential utility of MALAT-1 as a diagnostic and prognostic biomarker in RCC emerges, warranting further investigation and validation of its clinical significance. This comprehensive review provides an overview of the diverse functional roles exhibited by MALAT-1 in RCC.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Cell Proliferation/genetics ; Prognosis ; Cell Line, Tumor ; Tumor Microenvironment/genetics
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-023-03438-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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