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  1. Article ; Online: Effect of histamine-receptor antagonism on the circulating inflammatory cell and cytokine response to exercise: A pilot study.

    Ely, Matthew R / Mangum, Joshua E / Needham, Karen Wiedenfeld / Minson, Christopher T / Halliwill, John R

    Physiological reports

    2024  Volume 12, Issue 3, Page(s) e15936

    Abstract: The purpose of this study was to gain insight into histamine's role in the exercise inflammatory response and recovery from exercise. To explore this, young healthy participants (n = 12) performed 300 eccentric leg extensions under control (Placebo) ... ...

    Abstract The purpose of this study was to gain insight into histamine's role in the exercise inflammatory response and recovery from exercise. To explore this, young healthy participants (n = 12) performed 300 eccentric leg extensions under control (Placebo) versus histamine H
    MeSH term(s) Humans ; Histamine ; Pilot Projects ; Cytokines ; Exercise/physiology ; Histamine H2 Antagonists/pharmacology
    Chemical Substances Histamine (820484N8I3) ; Cytokines ; Histamine H2 Antagonists
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Measuring renal hemodynamics during exercise using doppler ultrasound.

    Chapman, Christopher L / Drew, Rachel C / Halliwill, John R / Minson, Christopher T / Schlader, Zachary J

    Physiological reports

    2024  Volume 12, Issue 8, Page(s) e16017

    MeSH term(s) Hemodynamics ; Ultrasonography ; Kidney/diagnostic imaging ; Ultrasonography, Doppler
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Letter
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.16017
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  3. Article ; Online: Sex Differences in VO

    Santisteban, Kelsey J / Lovering, Andrew T / Halliwill, John R / Minson, Christopher T

    International journal of environmental research and public health

    2022  Volume 19, Issue 9

    Abstract: It was not until 1984 that women were permitted to compete in the Olympic marathon. Today, more women than men participate in road racing in all distances except the marathon where participation is near equal. From the period of 1985 to 2004, the women's ...

    Abstract It was not until 1984 that women were permitted to compete in the Olympic marathon. Today, more women than men participate in road racing in all distances except the marathon where participation is near equal. From the period of 1985 to 2004, the women's marathon record improved at a rate three times greater than men's. This has led many to question whether women are capable of surpassing men despite the fact that there remains a 10-12% performance gap in all distance events. The progressive developments in sports performance research and training, beginning with A.V. Hill's establishment of the concept of VO
    MeSH term(s) Athletic Performance ; Female ; Humans ; Male ; Oxygen ; Oxygen Consumption/physiology ; Physical Endurance/physiology ; Sex Characteristics
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19094946
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  4. Article ; Online: Cholinergic nerve contribution to cutaneous active vasodilation during exercise is similar to whole body passive heating.

    Francisco, Michael A / Gibson, Brandon M / Simmons, Grant H / Halliwill, John R / Minson, Christopher T

    Journal of applied physiology (Bethesda, Md. : 1985)

    2023  Volume 134, Issue 4, Page(s) 933–940

    Abstract: Sympathetic cholinergic nerve cotransmission is widely accepted as the mechanism of cutaneous active vasodilation (CAVD) during whole body passive heating (passive heating). However, recent research suggests that there may be mechanistic differences in ... ...

    Abstract Sympathetic cholinergic nerve cotransmission is widely accepted as the mechanism of cutaneous active vasodilation (CAVD) during whole body passive heating (passive heating). However, recent research suggests that there may be mechanistic differences in CAVD to heating, depending on the modality of thermal loading. It is unknown whether sympathetic cholinergic cotransmission explains CAVD during exercise. This study sought to confirm the role of cholinergic nerves in CAVD during passive heating and expand these findings to exercise. It was hypothesized that CAVD during both exercise and passive heating would be abolished by cholinergic nerve blockade. Eight young (18-30 yr) recreationally active individuals exercised (1 h seated cycling at 60% V̇o
    MeSH term(s) Humans ; Botulinum Toxins, Type A ; Cholinergic Agents ; Cross-Over Studies ; Fever ; Heating ; Regional Blood Flow/physiology ; Skin/blood supply ; Vasodilation/physiology
    Chemical Substances Botulinum Toxins, Type A (EC 3.4.24.69) ; Cholinergic Agents
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00299.2022
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  5. Article ; Online: A brief history of the Physiology Majors Interest Group (P-MIG).

