Result 1 - 10 of total 1886
Chicago medical examiner
2023 Volume 10, Issue 2, Page(s) 93–94
| Language | English |
|---|---|
| Publishing date | 2023-07-20 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
International journal of molecular sciences
2023 Volume 24, Issue 21
Abstract: Endocannabinoids were implicated in a variety of pathological conditions including anxiety and are considered promising new targets for anxiolytic drug development. The optimism concerning the potentials of this system for anxiolysis is probably ... ...
| Abstract | Endocannabinoids were implicated in a variety of pathological conditions including anxiety and are considered promising new targets for anxiolytic drug development. The optimism concerning the potentials of this system for anxiolysis is probably justified. However, the complexity of the mechanisms affected by endocannabinoids, and discrepant findings obtained with various experimental approaches makes the interpretation of research results difficult. Here, we review the anxiety-related effects of the three main interventions used to study the endocannabinoid system: pharmacological agents active at endocannabinoid-binding sites present on both the cell membrane and in the cytoplasm, genetic manipulations targeting cannabinoid receptors, and function-enhancers represented by inhibitors of endocannabinoid degradation and transport. Binding-site ligands provide inconsistent findings probably because they activate a multitude of mechanisms concomitantly. More robust findings were obtained with genetic manipulations and particularly with function enhancers, which heighten ongoing endocannabinoid activation rather than affecting all mechanisms indiscriminately. The enhancement of ongoing activity appears to ameliorate stress-induced anxiety without consistent effects on anxiety in general. Limited evidence suggests that this effect is achieved by promoting active coping styles in critical situations. These findings suggest that the functional enhancement of endocannabinoid signaling is a promising drug development target for stress-related anxiety disorders. |
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| MeSH term(s) | Humans ; Cannabinoids/pharmacology ; Cannabinoids/therapeutic use ; Endocannabinoids/metabolism ; Cannabinoid Receptor Modulators/metabolism ; Anxiety/drug therapy ; Anxiety Disorders ; Receptors, Cannabinoid/metabolism ; Adaptation, Psychological |
| Chemical Substances | Cannabinoids ; Endocannabinoids ; Cannabinoid Receptor Modulators ; Receptors, Cannabinoid |
| Language | English |
| Publishing date | 2023-10-30 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms242115777 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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The Chicago medical journal
2023 Volume 26, Issue 6, Page(s) 176–177
| Language | English |
|---|---|
| Publishing date | 2023-07-06 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Chicago medical examiner
2023 Volume 10, Issue 8, Page(s) 499–500
| Language | English |
|---|---|
| Publishing date | 2023-07-20 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Chicago medical examiner
2023 Volume 10, Issue 4, Page(s) 217–218
| Language | English |
|---|---|
| Publishing date | 2023-07-20 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Frontiers in behavioral neuroscience
2022 Volume 16, Page(s) 936105
Abstract: Neural mechanisms of aggression and violence are often studied in the laboratory by means of animal models. A multitude of such models were developed over the last decades, which, however, were rarely if ever compared systematically from a ... ...
| Abstract | Neural mechanisms of aggression and violence are often studied in the laboratory by means of animal models. A multitude of such models were developed over the last decades, which, however, were rarely if ever compared systematically from a psychopathological perspective. By overviewing the main models, I show here that the classical ones exploited the natural tendency of animals to defend their territory, to fight for social rank, to defend themselves from imminent dangers and to defend their pups. All these forms of aggression are functional and adaptive; consequently, not necessarily appropriate for modeling non-natural states, e.g., aggression-related psychopathologies. A number of more psychopathology-oriented models were also developed over the last two decades, which were based on the etiological factors of aggression-related mental disorders. When animals were exposed to such factors, their aggressiveness suffered durable changes, which were deviant in the meaning that they broke the evolutionarily conserved rules that minimize the dangers associated with aggression. Changes in aggression were associated with a series of dysfunctions that affected other domains of functioning, like with aggression-related disorders where aggression is just one of the symptoms. The comparative overview of such models suggests that while the approach still suffers from a series of deficits, they hold the important potential of extending our knowledge on aggression control over the pathological domain of this behavior. |
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| Language | English |
| Publishing date | 2022-07-04 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2452960-6 |
| ISSN | 1662-5153 |
| ISSN | 1662-5153 |
| DOI | 10.3389/fnbeh.2022.936105 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Current topics in behavioral neurosciences
2022 Volume 54, Page(s) 209–243
Abstract: The effects of glucocorticoids on aggression can be conceptualized based on its mechanisms of action. These hormones can affect cell function non-genomically within minutes, primarily by affecting the cell membrane. Overall, such effects are activating ... ...
