LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 52

Search options

  1. Article ; Online: To die or not to die - How mitochondrial processes affect lifespan of Podospora anserina.

    Hamann, Andrea / Osiewacz, Heinz D

    Biochimica et biophysica acta. Bioenergetics

    2022  Volume 1863, Issue 6, Page(s) 148568

    Abstract: The filamentous ascomycete Podospora anserina is a well-established model system to study organismic aging. Its senescence syndrome has been investigated for more than fifty years and turned out to have a strong mitochondrial etiology. Several different ... ...

    Abstract The filamentous ascomycete Podospora anserina is a well-established model system to study organismic aging. Its senescence syndrome has been investigated for more than fifty years and turned out to have a strong mitochondrial etiology. Several different mitochondrial pathways were demonstrated to affect aging and lifespan. Here, we present an update of the literature focusing on the cooperative interplay between different processes.
    MeSH term(s) Longevity ; Mitochondria/metabolism ; Podospora/metabolism
    Language English
    Publishing date 2022-05-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2650 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2650 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbabio.2022.148568
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: To die or not to die – How mitochondrial processes affect lifespan of Podospora anserina

    Hamann, Andrea / Osiewacz, Heinz D.

    Biochimica et biophysica acta. 2022 Aug. 01, v. 1863, no. 6

    2022  

    Abstract: The filamentous ascomycete Podospora anserina is a well-established model system to study organismic aging. Its senescence syndrome has been investigated for more than fifty years and turned out to have a strong mitochondrial etiology. Several different ... ...

    Abstract The filamentous ascomycete Podospora anserina is a well-established model system to study organismic aging. Its senescence syndrome has been investigated for more than fifty years and turned out to have a strong mitochondrial etiology. Several different mitochondrial pathways were demonstrated to affect aging and lifespan. Here, we present an update of the literature focusing on the cooperative interplay between different processes.
    Keywords Podospora anserina ; etiology ; longevity ; mitochondria
    Language English
    Dates of publication 2022-0801
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 282711-6
    ISSN 0005-2728 ; 0304-4173
    ISSN 0005-2728 ; 0304-4173
    DOI 10.1016/j.bbabio.2022.148568
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Sordaria macrospora

    Hamann, Andrea / Osiewacz, Heinz D / Teichert, Ines

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 10

    Abstract: The formation of fruiting bodies is a highly regulated process that requires the coordinated formation of different cell types. By analyzing developmental mutants, many developmental factors have already been identified. Yet, a complete understanding of ... ...

    Abstract The formation of fruiting bodies is a highly regulated process that requires the coordinated formation of different cell types. By analyzing developmental mutants, many developmental factors have already been identified. Yet, a complete understanding of fruiting body formation is still lacking. In this study, we analyzed developmental mutant pro34 of the filamentous ascomycete
    Language English
    Publishing date 2022-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8101015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Lifespan Increase of

    Schürmanns, Lea / Hamann, Andrea / Osiewacz, Heinz D

    Cells

    2022  Volume 11, Issue 3

    Abstract: The maintenance of cellular homeostasis over time is essential to avoid the degeneration of biological systems leading to aging and disease. Several interconnected pathways are active in this kind of quality control. One of them is autophagy, the ... ...

    Abstract The maintenance of cellular homeostasis over time is essential to avoid the degeneration of biological systems leading to aging and disease. Several interconnected pathways are active in this kind of quality control. One of them is autophagy, the vacuolar degradation of cellular components. The absence of the sorting nexin PaATG24 (SNX4 in other organisms) has been demonstrated to result in impairments in different types of autophagy and lead to a shortened lifespan. In addition, the growth rate and the size of vacuoles are strongly reduced. Here, we report how an oleic acid diet leads to longevity of the wild type and a
    MeSH term(s) Autophagy ; Energy Metabolism ; Humans ; Longevity ; Mitochondria/metabolism ; Oleic Acid/metabolism ; Podospora
    Chemical Substances Oleic Acid (2UMI9U37CP)
    Language English
    Publishing date 2022-02-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11030519
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation.

    Key, Jana / Gispert, Suzana / Kandi, Arvind Reddy / Heinz, Daniela / Hamann, Andrea / Osiewacz, Heinz D / Meierhofer, David / Auburger, Georg

    Biomolecules

    2024  Volume 14, Issue 2

    Abstract: The serine peptidase CLPP is conserved among bacteria, chloroplasts, and mitochondria. In humans and mice, its loss causes Perrault syndrome, which presents with growth deficits, infertility, deafness, and ataxia. In the filamentous ... ...

    Abstract The serine peptidase CLPP is conserved among bacteria, chloroplasts, and mitochondria. In humans and mice, its loss causes Perrault syndrome, which presents with growth deficits, infertility, deafness, and ataxia. In the filamentous fungus
    MeSH term(s) Animals ; Mice ; Arginine ; Avena/metabolism ; Endopeptidase Clp/genetics ; Endopeptidase Clp/metabolism ; Eukaryota/metabolism ; Heme/metabolism ; Histidine ; Organic Anion Transporters
    Chemical Substances Arginine (94ZLA3W45F) ; Endopeptidase Clp (EC 3.4.21.92) ; Heme (42VZT0U6YR) ; Histidine (4QD397987E) ; CLPP protein, mouse (EC 3.4.21.92) ; CLPX protein, mouse (EC 3.6.1.3) ; Organic Anion Transporters
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14020241
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Simultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension.

