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  1. Article: A new tyrosinase inhibitor from Crinum yemense as potential treatment for hyperpigmentation.

    Abdel-Halim, O B / Marzouk, A M / Mothana, R / Awadh, N

    Die Pharmazie

    2008  Volume 63, Issue 5, Page(s) 405–407

    Abstract: A new pyran derivative, 6-hydroxy-2H-pyran-3-carbaldehyde, has been isolated from the methanolic extract of Crinum yemense along with the known alkaloid haemanthamine, benzoic acid and 1,1'-bis(1,1'-carboxyethyl) ether which is isolated from a natural ... ...

    Abstract A new pyran derivative, 6-hydroxy-2H-pyran-3-carbaldehyde, has been isolated from the methanolic extract of Crinum yemense along with the known alkaloid haemanthamine, benzoic acid and 1,1'-bis(1,1'-carboxyethyl) ether which is isolated from a natural source for the first time. Structure elucidation of these compounds based on spectroscopicevidences. The pyran derivative was found to be a tyrosinase inhibitor more potent than kojic acid.
    MeSH term(s) Agaricus/enzymology ; Aldehydes/isolation & purification ; Aldehydes/therapeutic use ; Crinum/chemistry ; Enzyme Inhibitors/isolation & purification ; Enzyme Inhibitors/therapeutic use ; Hyperpigmentation/drug therapy ; Levodopa/metabolism ; Magnetic Resonance Spectroscopy ; Melanins/biosynthesis ; Monophenol Monooxygenase/antagonists & inhibitors ; Plant Roots/chemistry ; Pyrans/isolation & purification ; Pyrans/therapeutic use ; Pyrones/pharmacology ; Spectrometry, Mass, Electrospray Ionization ; Spectrophotometry, Infrared ; Spectrophotometry, Ultraviolet
    Chemical Substances 6-hydroxy-2H-pyran-3-carbaldehyde ; Aldehydes ; Enzyme Inhibitors ; Melanins ; Pyrans ; Pyrones ; Levodopa (46627O600J) ; kojic acid (6K23F1TT52) ; Monophenol Monooxygenase (EC 1.14.18.1)
    Language English
    Publishing date 2008-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208793-5
    ISSN 0031-7144
    ISSN 0031-7144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Smoking among university students: a comparative study between Malaysian students in Malaysia and Australia.

    Hashami, B / Abdul Halim, O / Yusoff, K

    The Medical journal of Malaysia

    1994  Volume 49, Issue 2, Page(s) 149–157

    Abstract: A total of 209 randomly selected Malaysian university students (128 from Universiti Kebangsaan Malaysia, 81 from the University of New South Wales) completed a self-filled questionnaire enquiring about their smoking behaviour and psychosocial ... ...

    Abstract A total of 209 randomly selected Malaysian university students (128 from Universiti Kebangsaan Malaysia, 81 from the University of New South Wales) completed a self-filled questionnaire enquiring about their smoking behaviour and psychosocial characteristics. The prevalence of smoking was 26.6 per cent among students in Malaysia and 18.8 per cent among students in Australia (average 23.4%). Both samples have similar patterns in terms of age of starting smoking, time of the day when they smoked, family and peer history of smoking, and whether or not they inhaled deeply during smoking. The smokers tend to be male, studying beyond the first year, staying with peers outside the hostel, having financial sources other than a scholarship, and abnormal mental health score. However, the smokers from the Australian samples were noted to smoke less and made fewer attempts at quitting the habit.
    MeSH term(s) Adult ; Australia/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Malaysia/epidemiology ; Male ; Smoking/epidemiology ; Socioeconomic Factors ; Students
    Language English
    Publishing date 1994-06
    Publishing country Malaysia
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604286-7
    ISSN 0300-5283
    ISSN 0300-5283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Metabolism of parthenin by Beauveria bassiana ATCC 7159.

    Abdel Halim, O B / Maatooq, G T / Marzouk, A M

    Die Pharmazie

    2007  Volume 62, Issue 3, Page(s) 226–230

    Abstract: Two new metabolites were isolated from the biotransformation reaction of parthenin by Beauveria bassiana ATCC 7159 along with the known naturally occurring sesquiterpene lactones hymenolin and dihydrocoronopilin. The new metabolites: are 3beta,4beta, ... ...

