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Article ; Online: Assessing the additional health burden of antibiotic resistant Enterobacteriaceae in surface waters through an integrated QMRA and DALY approach.

Goh, Shin Giek / Haller, Laurence / Ng, Charmaine / Charles, Francis Rathinam / Jitxin, Lim / Chen, Hongjie / He, Yiliang / Gin, Karina Yew-Hoong

Journal of hazardous materials

2023 Volume 458, Page(s) 132058

Abstract: Antibiotic resistant Enterobacteriaceae pose a significant threat to public health. However, limited studies have evaluated the health risks associated with exposure to antibiotic-resistant bacteria (ARB), especially in natural environments. While ... ...

Abstract	Antibiotic resistant Enterobacteriaceae pose a significant threat to public health. However, limited studies have evaluated the health risks associated with exposure to antibiotic-resistant bacteria (ARB), especially in natural environments. While quantitative microbial risk assessment (QMRA) assesses microbial risks in terms of the probability of infection, it does not account for the severity of health outcomes. In this study, a QMRA-DALY model was developed to integrate QMRA with health burden (disability-adjusted life years (DALY)) from infections caused by ARB. The model considers uncertainties in probability of infection and health burden assessment using Monte Carlo simulations. The study collected antimicrobial resistance (AMR) surveillance data from surface waters with different land uses. Results revealed water bodies with agricultural land use to be the main AMR hotspots, with the highest additional health burden observed in infections caused by meropenem-resistant E. coli (∆DALY = 0.0105 DALY/event) compared to antibiotic-susceptible E. coli. The estimated ∆DALY for antibiotic-resistant K. pneumoniae was lower than for antibiotic-resistant E. coli (highest ∆DALY = 0.00048 DALY/event). The study highlights the need for better evaluation of AMR associated health burden, and effective measures to mitigate the risks associated with antibiotic-resistant bacteria in natural environments.
MeSH term(s)	Enterobacteriaceae ; Escherichia coli ; Quality-Adjusted Life Years ; Angiotensin Receptor Antagonists ; Disability-Adjusted Life Years ; Angiotensin-Converting Enzyme Inhibitors ; Risk Assessment ; Anti-Bacterial Agents
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Anti-Bacterial Agents
Language	English
Publishing date	2023-07-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.132058
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Removal efficiency of antibiotic residues, antibiotic resistant bacteria, and genes across parallel secondary settling tank and membrane bioreactor treatment trains in a water reclamation plant.

Chen, Hongjie / Ng, Charmaine / Tran, Ngoc Han / Haller, Laurence / Goh, Shin Giek / Charles, Francis Rathinam / Wu, Zhixin / Lim, Jit Xin / Gin, Karina Yew-Hoong

The Science of the total environment

2024 Volume 924, Page(s) 171723

Abstract: Antimicrobial resistance is recognized as a potent threat to human health. Wastewater treatment facilities are viewed as hotspots for the spread of antimicrobial resistance. This study provides comprehensive data on the occurrences of 3 different ... ...

Abstract	Antimicrobial resistance is recognized as a potent threat to human health. Wastewater treatment facilities are viewed as hotspots for the spread of antimicrobial resistance. This study provides comprehensive data on the occurrences of 3 different antibiotic resistant opportunistic pathogens (with resistance to up to 5 antibiotics), 13 antibiotic resistant genes and intI1, and 22 different antimicrobial residues in a large water reclamation plant (176 million gallons per day) that runs a conventional Modified Ludzack-Ettinger (MLE) reactor followed by a secondary settling tank (SST) and membrane bioreactor (MBR) in parallel. All the antibiotic resistant bacteria and most of the antibiotic resistance genes were present in the raw influent, ranging from 2.5 × 10
MeSH term(s)	Humans ; Anti-Bacterial Agents ; Genes, Bacterial ; Waste Disposal, Fluid ; RNA, Ribosomal, 16S/genetics ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Bacteria/genetics ; Erythromycin ; Bioreactors ; Water Purification
Chemical Substances	Anti-Bacterial Agents ; RNA, Ribosomal, 16S ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Erythromycin (63937KV33D)
Language	English
Publishing date	2024-03-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.171723
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Article ; Online: Draft Genome Sequences of a Ceftazidime-Resistant Acinetobacter baumannii Donor and a Conjugal Escherichia coli Recipient with Acquired Resistance.

