Article ; Online: Cell-Like Synthetic Supramolecular Soft Materials Realized in Multicomponent, Non-/Out-of-Equilibrium Dynamic Systems.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2023 Volume 11, Issue 8, Page(s) e2306830
Abstract: Living cells are complex, nonequilibrium supramolecular systems capable of independently and/or cooperatively integrating multiple bio-supramolecules to execute intricate physiological functions that cannot be accomplished by individual biomolecules. ... ...
| Abstract | Living cells are complex, nonequilibrium supramolecular systems capable of independently and/or cooperatively integrating multiple bio-supramolecules to execute intricate physiological functions that cannot be accomplished by individual biomolecules. These biological design strategies offer valuable insights for the development of synthetic supramolecular systems with spatially controlled hierarchical structures, which, importantly, exhibit cell-like responses and functions. The next grand challenge in supramolecular chemistry is to control the organization of multiple types of supramolecules in a single system, thus integrating the functions of these supramolecules in an orthogonal and/or cooperative manner. In this perspective, the recent progress in constructing multicomponent supramolecular soft materials through the hybridization of supramolecules, such as self-assembled nanofibers/gels and coacervates, with other functional molecules, including polymer gels and enzymes is highlighted. Moreover, results show that these materials exhibit bioinspired responses to stimuli, such as bidirectional rheological responses of supramolecular double-network hydrogels, temporal stimulus pattern-dependent responses of synthetic coacervates, and 3D hydrogel patterning in response to reaction-diffusion processes are presented. Autonomous active soft materials with cell-like responses and spatially controlled structures hold promise for diverse applications, including soft robotics with directional motion, point-of-care disease diagnosis, and tissue regeneration. |
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| MeSH term(s) | Polymers/chemistry ; Hydrogels/chemistry |
| Chemical Substances | Polymers ; Hydrogels |
| Language | English |
| Publishing date | 2023-11-28 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 2808093-2 |
| ISSN | 2198-3844 ; 2198-3844 |
| ISSN (online) | 2198-3844 |
| ISSN | 2198-3844 |
| DOI | 10.1002/advs.202306830 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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