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  1. Book: Immunmodulation in der Allergie- und Asthmatherapie

    Hamelmann, Eckard

    (UNI-MED Science)

    2006  

    Author's details [Hrsg.: Eckhard Hamelmann ...]
    Series title UNI-MED Science
    Keywords Allergie ; Immunmodulation ; Bronchialasthma
    Subject Immunsystem ; Immunomodulation ; Asthma bronchiale ; Asthma ; Hypersensibilität ; Allergose ; Allergische Krankheit ; Allergische Reaktion ; Allergien
    Language German
    Size 85 S. : zahlr. Ill.u. graph. Darst., 240 mm x 170 mm
    Edition 1. Aufl.
    Publisher UNI-MED-Verl
    Publishing place Bremen u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014724911
    ISBN 3-89599-729-3 ; 978-3-89599-729-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2006 A 2491 order for loan Magazin

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  2. Article ; Online: Corrigendum to "Managing Severe Asthma: A Role for the Long-Acting Muscarinic Antagonist Tiotropium".

    Hamelmann, Eckard

    BioMed research international

    2019  Volume 2019, Page(s) 8515804

    Abstract: This corrects the article DOI: 10.1155/2018/7473690.]. ...

    Abstract [This corrects the article DOI: 10.1155/2018/7473690.].
    Language English
    Publishing date 2019-01-29
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2019/8515804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Mechanismus der Allergen-induzierten Ausbildung von Atemwegs-Entzündung und Atemwegs-Hyperreaktivität

    Hamelmann, Eckard

    2002  

    Author's details vorgelegt von Eckard Hamelmann
    Language German
    Size 128 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Univ., Habil.-Schrift, 2002
    HBZ-ID HT013744523
    Database Catalogue ZB MED Medicine, Health

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    2003 E 2478 order to use in reading room Magazin

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  4. Article: Long-acting muscarinic antagonists for the treatment of asthma in children-a new kid in town.

    Hamelmann, Eckard

    Allergo journal international

    2018  Volume 27, Issue 7, Page(s) 220–227

    Abstract: Background: Asthma is the most prevalent chronic airway disease observed in children and adolescents, yet the variety of treatment options available for this age group is limited. With many factors influencing therapeutic efficacy including patient ... ...

    Abstract Background: Asthma is the most prevalent chronic airway disease observed in children and adolescents, yet the variety of treatment options available for this age group is limited. With many factors influencing therapeutic efficacy including patient knowledge, adherence, and therapy choice as well as delivery device, it is important to have more options to tailor to individual patient needs.
    Methods: This article is an overview of recent scientific articles using a systematic literature search in PubMed and specialist databases.
    Results: Tiotropium is the first long-acting muscarinic antagonist to be licensed for treatment of asthma and has been demonstrated to be an effective add-on therapy across all age groups. Its therapeutic success in clinical trials resulted in Food and Drug Administration and the European Medicines Agency approval for asthma treatment in people over the age of 6 years in the US and EU.
    Conclusion: Further studies into the use of tiotropium, especially in younger children, could be of interest for future treatment decisions.
    Language English
    Publishing date 2018-04-26
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2197-0378
    ISSN 2197-0378
    DOI 10.1007/s40629-018-0066-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Managing Severe Asthma: A Role for the Long-Acting Muscarinic Antagonist Tiotropium.

    Hamelmann, Eckard

    BioMed research international

    2018  Volume 2018, Page(s) 7473690

    Abstract: Severe asthma is associated with substantial morbidity and mortality. Therapies must be maximized to gain control of a patient's severe asthma; however, avoiding overtreatment is also important. The mainstays of asthma maintenance treatment are inhaled ... ...

    Abstract Severe asthma is associated with substantial morbidity and mortality. Therapies must be maximized to gain control of a patient's severe asthma; however, avoiding overtreatment is also important. The mainstays of asthma maintenance treatment are inhaled corticosteroids (ICS) and long-acting
    MeSH term(s) Administration, Inhalation ; Adrenal Cortex Hormones/therapeutic use ; Asthma/drug therapy ; Clinical Trials, Phase III as Topic ; Drug Therapy, Combination/methods ; Humans ; Muscarinic Antagonists/therapeutic use ; Tiotropium Bromide/therapeutic use
    Chemical Substances Adrenal Cortex Hormones ; Muscarinic Antagonists ; Tiotropium Bromide (XX112XZP0J)
    Language English
    Publishing date 2018-10-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2018/7473690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: SQ sublingual immunotherapy tablets for children with allergic rhinitis: A review of phase three trials.

