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Book ; Thesis: Verbesserung der Anzüchtmethoden des Prostatakarzinoms in der Primärkultur

Hallermann, Christian

1995

Author's details	vorgelegt von Christian Hallermann
Language	German
Size	37 S. : Ill., graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Würzburg, Univ., Diss., 1996
HBZ-ID	HT007317694
Database	Catalogue ZB MED Medicine, Health

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Article: IMP3 Expression as a Potential Tumour Marker in High-Risk Localisations of Cutaneous Squamous Cell Carcinoma: IMP3 in Metastatic cSCC.

Klein, Maurice / Wefers, Merle / Hallermann, Christian / Fischer, Henrike J / Hölzle, Frank / Wermker, Kai

Cancers

2023 Volume 15, Issue 16

Abstract: Background: High IMP3 expression is correlated with a worse outcome. Until now, there have been no data about IMP3 expression and clinical outcome for high-risk localisation of squamous cell carcinoma of the skin (cSCC).: Methods: One-hundred twenty- ... ...

Abstract	Background: High IMP3 expression is correlated with a worse outcome. Until now, there have been no data about IMP3 expression and clinical outcome for high-risk localisation of squamous cell carcinoma of the skin (cSCC). Methods: One-hundred twenty-two patients with cSCC of the lip and ear were included, and IMP3 expression in the tumours was immunohistochemically assessed in different evaluation approaches. Subsequently, subgroups were analysed in a matched pair approach and correlated with clinical pathologic parameters. In the following, different IMP3 analysis methods were tested for clinical suitability. Results: We found a significant correlation between IMP3 expression and risk for lymph node metastasis, local relapse, and progression-free survival. Conclusions: On basis of our data, we suggest a prognostic benefit cutoff value for high (>50%) and low (<50%) IMP3 expression. Thus, IMP3 expression has a high scientific potential for further studies and could potentially be used as a prognostic marker in diagnostic and therapeutic decision-making.
Language	English
Publishing date	2023-08-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15164087
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Article ; Online: Primary head and neck mucosal melanoma: Predictors of survival and a case series on sentinel node biopsy.

Prinzen, Tom / Klein, Martin / Hallermann, Christian / Wermker, Kai

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

2019 Volume 47, Issue 9, Page(s) 1370–1377

Abstract: Introduction: Head and neck mucosal melanoma (HNMM) is a rare tumor with a poor outcome. The objective of this study was to assess outcome and prognostic factors for a cohort of patients treated in a head and neck cancer center. In addition, a case ... ...

Abstract	Introduction: Head and neck mucosal melanoma (HNMM) is a rare tumor with a poor outcome. The objective of this study was to assess outcome and prognostic factors for a cohort of patients treated in a head and neck cancer center. In addition, a case series on sentinel lymph node biopsy (SLNB) was included to evaluate it as a method for staging the node-negative neck. Methods: A retrospective study design was chosen, and 50 patients who were treated from 1973 to 2015 in our institution for primary HNMM were included. The Kaplan-Meier method was used to estimate survival rates. Uni- and multivariate analyses were used to study the influence of possible risk factors on the patients' outcome. These risk factors included patient demographics, tumor characteristics, and treatment modalities. Results: All patients were treated surgically and 50% received adjuvant treatment. The median disease specific survival (DSS) was 38 months, with a 5-year survival rate of 44%. Positive surgical margin (p = 0.004) and distant failure (p = 0.005) were associated with a worse DSS. The median disease-free survival (DFS) was 27 months, with a 5-year disease-free rate of 12%. Only tumor depth >5 mm (p = 0.002) was associated with a worse DFS. Five clinically node-negative patients received SLNB and only the two SLN-positive individuals suffered from distant failure. Radiotherapy, chemotherapy, and AJCC/UICC stage had no influence on any outcome measure. Conclusions: Positive surgical margin and distant failure are the only independent prognostic factors for DSS. Tumor depth can predict distant failure. SLNB may be a valuable staging tool for the node-negative neck.
MeSH term(s)	Disease-Free Survival ; Head ; Head and Neck Neoplasms ; Humans ; Melanoma ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Sentinel Lymph Node Biopsy ; Skin Neoplasms
Language	English
Publishing date	2019-06-25
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	91267-0
ISSN	1878-4119 ; 1010-5182 ; 0301-0503
ISSN (online)	1878-4119
ISSN	1010-5182 ; 0301-0503
DOI	10.1016/j.jcms.2019.06.012
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Article: Kutane Vaskulitis als Seltene, aber charakteristische Nebenwirkung von Ixazomib

Hallermann, Christian / Ter-Nedden, Jan / Reusch, Ursula / Mielke, Volker / Kokkori-Steinbrecher, Aikaterini / Reusch, Michael

Derm

2022 Volume 28, Issue 4, Page(s) 441

Language	German
Document type	Article
ZDB-ID	1315453-9
ISSN	0949-7633
Database	Current Contents Medicine

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Article ; Online: Twenty-Eight Cases of Extraocular Sebaceous Carcinoma: A Correlative Clinicopathological and Immunohistochemical Analysis of Extraocular Sebaceous Carcinomas and Benign Sebaceous Gland Tumors.

