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  1. AU="Hamaker, Marije E"
  2. AU="Ivens, Martijn"
  3. AU="Morales-Rodríguez, Francisco Manuel"
  4. AU="Wolske, Sara"
  5. AU="Pool Marco H" AU="Pool Marco H"
  6. AU="Martin, Dave"
  7. AU="Jane L. Lynch"
  8. AU="Li, Hongzhi" AU="Li, Hongzhi"
  9. AU="Steinberg, Karl E"
  10. AU="Barbara Stöckigt"
  11. AU="Dutoit, Julie"
  12. AU="Crumley, Andrew B"
  13. AU="Abdul Karim, Mustafa"
  14. AU="Bose, Chirantan"
  15. AU="Bell, J. F."
  16. AU="Creavin, Samuel T"
  17. AU="Boonprasong, Sakarin"
  18. AU="Sara Carvalho"
  19. AU="Xia, Zhenqing"

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  1. Artikel ; Online: Achieving harmony in oncological geriatric assessment - Should we agree on a best set of tools?

    Rostoft, Siri / Seghers, Nelleke / Hamaker, Marije E

    Journal of geriatric oncology

    2023  Band 14, Heft 7, Seite(n) 101473

    Mesh-Begriff(e) Humans ; Aged ; Geriatric Assessment ; Medical Oncology ; Neoplasms
    Sprache Englisch
    Erscheinungsdatum 2023-03-17
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2023.101473
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  2. Artikel ; Online: Geriatric assessment in older patients with cancer: a new standard of care.

    Hamaker, Marije E / Rostoft, Siri

    Lancet (London, England)

    2021  Band 398, Heft 10314, Seite(n) 1853–1855

    Mesh-Begriff(e) Aged ; Geriatric Assessment ; Humans ; Medical Oncology ; Neoplasms/epidemiology ; Neoplasms/therapy ; Standard of Care
    Sprache Englisch
    Erscheinungsdatum 2021-11-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)01998-X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.5: Hefte anzeigen Standort:
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  3. Artikel ; Online: De juiste zorg op de juiste plek.

    Hamaker, Marije E / Baden, David / van Tuyl, Sebastiaan A C

    Nederlands tijdschrift voor geneeskunde

    2023  Band 167

    Abstract: Older patients who experience a fall may be admitted to hospital without a strict medical necessity. An unexplained fall incident requires thorough history taking and, if necessary, further investigation into the cause of the fall. Possible underlying ... ...

    Titelübersetzung The right care in the right place.
    Abstract Older patients who experience a fall may be admitted to hospital without a strict medical necessity. An unexplained fall incident requires thorough history taking and, if necessary, further investigation into the cause of the fall. Possible underlying multimorbidity must also be examined to prevent recurrence and complications. Admission to hospital without medical necessity is undesirable, but often unavoidable due to a lack of alternatives for patients who can no longer care for themselves in an acute situation. Reducing this unnecessary health care consumption is only possible if the options for care outside the hospital are expanded. In addition to regional cooperation to gain insight into available home care and places to stay, the use of unlabeled beds in care homes for further assessment of care needs and triage could help resolve this issue. In this way we can work together to provide the right care in the right place.
    Mesh-Begriff(e) Humans ; Hospitalization ; Triage ; Home Care Services
    Sprache Niederländisch
    Erscheinungsdatum 2023-10-11
    Erscheinungsland Netherlands
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Ua VI Zs.18: Hefte anzeigen Standort:
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  4. Artikel: Advances in Geriatric Oncology: Exploring Practical Ways to Optimize Treatment in Older Patients with Cancer.

    Paillaud, Elena / Hamaker, Marije E / Soubeyran, Pierre

    Cancers

    2022  Band 14, Heft 17

    Abstract: Cancer is a disease associated with aging, with patients over 70 accounting for 50% of newly diagnosed malignancies and 70% of all cancer deaths [ ... ]. ...

