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  1. Article: Non-Invasive Assessment and Management of Liver Involvement in Adults With Alpha-1 Antitrypsin Deficiency.

    Hamesch, Karim / Strnad, Pavel

    Chronic obstructive pulmonary diseases (Miami, Fla.)

    2020  Volume 7, Issue 3, Page(s) 260–271

    Abstract: Alpha-1 antitrypsin deficiency (AATD) is a systemic disorder affecting mainly the lung and the liver and is caused by mutations ... ...

    Abstract Alpha-1 antitrypsin deficiency (AATD) is a systemic disorder affecting mainly the lung and the liver and is caused by mutations in
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2771715-X
    ISSN 2372-952X
    ISSN 2372-952X
    DOI 10.15326/jcopdf.7.3.2019.0161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: How we achieve satisfaction in training - A German-wide survey on preferred training conditions among trainers and trainees for board certification in gastroenterology.

    Schlosser, Sophie / Garbe, Jakob / Hamesch, Karim / Dimitriadis, Stavros / Staudacher, Jonas Jaromir

    Zeitschrift fur Gastroenterologie

    2023  Volume 62, Issue 3, Page(s) 388–398

    Abstract: Background: a majority of resident physicians in Germany are not satisfied with their training conditions. However, training satisfaction is important for physician retention and patient care. Although federal and state laws define the general training ... ...

    Title translation Wie erreichen wir Zufriedenheit bei der Weiterbildung – Deutschlandweite Umfrage zu bevorzugten Weiterbildungsbedingungen zum Facharzt für Gastroenterologie aus Sicht von Ausbilder:innen und Auszubildenden.
    Abstract Background: a majority of resident physicians in Germany are not satisfied with their training conditions. However, training satisfaction is important for physician retention and patient care. Although federal and state laws define the general training regulations and conditions, considerable variability still exists concerning their implementation in the healthcare units. Little is known about the expectations concerning training for gastroenterology board certification by trainers and trainees in Germany. This lack of data hinders discussion on and improvement of training in gastroenterology in Germany.
    Aim: assessment of preferred training conditions among trainers and trainees for board certification in gastroenterology in Germany.
    Methods: an anonymous, voluntary survey consisting of single- and multiple-choice questions utilizing the Likert scale and fill-in responses was circulated to all members of the German Society for Digestive and Metabolic Diseases (DGVS - Deutsche Gesellschaft für Gastroenterologie, Verdauungs und Stoffwechselerkrankungen), as well as through the student council mailing lists of all German medical schools. The survey aimed to assess the consent regarding the ideal implementation of training regulations for gastroenterology board certification. Department heads, senior physicians, board-certified physicians, and outpatient-care physicians were classified as trainers and residents and students as trainees. Subgroups defined by place of work, age, gender, professional position, employment status, and parental status were investigated.
    Results: 958 responses were included in the final analysis. We found a broad consensus among trainers and trainees on most aspects of our survey. Considerable differences were seen in items on part-time work, overtime, protected time for research, and advanced endoscopy training.
    Conclusion: the broad consensus seen in this survey is indicative of a shared vision for training conditions among trainers and trainees. However, the areas of dissent identified in this survey may assist trainers to better understand the expectations of trainees. Furthermore, this survey creates a sound basis upon which training conditions for board certification in gastroenterology in Germany can be discussed and improved.
    MeSH term(s) Humans ; Gastroenterology/education ; Surveys and Questionnaires ; Germany ; Certification ; Personal Satisfaction
    Language English
    Publishing date 2023-08-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0172-8504 ; 0044-2771
    ISSN (online) 1439-7803
    ISSN 0172-8504 ; 0044-2771
    DOI 10.1055/a-2119-3069
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  3. Article ; Online: Efficacy of allogenous fascia lata grafts in the management of lower eyelid retraction.

    Prinz, Julia / Hartmann, Kathi / Migliorini, Filippo / Hamesch, Karim / Walter, Peter / Fuest, Matthias / Kuerten, David

    International ophthalmology

    2023  Volume 43, Issue 12, Page(s) 4729–4737

    Abstract: Purpose: To report on the use of allogenous fascia lata (FL) grafts in patients with lower eyelid retraction (LER).: Methods: In this retrospective study, a consecutive series of 27 patients (39 eyes) with LER who underwent lower eyelid elevation ... ...

