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  1. Book: C. elegans atlas

    Hall, David H. / Altun, Zeynep F.

    2008  

    Author's details David H. Hall and Zeynep F. Altun
    Language English
    Size X, 348 S. : zahlr. Ill.
    Publisher Cold Spring Harbor Laboratory Press
    Publishing place Cold Spring Harbor, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT015030948
    ISBN 978-0-87969-794-5 ; 978-0-87969-715-0 ; 0-87969-715-6 ; 0-87969-794-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 C 74 order for loan Magazin

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  2. Article: Announcement of WormAtlas partnership with the Journal of Nematology.

    Schroeder, Nathan E / Hall, David H

    Journal of nematology

    2021  Volume 53

    Abstract: A detailed understanding of nematode anatomy can be leveraged for the development of new parasitic nematode control strategies and for fundamental biological insights through nematode model organisms. The Center ... ...

    Abstract A detailed understanding of nematode anatomy can be leveraged for the development of new parasitic nematode control strategies and for fundamental biological insights through nematode model organisms. The Center for
    Language English
    Publishing date 2021-11-03
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 410426-2
    ISSN 0022-300X
    ISSN 0022-300X
    DOI 10.21307/jofnem-2021-090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2645: Show issues

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  3. Article ; Online: Preferential transport of synaptic vesicles across neuronal branches is regulated by the levels of the anterograde motor UNC-104/KIF1A in vivo.

    Vasudevan, Amruta / Ratnakaran, Neena / Murthy, Kaushalya / Kumari, Shikha / Hall, David H / Koushika, Sandhya P

    Genetics

    2024  

    Abstract: Asymmetric transport of cargo across axonal branches is a field of active research. Mechanisms contributing to preferential cargo transport along specific branches in vivo in wild type neurons are poorly understood. We find that anterograde synaptic ... ...

    Abstract Asymmetric transport of cargo across axonal branches is a field of active research. Mechanisms contributing to preferential cargo transport along specific branches in vivo in wild type neurons are poorly understood. We find that anterograde synaptic vesicles preferentially enter the synaptic branch or pause at the branch point in C. elegans PLM neurons. The synaptic vesicle anterograde kinesin motor UNC-104/KIF1A regulates this vesicle behaviour at the branch point. Reduced levels of functional UNC-104 cause vesicles to predominantly pause at the branch point and lose their preference for turning into the synaptic branch. SAM-4/Myrlysin, which aids in recruitment/activation of UNC-104 on synaptic vesicles, regulates vesicle behaviour at the branch point similar to UNC-104. Increasing the levels of UNC-104 increases the preference of vesicles to go straight towards the asynaptic end. This suggests that the neuron optimises UNC-104 levels on the cargo surface to maximise the fraction of vesicles entering the branch and minimise the fraction going to the asynaptic end.
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/iyae021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 767: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The role of gap junctions in the C. elegans connectome.

    Hall, David H

    Neuroscience letters

    2017  Volume 695, Page(s) 12–18

    MeSH term(s) Animals ; Caenorhabditis elegans/anatomy & histology ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/physiology ; Connectome/methods ; Connexins/physiology ; Gap Junctions/physiology ; Motor Neurons/physiology
    Chemical Substances Caenorhabditis elegans Proteins ; Connexins
    Language English
    Publishing date 2017-09-05
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2017.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Gap junctions in C. elegans: Their roles in behavior and development.

    Hall, David H

    Developmental neurobiology

    2016  Volume 77, Issue 5, Page(s) 587–596

    Abstract: The nematode Caenorhabditis elegans utilizes gap junctions in different fashions in virtually all of its cells. This model animal has a surprisingly large number of innexin genes within its genome, and many nematode cell types can express multiple ... ...

    Abstract The nematode Caenorhabditis elegans utilizes gap junctions in different fashions in virtually all of its cells. This model animal has a surprisingly large number of innexin genes within its genome, and many nematode cell types can express multiple innexins at once, leading to the formation of diverse junction types and enough redundancy to limit the effect of single gene knockdowns on animal development or behavioral phenotypes. Here, we review the general properties of these junctions, their expression patterns, and their known roles in tissue development and in the animal's connectome. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 587-596, 2017.
    MeSH term(s) Animals ; Behavior, Animal/physiology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/growth & development ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/metabolism ; Gap Junctions/metabolism ; Gap Junctions/physiology
    Chemical Substances Caenorhabditis elegans Proteins
    Language English
    Publishing date 2016-06-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2256184-5
    ISSN 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034
    ISSN (online) 1932-846X ; 1097-4695
    ISSN 1932-8451 ; 0022-3034
    DOI 10.1002/dneu.22408
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 853: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: NEKL-4 regulates microtubule stability and mitochondrial health in

    Power, Kaiden M / Nguyen, Ken C / Silva, Andriele / Singh, Shaneen / Hall, David H / Rongo, Christopher / Barr, Maureen M

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is abundant in cilia, and its dysregulation may contribute to ciliopathies and neurodegeneration. Mutation of the deglutamylase CCP1 causes infantile-onset ... ...

    Abstract Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is abundant in cilia, and its dysregulation may contribute to ciliopathies and neurodegeneration. Mutation of the deglutamylase CCP1 causes infantile-onset neurodegeneration. In
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.14.580304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Ciliary intrinsic mechanisms regulate dynamic ciliary extracellular vesicle release from sensory neurons.