Chen, Hongjie / Gu, Xiaoqiong / Ng, Charmaine / Haller, Laurence / Rathinam Charles, Francis / Gin, Karina Yew-Hoong

Microbiology resource announcements

2019 Volume 8, Issue 13

Abstract: A ceftazidime- ... ...

Abstract	A ceftazidime-resistant
Language	English
Publishing date	2019-03-28
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/MRA.00024-19
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Article: A new modelling framework for assessing the relative burden of antimicrobial resistance in aquatic environments

Goh, Shin Giek / Jiang, Peng / Ng, Charmaine / Le, Thai-Hoang / Haller, Laurence / Chen, Hongjie / Charles, Francis Rathinam / Chen, Huiting / Liu, Xiao / He, Yiliang / Gin, Karina Yew-Hoong

Journal of hazardous materials. 2022 Feb. 15, v. 424

2022

Abstract: The infections caused by antibiotic resistant bacteria (ARB) can lead to higher medical costs, prolonged hospital stays, and increased mortality compared to bacteria that are susceptible to antibiotics. Challenges exist in quantifying the potential risk/ ... ...

Abstract	The infections caused by antibiotic resistant bacteria (ARB) can lead to higher medical costs, prolonged hospital stays, and increased mortality compared to bacteria that are susceptible to antibiotics. Challenges exist in quantifying the potential risk/burden associated with antimicrobial resistance (AMR) as there is a lack of dose-response models available for pathogens which are resistant to antibiotics, in addition to the fact that very little is known regarding the health risks posed by antibiotic resistant genes (ARG). In this paper, we proposed a new modelling framework to evaluate the relative burden of AMR in natural aquatic environments. With this framework, an AMR burden score for each sample was calculated based on burden coefficients assigned for each ARB and ARG, as well as weighted burdens for the separate ARBs and ARGs components. The method developed in this study was applied to assess the relative burden of AMR in local aquatic environments with different land uses at different seasons. The collected filed data were used to verify the applicability of the proposed relative burden assessment method. Through the established method, the spatial and temporal hotspots of AMR were identified, which could provide useful information to agencies for better control and management of AMR emergence in natural aquatic environments.
Keywords	antibiotic resistance ; dose response ; hospitals ; mortality ; risk
Language	English
Dates of publication	2022-0215
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.127621
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A new modelling framework for assessing the relative burden of antimicrobial resistance in aquatic environments.

Goh, Shin Giek / Jiang, Peng / Ng, Charmaine / Le, Thai-Hoang / Haller, Laurence / Chen, Hongjie / Charles, Francis Rathinam / Chen, Huiting / Liu, Xiao / He, Yiliang / Gin, Karina Yew-Hoong

Journal of hazardous materials

2021 Volume 424, Issue Pt C, Page(s) 127621

Abstract	The infections caused by antibiotic resistant bacteria (ARB) can lead to higher medical costs, prolonged hospital stays, and increased mortality compared to bacteria that are susceptible to antibiotics. Challenges exist in quantifying the potential risk/burden associated with antimicrobial resistance (AMR) as there is a lack of dose-response models available for pathogens which are resistant to antibiotics, in addition to the fact that very little is known regarding the health risks posed by antibiotic resistant genes (ARG). In this paper, we proposed a new modelling framework to evaluate the relative burden of AMR in natural aquatic environments. With this framework, an AMR burden score for each sample was calculated based on burden coefficients assigned for each ARB and ARG, as well as weighted burdens for the separate ARBs and ARGs components. The method developed in this study was applied to assess the relative burden of AMR in local aquatic environments with different land uses at different seasons. The collected filed data were used to verify the applicability of the proposed relative burden assessment method. Through the established method, the spatial and temporal hotspots of AMR were identified, which could provide useful information to agencies for better control and management of AMR emergence in natural aquatic environments.
MeSH term(s)	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Genes, Bacterial
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Anti-Bacterial Agents
Language	English
Publishing date	2021-10-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.127621
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Microbial water quality and the detection of multidrug resistant E. coli and antibiotic resistance genes in aquaculture sites of Singapore

Ng, Charmaine / Chen, Hongjie / Goh, Shin Giek / Haller, Laurence / Wu, Zhixin / Charles, Francis Rathinam / Trottet, Aurore / Gin, Karina

Marine pollution bulletin. 2018 Oct., v. 135

2018

Abstract: Poor microbial water quality jeopardizes the health and safety of food produced by aquaculture farms. Three fish farms and transect sites in Singapore were assessed for microbial water quality and antimicrobial resistance determinants. Of the 33 ... ...