    Abstract Purpose: To report on the use of allogenous fascia lata (FL) grafts in patients with lower eyelid retraction (LER).
    Methods: In this retrospective study, a consecutive series of 27 patients (39 eyes) with LER who underwent lower eyelid elevation with FL was included. Examinations including measurement of the palpebral fissure vertical height (PFVH), the inferior scleral show distance, the margin reflex distance 2 (MRD 2), and the evaluation of conjunctival hyperemia were conducted at baseline and after a mean postoperative time of 25.9 ± 25.5 (5.0-81.0, median 13.0, last follow-up) months in all patients.
    Results: At the last follow-up, a significant reduction of the PFVH (11.3 ± 1.7 versus 12.8 ± 2.1 at baseline, p < 0.001), the inferior scleral show distance (0.7 ± 1.0 mm versus 2.1 ± 1.1 at baseline, p < 0.001), and the MRD 2 (6.4 ± 0.9 versus 7.8 ± 1.3 at baseline, p < 0.001) occurred. The conjunctival hyperemia grading score (McMonnies) was significantly reduced (1.8 ± 0.7) at the last follow-up compared to baseline (2.6 ± 0.6, p < 0.001). No case of ectropion or entropion was observed at the last follow-up visit.
    Conclusion: In this case series, lower eyelid elevation with FL grafts as a spacer led to a significant reduction of the PFVH, MRD 2, inferior scleral show distance, and conjunctival hyperemia. No severe surgery-related complications occurred.
    MeSH term(s) Humans ; Retrospective Studies ; Fascia Lata ; Hyperemia/complications ; Eyelid Diseases/surgery ; Eyelid Diseases/etiology ; Eyelids/surgery ; Ectropion/complications ; Conjunctivitis
    Language English
    Publishing date 2023-09-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-023-02873-1
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  4. Article ; Online: Reply.

    Schneider, Carolin V / Hamesch, Karim / Strnad, Pavel

    Gastroenterology

    2021  Volume 160, Issue 5, Page(s) 1875–1877

    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.01.002
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  5. Article ; Online: Elongation of the inferior rectus tendon with fascia lata graft for large vertical squint angles in patients with Graves' orbitopathy.

    Prinz, Julia / Hartmann, Kathi / Migliorini, Filippo / Hamesch, Karim / Walter, Peter / Fuest, Matthias / Kuerten, David

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2022  Volume 260, Issue 10, Page(s) 3365–3373

    Abstract: Purpose: To investigate the use of fascia lata (FL) grafts for inferior rectus muscle (IRM) tendon elongation in patients with large vertical squint angles with Graves' orbitopathy (GO).: Methods: In this retrospective study, we included a ... ...

    Abstract Purpose: To investigate the use of fascia lata (FL) grafts for inferior rectus muscle (IRM) tendon elongation in patients with large vertical squint angles with Graves' orbitopathy (GO).
    Methods: In this retrospective study, we included a consecutive series of 20 eyes of 13 patients with GO who underwent IRM tendon elongation with FL. Orthoptic and ophthalmologic examinations including measurement of the head posture, the extent of deviation in primary position (PP), elevation, motility, and binocular diplopia at the tangent of Harms were conducted preoperatively and after a mean postoperative time of 10.8 (5.0-35.0) months in all patients.
    Results: The mean total repositioning distance was 9.3 ± 3.6 (3.5-16.0) mm. Postoperatively, we found a significant increase in elevation (5.4 ± 2.4 vs. 2.7 ± 2.4 mm preoperatively, p = 0.011). A significant reduction in vertical squint angle (2.8 ± 3.7 vs. 20.2 ± 18.8 Δ preoperatively, p = 0.004), chin elevation (2.3 ± 3.7 vs. 12.9 ± 6.3° preoperatively, p < 0.001), extorsion in PP (0.1 ± 3.8 vs. 8.4 ± 7.8° preoperatively, p = 0.002), and in elevation (1.8 ± 4.8 vs. 11.1 ± 10.9° preoperatively, p = 0.004) occurred postoperatively. A mean dose-effect relation of 2.6 ± 2.9 Δ/mm was calculated. Postoperatively, the lower eyelid retraction was significantly increased (1.5 ± 1.4 vs. 0.4 ± 0.5 mm preoperatively, p = 0.005).
    Conclusion: IRM tendon elongation with FL is a feasible and effective procedure without relevant risk for surgery-related complications.
    MeSH term(s) Fascia Lata ; Graves Ophthalmopathy/complications ; Graves Ophthalmopathy/diagnosis ; Graves Ophthalmopathy/surgery ; Humans ; Oculomotor Muscles/surgery ; Ophthalmologic Surgical Procedures/methods ; Retrospective Studies ; Strabismus/etiology ; Strabismus/surgery ; Tendons/surgery ; Treatment Outcome
    Language English
    Publishing date 2022-05-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-022-05696-5
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  6. Article: How we achieve satisfaction in training – A German-wide survey on preferred training conditions among trainers and trainees for board certification in gastroenterology

