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Article ; Online: Pyrogenic lower limbs.

Angeli, Eurydice / Padrón González, Alexander Ariel / Hamdan, Diaddin / Pop, Gabriel / Falgarone, Géraldine / Bousquet, Guilhem

Annals of the rheumatic diseases

2022 Volume 82, Issue 5, Page(s) 719–720

Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/ard-2022-222938
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Genomics of Breast Cancer Brain Metastases: A Meta-Analysis and Therapeutic Implications.

Nguyen, Thuy Thi / Hamdan, Diaddin / Angeli, Eurydice / Feugeas, Jean-Paul / Le, Quang Van / Pamoukdjian, Frédéric / Bousquet, Guilhem

Cancers

2023 Volume 15, Issue 6

Abstract: Breast cancer brain metastases are a challenging daily practice, and the biological link between gene mutations and metastatic spread to the brain remains to be determined. Here, we performed a meta-analysis on genomic data obtained from primary tumors, ... ...

Abstract	Breast cancer brain metastases are a challenging daily practice, and the biological link between gene mutations and metastatic spread to the brain remains to be determined. Here, we performed a meta-analysis on genomic data obtained from primary tumors, extracerebral metastases and brain metastases, to identify gene alterations associated with metastatic processes in the brain. Articles with relevant findings were selected using Medline via PubMed, from January 1999 up to February 2022. A critical review was conducted according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement (PRISMA). Fifty-seven publications were selected for this meta-analysis, including 37,218 patients in all, 11,906 primary tumor samples, 5541 extracerebral metastasis samples, and 1485 brain metastasis samples. We report the overall and sub-group prevalence of gene mutations, including comparisons between primary tumors, extracerebral metastases and brain metastases. In particular, we identified six genes with a higher mutation prevalence in brain metastases than in extracerebral metastases, with a potential role in metastatic processes in the brain:
Language	English
Publishing date	2023-03-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15061728
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Olaparib in the Setting of Radiotherapy-Associated Sarcoma: What Can Precision Medicine Offer For Rare Cancers?

Hamdan, Diaddin / Marisa, Laetitia / Tlemsani, Camille / Angeli, Eurydice / Soussan, Michael / Derive, Nicolas / Laurent-Puig, Pierre / Bousquet, Guilhem

JCO precision oncology

2023 Volume 7, Page(s) e2200582

MeSH term(s)	Humans ; Precision Medicine ; Sarcoma/drug therapy ; Phthalazines/therapeutic use ; Piperazines/adverse effects
Chemical Substances	olaparib (WOH1JD9AR8) ; Phthalazines ; Piperazines
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.22.00582
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Sub-Group of Kidney-Transplant Recipients with Highly Aggressive Squamous Cell Carcinoma Expressing Phosphorylated Serine392p53.

Hamdan, Diaddin / Gardair, Charlotte / Pamoukdjian, Frédéric / Peraldi Gardin, Marie-Noëlle / Nakouri, Inès / Leboeuf, Christophe / Janin, Anne / Lebbé, Céleste / Battistella, Maxime / Bousquet, Guilhem

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Cutaneous squamous cell carcinomas in kidney-transplant recipients are frequent, with an increasing incidence linked to long immunosuppression durations and exposure to ultraviolet radiation. p53 is at the cornerstone of ultraviolet-induced DNA damage, ... ...