Abstract	Poor microbial water quality jeopardizes the health and safety of food produced by aquaculture farms. Three fish farms and transect sites in Singapore were assessed for microbial water quality and antimicrobial resistance determinants. Of the 33 multidrug resistant E. coli isolated from surface waters of the Johor Straits, 81.8% were ESBL producers. The relative abundance of sul1, qnrA and intI1 genes were higher in sediments than surface waters. Among the surface water samples, higher concentrations (10−1−101) of beta-lactamases (blaSHV, blaOXA, blaCTX-M) were detected in the transect sites. This study highlights a potential antimicrobial resistance transmission chain from environmental waters, to animal carriers and humans.
Keywords	Escherichia coli ; antibiotic resistance ; antibiotic resistance genes ; aquaculture ; beta-lactamase ; fish farms ; food safety ; humans ; multiple drug resistance ; sediments ; surface water ; water pollution ; water quality ; Singapore
Language	English
Dates of publication	2018-10
Size	p. 475-480.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2018.07.055
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Draft Genome Sequences of Four Multidrug-Resistant Pseudomonas aeruginosa Isolates from Hospital Wastewater in Singapore.

Ng, Charmaine / Gu, Xiaoqiong / Goh, Shin Giek / Chen, Hongjie / Haller, Laurence / Tan, Boonfei / Gin, Karina Yew-Hoong

Microbiology resource announcements

2018 Volume 7, Issue 19

Abstract: Four multidrug-resistant Pseudomonas aeruginosa isolates were cultured from intensive care unit wastewater. All isolates exhibited resistance to carbapenem and extended-spectrum beta-lactam antibiotics. Genome characterization revealed the presence of ... ...

Abstract	Four multidrug-resistant Pseudomonas aeruginosa isolates were cultured from intensive care unit wastewater. All isolates exhibited resistance to carbapenem and extended-spectrum beta-lactam antibiotics. Genome characterization revealed the presence of beta-lactamase resistance genes (
Language	English
Publishing date	2018-11-15
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/MRA.01193-18
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Article ; Online: Occurrence and characteristics of extended-spectrum β-lactamase- and carbapenemase- producing bacteria from hospital effluents in Singapore.

Haller, Laurence / Chen, Hongjie / Ng, Charmaine / Le, Thai Hoang / Koh, Tse Hsien / Barkham, Timothy / Sobsey, Mark / Gin, Karina Yew-Hoong

The Science of the total environment

2018 Volume 615, Page(s) 1119–1125

Abstract: One of the most important resistance mechanisms in Gram-negative bacteria today is the production of enzymes causing resistance to cephalosporin and carbapenem antibiotics. The spread of extended-spectrum β-lactamases (ESBL)- and carbapenemase- producing ...

Abstract	One of the most important resistance mechanisms in Gram-negative bacteria today is the production of enzymes causing resistance to cephalosporin and carbapenem antibiotics. The spread of extended-spectrum β-lactamases (ESBL)- and carbapenemase- producing Gram-negative bacteria is an emerging global public health problem. The aim of the present study was to (i) assess the prevalence of carbapenem-resistant bacteria (CRB) and ESBL-producing strains in sewage effluents from two major hospitals in Singapore, (ii) characterize the isolated strains and (iii) identify some of the ESBL and carbapenemase genes responsible for the resistance. CHROMagar ESBL and KPC plates were used to rapidly screen for ESBL-producing bacteria and those expressing reduced susceptibility to carbapenems, respectively. The abundance of ESBL-producers and CRB in hospital wastewater ranged between 10
MeSH term(s)	Bacterial Proteins/analysis ; Environmental Monitoring ; Singapore ; Waste Water/chemistry ; Waste Water/microbiology ; Water Microbiology ; beta-Lactamases/analysis
Chemical Substances	Bacterial Proteins ; Waste Water ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
Language	English
Publishing date	2018-02-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2017.09.217
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 949: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Microbial water quality and the detection of multidrug resistant E. coli and antibiotic resistance genes in aquaculture sites of Singapore.