    Wehrwein, Erica A / Poteracki, James M / Halliwill, John R

    Advances in physiology education

    2020  Volume 44, Issue 4, Page(s) 607–612

    MeSH term(s) Curriculum ; Educational Measurement ; Humans ; Physiology/education ; Public Opinion
    Language English
    Publishing date 2020-09-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 1024917-5
    ISSN 1522-1229 ; 1043-4046
    ISSN (online) 1522-1229
    ISSN 1043-4046
    DOI 10.1152/advan.00176.2019
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  6. Article: Transcutaneous delivery of sodium bicarbonate increases intramuscular pH.

    Gibson, Brandon M / Needham, Karen Wiedenfeld / Kaiser, Brendan W / Wilkins, Brad W / Minson, Christopher T / Halliwill, John R

    Frontiers in physiology

    2023  Volume 14, Page(s) 1142567

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1142567
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  7. Article ; Online: The Intriguing Role of Histamine in Exercise Responses.

    Luttrell, Meredith J / Halliwill, John R

    Exercise and sport sciences reviews

    2017  Volume 45, Issue 1, Page(s) 16–23

    Abstract: In humans, histamine is a molecular transducer of physical activity responses, and antihistamines modify more than 25% of the genes responding to exercise. Although the upstream signal that results in release of histamine within exercising skeletal ... ...

    Abstract In humans, histamine is a molecular transducer of physical activity responses, and antihistamines modify more than 25% of the genes responding to exercise. Although the upstream signal that results in release of histamine within exercising skeletal muscle remains to be identified, it is likely a fundamental exercise response and not an allergic reaction.
    MeSH term(s) Athletic Performance/physiology ; Exercise/physiology ; Glucose/metabolism ; Glycogen/metabolism ; Heart Rate/physiology ; Histamine/metabolism ; Histamine/physiology ; Histamine Antagonists/pharmacology ; Humans ; Inflammation/physiopathology ; Muscle, Skeletal/metabolism ; Pain Perception/physiology ; Receptors, Histamine/metabolism ; Vasodilation/physiology
    Chemical Substances Histamine Antagonists ; Receptors, Histamine ; Histamine (820484N8I3) ; Glycogen (9005-79-2) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 187040-3
    ISSN 1538-3008 ; 0091-6331
    ISSN (online) 1538-3008
    ISSN 0091-6331
    DOI 10.1249/JES.0000000000000093
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  8. Article ; Online: Hypohydration attenuates increases in creatinine clearance to oral protein loading and the renal hemodynamic response to exercise pressor reflex.

    Chapman, Christopher L / Holt, Sadie M / O'Connell, Cameron T / Brazelton, Shaun C / Medved, Hannah N / Howells, William A B / Reed, Emma L / Needham, Karen Wiedenfeld / Halliwill, John R / Minson, Christopher T

    Journal of applied physiology (Bethesda, Md. : 1985)

    2024  Volume 136, Issue 3, Page(s) 492–508

    Abstract: Insufficient hydration is prevalent among free living adults. This study investigated whether hypohydration ... ...

    Abstract Insufficient hydration is prevalent among free living adults. This study investigated whether hypohydration alters
    MeSH term(s) Female ; Male ; Young Adult ; Humans ; Creatinine ; Hand Strength ; Reflex ; Hemodynamics ; Water
    Chemical Substances Creatinine (AYI8EX34EU) ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00728.2023
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  9. Article ; Online: Evening but not morning aerobic training improves sympathetic activity and baroreflex sensitivity in elderly patients with treated hypertension.

