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  1. Article ; Online: Mature teratoma of liver in an adult male patient.

    Saba, Firdos / Hamid, Tahira / M Alrawashdeh, Hamzeh Younes / Iqbal, Mohammad Shahid / Tabassum, Aisha

    Indian journal of pathology & microbiology

    2023  Volume 66, Issue 4, Page(s) 848–851

    Abstract: Teratomas are germ cell tumors occurring usually in gonadal organs. They are neoplasms composed of one or more of the three germ layers. Extragonadal teratomas are uncommonly reported in the literature. The liver is an extremely rare site for teratoma, ... ...

    Abstract Teratomas are germ cell tumors occurring usually in gonadal organs. They are neoplasms composed of one or more of the three germ layers. Extragonadal teratomas are uncommonly reported in the literature. The liver is an extremely rare site for teratoma, constituting < 1% of all teratomas. The majority of the liver teratomas are found in the pediatric population with only a dozen cases reported in adults to the best of our knowledge. We present a case of a 27-year-old male with a history of abdominal pain of 5 months duration. CT scan revealed liver mass suggesting teratoma. The patient underwent cholecystectomy and segmental liver resection. Histopathology revealed mature cystic teratoma. Complete resection remains the best treatment option. Teratomas of the liver are extremely rare, constituting < 1% of all teratomas. An extensive review of the literature yielded < 50 cases of primary hepatic teratomas with only a dozen cases in adults and only two cases in males.
    MeSH term(s) Adult ; Humans ; Male ; Dermoid Cyst ; Hepatectomy ; Liver/diagnostic imaging ; Liver/surgery ; Liver/pathology ; Neoplasms, Germ Cell and Embryonal/surgery ; Teratoma/diagnosis ; Teratoma/surgery ; Teratoma/pathology
    Language English
    Publishing date 2023-12-11
    Publishing country India
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/ijpm.ijpm_430_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 862: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Cauda Equina Syndrome Secondary to Leptomeningeal Carcinomatosis of Gastroesophageal Junction Cancer.

    Alkhotani, Amal / Alrishi, Nouf / Alhalabi, M Salem / Hamid, Tahira

    Case reports in neurology

    2016  Volume 8, Issue 1, Page(s) 87–91

    Abstract: Leptomeningeal carcinomatosis (LMC) is a diffuse or multifocal malignant infiltration of the pia matter and arachnoid membrane. The most commonly reported cancers associated with LMC are breast, lung, and hematological malignancies. Patients with LMC ... ...

    Abstract Leptomeningeal carcinomatosis (LMC) is a diffuse or multifocal malignant infiltration of the pia matter and arachnoid membrane. The most commonly reported cancers associated with LMC are breast, lung, and hematological malignancies. Patients with LMC commonly present with multifocal neurological symptoms. We report a case of LMC secondary to gastroesopha-geal junction cancer present initially with cauda equina syndrome. A 51-year-old male patient with treated adenocarcinoma of the gastroesophageal junction presented with left leg pain, mild weakness, and saddle area numbness. Initial radiological examinations were unremarkable. Subsequently, he had worsening of his leg weakness, fecal incontinence, and urine retention. Two days later, he developed rapidly progressive cranial neuropathies including facial diplegia, sensorineural hearing loss, dysarthria, and dysphagia. MRI with and without contrast showed diffuse enhancement of leptomeninges surrounding the brain, spinal cord, and cauda equina extending to the nerve roots. Cerebrospinal fluid cytology was positive for malignant cells. The patient died within 10 days from the second presentation. In cancer patients with cauda equina syndrome and absence of structural lesion on imaging, LMC should be considered. To our knowledge, this is the first case of LMC secondary to gastroesophageal cancer presenting with cauda equina syndrome.
    Language English
    Publishing date 2016-04-30
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2505302-4
    ISSN 1662-680X
    ISSN 1662-680X
    DOI 10.1159/000445869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): A rare case after in vitro fertilization (IVF).