| Abstract | The effects of glucocorticoids on aggression can be conceptualized based on its mechanisms of action. These hormones can affect cell function non-genomically within minutes, primarily by affecting the cell membrane. Overall, such effects are activating and promote both metabolic preparations for the fight and aggressive behavior per se. Chronic increases in glucocorticoids activate genomic mechanisms and are depressing overall, including the inhibition of aggressive behavior. Finally, excessive stressors trigger epigenetic phenomena that have a large impact on brain programming and may also induce the reprogramming of neural functions. These induce qualitative changes in aggression that are deemed abnormal in animals, and psychopathological and criminal in humans. This review aims at deciphering the roles of glucocorticoids in aggression control by taking in view the three mechanisms of action often categorized as acute, chronic, and toxic stress based on the duration and the consequences of the stress response. It is argued that the tripartite way of influencing aggression can be recognized in all three animal, psychopathological, and criminal aggression and constitute a framework of mechanisms by which aggressive behavior adapts to short-term and log-term changes in the environment. |
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| MeSH term(s) | Aggression ; Animals ; Brain/physiology ; Glucocorticoids/metabolism ; Glucocorticoids/pharmacology |
| Chemical Substances | Glucocorticoids |
| Language | English |
| Publishing date | 2022-03-30 |
| Publishing country | Germany |
| Document type | Journal Article ; Review |
| ISSN | 1866-3370 |
| ISSN | 1866-3370 |
| DOI | 10.1007/7854_2022_307 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Auswahl ökologischer Alternativen
(TFZWissen ; #3 (Juli 2015))
2015
| Author's details | Autoren: Julia Haller, Dr. Maendy Fritz |
|---|---|
| Series title | TFZWissen ; #3 (Juli 2015) |
| Collection | |
| Language | German |
| Size | 1 Online-Ressource (57 Seiten), Illustrationen, Diagramme |
| Publisher | Technologie- und Förderzentrum (TFZ) |
| Publishing place | Straubing |
| Publishing country | Germany |
| Document type | Book ; Online |
| HBZ-ID | HT019316347 |
| Database | ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture |
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2021 Volume 36, Issue 1, Page(s) e40–e41
Abstract: Clinical vignette: A 55-year-old retired overweight male contractor with controlled type 2 diabetes is performing repairs on his barn when he slips and falls from a ladder. He catches his foot in the rungs and sustains a type 2 open pilon fracture with ... ...
| Abstract | Clinical vignette: A 55-year-old retired overweight male contractor with controlled type 2 diabetes is performing repairs on his barn when he slips and falls from a ladder. He catches his foot in the rungs and sustains a type 2 open pilon fracture with metaphyseal comminution (OTA/AO 43-C family) and an associated fibula fracture. The 6-cm open wound is located medially and is contaminated with clothing but not the surrounding environment. One of your partners performs a thorough surgical debridement, is able to close the wound, and applies a spanning ankle external fixator and asks you to care for the patient to provide a definitive operation. Please argue for and against inclusion of a medially based plate in the fixation construct through the open wound at the time of definitive fixation. |
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| MeSH term(s) | Ankle Fractures/diagnostic imaging ; Ankle Fractures/surgery ; Diabetes Mellitus, Type 2 ; External Fixators ; Fracture Fixation, Internal ; Fractures, Open/diagnostic imaging ; Fractures, Open/surgery ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Tibial Fractures/diagnostic imaging ; Tibial Fractures/surgery ; Treatment Outcome |
| Language | English |
| Publishing date | 2021-12-17 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 639099-7 |
| ISSN | 1531-2291 ; 0890-5339 |
| ISSN (online) | 1531-2291 |
| ISSN | 0890-5339 |
| DOI | 10.1097/BOT.0000000000002147 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2234: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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eine retrospektive Analyse
2006
| Author's details | vorgelegt von Julia Haller |
|---|---|
| Language | German |
| Size | 108 S. : graph. Darst. |
| Publishing country | Germany |
| Document type | Book ; Thesis |
| Thesis / German Habilitation thesis | Köln, Univ., Diss., 2006 |
| HBZ-ID | HT014997723 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 2007 D 421 | order for loan | Magazin |
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