    Csonka, Péter / Hamelmann, Eckard / Turkalj, Mirjana / Roberts, Graham / Mack, Douglas P

    Acta paediatrica (Oslo, Norway : 1992)

    2024  

    Abstract: Aim: To provide paediatricians with a summary of efficacy and safety of SQ sublingual immunotherapy (SLIT) tablets from phase three, randomised, double-blind, placebo-controlled trials in children and adolescents with allergic rhinitis or ... ...

    Abstract Aim: To provide paediatricians with a summary of efficacy and safety of SQ sublingual immunotherapy (SLIT) tablets from phase three, randomised, double-blind, placebo-controlled trials in children and adolescents with allergic rhinitis or rhinoconjunctivitis, with and without asthma.
    Methods: PubMed searches were conducted and unpublished data were included if necessary.
    Results: Of the 93 publications, 12 were identified reporting 10 trials. One trial was excluded as paediatric-specific efficacy data were unavailable. The nine eligible trials evaluated grass, house dust mite, ragweed and tree SLIT tablets. Consistent reductions in allergic rhinitis or rhinoconjunctivitis symptoms and medication use were observed with SQ SLIT tablets versus placebo. In a five-year trial, sustained reduction of allergic rhinoconjunctivitis symptoms, asthma symptoms and medication use were observed with SQ grass SLIT tablet versus placebo. The number-needed-to-treat to prevent asthma symptoms and medication use in one additional child during follow-up was lowest in younger children. SQ SLIT tablets were generally well tolerated across trials.
    Conclusion: Evidence supports use of SQ SLIT tablets in children and adolescents with allergic rhinitis or rhinoconjunctivitis, with and without asthma. Long-term data demonstrate disease-modifying effects of SQ grass SLIT tablet and suggest the clinical relevance of initiating allergy immunotherapy earlier in the disease course.
    Language English
    Publishing date 2024-03-26
    Publishing country Norway
    Document type Journal Article ; Review
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.17221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Chronic stridor in a toddler after ingestion of a discharged button battery: a case report.

    Oftring, Zoe S / Mehrtens, Doortje M / Mollin, Julian / Hamelmann, Eckard / Gaus, Sebastian

    BMC pediatrics

    2024  Volume 24, Issue 1, Page(s) 246

    Abstract: Background: Button battery (BB) ingestions (BBI) are increasingly prevalent in children and constitute a significant, potentially life-threatening health hazard, and thus a pediatric emergency. Ingested BBs are usually charged and can cause severe ... ...

    Abstract Background: Button battery (BB) ingestions (BBI) are increasingly prevalent in children and constitute a significant, potentially life-threatening health hazard, and thus a pediatric emergency. Ingested BBs are usually charged and can cause severe symptom within 2 h. Discharged BBs ingestion is very rare and protracted symptom trajectories complicate diagnosis. Timely imaging is all the more important. Discharged BBs pose specific hazards, such as impaction, and necessitate additional interventions.
    Case presentation: We present the case of a previously healthy 19-month-old girl who was admitted to our pediatric university clinic in Germany for assessment of a three-month history of intermittent, mainly inspiratory stridor, snoring and feeding problems (swallowing, crying at the sight of food). The child's physical examination and vital signs were normal. Common infectious causes, such as bronchitis, were ruled out by normal lab results including normal infection parameters, negative serology for common respiratory viruses, and normal blood gas analysis, the absence of fever or pathological auscultation findings. The patient's history contained no evidence of an ingestion or aspiration event, no other red flags (e.g., traveling, contact to TBC). Considering this and with bronchoscopy being the gold standard for foreign body (FB) detection, an x-ray was initially deferred. A diagnostic bronchoscopy, performed to check for airway pathologies, revealed normal mucosal and anatomic findings, but a non-pulsatile bulge in the trachea. Subsequent esophagoscopy showed an undefined FB, lodged in the upper third of the otherwise intact esophagus. The FB was identified as a BB by a chest X-ray. Retrieval of the battery proved extremely difficult due to its wedged position and prolonged ingestion and required a two-stage procedure with consultation of Ear Nose Throat colleagues. Recurring stenosis and regurgitation required one-time esophageal bougienage during follow-up examinations. Since then, the child has been asymptomatic in the biannual endoscopic controls and is thriving satisfactorily.
    Conclusion: This case describes the rare and unusual case of a long-term ingested, discharged BB. It underscores the need for heightened vigilance among healthcare providers regarding the potential hazards posed by discharged BBIs in otherwise healthy children with newly, unexplained stridor and feeding problems. This case emphasizes the critical role of early diagnostic imaging and interdisciplinary interventions in ensuring timely management and preventing long-term complications associated even to discharged BBs.
    MeSH term(s) Female ; Humans ; Infant ; Eating ; Esophagoscopy ; Esophagus ; Foreign Bodies/complications ; Foreign Bodies/diagnostic imaging ; Respiratory Sounds/etiology
    Language English
    Publishing date 2024-04-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-024-04730-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Thesis: Anwendung von Antikörpern gegen Haupthistokompatibilitätsantigene der Klasse II in der allogenen Knochenmarktransplantation bei der Ratte