    Ghazi, Ahmed / Ayaz, Aqueela / Hamid, Tahira / Farooq, Mian Usman / Islam, Nikita

    Pakistan journal of medical sciences

    2017  Volume 33, Issue 1, Page(s) 241–244

    Abstract: Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a very rare and lethal tumor, mostly affecting young women, with aggressive clinical course. It has a worse prognosis in younger women and most of them died within two years of diagnosis. ... ...

    Abstract Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a very rare and lethal tumor, mostly affecting young women, with aggressive clinical course. It has a worse prognosis in younger women and most of them died within two years of diagnosis. We are reporting a unique case of SCCOHT in a 35 years old, nulliparous lady with primary infertility in which symptomatic hypercalcemia was a presenting feature of her cancer. She was completely healthy before third cycle of IVF. Within two months of her third IVF cycle, she developed SCCOHT with a very rapid and aggressive course of disease and fatal outcome. Patient died within one month of her first symptom presentation (3 months after IVF cycle).
    Language English
    Publishing date 2017-03-07
    Publishing country Pakistan
    Document type Case Reports
    ZDB-ID 2032827-8
    ISSN 1681-715X ; 1682-024X ; 1017-4699
    ISSN (online) 1681-715X
    ISSN 1682-024X ; 1017-4699
    DOI 10.12669/pjms.331.11634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3948: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Profiling Activins and Follistatin in Colorectal Cancer According to Clinical Stage, Tumour Sidedness and Smad4 Status.

    Refaat, Bassem / Zekri, Jamal / Aslam, Akhmed / Ahmad, Jawwad / Baghdadi, Mohammed A / Meliti, Abdelrazak / Idris, Shakir / Sultan, Sufian / Alardati, Hosam / Saimeh, Haitham Akram / Alsaegh, Aiman / Alhadrami, Mai / Hamid, Tahira / Naeem, Mohammed E / Elsamany, Shereef Ahmed

    Pathology oncology research : POR

    2021  Volume 27, Page(s) 1610032

    Abstract: This study explored the roles of activins and follistatin in colorectal cancers. Paired malignant and normal colonic tissues were collected from archived paraffin-embedded ( ...

    Abstract This study explored the roles of activins and follistatin in colorectal cancers. Paired malignant and normal colonic tissues were collected from archived paraffin-embedded (
    MeSH term(s) Activins/genetics ; Activins/metabolism ; Activins/pharmacology ; Apoptosis/drug effects ; Biomarkers, Tumor/metabolism ; Cell Cycle/drug effects ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Disease Progression ; Female ; Follistatin/genetics ; Follistatin/metabolism ; Follistatin/pharmacology ; Humans ; Inhibin-beta Subunits/metabolism ; Male ; RNA, Messenger/genetics ; Smad4 Protein/genetics ; Smad4 Protein/metabolism
    Chemical Substances Biomarkers, Tumor ; Cell Cycle Proteins ; FST protein, human ; Follistatin ; RNA, Messenger ; SMAD4 protein, human ; Smad4 Protein ; Activins (104625-48-1) ; Inhibin-beta Subunits (93443-12-0)
    Language English
    Publishing date 2021-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1375979-6
    ISSN 1532-2807 ; 1219-4956
    ISSN (online) 1532-2807
    ISSN 1219-4956
    DOI 10.3389/pore.2021.1610032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4936: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Cauda Equina Syndrome Secondary to Leptomeningeal Carcinomatosis of Gastroesophageal Junction Cancer

    Alkhotani, Amal / Alrishi, Nouf / Alhalabi, M. Salem / Hamid, Tahira

    Case Reports in Neurology

    2016  Volume 8, Issue 1, Page(s) 87–91

    Abstract: Leptomeningeal carcinomatosis (LMC) is a diffuse or multifocal malignant infiltration of the pia matter and arachnoid membrane. The most commonly reported cancers associated with LMC are breast, lung, and hematological malignancies. Patients with LMC ... ...