    Schlosser, Sophie / Garbe, Jakob / Hamesch, Karim / Dimitriadis, Stavros / Staudacher, Jonas Jaromir

    Zeitschrift für Gastroenterologie

    2023  Volume 62, Issue 03, Page(s) 388–398

    Abstract: Background: a majority of resident physicians in Germany are not satisfied with their training conditions. However, training satisfaction is important for physician retention and patient care. Although federal and state laws define the general training ... ...

    Abstract Background: a majority of resident physicians in Germany are not satisfied with their training conditions. However, training satisfaction is important for physician retention and patient care. Although federal and state laws define the general training regulations and conditions, considerable variability still exists concerning their implementation in the healthcare units. Little is known about the expectations concerning training for gastroenterology board certification by trainers and trainees in Germany. This lack of data hinders discussion on and improvement of training in gastroenterology in Germany.
    Aim: assessment of preferred training conditions among trainers and trainees for board certification in gastroenterology in Germany.
    Methods: an anonymous, voluntary survey consisting of single- and multiple-choice questions utilizing the Likert scale and fill-in responses was circulated to all members of the German Society for Digestive and Metabolic Diseases (DGVS – Deutsche Gesellschaft für Gastroenterologie, Verdauungs und Stoffwechselerkrankungen), as well as through the student council mailing lists of all German medical schools. The survey aimed to assess the consent regarding the ideal implementation of training regulations for gastroenterology board certification. Department heads, senior physicians, board-certified physicians, and outpatient-care physicians were classified as trainers and residents and students as trainees. Subgroups defined by place of work, age, gender, professional position, employment status, and parental status were investigated.
    Results: 958 responses were included in the final analysis. We found a broad consensus among trainers and trainees on most aspects of our survey. Considerable differences were seen in items on part-time work, overtime, protected time for research, and advanced endoscopy training.
    Conclusion: the broad consensus seen in this survey is indicative of a shared vision for training conditions among trainers and trainees. However, the areas of dissent identified in this survey may assist trainers to better understand the expectations of trainees. Furthermore, this survey creates a sound basis upon which training conditions for board certification in gastroenterology in Germany can be discussed and improved.
    Keywords Training ; Board Certification Gastroenterology ; Survey ; Training Satisfaction ; Generational Differences ; Weiterbildung ; Facharzt Gastroenterologie ; Umfrage ; Zufriedenheit ; Generationenkonflikt
    Language English
    Publishing date 2023-08-16
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/a-2119-3069
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  7. Article: Soluble Semaphorin 4D Serum Concentrations Are Elevated in Critically Ill Patients with Liver Cirrhosis and Correlate with Aminotransferases.

    Abu Jhaisha, Samira / Hohlstein, Philipp / Yagmur, Eray / Köller, Vera / Pollmanns, Maike R / Adams, Jule K / Wirtz, Theresa H / Brozat, Jonathan F / Bündgens, Lukas / Hamesch, Karim / Weiskirchen, Ralf / Tacke, Frank / Trautwein, Christian / Koch, Alexander

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: Semaphorin 4D (Sema4D), also known as CD100, is a multifunctional transmembrane protein with immunoregulatory functions. Upon the activation of immune cells, soluble Semaphorin 4D (sSema4D) is proteolytically cleaved from the membrane by ... ...