    Heinz, Daniela / Krotova, Evgeniia / Hamann, Andrea / Osiewacz, Heinz D

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 616520

    Abstract: Organismic aging is known to be controlled by genetic and environmental traits. Pathways involved in the control of cellular metabolism play a crucial role. Previously, we identified a role of PaCLPP, a mitochondrial matrix protease, in the control of ... ...

    Abstract Organismic aging is known to be controlled by genetic and environmental traits. Pathways involved in the control of cellular metabolism play a crucial role. Previously, we identified a role of PaCLPP, a mitochondrial matrix protease, in the control of the mitochondrial energy metabolism, aging, and lifespan of the fungal aging model
    Language English
    Publishing date 2021-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.616520
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Mitochondrial Phospholipid Homeostasis Is Regulated by the i-AAA Protease PaIAP and Affects Organismic Aging.

    Löser, Timo / Joppe, Aljoscha / Hamann, Andrea / Osiewacz, Heinz D

    Cells

    2021  Volume 10, Issue 10

    Abstract: Mitochondria are ubiquitous organelles of eukaryotic organisms with a number of essential functions, including synthesis of iron-sulfur clusters, amino acids, lipids, and adenosine triphosphate (ATP). During aging of the fungal aging ... ...

    Abstract Mitochondria are ubiquitous organelles of eukaryotic organisms with a number of essential functions, including synthesis of iron-sulfur clusters, amino acids, lipids, and adenosine triphosphate (ATP). During aging of the fungal aging model
    MeSH term(s) ATPases Associated with Diverse Cellular Activities/metabolism ; Cardiolipins/metabolism ; Fermentation/drug effects ; Fungal Proteins/metabolism ; Gene Deletion ; Glycerol/pharmacology ; Homeostasis/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondrial Dynamics/drug effects ; Mitochondrial Proteins/metabolism ; Phospholipids/metabolism ; Podospora/drug effects ; Podospora/genetics ; Podospora/growth & development ; Podospora/metabolism ; Proteolysis/drug effects
    Chemical Substances Cardiolipins ; Fungal Proteins ; Mitochondrial Proteins ; Phospholipids ; ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-) ; Glycerol (PDC6A3C0OX)
    Language English
    Publishing date 2021-10-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10102775
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book ; Online: Le contentieux de la mise en conformité dans le règlement des différends de l'O.M.C. / Adjudicating Compliance in the WTO Dispute Settlement System

    Hamann, Andrea

    (Études de Droit International)

    2014  

    Abstract: Le contentieux de la mise en conformité dans le règlement des différends de l'O.M.C. offers an analysis of the unique design of the WTO dispute settlement system, which draws the implementation process into the sphere of adjudication.Le contentieux de la ...

    Series title Études de Droit International
    Abstract Le contentieux de la mise en conformité dans le règlement des différends de l'O.M.C. offers an analysis of the unique design of the WTO dispute settlement system, which draws the implementation process into the sphere of adjudication.Le contentieux de la mise en conformité dans le règlement des différends de l'O.M.C. vise à démontrer la conception unique de la fonction juridictionnelle à l'O.M.C., de laquelle l'exécution des décisions rendues est une partie intégrante
    Language French
    Size Online-Ressource (860 p)
    Publisher BRILL
    Publishing place Leiden
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9789004263109 ; 9004263101
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Reconstruction of Protein-Protein Interaction Networks Using Homology-Based Search: Application to the Autophagy Pathway of Aging in Podospora anserina.

    Koch, Ina / Philipp, Oliver / Hamann, Andrea / Osiewacz, Heinz

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 2074, Page(s) 45–55

    Abstract: The integration of the available experimental data represents a main problem in systems biology. In particular, in medical sciences, many new data became available, but often data are incomplete and of different quality and quantity. Here, we describe a ... ...

    Abstract The integration of the available experimental data represents a main problem in systems biology. In particular, in medical sciences, many new data became available, but often data are incomplete and of different quality and quantity. Here, we describe a method for the automatic derivation of protein-protein interaction networks based on homology search, which is applicable to arbitrary pathways and species. We implemented the method as a freely available open-source R package. To demonstrate the application of the method, we consider the autophagy pathway in the filamentous fungus Podospora anserina, which represents an established model organism to unravel the mechanisms of biological aging. Further, we apply network analysis methods to prove the reliability of the network.
    MeSH term(s) Aging/physiology ; Autophagy ; Fungal Proteins/chemistry ; Fungal Proteins/metabolism ; Podospora/metabolism ; Podospora/physiology ; Protein Interaction Maps
    Chemical Substances Fungal Proteins
    Language English
    Publishing date 2019-10-03
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9873-9_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Book ; Online: Schlussbericht zum GerontoSys-Projekt GerontoMitoSys ( Teilprojekt A)

    Hamann, Andrea / Osiewacz, Heinz D

    Netzwerke mitochondrialer Reaktionswege der Kontrolle von Alterung und Lebensspanne - ein systembiologischer Ansatz ; Veröffentlichung der Ergebnisse von Forschungsvorhaben im BMBF-Programm GerontoSys

    2014  

    Author's details Autoren dieses Berichtes: Heinz D. Osiewacz, Andrea Hamann
    Language German
    Size Online-Ressource (21 S., 650 KB)
    Publisher Technische Informationsbibliothek u. Universitätsbibliothek ; Univ., Inst. für Molekulare Biowiss
    Publishing place Hannover ; Frankfurt
    Document type Book ; Online
    Note Förderkennzeichen BMBF 0315584A. - Verbund-Nr. 01074783 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top