Abstract	Cutaneous squamous cell carcinomas in kidney-transplant recipients are frequent, with an increasing incidence linked to long immunosuppression durations and exposure to ultraviolet radiation. p53 is at the cornerstone of ultraviolet-induced DNA damage, but the role of p53 post-translational modifications in this context is not yet deciphered. Here, we investigated the phosphorylation status of p53 at Serine 392 in 25 cutaneous squamous cell carcinomas in kidney-transplant recipients, compared with 22 non-transplanted patients. Cutaneous squamous cell carcinomas in transplanted patients occurred after a median period of 19 years of immunosuppression, with a median number of 15 cutaneous squamous cell carcinomas and more aggressive histological and clinical characteristics. There was no significant difference between Ki67, p53, and pSer392p53 expression in the two groups. Using principal component analysis, we identified a cluster of exclusively transplanted patients with a median of 23 years of immunosuppression duration, significantly more aggressive biological characteristics, and higher pSer392p53 expression. pSer392p53 was expressed in the whole tumor, suggesting an early carcinogenic event in the course of prolonged immunosuppression. This high, diffuse pSer392p53 expression, corresponding to a high level of DNA damage, might be useful to identify aggressive cutaneous squamous cell carcinomas in kidney-transplant recipients to treat them more aggressively.
MeSH term(s)	Humans ; Transplant Recipients ; Tumor Suppressor Protein p53/genetics ; Ultraviolet Rays ; Carcinoma, Squamous Cell/genetics ; Kidney
Chemical Substances	Tumor Suppressor Protein p53
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021147
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A massive open online course to teach undergraduate medical students in oncology: keys of success

Hamdan, Diaddin / Pamoukdjian, Frédéric / Lehmann-Che, Jaqueline / de Bazelaire, Cédric / Vercellino, Laetitia / Calvani, Julien / Battistella, Maxime / Bertheau, Philippe / Falgarone, Géraldine / Bousquet, Guilhem

Heliyon. 2022 Nov., v. 8, no. 11 p.e11306-

2022

Abstract: Massive Open Online Courses (MOOCs) are gaining popularity in education while classroom lectures are being deserted, especially after COVID-19 pandemic. Their added value in teaching undergraduate medical students remains to be confirmed. This study ... ...

Abstract	Massive Open Online Courses (MOOCs) are gaining popularity in education while classroom lectures are being deserted, especially after COVID-19 pandemic. Their added value in teaching undergraduate medical students remains to be confirmed. This study evaluated a MOOC devoted to undergraduate medical students in a blended oncology-teaching university program. It was the first to target undergraduate medical students in oncology at its beginning. Students were asked to participate in a survey before and after MOOC to explore interactions between their characteristics and final grades, 65% of the participating students belonged to the rich class. 70% of the students completed the MOOC. Grades distributions were similar before and after MOOC implementation, so MOOC doesn't alter overall results. In addition, there was a positive effect of the MOOC on median grades on the immediate test. The univariate and multivariate analysis showed that socioeconomic status and student's willingness to participate interacted significantly with final results. Particularly, students' motivation and satisfaction were associated with better results; Almost 70% of students asked for blended learning. E-learning is reliable to teach oncology to undergraduate medical students. The success is directly linked to students’ willingness to participate, and can be improved using blended methods including tutorials.
Keywords	COVID-19 infection ; electronic learning ; motivation ; multivariate analysis ; online courses ; socioeconomic status ; surveys ; university programs ; MOOC ; Oncology ; Medical undergraduates ; Student perception ; Success factors
Language	English
Dates of publication	2022-11
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e11306
Database	NAL-Catalogue (AGRICOLA)

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Article: A Fab of trastuzumab to treat HER2 overexpressing breast cancer brain metastases.

Angeli, Eurydice / Paris, Justine / Le Tilly, Olivier / Desvignes, Céline / Gapihan, Guillaume / Boquet, Didier / Pamoukdjian, Frédéric / Hamdan, Diaddin / Rigal, Marthe / Poirier, Florence / Lutomski, Didier / Azibani, Feriel / Mebazaa, Alexandre / Herbet, Amaury / Mabondzo, Aloïse / Falgarone, Géraldine / Janin, Anne / Paintaud, Gilles / Bousquet, Guilhem

Experimental hematology & oncology

2024 Volume 13, Issue 1, Page(s) 41

Abstract: Despite major therapeutic advances for two decades, including the most recently approved anti-HER2 drugs, brain metastatic localizations remain the major cause of death for women with metastatic HER2 breast cancer. The main reason is the limited drug ... ...