    Abstract Semaphorin 4D (Sema4D), also known as CD100, is a multifunctional transmembrane protein with immunoregulatory functions. Upon the activation of immune cells, soluble Semaphorin 4D (sSema4D) is proteolytically cleaved from the membrane by metalloproteinases. sSema4D levels are elevated in various (auto-)inflammatory diseases. Our aim was to investigate sSema4D levels in association with sepsis and critical illnesses and to evaluate sSema4D's potential as a prognostic biomarker. We measured sSema4D levels in 192 patients upon admission to our medical intensive care unit. We found similar levels of sSema4D in 125 patients with sepsis compared to 67 non-septic patients. sSema4D levels correlated with leukocytes but not with other markers of systemic inflammation such as C-reactive protein or procalcitonin. Most interestingly, in a subgroup of patients suffering from pre-existing liver cirrhosis, we observed significantly higher levels of sSema4D. Consistently, sSema4D was also positively correlated with markers of hepatic and cholestatic injury. Our study suggests that sSema4D is not regulated in sepsis compared to other causes of critical illness. However, sSema4D seems to be associated with hepatic injury and inflammation.
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14040370
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  8. Article ; Online: Impact of power consumption and power saving for GI endoscopy (power on study) on reducing CO

    Fichtl, Anna / Tacheva, Veronika / Sturm, Niklas / Hamesch, Karim / Wichmann, Doerte / Mayer, Benjamin / Müller, Martin / Wagner, Martin / Seufferlein, Thomas / Walter, Benjamin M

    Gut

    2024  Volume 73, Issue 6, Page(s) 892–896

    MeSH term(s) Humans ; Carbon Dioxide/analysis ; Endoscopy, Gastrointestinal/methods ; Electric Power Supplies
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2024-05-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Letter
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-331867
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  9. Article ; Online: Elevated Midkine Serum Levels Are Associated with Long-Term Survival in Critically Ill Patients.

    Hohlstein, Philipp / Abu Jhaisha, Samira / Yagmur, Eray / Wawer, Dennis / Pollmanns, Maike R / Adams, Jule K / Wirtz, Theresa H / Brozat, Jonathan F / Bündgens, Lukas / Hamesch, Karim / Weiskirchen, Ralf / Tacke, Frank / Trautwein, Christian / Koch, Alexander

    International journal of molecular sciences

    2023  Volume 25, Issue 1

    Abstract: Midkine (Mdk) is a multifunctional protein involved in inflammatory processes. Hence, circulating Mdk is increased in sepsis and has been previously suggested as a potential biomarker in these patients. The aim of this study was to elucidate the role of ... ...

    Abstract Midkine (Mdk) is a multifunctional protein involved in inflammatory processes. Hence, circulating Mdk is increased in sepsis and has been previously suggested as a potential biomarker in these patients. The aim of this study was to elucidate the role of Mdk serum concentrations in critical illness and sepsis and to verify its value as a prognostic biomarker. Thus, we analyzed the Mdk serum concentrations of 192 critically ill patients on admission to the medical intensive care unit (ICU). While the serum levels of Mdk at admission were similar in septic and nonseptic critical illness (362 vs. 337 ng/L,
    MeSH term(s) Humans ; Biomarkers ; Critical Illness ; Hospitalization ; Midkine ; Sepsis
    Chemical Substances Biomarkers ; Midkine (137497-38-2) ; MDK protein, human
    Language English
    Publishing date 2023-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010454
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  10. Article: Secreted Frizzled Related Protein 5 (SFRP5) Serum Levels Are Decreased in Critical Illness and Sepsis and Are Associated with Short-Term Mortality.

    Hohlstein, Philipp / Brozat, Jonathan F / Schuler, Julia / Abu Jhaisha, Samira / Pollmanns, Maike R / Bündgens, Lukas / Wirtz, Theresa H / Yagmur, Eray / Hamesch, Karim / Weiskirchen, Ralf / Tacke, Frank / Trautwein, Christian / Koch, Alexander

    Biomedicines

    2023  Volume 11, Issue 2

    Abstract: Sepsis is a major health burden with insufficiently understood mechanisms of inflammation and immune paralysis, leading to a life-threatening critical illness. The secreted frizzled related protein 5 (SFRP5) acts as an anti-inflammatory adipokine by ... ...

    Abstract Sepsis is a major health burden with insufficiently understood mechanisms of inflammation and immune paralysis, leading to a life-threatening critical illness. The secreted frizzled related protein 5 (SFRP5) acts as an anti-inflammatory adipokine by antagonizing the Wnt5a pathway. The aim of this study was to elucidate the role of SFRP5 in critical illness and sepsis and to determine its value as a prognostic biomarker for mortality. We analyzed SFRP5 serum concentrations of 223 critically ill patients at admission to a medical intensive care unit (ICU) and compared those to 24 healthy individuals. SFRP5 serum concentrations were significantly decreased in critical illness as compared to healthy controls (24.66 vs. 100 ng/mL,
    Language English
    Publishing date 2023-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11020313
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