    Abstract Cancer is a disease associated with aging, with patients over 70 accounting for 50% of newly diagnosed malignancies and 70% of all cancer deaths [...].
    Sprache Englisch
    Erscheinungsdatum 2022-08-26
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14174129
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Geriatrische analyse nuttig bij chemotherapie voor ouderen.

    Hamaker, Marije E / de Glas, Nienke A

    Nederlands tijdschrift voor geneeskunde

    2022  Band 166

    Abstract: The recent publication of the GAP70+ study in The Lancet is an important step in the field of geriatric oncology. This study shows that combining a geriatric assessment with oncologic and geriatric management recommendations has the potential to decrease ...

    Titelübersetzung Geriatric assessment to improve geriatric oncology.
    Abstract The recent publication of the GAP70+ study in The Lancet is an important step in the field of geriatric oncology. This study shows that combining a geriatric assessment with oncologic and geriatric management recommendations has the potential to decrease toxicity. We discuss the implications of the study, performed in the United States, for clinical practice and future research in the Netherlands. The results of the GAP70+ study are promising, and the study has landmark potential. Although there are relevant differences in oncologic care between the Netherlands and the United states, this study provides new opportunities for expanding and improving geriatric oncology care.
    Mesh-Begriff(e) Aged ; Geriatric Assessment/methods ; Humans ; Medical Oncology/standards ; Neoplasms/therapy ; Netherlands ; United States
    Sprache Niederländisch
    Erscheinungsdatum 2022-01-24
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Ua VI Zs.18: Hefte anzeigen Standort:
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  6. Artikel ; Online: Preferred and actual involvement of caregivers in oncologic treatment decision-making: A systematic review.

    Tielemans, Laura M L / van Heugten, Kirsten D / Hamaker, Marije E / van Walree, Inez C

    Journal of geriatric oncology

    2023  Band 14, Heft 6, Seite(n) 101525

    Abstract: Introduction: Treatment decision-making in cancer is complex and many patients bring their caregiver to appointments to help them make those decisions. Multiple studies show the importance of involving caregivers in the treatment decision-making process. ...

    Abstract Introduction: Treatment decision-making in cancer is complex and many patients bring their caregiver to appointments to help them make those decisions. Multiple studies show the importance of involving caregivers in the treatment decision-making process. We aimed to explore the preferred and actual involvement of caregivers in the decision-making process of patients with cancer and to see if there are age or cultural background related differences in caregiver involvement.
    Materials and methods: A systematic review of Pubmed and Embase was performed on January 2, 2022. Studies containing numerical data regarding caregiver involvement were included, as were studies describing the agreement between patients and caregivers regarding treatment decisions. Studies assessing solely patients aged younger than 18 years old or terminally ill patients, and studies without extractable data were excluded. Risk of bias was assessed by two independent reviewers using an adapted version of the Newcastle-Ottawa scale. Results were analysed in two separate age groups, one <62 years and one ≥62 years.
    Results: Twenty-two studies with a total of 11,986 patients and 6,260 caregivers were included in this review. A median of 75% of patients preferred caregivers to be involved in decision-making and a median of 85% of caregivers preferred to be involved. With regards to age groups, the preferred involvement of caregivers was more frequent in the younger study populations. With regards to geographical differences, studies performed in Western countries showed a lower preference for caregiver's involvement compared to studies from Asian countries. A median of 72% of the patients reported the caregiver was actually involved in the treatment decision-making and a median of 78% of the caregivers reported they were actually involved. The most important role of caregivers was to listen and provide emotional support.
    Discussion: Patients and caregivers both want caregivers to be involved in the treatment decision-making process and most caregivers are actually involved. An ongoing dialogue between clinicians, patients and caregivers about decision-making is important to meet the individual patient's and caregiver's needs when involved in the decision-making process. Important limitations were a lack of studies in older patients and significant differences in outcome measures among studies.
    Mesh-Begriff(e) Humans ; Aged ; Caregivers/psychology ; Decision Making ; Neoplasms/therapy ; Neoplasms/psychology
    Sprache Englisch
    Erscheinungsdatum 2023-05-15
    Erscheinungsland Netherlands
    Dokumenttyp Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2023.101525
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  7. Artikel ; Online: A care pathway for older patients with multimorbidity including cancer - Design of the GERONTE pathway.