Abstract	Despite major therapeutic advances for two decades, including the most recently approved anti-HER2 drugs, brain metastatic localizations remain the major cause of death for women with metastatic HER2 breast cancer. The main reason is the limited drug passage of the blood-brain barrier after intravenous injection and the significant efflux of drugs, including monoclocal antibodies, after administration into the cerebrospinal fluid. We hypothesized that this efflux was linked to the presence of a FcRn receptor in the blood-brain barrier. To overcome this efflux, we engineered two Fab fragments of trastuzumab, an anti-HER2 monoclonal antibody, and did a thorough preclinical development for therapeutic translational purpose. We demonstrated the safety and equal efficacy of the Fabs with trastuzumab in vitro, and in vivo using a patient-derived xenograft model of HER2 overexpressing breast cancer. For the pharmacokinetic studies of intra-cerebrospinal fluid administration, we implemented original rat models with catheter implanted into the cisterna magna. After intraventricular administration in rats, we demonstrated that the brain-to-blood efflux of Fab was up to 10 times lower than for trastuzumab, associated with a two-fold higher brain penetration compared to trastuzumab. This Fab, capable of significantly reducing brain-to-blood efflux and enhancing brain penetration after intra-cerebrospinal fluid injection, could thus be a new and original effective drug in the treatment of HER2 breast cancer brain metastases, which will be demonstrated by a phase I clinical trial dedicated to women in resort situations.
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Letter
ZDB-ID	2669066-4
ISSN	2162-3619
ISSN	2162-3619
DOI	10.1186/s40164-024-00513-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: PROM2 overexpression induces metastatic potential through epithelial-to-mesenchymal transition and ferroptosis resistance in human cancers.

Paris, Justine / Wilhelm, Claire / Lebbé, Celeste / Elmallah, Mohammed / Pamoukdjian, Frédéric / Héraud, Audrey / Gapihan, Guillaume / Walle, Aurore Van De / Tran, Van Nhan / Hamdan, Diaddin / Allayous, Clara / Battistella, Maxime / Van Glabeke, Emmanuel / Lim, Kah Wai / Leboeuf, Christophe / Roger, Sébastien / Falgarone, Géraldine / Phan, Anh Tuan / Bousquet, Guilhem

Clinical and translational medicine

2024 Volume 14, Issue 3, Page(s) e1632

Abstract: Introduction: Despite considerable therapeutic advances in the last 20 years, metastatic cancers remain a major cause of death. We previously identified prominin-2 (PROM2) as a biomarker predictive of distant metastases and decreased survival, thus ... ...

Abstract	Introduction: Despite considerable therapeutic advances in the last 20 years, metastatic cancers remain a major cause of death. We previously identified prominin-2 (PROM2) as a biomarker predictive of distant metastases and decreased survival, thus providing a promising bio-target. In this translational study, we set out to decipher the biological roles of PROM2 during the metastatic process and resistance to cell death, in particular for metastatic melanoma. Methods and results: Methods and results: We demonstrated that PROM2 overexpression was closely linked to an increased metastatic potential through the increase of epithelial-to-mesenchymal transition (EMT) marker expression and ferroptosis resistance. This was also found in renal cell carcinoma and triple negative breast cancer patient-derived xenograft models. Using an oligonucleotide anti-sense anti-PROM2, we efficaciously decreased PROM2 expression and prevented metastases in melanoma xenografts. We also demonstrated that PROM2 was implicated in an aggravation loop, contributing to increase the metastatic burden both in murine metastatic models and in patients with metastatic melanoma. The metastatic burden is closely linked to PROM2 expression through the expression of EMT markers and ferroptosis cell death resistance in a deterioration loop. Conclusion: Our results open the way for further studies using PROM2 as a bio-target in resort situations in human metastatic melanoma and also in other cancer types.
MeSH term(s)	Humans ; Animals ; Mice ; Melanoma ; Ferroptosis/genetics ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition/genetics ; Membrane Glycoproteins
Chemical Substances	PROM2 protein, human ; Membrane Glycoproteins
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2697013-2
ISSN	2001-1326 ; 2001-1326
ISSN (online)	2001-1326
ISSN	2001-1326
DOI	10.1002/ctm2.1632
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The germline genetics of mild-to-moderate penetrance: An intriguing role of

