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  1. Article ; Online: The intricate triangular interaction between protective microbe, pathogen and host determines fitness of the metaorganism.

    Griem-Krey, Hanne / Petersen, Carola / Hamerich, Inga K / Schulenburg, Hinrich

    Proceedings. Biological sciences

    2023  Volume 290, Issue 2012, Page(s) 20232193

    Abstract: The microbiota shapes host biology in numerous ways. One example is protection against pathogens, which is likely critical for host fitness in consideration of the ubiquity of pathogens. The host itself can affect abundance of microbiota or pathogens, ... ...

    Abstract The microbiota shapes host biology in numerous ways. One example is protection against pathogens, which is likely critical for host fitness in consideration of the ubiquity of pathogens. The host itself can affect abundance of microbiota or pathogens, which has usually been characterized in separate studies. To date, however, it is unclear how the host influences the interaction with both simultaneously and how this triangular interaction determines fitness of the host-microbe assemblage, the so-called metaorganism. To address this current knowledge gap, we focused on a triangular model interaction, consisting of the nematode
    MeSH term(s) Animals ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins ; Microbiota ; Bacillus thuringiensis
    Chemical Substances Caenorhabditis elegans Proteins
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2023.2193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1364: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The

    Pees, Barbara / Peters, Lena / Treitz, Christian / Hamerich, Inga K / Kissoyan, Kohar A B / Tholey, Andreas / Dierking, Katja

    mBio

    2024  Volume 15, Issue 4, Page(s) e0346323

    Abstract: ... ...

    Abstract The
    MeSH term(s) Animals ; Caenorhabditis elegans/microbiology ; Proteome/metabolism ; Pseudomonas/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Anti-Infective Agents/metabolism ; Vitamins
    Chemical Substances Proteome ; Caenorhabditis elegans Proteins ; Anti-Infective Agents ; Vitamins
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03463-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics.

    Marinos, Georgios / Hamerich, Inga K / Debray, Reena / Obeng, Nancy / Petersen, Carola / Taubenheim, Jan / Zimmermann, Johannes / Blackburn, Dana / Samuel, Buck S / Dierking, Katja / Franke, Andre / Laudes, Matthias / Waschina, Silvio / Schulenburg, Hinrich / Kaleta, Christoph

    Microbiology spectrum

    2024  Volume 12, Issue 2, Page(s) e0114423

    Abstract: While numerous health-beneficial interactions between host and microbiota have been identified, there is still a lack of targeted approaches for modulating these interactions. Thus, we here identify precision prebiotics that specifically modulate the ... ...

    Abstract While numerous health-beneficial interactions between host and microbiota have been identified, there is still a lack of targeted approaches for modulating these interactions. Thus, we here identify precision prebiotics that specifically modulate the abundance of a microbiome member species of interest. In the first step, we show that defining precision prebiotics by compounds that are only taken up by the target species but no other species in a community is usually not possible due to overlapping metabolic niches. Subsequently, we use metabolic modeling to identify precision prebiotics for a two-member
    MeSH term(s) Animals ; Humans ; Prebiotics ; Caenorhabditis elegans ; Microbiota ; Serine ; Pseudomonas
    Chemical Substances Prebiotics ; Serine (452VLY9402)
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01144-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Microbes to‐go: slugs as source for Caenorhabditis elegans microbiota acquisition

    Pees, Barbara / Johnke, Julia / Möhl, Michelle / Hamerich, Inga K. / Leippe, Matthias / Petersen, Carola

    Environmental microbiology. 2021 Nov., v. 23, no. 11

    2021  

    Abstract: Research on the Caenorhabditis elegans microbiota only recently started, with little known about how C. elegans acquires its microbiota. Slugs live in the same habitat as C. elegans and are known vectors for the worm. Hence, we wondered how the passage ... ...

    Abstract Research on the Caenorhabditis elegans microbiota only recently started, with little known about how C. elegans acquires its microbiota. Slugs live in the same habitat as C. elegans and are known vectors for the worm. Hence, we wondered how the passage through a slug affects the C. elegans gut microbiota and whether worms can acquire bacteria from the slug. Using fluorescently labelled microbiota and 16S rRNA gene amplicon sequencing, we evaluated microbiota persistence and acquisition in C. elegans after slug passage. We compared C. elegans gut microbiomes isolated from wild‐caught slugs to the microbiomes of worms after experimental slug passage to compare similarities and differences in microbiome composition. We found that microbiota persists in C. elegans while passing the slug gut and that worms simultaneously acquire additional bacteria species from the slug. Although the amplicon sequencing variant (ASV) richness of worms from the experiment did not exceed the richness of worms that naturally occur in slugs, we found a high number of shared ASVs indicating the importance of commonly associated microbiota. We demonstrate that C. elegans can take advantage of its passage through the slug by acquiring new potential microbiota without losing its native microbiota.
    Keywords Caenorhabditis elegans ; digestive system ; genes ; habitats ; intestinal microorganisms ; microbiome ; slugs
    Language English
    Dates of publication 2021-11
    Size p. 6721-6733.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.15730
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Microbes to-go: slugs as source for Caenorhabditis elegans microbiota acquisition.

    Pees, Barbara / Johnke, Julia / Möhl, Michelle / Hamerich, Inga K / Leippe, Matthias / Petersen, Carola

    Environmental microbiology

    2021  Volume 23, Issue 11, Page(s) 6721–6733

    Abstract: Research on the Caenorhabditis elegans microbiota only recently started, with little known about how C. elegans acquires its microbiota. Slugs live in the same habitat as C. elegans and are known vectors for the worm. Hence, we wondered how the passage ... ...