    Hamelmann, Eckard

    1992  

    Author's details vorgelegt von Eckard Hamelmann
    Size 78 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 1992
    HBZ-ID HT004429113
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    93 D 429 order for loan Magazin

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  9. Article: Future perspectives of anticholinergics for the treatment of asthma in adults and children.

    Buhl, Roland / Hamelmann, Eckard

    Therapeutics and clinical risk management

    2019  Volume 15, Page(s) 473–485

    Abstract: Despite major advances in therapeutic interventions and the availability of detailed treatment guidelines, a high proportion of patients with symptomatic asthma remain uncontrolled. Asthma management is largely guided by the Global Initiative for Asthma ( ...

    Abstract Despite major advances in therapeutic interventions and the availability of detailed treatment guidelines, a high proportion of patients with symptomatic asthma remain uncontrolled. Asthma management is largely guided by the Global Initiative for Asthma (GINA) strategy and is based on a backbone of inhaled corticosteroid (ICS) therapy with the use of additional therapies to achieve disease control. Inhaled long-acting bronchodilators alone and in combination are the preferred add-on treatment options. Although long-acting muscarinic antagonists (LAMAs) are a relatively recent addition to disease management recommendations for asthma, tiotropium has been extensively studied in a large clinical trial program. In Europe and the United States, tiotropium is approved for patients aged ≥6 years and uncontrolled on medium- to high-dose ICS/long-acting β
    Language English
    Publishing date 2019-03-14
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186560-7
    ISSN 1178-203X ; 1176-6336
    ISSN (online) 1178-203X
    ISSN 1176-6336
    DOI 10.2147/TCRM.S180890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Quantifying the benefits of early sublingual allergen immunotherapy tablet initiation in children.

    Hamelmann, Eckard / Hammerby, Eva / Scharling, Katrine Skaarup / Pedersen, Mikkel / Okkels, Anna / Schmitt, Jochen

    Allergy

    2023  Volume 79, Issue 4, Page(s) 1018–1027

    Abstract: Background: Allergic rhinitis (AR) is a chronic inflammatory disease of the upper airway, which progresses into allergic asthma (AA) in up to 45% of children. This analysis aimed to investigate clinical and economic benefits of sublingual allergen ... ...

    Abstract Background: Allergic rhinitis (AR) is a chronic inflammatory disease of the upper airway, which progresses into allergic asthma (AA) in up to 45% of children. This analysis aimed to investigate clinical and economic benefits of sublingual allergen immunotherapy (SLIT tablets) initiated early in childhood for the treatment of AR by quantifying the long-term reduction in new cases of AA.
    Methods: A Markov model was developed to estimate the long-term effects of SLIT tablets on the risk of developing asthma. Key parameters were primarily based on data from the GRAZAX® Asthma Prevention trial and included the age- and treatment-dependent risk of developing AA as well as annual probabilities of progression/remission in AR severity. Healthcare costs were estimated using data from the REACT study.
    Results: In a modelled cohort of children with moderate-to-severe seasonal AR initiated on SLIT tablets at ages 7 and 12, 24% and 29%, respectively, develop AA during a 20-year period. In comparison, when initiated at age 5, 19% develop AA. Additionally, initiation of SLIT tablets at age 5 is associated with a total healthcare cost of EUR 20,429 per patient, whereas initiation at ages 7 and 12 is associated with, respectively, EUR 21,050 and EUR 22,379 per patient 20 years after AR diagnosis.
    Conclusion: Initiation of SLIT tablets in early childhood is associated with a clinically meaningful and permanent reduction in new cases of AA and lower healthcare costs among children with AR. This finding supports the clinical relevance of initiating SLIT tablets early for children with AR to obtain long-term clinical benefits.
    MeSH term(s) Child, Preschool ; Humans ; Allergens/therapeutic use ; Asthma/drug therapy ; Desensitization, Immunologic ; Rhinitis, Allergic/drug therapy ; Rhinitis, Allergic, Seasonal/prevention & control ; Rhinitis, Allergic, Seasonal/drug therapy ; Sublingual Immunotherapy ; Tablets ; Treatment Outcome ; Clinical Trials as Topic
    Chemical Substances Allergens ; Tablets
    Language English
    Publishing date 2023-12-26
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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