    Seghers, P A L Nelleke / Rostoft, Siri / O'Hanlon, Shane / Degol, Lien / Kenis, Cindy / Wildiers, Hans / Soubeyran, Pierre / Hamaker, Marije E

    Journal of geriatric oncology

    2023  Band 15, Heft 2, Seite(n) 101654

    Mesh-Begriff(e) Humans ; Critical Pathways ; Multimorbidity ; Patient-Centered Care ; Quality of Life ; Neoplasms/epidemiology ; Neoplasms/therapy
    Sprache Englisch
    Erscheinungsdatum 2023-11-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2023.101654
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: The prognostic value of a geriatric risk score for older patients undergoing emergency surgery of colorectal cancer: A retrospective cohort study.

    Hultink, Daniëlle / Souwer, Esteban T D / Bastiaannet, Esther / Dekker, Jan-Willem T / Steup, W H / Hamaker, Marije E / Sonneveld, Dirk J A / Consten, Esther C J / Neijenhuis, Peter A / Portielje, Johanna E A / van den Bos, Frederiek

    Journal of geriatric oncology

    2024  Band 15, Heft 2, Seite(n) 101711

    Abstract: Introduction: Emergency surgery of colorectal cancer is associated with high mortality rates in older patients. We investigated whether information on four geriatric domains has prognostic value for 30-day mortality and postoperative morbidity including ...

    Abstract Introduction: Emergency surgery of colorectal cancer is associated with high mortality rates in older patients. We investigated whether information on four geriatric domains has prognostic value for 30-day mortality and postoperative morbidity including severe complications.
    Materials and methods: All consecutive patients aged 70 years or older who underwent emergency colorectal cancer surgery in six Dutch hospitals (2014-2017) were studied. Presence of geriatric risk factors was scored prior to surgery as either 0 (risk absent) or 1 (risk present) in each of four geriatric domains and summed up to calculate a sumscore with a value between 0 and 4. In addition, we separately investigated the use of a mobility aid. Primary outcome was 30-day mortality. Secondary outcomes were any postoperative complications and severe complications. Multivariable logistic regression model was used to evaluate the sumscore and outcomes.
    Results: Two hundred seven patients were included. Median age was 79.4 years. One hundred seventy-five patients (76%) presented with obstruction, 22 (11%) with a perforation, and 17 (8%) with severe anemia. Mortality rates were 2.9%, 13.6%, and 29.6% for patients with a sumscore of 0, 1-2, and 3-4 respectively, with odds ratio (OR) 4.8 [95% confidence interval (CI) 1.03-22.95] and OR 10.6 [95% CI 1.99-56.34] for a sumscore of 1-2 and 3-4 respectively. Use of a mobility aid was associated with increased mortality OR 8.0 [95% CI 2.74-23.43] and severe complications OR 2.31 [95% CI 1.17-4.55].
    Discussion: This geriatric sumscore and the use of a mobility aid have strong association with 30-day mortality after emergency surgery of colorectal cancer. This could provide better insight into surgical risk and help select high-risk patients for alternative strategies.
    Mesh-Begriff(e) Humans ; Aged ; Prognosis ; Retrospective Studies ; Risk Factors ; Postoperative Complications ; Colorectal Neoplasms/surgery
    Sprache Englisch
    Erscheinungsdatum 2024-02-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2024.101711
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Diagnostiek bij zeer oude ouderen.

