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  1. Article ; Online: How persons with systemic mastocytosis describe the time between symptom onset and receiving diagnosis.

    Hamberg Levedahl, Kerstin / Nilsson, Annika / Johansson, Birgitta / Hedström, Mariann

    Primary health care research & development

    2022  Volume 23, Page(s) e54

    Abstract: Aim: The aim of the study was to explore how persons with systemic mastocytosis (SM) described the time between the onset of symptoms and signs and getting the diagnosis.: Background: SM is a rare disease caused by the accumulation of clonal mast ... ...

    Abstract Aim: The aim of the study was to explore how persons with systemic mastocytosis (SM) described the time between the onset of symptoms and signs and getting the diagnosis.
    Background: SM is a rare disease caused by the accumulation of clonal mast cells with abnormal function. The symptoms and signs of the disease are varied, often diffuse and affect individuals differently. Due to this complexity, a multi-disciplinary diagnostic approach is required, in which general practitioners play an important part in identifying and referring patients relevant for such investigations.
    Methods: Sixteen persons with SM were interviewed about their experiences of the time before the diagnosis was received. Systematic text condensation was used in the analysis process.
    Findings: The time between symptom and signs onset and diagnosis was perceived as difficult. SM often had a complex and unpredictable effect on a person's daily life, long before diagnosis. In the analysis, three themes were found.
    MeSH term(s) Humans ; Mast Cells ; Mastocytosis, Systemic/diagnosis ; Surveys and Questionnaires
    Language English
    Publishing date 2022-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2027892-5
    ISSN 1477-1128 ; 1477-1128
    ISSN (online) 1477-1128
    ISSN 1477-1128
    DOI 10.1017/S146342362200024X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Delineating functional and molecular impact of ex vivo sample handling in precision medicine.

    Struyf, Nona / Österroos, Albin / Vesterlund, Mattias / Arnroth, Cornelia / James, Tojo / Sunandar, Stephanie / Mermelekas, Georgios / Bohlin, Anna / Hamberg Levedahl, Kerstin / Bengtzén, Sofia / Jafari, Rozbeh / Orre, Lukas M / Lehtiö, Janne / Lehmann, Sören / Östling, Päivi / Kallioniemi, Olli / Seashore-Ludlow, Brinton / Erkers, Tom

    NPJ precision oncology

    2024  Volume 8, Issue 1, Page(s) 38

    Abstract: Consistent handling of samples is crucial for achieving reproducible molecular and functional testing results in translational research. Here, we used 229 acute myeloid leukemia (AML) patient samples to assess the impact of sample handling on high- ... ...

    Abstract Consistent handling of samples is crucial for achieving reproducible molecular and functional testing results in translational research. Here, we used 229 acute myeloid leukemia (AML) patient samples to assess the impact of sample handling on high-throughput functional drug testing, mass spectrometry-based proteomics, and flow cytometry. Our data revealed novel and previously described changes in cell phenotype and drug response dependent on sample biobanking. Specifically, myeloid cells with a CD117 (c-KIT) positive phenotype decreased after biobanking, potentially distorting cell population representations and affecting drugs targeting these cells. Additionally, highly granular AML cell numbers decreased after freezing. Secondly, protein expression levels, as well as sensitivity to drugs targeting cell proliferation, metabolism, tyrosine kinases (e.g., JAK, KIT, FLT3), and BH3 mimetics were notably affected by biobanking. Moreover, drug response profiles of paired fresh and frozen samples showed that freezing samples can lead to systematic errors in drug sensitivity scores. While a high correlation between fresh and frozen for the entire drug library was observed, freezing cells had a considerable impact at an individual level, which could influence outcomes in translational studies. Our study highlights conditions where standardization is needed to improve reproducibility, and where validation of data generated from biobanked cohorts may be particularly important.
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-024-00528-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Strict self-isolation did not protect Swedish cancer patients on active treatment from the risk of becoming seropositive for SARS-CoV-2.

    Ginman, Beatrice / Pahnke, Simon / Freyhult, Eva / Hoffman, Tove / Kolstad, Linda / Rönnberg, Bengt / Lundkvist, Åke / Hamberg Levedahl, Kerstin / Enblad, Gunilla / Glimelius, Ingrid

    Acta oncologica (Stockholm, Sweden)

    2023  Volume 62, Issue 12, Page(s) 1707–1715

    Abstract: Background: Swedish recommendations to reduce the risk of COVID-19 relied on each citizen's own sense of responsibility rather than mandatory lockdowns. We studied how COVID-19-related self-isolation and anxiety correlated to SARS-CoV-2 seropositivity ... ...

    Abstract Background: Swedish recommendations to reduce the risk of COVID-19 relied on each citizen's own sense of responsibility rather than mandatory lockdowns. We studied how COVID-19-related self-isolation and anxiety correlated to SARS-CoV-2 seropositivity and PCR-positivity in patients with active cancer treatment.
    Methods: In a longitudinal cohort study at Uppsala University Hospital patients and cancer personnel were included between April 1
    Results: A total of 622 patients [
    Conclusion: For Swedish patients on active cancer treatment, high self-assessed COVID-19-related anxiety or strict adherence to self-isolation guidelines were not associated with
    MeSH term(s) Humans ; Female ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/prevention & control ; Sweden/epidemiology ; Longitudinal Studies ; Communicable Disease Control ; Neoplasms/epidemiology ; Neoplasms/therapy
    Language English
    Publishing date 2023-11-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 896449-x
    ISSN 1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
    ISSN (online) 1651-226X
    ISSN 0349-652X ; 0284-186X ; 1100-1704
    DOI 10.1080/0284186X.2023.2257873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: CD203c distinguishes the erythroid and mast cell-basophil differentiation trajectories among human FcεRI

    Grootens, Jennine / Ungerstedt, Johanna S / Wu, Chenyan / Hamberg Levedahl, Kerstin / Nilsson, Gunnar / Dahlin, Joakim S

    Allergy

    2019  Volume 75, Issue 1, Page(s) 211–214

    MeSH term(s) Basophils/immunology ; Bone Marrow Cells/immunology ; Cell Differentiation/immunology ; Hematopoietic Stem Cells/immunology ; Humans ; Mast Cells/immunology ; Phosphoric Diester Hydrolases/immunology ; Pyrophosphatases/immunology ; Receptors, IgE/immunology
    Chemical Substances ENPP3 protein, human ; Receptors, IgE ; Phosphoric Diester Hydrolases (EC 3.1.4.-) ; Pyrophosphatases (EC 3.6.1.-)
    Language English
    Publishing date 2019-08-01
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.13981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.150: Show issues Location:
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    Zs.MO 125: Show issues

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