Boecker, Werner / Reusch, Michael / Mielke, Volker / Reusch, Ursula / Hallermann, Christian / Loening, Thomas / Tiemann, Markus / Buchwalow, Igor

The American Journal of dermatopathology

2020 Volume 43, Issue 2, Page(s) 93–102

Abstract: Abstract: Extraocular sebaceous carcinoma (ESC) is a rare appendiceal skin tumor. In contrast to ocular sebaceous carcinoma, information about the exact cellular architecture of these lesions is scarce and the histogenesis of ESC is unknown. Here, we ... ...

Abstract	Abstract: Extraocular sebaceous carcinoma (ESC) is a rare appendiceal skin tumor. In contrast to ocular sebaceous carcinoma, information about the exact cellular architecture of these lesions is scarce and the histogenesis of ESC is unknown. Here, we extend our previous study and investigate 28 extraocular carcinomas in comparison to 54 benign sebaceous tumors and 8 cases of normal sebaceous glands using a broad spectrum of antibodies against p63, several keratins, adipophilin, EMA, Ki67, androgen receptor, and mismatch repair proteins. This observational study demonstrates that p63- and K5/14-positive basaloid cells are key cells in normal sebaceous gland and in all sebaceous tumors and that these basaloid cells give rise to EMA+, adipophilin+ sebocytes, and K5/14+, K7±, K10± ductal structures. Finally, about half of ESC is associated with superficial in situ neoplasia, which provides evidence that at least part of these carcinomas arises from flat superficial in situ carcinoma. In contrast to the normal sebaceous gland, about half of all sebaceous tumors lack keratin K7. MMR protein IHC-profiles role will be discussed.
MeSH term(s)	Adenoma/chemistry ; Adenoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Biopsy ; Carcinoma/chemistry ; Carcinoma/pathology ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Predictive Value of Tests ; Sebaceous Gland Neoplasms/chemistry ; Sebaceous Gland Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2020-06-22
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	448469-1
ISSN	1533-0311 ; 0193-1091
ISSN (online)	1533-0311
ISSN	0193-1091
DOI	10.1097/DAD.0000000000001667
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Zs.A 1518: Show issues

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Article ; Online: New and established treatment options for mycosis fungoides and Sézary syndrome - an update.

Dugas-Breit, Susanne / Schulze, Hans-Joachim / Hallermann, Christian

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

2014 Volume 12, Issue 7, Page(s) 561–569

Abstract: At the time of diagnosis primary cutaneous lymphomas are limited to the skin. T-cell lymphomas represent at least two thirds of all primary cutaneous lymphomas with mycosis fungoides and Sézary syndrome being the most frequent entities. A precise staging ...

Abstract	At the time of diagnosis primary cutaneous lymphomas are limited to the skin. T-cell lymphomas represent at least two thirds of all primary cutaneous lymphomas with mycosis fungoides and Sézary syndrome being the most frequent entities. A precise staging based on clinical, histological, immunohistological and molecular biological criteria is crucial for selecting the appropriate therapy. Since curative treatment is only possible in exceptional cases, the aim of any therapy is to achieve healing of the skin lesions, minimizing relapses, preventing progression and maintaining the quality of life. While in early disease stages skin-directed therapy is being used, in later stages systemic treatments become more important. This work aims to provide an overview of established and new therapies for the treatment of mycosis fungoides and Sézary syndrome.
MeSH term(s)	Antineoplastic Agents/administration & dosage ; Humans ; Molecular Targeted Therapy/methods ; Mycosis Fungoides/drug therapy ; Mycosis Fungoides/pathology ; PUVA Therapy/methods ; Radiation-Sensitizing Agents/therapeutic use ; Sezary Syndrome/drug therapy ; Sezary Syndrome/pathology ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology
Chemical Substances	Antineoplastic Agents ; Radiation-Sensitizing Agents
Language	English
Publishing date	2014-07
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2093479-8
ISSN	1610-0387 ; 1610-0379
ISSN (online)	1610-0387
ISSN	1610-0379
DOI	10.1111/ddg.12376
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Article ; Online: Symmetric nodules on both soles in a 4-month-old baby.

Schulz, Alina / Schulze, Hans-Joachim / Hallermann, Christian

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

2013 Volume 11, Issue 12, Page(s) 1209–1210

MeSH term(s)	Diagnosis, Differential ; Foot Dermatoses/pathology ; Hamartoma/congenital ; Hamartoma/pathology ; Heel/abnormalities ; Heel/pathology ; Humans ; Infant ; Male ; Skin Neoplasms/congenital ; Skin Neoplasms/pathology
Language	English
Publishing date	2013-12
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	2093479-8
ISSN	1610-0387 ; 1610-0379
ISSN (online)	1610-0387
ISSN	1610-0379
DOI	10.1111/ddg.12176
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Article: Linearer Lichen nitidus am Penisschaft

Ter-Nedden, Jan / Hallermann, Christian / Reusch, Ursula / Mielke, Volker / Kokkori-Steinbrecher, Akaterini / Reusch, Michael / Kämmerer, Eva

Derm

2020 Volume 26, Issue 4, Page(s) 321

Language	German
Document type	Article
ZDB-ID	1315453-9
ISSN	0949-7633
Database	Current Contents Medicine

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Zs.A 5786: Show issues

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Article ; Online: Prognostic value of S100/CD31 and S100/podoplanin double immunostaining in mucosal malignant melanoma of the head and neck.