    Abstract Two new metabolites were isolated from the biotransformation reaction of parthenin by Beauveria bassiana ATCC 7159 along with the known naturally occurring sesquiterpene lactones hymenolin and dihydrocoronopilin. The new metabolites: are 3beta,4beta,6beta-trihydroxy-10alphaH,11alpha-methyl-ambrosa-1 -en-12-oic acid-gamma-lactone and 3alpha,6beta-dihydroxy-4beta-hydroperoxy-10alphaH, 11alpha-methyl-ambrosa-1-en-12-oic acid-gamma-lactone. The structure elucidation of these compounds was achieved by different spectroscopic methods.
    MeSH term(s) Beauveria/metabolism ; Fermentation ; Hydroxyl Radical/metabolism ; Magnetic Resonance Spectroscopy ; Molecular Conformation ; Sesquiterpenes/analysis ; Sesquiterpenes/metabolism ; Spectrophotometry, Infrared ; Spectrophotometry, Ultraviolet
    Chemical Substances 3alpha,6beta-dihydroxy-4beta-hydroperoxy-10alphaH,11alpha-methyl-ambrosa-1-en-12-oic acid-gamma-lactone ; 3beta,4beta,6beta-trihydroxy-10alphaH,11alpha-methyl-ambrosa-1 -en-12-oic acid-gamma-lactone ; Sesquiterpenes ; Hydroxyl Radical (3352-57-6) ; parthenin (982DJP4W6A)
    Language English
    Publishing date 2007-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208793-5
    ISSN 0031-7144
    ISSN 0031-7144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Serum Levels of Some Micronutrients and Congenital Malformations: A Prospective Cohort Study in Healthy Saudi-Arabian First-Trimester Pregnant Women

    Hammouda, S. A. I. / Abd Al-Halim, O. A. F. / Mohamadin, A. M.

    International journal for vitamin and nutrition research

    2013  Volume 83, Issue 6, Page(s) 346

    Language English
    Document type Article
    ZDB-ID 120692-8
    ISSN 0300-9831
    Database Current Contents Nutrition, Environment, Agriculture

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  5. Article: (-)-6-alpha-hydroxylupanine, a lupin alkaloid from Lygos raetam var. sarcocarpa

    Abdel-Halim, O.B

    Phytochemistry. Nov 1995. v. 40 (4)

    1995  

    Abstract: A new lupin alkaloid, (-)-6 alpha-hydroxylupanine, was isolated from aerial parts of Lygos raetam var. sarcocarpa. Its structure, including absolute configuration, was determined by different spectroscopic methods and by chemical transformation into (+)- ... ...

    Abstract A new lupin alkaloid, (-)-6 alpha-hydroxylupanine, was isolated from aerial parts of Lygos raetam var. sarcocarpa. Its structure, including absolute configuration, was determined by different spectroscopic methods and by chemical transformation into (+)-5, 6-dehydrolupanine.
    Keywords Fabaceae ; spectral analysis ; alkaloids ; molecular conformation ; chemical constituents of plants ; chemical structure ; Egypt
    Language English
    Dates of publication 1995-11
    Size p. 1323-1325.
    Document type Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense

    Abdel-Halim, O.B / Morikawa, T / Ando, S / Matsuda, H / Yoshikawa, M

    Journal of natural products. 2004 July, v. 67, no. 7

    2004  

    Language English
    Dates of publication 2004-07
    Size p. 1119-1124.
    Document type Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
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  7. Article: Dendrocyin: an isocucurbitacin with novel cyclic side chain from Dendrosicyos socotrana

    Hussein, H.A / Abdel-Halim, O.B / Marwan, E.S.M / El-Gamal, A.A / Mosana, R

    Phytochemistry. 2004 Sept., v. 65, no. 18

    2004  

    Abstract: Dendrosicyos socotrana Balf.f. is a unique species (Cucurbitaceae) native to Socotra island in the horn of Africa. From the chloroform extract of the stems, A new isocucurbitacin (Dendrocyin) with unusual cyclization in the side chain; 24beta-ethoxy-20- ... ...

    Abstract Dendrosicyos socotrana Balf.f. is a unique species (Cucurbitaceae) native to Socotra island in the horn of Africa. From the chloroform extract of the stems, A new isocucurbitacin (Dendrocyin) with unusual cyclization in the side chain; 24beta-ethoxy-20-25-epoxy-3alpha,16alpha-dihydroxy-9-methyl-19-norlanost-5(6) ene-2,11,22-trione has been isolated alongside isocucurbitacin R. Their structural configuration were established by usual spectroscopic (1H NMR, 13C NMR and DEPT) and two-dimensional NMR techniques (1H-1H Cosy, HMBC and HMQC).
    Keywords Cucurbitaceae ; cucurbitacins ; isomers ; chemical structure ; spectral analysis ; stereochemistry ; chemical reactions ; Yemen
    Language English
    Dates of publication 2004-09
    Size p. 2551-2556.
    Document type Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Glycosidic alkaloids from Lupinus varius. [Erratum: Nov 1999, v. 52 (5), p. 965.]