    Institution Umm AlQura University and King Abdulla Medical City, Makkah, Saudi Arabia
    Abstract Leptomeningeal carcinomatosis (LMC) is a diffuse or multifocal malignant infiltration of the pia matter and arachnoid membrane. The most commonly reported cancers associated with LMC are breast, lung, and hematological malignancies. Patients with LMC commonly present with multifocal neurological symptoms. We report a case of LMC secondary to gastroesophageal junction cancer present initially with cauda equina syndrome. A 51-year-old male patient with treated adenocarcinoma of the gastroesophageal junction presented with left leg pain, mild weakness, and saddle area numbness. Initial radiological examinations were unremarkable. Subsequently, he had worsening of his leg weakness, fecal incontinence, and urine retention. Two days later, he developed rapidly progressive cranial neuropathies including facial diplegia, sensorineural hearing loss, dysarthria, and dysphagia. MRI with and without contrast showed diffuse enhancement of leptomeninges surrounding the brain, spinal cord, and cauda equina extending to the nerve roots. Cerebrospinal fluid cytology was positive for malignant cells. The patient died within 10 days from the second presentation. In cancer patients with cauda equina syndrome and absence of structural lesion on imaging, LMC should be considered. To our knowledge, this is the first case of LMC secondary to gastroesophageal cancer presenting with cauda equina syndrome.
    Keywords Cauda equina ; Leptomeningeal carcinomatosis ; Gastroesophageal cancer
    Language English
    Publishing date 2016-04-30
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Published: April 2016 ; This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC).
    ZDB-ID 2505302-4
    ISSN 1662-680X ; 1662-680X
    ISSN (online) 1662-680X
    ISSN 1662-680X
    DOI 10.1159/000445869
    Database Karger publisher's database

    Full text online

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  6. Article ; Online: Comparison of fine needle aspiration cytology and thyroid scan in solitary thyroid nodule.

    Basharat, Rabia / Bukhari, Mulazim Hussain / Saeed, Shahzad / Hamid, Tahira

    Pathology research international

    2011  Volume 2011, Page(s) 754041

    Abstract: Objective. This was a comparative study between FNAC and thyroid scan used to diagnose the solitary thyroid nodule and histopathology was used as gold standard to compare the results of both modalities. We hypothesized that Fine needle aspiration ... ...

    Abstract Objective. This was a comparative study between FNAC and thyroid scan used to diagnose the solitary thyroid nodule and histopathology was used as gold standard to compare the results of both modalities. We hypothesized that Fine needle aspiration cytology and thyroid scan diagnose solitary thyroid nodule (STN) as accurately as histopathology. Materials and Methods. This study comprised of 50 patients with solitary thyroid nodules (STN) presented to OPD. After clinical examination these patients were referred to Centre for Nuclear Medicine, Mayo Hospital Lahore for thyroid function tests and thyroid scan (TS). These patients underwent FNAC in the department of Pathology and surgery in Mayo Hospital. The cases were operated and evaluated for histopathological changes. Results. On thyroid scan, 40 patients (80%) having cold nodule were labeled as suspicious 10 patients (20%) had hot nodule. On FNAC 23 patients (46%) had benign lesion, 22 patients (44%) had indeterminate lesion and 5 patients (10%) had malignant lesions. On histopathology, 45 patients (90%) were confirmed to have benign lesions and 5 patients (10%), malignant lesions. After comparison of results of thyroid scan and FNAC with histopathology, the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of thyroid scan were 80%, 20%, 10%, 90% and 26%, respectively whereas those of FNAC were 80%, 97.7%, 80%, 97.7% and 96%, respectively. Conclusion. Fine needle aspiration was a significantly better predictor of malignancy than thyroid scan and resulted in a smaller proportion of excisions for benign nodules.
    Language English
    Publishing date 2011-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573922-0
    ISSN 2042-003X ; 2042-003X
    ISSN (online) 2042-003X
    ISSN 2042-003X
    DOI 10.4061/2011/754041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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