Wermker, Kai / Brauckmann, Till / Klein, Martin / Haßfeld, Stefan / Schulze, Hans-Joachim / Hallermann, Christian

Head & neck

2015 Volume 37, Issue 9, Page(s) 1368–1374

Abstract: Background: In uncommon mucosal melanomas of the head and neck established prognostic factors are rare and controversially discussed. The purpose of this study was to evaluate outcome and value of S100/podoplanin and S100/CD31 double immunostaining in ... ...

Abstract	Background: In uncommon mucosal melanomas of the head and neck established prognostic factors are rare and controversially discussed. The purpose of this study was to evaluate outcome and value of S100/podoplanin and S100/CD31 double immunostaining in head and neck mucosal melanomas. Methods: Retrospectively, patients with head and neck mucosal melanomas treated between 1973 and 2008 were analyzed. S100/podoplanin and S100/CD31 immunostaining were performed to detect lymph vessel invasion (LVI) and blood vessel invasion (BVI). Predictive parameters for disease-specific survival (DSS) were identified using univariate and multivariate statistics. Results: Forty-two patients with head and neck mucosal melanoma were included. Three-year, 5-year, and 10-year DSS rates were 59%, 44%, and 20%, respectively. Age above 70 years, occurrence of distant metastasis, LVI, and BVI were significantly associated with shorter DSS time (p < .05), whereas localization at the conjunctiva showed better outcome. Conclusion: S100/podoplanin and S100/CD31 double immunostaining detect reliable LVI and BVI in head and neck mucosal melanoma and both are associated significantly with worse prognosis.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Biopsy, Needle ; Cohort Studies ; Female ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/therapy ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Melanoma/mortality ; Melanoma/pathology ; Melanoma/therapy ; Membrane Glycoproteins ; Middle Aged ; Mucous Membrane/pathology ; Multivariate Analysis ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; S100A12 Protein ; Survival Analysis
Chemical Substances	Membrane Glycoproteins ; PDPN protein, human ; S100A12 Protein
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.23761
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Zs.A 1493: Show issues

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Article ; Online: Basosquamous carcinoma of the head and neck: clinical and histologic characteristics and their impact on disease progression.

Wermker, Kai / Roknic, Nikola / Goessling, Katharina / Klein, Martin / Schulze, Hans-Joachim / Hallermann, Christian

Neoplasia (New York, N.Y.)

2015 Volume 17, Issue 3, Page(s) 301–305

Abstract: Objectives: Basosquamous carcinoma (BSC) is a rare tumor entity, and the most common onset is in the head and neck region (BSC-HN). The data on diagnosis, treatment, and especially risk assessment concerning disease course and outcome are deficient or ... ...

Abstract	Objectives: Basosquamous carcinoma (BSC) is a rare tumor entity, and the most common onset is in the head and neck region (BSC-HN). The data on diagnosis, treatment, and especially risk assessment concerning disease course and outcome are deficient or inconsistent. This study aimed to evaluate risk factors for local relapse (LR) and lymph node metastasis (LNM) and their impact on progression-free survival (PFS). Materials and methods: In a retrospective monocentric study, patients with BSC-HN treated between 1999 and 2011 were analyzed regarding clinical and histologic characteristics. Prognostic parameters for LR, LNM, and PFS were evaluated. In total, 89 patients (55 male, 34 female, mean age of 71.8 years) with a mean follow-up time of 47.7 months (range 12-112) were included. Results: LR occurred in four patients (4.5%), LNM occurred in five patients (5.6%). Patients with LNM had a significantly shorter PFS time (16.1 months) compared with patients without LNM (154.2 months; P < .001). Tumor depth and size (T classification), incomplete resection, localization at the ear, deep maximal vertical infiltration, muscle and vessel invasion all showed significant (P < .05) associations with LR, LNM, and shorter PFS time. BSC showed more histologic features of basal cell carcinoma (BCC), especially with regard to BerEP4 expression. Conclusion: While histology shows some typical characteristics of BCC, the biologic behavior and aggressiveness of BSC are similar to those of cutaneous squamous cell carcinoma. This is the first study to show that LR and, especially, LNM indicate a higher risk of an unfavorable outcome.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma, Basosquamous/diagnosis ; Carcinoma, Basosquamous/epidemiology ; Carcinoma, Basosquamous/mortality ; Comorbidity ; Disease Progression ; Female ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/mortality ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Mortality ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Prognosis ; Young Adult
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1483840-0
ISSN	1476-5586 ; 1522-8002
ISSN (online)	1476-5586
ISSN	1522-8002
DOI	10.1016/j.neo.2015.01.007
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