    Abdel-Halim, O.B / El-Gammal, A.A / Abdel-Fattah, H / Takeya, K

    Phytochemistry. May 1999. v. 51 (1)

    1999  

    Abstract: A new glycosidic alkaloid, (-)-(trans-3'-methoxy-4'-alpha-L-rhamnosyloxy cinnamoyl) epilupinine, was isolated from the aerial parts of Lupinus varius, together with the eight known alkaloids, (-)-(trans-4'-alpha-L-rhamnosyloxycinnamoyl) epilupinine, (+)-( ...

    Abstract A new glycosidic alkaloid, (-)-(trans-3'-methoxy-4'-alpha-L-rhamnosyloxy cinnamoyl) epilupinine, was isolated from the aerial parts of Lupinus varius, together with the eight known alkaloids, (-)-(trans-4'-alpha-L-rhamnosyloxycinnamoyl) epilupinine, (+)-(trans-4'-hydroxy-3'-methoxy-cinnamoyl) epilupinine, (+)-epilupinine, (+)-epilupinine-N-oxide, (-)-multiflorine, (-)-delta(5)-dehydromultiflorine, (+)-ammodendrine and (-)-sparteine. Benzoyl epilupinine was identified by GC-mass spectral analysis. The structure of new glycosidic alkaloid was determined by chemical and spectroscopic methods.
    Keywords glycosides ; alkaloids ; leaves ; chemical structure ; chemical constituents of plants ; spectral analysis ; nuclear magnetic resonance spectroscopy ; Libya
    Language English
    Dates of publication 1999-05
    Size p. 5-9.
    Document type Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Chemical constituents of aquatic fern Azolla nilotica

    Arai, Y / Nakagawa, T / Hitosugi, M / Shojima, K / Ageta, H / Abdel-Halim, O.B

    Phytochemistry. June 1998. v. 48 (3)

    1998  

    Abstract: Two new components, (24R)-6 beta-hydroxy-24-ethyl-cholest-4-en-3-one and phytyl-3,7,11,15-tetra-methyl-2-hexadecanenate were isolated from the whole plants of aquatic fern Azolla nilotica. Their structures were established by spectroscopic techniques and ...

    Abstract Two new components, (24R)-6 beta-hydroxy-24-ethyl-cholest-4-en-3-one and phytyl-3,7,11,15-tetra-methyl-2-hexadecanenate were isolated from the whole plants of aquatic fern Azolla nilotica. Their structures were established by spectroscopic techniques and chemical correlation. Some typical triterpenoids of ferns were also detected.
    Keywords Azolla ; aquatic plants ; ketones ; diterpenoids ; chemical structure ; chemical constituents of plants ; spectral analysis ; nuclear magnetic resonance spectroscopy ; Egypt
    Language English
    Dates of publication 1998-06
    Size p. 471-474.
    Document type Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Comparative chemical and biological studies of the alkaloidal content of Lygos species and varieties growing in Egypt.

    Abdel Halim, O B / Abdel Fattah, H / Halim, A F / Murakoshi, I

    Acta pharmaceutica Hungarica

    1997  Volume 67, Issue 6, Page(s) 241–247

    Abstract: Quinolizidine and dipiperidyl alkaloids profiles have been determined for various plant organs of Lygos raetam Forssk. L. raetam var. sarcocarpa and L. raetam var. bovei, using TLC, GC, GC-MS and HPLC techniques. Sixteen quinolizidine and dipiperidyl ... ...

    Abstract Quinolizidine and dipiperidyl alkaloids profiles have been determined for various plant organs of Lygos raetam Forssk. L. raetam var. sarcocarpa and L. raetam var. bovei, using TLC, GC, GC-MS and HPLC techniques. Sixteen quinolizidine and dipiperidyl alkaloids were identified including baptofoline alkaloid which have not previously been reported in the genus Lygos. Biological evaluulation including hypoglycemic effect, anti-inflammatory activity, and some pharmacological studies of the different extracts as well as some of the isolated alkaloids were also performed. N-methylcytisine was proved to have a significant hypoglycemic effect on the induced diabetic mice and anti-inflammatory effect against the induced odema as well as a sedation effect on locomotor activity enhanced by methamphetamine.
    MeSH term(s) Alkaloids/chemistry ; Alkaloids/isolation & purification ; Alkaloids/pharmacology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/isolation & purification ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/blood ; Egypt ; Fabaceae/chemistry ; Female ; Guinea Pigs ; In Vitro Techniques ; Mice ; Muscle Contraction/drug effects ; Plant Roots ; Plant Stems ; Plants, Medicinal ; Rats ; Seeds ; Trachea/drug effects ; Trachea/physiology ; Uterine Contraction/drug effects ; Uterus/drug effects ; Uterus/physiology
    Chemical Substances Alkaloids ; Anti-Inflammatory Agents, Non-Steroidal ; Blood Glucose
    Language English
    Publishing date 1997-11
    Publishing country Hungary
    Document type Comparative Study ; Journal Article
    ZDB-ID 392228-5
    ISSN 0001-6659
    ISSN 0001-6659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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