    Abstract Research on the Caenorhabditis elegans microbiota only recently started, with little known about how C. elegans acquires its microbiota. Slugs live in the same habitat as C. elegans and are known vectors for the worm. Hence, we wondered how the passage through a slug affects the C. elegans gut microbiota and whether worms can acquire bacteria from the slug. Using fluorescently labelled microbiota and 16S rRNA gene amplicon sequencing, we evaluated microbiota persistence and acquisition in C. elegans after slug passage. We compared C. elegans gut microbiomes isolated from wild-caught slugs to the microbiomes of worms after experimental slug passage to compare similarities and differences in microbiome composition. We found that microbiota persists in C. elegans while passing the slug gut and that worms simultaneously acquire additional bacteria species from the slug. Although the amplicon sequencing variant (ASV) richness of worms from the experiment did not exceed the richness of worms that naturally occur in slugs, we found a high number of shared ASVs indicating the importance of commonly associated microbiota. We demonstrate that C. elegans can take advantage of its passage through the slug by acquiring new potential microbiota without losing its native microbiota.
    MeSH term(s) Animals ; Caenorhabditis elegans/microbiology ; Gastrointestinal Microbiome ; Gastropoda/genetics ; Microbiota/genetics ; RNA, Ribosomal, 16S/genetics
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.15730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exploring Effects of

    Kissoyan, Kohar Annie B / Peters, Lena / Giez, Christoph / Michels, Jan / Pees, Barbara / Hamerich, Inga K / Schulenburg, Hinrich / Dierking, Katja

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 775728

    Abstract: ... ...

    Abstract The
    MeSH term(s) Animals ; Bacillus thuringiensis ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins ; Intestines ; Microbiota
    Chemical Substances Caenorhabditis elegans Proteins
    Language English
    Publishing date 2022-02-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.775728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics.

    Marinos, Georgios / Hamerich, Inga K / Debray, Reena / Obeng, Nancy / Petersen, Carola / Taubenheim, Jan / Zimmermann, Johannes / Blackburn, Dana / Samuel, Buck S / Dierking, Katja / Franke, Andre / Laudes, Matthias / Waschina, Silvio / Schulenburg, Hinrich / Kaleta, Christoph

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The microbiome is increasingly receiving attention as an important modulator of host health and disease. However, while numerous mechanisms through which the microbiome influences its host have been identified, there is still a lack of approaches that ... ...

    Abstract The microbiome is increasingly receiving attention as an important modulator of host health and disease. However, while numerous mechanisms through which the microbiome influences its host have been identified, there is still a lack of approaches that allow to specifically modulate the abundance of individual microbes or microbial functions of interest. Moreover, current approaches for microbiome manipulation such as fecal transfers often entail a non-specific transfer of entire microbial communities with potentially unwanted side effects. To overcome this limitation, we here propose the concept of precision prebiotics that specifically modulate the abundance of a microbiome member species of interest. In a first step, we show that defining precision prebiotics by compounds that are only taken up by the target species but no other species in a community is usually not possible due to overlapping metabolic niches. Subsequently, we present a metabolic modeling network framework that allows us to define precision prebiotics for a two-member
    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.17.528811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Host and microbiome jointly contribute to environmental adaptation.

    Petersen, Carola / Hamerich, Inga K / Adair, Karen L / Griem-Krey, Hanne / Torres Oliva, Montserrat / Hoeppner, Marc P / Bohannan, Brendan J M / Schulenburg, Hinrich

    The ISME journal

    2023  Volume 17, Issue 11, Page(s) 1953–1965

    Abstract: Most animals and plants have associated microorganisms, collectively referred to as their microbiomes, which can provide essential functions. Given their importance, host-associated microbiomes have the potential to contribute substantially to adaptation ...

    Abstract Most animals and plants have associated microorganisms, collectively referred to as their microbiomes, which can provide essential functions. Given their importance, host-associated microbiomes have the potential to contribute substantially to adaptation of the host-microbiome assemblage (the "metaorganism"). Microbiomes may be especially important for rapid adaptation to novel environments because microbiomes can change more rapidly than host genomes. However, it is not well understood how hosts and microbiomes jointly contribute to metaorganism adaptation. We developed a model system with which to disentangle the contributions of hosts and microbiomes to metaorganism adaptation. We established replicate mesocosms containing the nematode Caenorhabditis elegans co-cultured with microorganisms in a novel complex environment (laboratory compost). After approximately 30 nematode generations (100 days), we harvested worm populations and associated microbiomes, and subjected them to a common garden experiment designed to unravel the impacts of microbiome composition and host genetics on metaorganism adaptation. We observed that adaptation took different trajectories in different mesocosm lines, with some increasing in fitness and others decreasing, and that interactions between host and microbiome played an important role in these contrasting evolutionary paths. We chose two exemplary mesocosms (one with a fitness increase and one with a decrease) for detailed study. For each example, we identified specific changes in both microbiome composition (for both bacteria and fungi) and nematode gene expression associated with each change in fitness. Our study provides experimental evidence that adaptation to a novel environment can be jointly influenced by host and microbiome.
    MeSH term(s) Animals ; Microbiota ; Biological Evolution ; Genome ; Bacteria/genetics
    Language English
    Publishing date 2023-09-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2406536-5
    ISSN 1751-7370 ; 1751-7362
    ISSN (online) 1751-7370
    ISSN 1751-7362
    DOI 10.1038/s41396-023-01507-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7773: Show issues

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