    Wang, Juan / Saul, Josh / Nikonorova, Inna A / Cruz, Carlos Nava / Power, Kaiden M / Nguyen, Ken C / Hall, David H / Barr, Maureen M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Cilia-derived extracellular vesicles (EVs) contain signaling proteins and act in intercellular communication. Polycystin-2 (PKD-2), a transient receptor potential channel, is a conserved ciliary EVs cargo. ...

    Abstract Cilia-derived extracellular vesicles (EVs) contain signaling proteins and act in intercellular communication. Polycystin-2 (PKD-2), a transient receptor potential channel, is a conserved ciliary EVs cargo.
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.01.565151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comparative connectomics of dauer reveals developmental plasticity.

    Yim, Hyunsoo / Choe, Daniel T / Bae, J Alexander / Choi, Myung-Kyu / Kang, Hae-Mook / Nguyen, Ken C Q / Ahn, Soungyub / Bahn, Sang-Kyu / Yang, Heeseung / Hall, David H / Kim, Jinseop S / Lee, Junho

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1546

    Abstract: A fundamental question in neurodevelopmental biology is how flexibly the nervous system changes during development. To address this, we reconstructed the chemical connectome of dauer, an alternative developmental stage of nematodes with distinct ... ...

    Abstract A fundamental question in neurodevelopmental biology is how flexibly the nervous system changes during development. To address this, we reconstructed the chemical connectome of dauer, an alternative developmental stage of nematodes with distinct behavioral characteristics, by volumetric reconstruction and automated synapse detection using deep learning. With the basic architecture of the nervous system preserved, structural changes in neurons, large or small, were closely associated with connectivity changes, which in turn evoked dauer-specific behaviors such as nictation. Graph theoretical analyses revealed significant dauer-specific rewiring of sensory neuron connectivity and increased clustering within motor neurons in the dauer connectome. We suggest that the nervous system in the nematode has evolved to respond to harsh environments by developing a quantitatively and qualitatively differentiated connectome.
    MeSH term(s) Animals ; Caenorhabditis elegans/physiology ; Connectome ; Nematoda ; Synapses ; Motor Neurons
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45943-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Ultrastructural analysis reveals mitochondrial placement independent of synapse placement in fine caliber C. elegans neurons.

    Riboul, Danielle V / Crill, Sarah / Oliva, Carlos D / Restifo, Maria G / Joseph, Reggie / Joseph, Kerdes / Nguyen, Ken Cq / Hall, David H / Fily, Yaouen / Macleod, Gregory T

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Neurons rely on mitochondria for an efficient supply of ATP and other metabolites. However, while neurons are highly elongated, mitochondria are discrete and limited in number. Due to the slow rates of diffusion over long distances it follows that ... ...

    Abstract Neurons rely on mitochondria for an efficient supply of ATP and other metabolites. However, while neurons are highly elongated, mitochondria are discrete and limited in number. Due to the slow rates of diffusion over long distances it follows that neurons would benefit from an ability to control the distribution of mitochondria to sites of high metabolic activity, such as synapses. It is assumed that neurons' possess this capacity, but ultrastructural data over substantial portions of a neuron's extent that would allow for tests of such hypotheses are scarce. Here, we mined the Caenorhabditis elegans electron micrographs of John White and Sydney Brenner and found systematic differences in average mitochondrial length (ranging from 1.3 to 2.4 μm), volume density (3.7% to 6.5%) and diameter (0.18 to 0.24 μm) between neurons of different neurotransmitter type and function, but found limited differences in mitochondrial morphometrics between axons and dendrites of the same neurons. Analyses of distance intervals found mitochondria to be distributed randomly with respect to presynaptic specializations, and an indication that mitochondria were displaced from postsynaptic specializations. Presynaptic specializations were primarily localized to varicosities, but mitochondria were no more likely to be found in synaptic varicosities than non-synaptic varicosities. Consistently, mitochondrial volume density was no greater in varicosities with synapses. Therefore, beyond the capacity to disperse mitochondria throughout their length, at least in C. elegans, fine caliber neurons manifest limited sub-cellular control of mitochondrial size and distribution.
    Language English
    Publishing date 2024-03-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.30.542959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A multi-scale brain map derived from whole-brain volumetric reconstructions.

    Brittin, Christopher A / Cook, Steven J / Hall, David H / Emmons, Scott W / Cohen, Netta

    Nature

    2021  Volume 591, Issue 7848, Page(s) 105–110

    Abstract: Animal nervous system organization is crucial for all body functions and its disruption can lead to severe cognitive and behavioural ... ...

    Abstract Animal nervous system organization is crucial for all body functions and its disruption can lead to severe cognitive and behavioural impairment
    MeSH term(s) Animals ; Brain/anatomy & histology ; Brain/cytology ; Brain/physiology ; Caenorhabditis elegans/anatomy & histology ; Caenorhabditis elegans/cytology ; Caenorhabditis elegans/physiology ; Connectome ; Gap Junctions ; Models, Biological ; Neural Pathways ; Neurites ; Neuropil/cytology ; Neuropil/physiology ; Synapses/metabolism
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-021-03284-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
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