    Brito, Leandro C / Azevêdo, Luan M / Amaro-Vicente, Graziela / Costa, Luis R / da Silva Junior, Natan D / Halliwill, John R / Rondon, Maria U P B / Forjaz, Cláudia L M

    The Journal of physiology

    2024  Volume 602, Issue 6, Page(s) 1049–1063

    Abstract: The blood pressure-lowering effect of aerobic training is preceded by improving cardiovascular autonomic control. We previously demonstrated that aerobic training conducted in the evening (ET) induces a greater decrease in blood pressure than morning ... ...

    Abstract The blood pressure-lowering effect of aerobic training is preceded by improving cardiovascular autonomic control. We previously demonstrated that aerobic training conducted in the evening (ET) induces a greater decrease in blood pressure than morning training (MT). To study whether the greater blood pressure decrease after ET occurs through better cardiovascular autonomic regulation, this study aimed to compare MT versus ET on muscle sympathetic nerve activity (MSNA) and baroreflex sensitivity (BRS) in treated patients with hypertension. Elderly patients treated for hypertension were randomly allocated into MT (n = 12, 07.00-10.00 h) or ET (n = 11, 17.00-20.00 h) groups. Both groups trained for 10 weeks, 3 times/week, cycling for 45 min at moderate intensity. Beat-to-beat blood pressure (finger photoplethysmography), heart rate (electrocardiography) and MSNA (microneurography) were assessed at the initial and final phases of the study at baseline and during sequential bolus infusions of sodium nitroprusside and phenylephrine (modified-Oxford technique) to evaluate cardiac and sympathetic BRS. Mean blood pressure decreased significantly after ET but not after MT (-9 ± 11 vs. -1 ± 8 mmHg, P = 0.042). MSNA decreased significantly only after ET with no change after MT (-12 ± 5 vs. -3 ± 7 bursts/100 heart beats, P = 0.013). Sympathetic BRS improved after ET but not after MT (-0.8 ± 0.7 vs. 0.0 ± 0.8 bursts/100 heart beats/mmHg, P = 0.052). Cardiac BRS improved similarly in both groups (ET: +1.7 ± 1.8 vs. MT: +1.4 ± 1.9 ms/mmHg, P
    MeSH term(s) Humans ; Aged ; Baroreflex/physiology ; Hypertension/therapy ; Blood Pressure/physiology ; Cardiovascular System ; Heart ; Sympathetic Nervous System/physiology ; Heart Rate/physiology ; Muscle, Skeletal
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP285966
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  10. Article: Recovery from exercise: vulnerable state, window of opportunity, or crystal ball?

    Luttrell, Meredith J / Halliwill, John R

    Frontiers in physiology

    2015  Volume 6, Page(s) 204

    Abstract: Why should we study the recovery from exercise as a discrete phenomenon from exercise itself? We identify three distinct (but not mutually exclusive) rationales that drive the need to investigate the physiology of recovery from exercise. (1) Some ... ...

    Abstract Why should we study the recovery from exercise as a discrete phenomenon from exercise itself? We identify three distinct (but not mutually exclusive) rationales that drive the need to investigate the physiology of recovery from exercise. (1) Some individuals are at a heightened risk of clinical outcomes in the immediate post-exercise period; thus the potential negative outcomes of this "vulnerable state" must be weighed against the numerous benefits of exercise training, and may be mitigated to reduce risk. (2) Many of the signaling mechanisms responsible for the beneficial effects of exercise training remain amplified during the exercise recovery period, and may present a "window of opportunity" that can be exploited by interventions to enhance the beneficial adaptations to exercise training, especially in clinical populations. (3) On an individual level, exercise recovery responses may provide investigators with a "crystal ball" ability to predict future clinical outcomes even in apparently healthy individuals. In short, the physiology of recovery is a multi-faceted and complex process, likely involving systems and pathways that are distinct from the physiology of exercise itself. For these reasons, it merits ongoing study.
    Language English
    Publishing date 2015-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2015.00204
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