    Hamaker, Marije E / van Huis, Lieke H

    Nederlands tijdschrift voor geneeskunde

    2019  Band 163

    Abstract: This paper focuses on considerations regarding diagnostics in case of a suspected malignancy in a very old or frail patient. The patient's preference and life-perspective lie at the core of shared decision-making. From a medical point of view, the ... ...

    Titelübersetzung Diagnostics in very old patients; when to apply it or not in cases of suspected malignancy?
    Abstract This paper focuses on considerations regarding diagnostics in case of a suspected malignancy in a very old or frail patient. The patient's preference and life-perspective lie at the core of shared decision-making. From a medical point of view, the estimated life-expectancy may be so short that further diagnostic testing for a malignancy may only be useful when there are treatable symptoms in play. In other cases, prior to diagnostics there may already be a suspicion that there will be no feasible oncologic treatment options. From the perspective of advance care planning and symptomatic treatment, it can nonetheless still be useful to confirm the presence of a malignancy through imaging diagnostics. Obtaining tissue for further specification in very old or frail patients is only useful when an easily tolerated, yet effective treatment is likely or possible, such as endocrine treatment in case of prostate cancer or breast cancer.
    Mesh-Begriff(e) Advance Care Planning ; Aged ; Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Frail Elderly ; Humans ; Male ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/drug therapy ; Treatment Outcome
    Chemische Substanzen Antineoplastic Agents, Hormonal
    Sprache Niederländisch
    Erscheinungsdatum 2019-05-27
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Ua VI Zs.18: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Artikel: How to incorporate chronic health conditions in oncologic decision-making and care for older patients with cancer? A survey among healthcare professionals.

    Seghers, P A L Nelleke / Rostoft, Siri / O'Hanlon, Shane / O'Donovan, Anita / Schulkes, Karlijn / Montroni, Isacco / Portielje, Johanneke E A / Wildiers, Hans / Soubeyran, Pierre / Hamaker, Marije E

    European geriatric medicine

    2024  

    Abstract: Purpose: A substantial proportion of patients with cancer are older and experience multimorbidity. As the population is ageing, the management of older patients with multimorbidity including cancer will represent a significant challenge to current ... ...

    Abstract Purpose: A substantial proportion of patients with cancer are older and experience multimorbidity. As the population is ageing, the management of older patients with multimorbidity including cancer will represent a significant challenge to current clinical practice.
    Methods: This study aimed to (1) identify which chronic health conditions may cause change in oncologic decision-making and care in older patients and (2) provide guidance on how to incorporate these in decision-making and care provision of older patients with cancer. Based on a scoping literature review, an initial list of prevalent morbidities was developed. A subsequent survey among healthcare providers involved in the care for older patients with cancer assessed which chronic health conditions were relevant and why.
    Results: A list of 53 chronic health conditions was developed, of which 34 were considered likely or very likely to influence decision-making or care according to the 39 healthcare professionals who responded. These conditions were further categorized into five patient profiles. From these conditions, five patient profiles were developed, namely, (1) a somatic profile consisting of cardiovascular, metabolic, and pulmonary disease, (2) a functional profile, including conditions that cause disability, dependency or a high caregiver burden, (3) a psychosocial profile, including cognitive impairment, (4) a nutritional profile also including digestive system diseases, and finally, (5) a concurrent cancer profile. All profiles were considered likely to impact decision-making with differences between treatment modalities. The impact on the care trajectory was generally considered less significant, except for patients with care dependency and psychosocial health problems.
    Conclusions: Chronic health conditions have various ways of influencing oncologic decision-making and the care trajectory in older adults with cancer. Understanding why specific chronic health conditions may impact the oncologic care trajectory can aid clinicians in the management of older patients with multimorbidity, including cancer.
    Sprache Englisch
    Erscheinungsdatum 2024-03-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2556794-9
    ISSN 1878-7657 ; 1878-7649
    ISSN (online) 1878-7657
    ISSN 1878-7649
    DOI 10.1007/s41999-023-00919-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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