Hamdan, Diaddin / Nguyen, Van Tai / Paris, Justine / Leboeuf, Christophe / El Bouchtaoui, Morad / Espié, Marc / Janin, Anne / Falgarone, Géraldine / Di Benedetto, Mélanie / Bousquet, Guilhem

Genes & diseases

2023 Volume 11, Issue 3, Page(s) 101003

Language	English
Publishing date	2023-06-30
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	2821806-1
ISSN	2352-3042 ; 2352-3042
ISSN (online)	2352-3042
ISSN	2352-3042
DOI	10.1016/j.gendis.2023.04.034
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Article ; Online: Genomics applied to the treatment of breast cancer.

Hamdan, Diaddin / Nguyen, Thi Thuy / Leboeuf, Christophe / Meles, Solveig / Janin, Anne / Bousquet, Guilhem

Oncotarget

2019 Volume 10, Issue 46, Page(s) 4786–4801

Abstract: Breast cancer remains a major health issue in the world with 1.7 million new cases in 2012 worldwide. It is the second cause of death from cancer in western countries. Genomics have started to modify the treatment of breast cancer, and the developments ... ...

Abstract	Breast cancer remains a major health issue in the world with 1.7 million new cases in 2012 worldwide. It is the second cause of death from cancer in western countries. Genomics have started to modify the treatment of breast cancer, and the developments should become more and more significant, especially in the present era of treatment personalization and with the implementation of new technologies. With molecular signatures, genomics enabled a de-escalation of chemotherapy and personalized treatments of localized forms of estrogen-dependent breast cancers. Genomics can also make a real contribution to constitutional genetics, so as to identify mutations in a panel of candidate genes. In this review, we will discuss the contributions of genomics applied to the treatment of breast cancer, whether already validated contributions or possible future applications linked to research data.
Language	English
Publishing date	2019-07-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.27102
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Re-exploring immune-related side effects of docetaxel in an observational study: Blood hypereosinophilia.

Hamdan, Diaddin / Leboeuf, Christophe / Le Foll, Christine / Bousquet, Guilhem / Janin, Anne

Cancer medicine

2019 Volume 8, Issue 5, Page(s) 2005–2012

Abstract: Docetaxel is a major anticancer drug that can induce hypersensitivity reactions leading to deleterious treatment interruptions. Blood hypereosinophilia could be a biological sign, potentially lethal, of delayed visceral hypersensitivity reactions. We ... ...

Abstract	Docetaxel is a major anticancer drug that can induce hypersensitivity reactions leading to deleterious treatment interruptions. Blood hypereosinophilia could be a biological sign, potentially lethal, of delayed visceral hypersensitivity reactions. We hypothesized this biological event is probably underreported. In this prospective observational study, we followed up 149 patients treated with docetaxel monotherapy for breast or lung cancer. For each patient, blood eosinophil counts were recorded during docetaxel treatment and up to 3 months after the end of docetaxel treatment. For all patients, blood eosinophil counts significantly increased under docetaxel chemotherapy (P < 0.01). Seven percent had persistent eosinophilia after the end of treatment. Four patients had blood eosinophil counts over 1000/mm
MeSH term(s)	Antineoplastic Agents/adverse effects ; Docetaxel/adverse effects ; Drug Hypersensitivity/blood ; Drug Hypersensitivity/etiology ; Eosinophilia/etiology ; Humans ; Leukocyte Count ; Middle Aged
Chemical Substances	Antineoplastic Agents ; Docetaxel (15H5577CQD)
Language	English
Publishing date	2019-03-10
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	2045-7634
ISSN (online)	2045-7634
DOI	10.1002/cam4.2062
Database	MEDical Literature Analysis and Retrieval System OnLINE

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