Ng, Charmaine / Chen, Hongjie / Goh, Shin Giek / Haller, Laurence / Wu, Zhixin / Charles, Francis Rathinam / Trottet, Aurore / Gin, Karina

Marine pollution bulletin

2018 Volume 135, Page(s) 475–480

Abstract	Poor microbial water quality jeopardizes the health and safety of food produced by aquaculture farms. Three fish farms and transect sites in Singapore were assessed for microbial water quality and antimicrobial resistance determinants. Of the 33 multidrug resistant E. coli isolated from surface waters of the Johor Straits, 81.8% were ESBL producers. The relative abundance of sul1, qnrA and intI1 genes were higher in sediments than surface waters. Among the surface water samples, higher concentrations (10
MeSH term(s)	Animals ; Aquaculture ; Drug Resistance, Microbial/genetics ; Drug Resistance, Multiple, Bacterial ; Escherichia coli/drug effects ; Escherichia coli/isolation & purification ; Humans ; Singapore ; Water Quality
Language	English
Publishing date	2018-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2018.07.055
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Occurrence and characteristics of extended-spectrum β-lactamase- and carbapenemase- producing bacteria from hospital effluents in Singapore

Haller, Laurence / Charmaine Ng / Hongjie Chen / Karina Yew-Hoong Gin / Mark Sobsey / Thai Hoang Le / Timothy Barkham / Tse Hsien Koh

Science of the total environment. 2018 Feb. 15, v. 615

2018

Abstract	One of the most important resistance mechanisms in Gram-negative bacteria today is the production of enzymes causing resistance to cephalosporin and carbapenem antibiotics. The spread of extended-spectrum β-lactamases (ESBL)- and carbapenemase- producing Gram-negative bacteria is an emerging global public health problem. The aim of the present study was to (i) assess the prevalence of carbapenem-resistant bacteria (CRB) and ESBL-producing strains in sewage effluents from two major hospitals in Singapore, (ii) characterize the isolated strains and (iii) identify some of the ESBL and carbapenemase genes responsible for the resistance. CHROMagar ESBL and KPC plates were used to rapidly screen for ESBL-producing bacteria and those expressing reduced susceptibility to carbapenems, respectively. The abundance of ESBL-producers and CRB in hospital wastewater ranged between 103 and 106CFU/mL. Out of the 66 isolates picked from ESBL and KPC plates, 95%, 82%, 82% and 76% were resistant to ceftriaxone, ceftazidime (3rd generation cephalosporin family), ertapenem and meropenem (carbapenem family), respectively. Among the resistant isolates, the most predominant taxa identified were Pseudomonas spp. (28.2%), Klebsiella spp. (28.2%), Enterobacter spp. (18.3%) and Citrobacter spp. (11.3%). PCR and sequencing analysis showed that the predominant β-lactamase genes were blaSHV (41.1%) followed by blaNDM-1 (35.6%), blaCTX (35.6%) and blaKPC (28.8%). The results of this study show a high prevalence of bacteria resistant to modern extended-spectrum cephalosporins and carbapenems and the presence of ESBL- and carbapenemase producers in hospital effluents. These findings support the need to improve management of hospital wastewater in order to minimize the spread of antimicrobial resistant microorganisms from this source.
Keywords	beta-lactamase ; ceftazidime ; ceftriaxone ; Citrobacter ; effluents ; Enterobacter ; ertapenem ; genes ; Gram-negative bacteria ; hospitals ; Klebsiella ; meropenem ; polymerase chain reaction ; Pseudomonas ; public health ; resistance mechanisms ; sequence analysis ; wastewater ; Singapore
Language	English
Dates of publication	2018-0215
Size	p. 1119-1125.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2017.09.217
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 949: Show issues

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ab Jg. 2022: Lesesaal (EG)

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