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Article ; Online: Effects of Parathion Toxin on Glutamate Dehydrogenase Enzyme Activity and Diabetes Induction

Hamid Reza Jamshidi / Elham Ebrahimi

Toloo-e-behdasht, Vol 18, Iss 1, Pp 83-

2019 Volume 93

Abstract: Introduction: The main propose of this study was to determine the effect of parathion on activity of glutamate dehydrogenase (GDH) as a key enzyme in second phase secretion of insulin and to determine serum glucose levels in rats. Methods: To conduct the ...

Abstract	Introduction: The main propose of this study was to determine the effect of parathion on activity of glutamate dehydrogenase (GDH) as a key enzyme in second phase secretion of insulin and to determine serum glucose levels in rats. Methods: To conduct the study, 35 rats were randomly divided into five groups (n=7). The serum glucose level of each group was measured and the total average was calculated with a glucometer. The experimental groups (groups 1,2,3,4) received 0.5, 1, 1.5, and 2 mg/kg of parathion pesticide via IP injection; whereas, the control group received no treatment. All rats were kept in similar condition. Serum glucose levels of rats were measured 24h after the final injection. Glutamate dehydrogenase (GDH) activity in rat’s pancreas was measured by GDH activity assay kit and using a spectrophotometer at 570nm. Results: The levels of glucose in treatment groups significantly increased compared with the control group (P<0.01). The levels of GDH activity in rats increased after receiving 1.5 and 2 mg/kg of parathion pesticides compared with the control group (P<0.01, p<0.05). Conclusion: Regarding the results, parathion affects the GDH enzyme in the pancreatic islets and leads to insufficient secretion of insulin. Although insulin was increased and increased the intermediates of Krebs cycle, the rate of insulin secretion was not so high to overcome the increase of glucose caused by parathion organophosphate
Keywords	parathion ; glutamate dehydrogenase ; pancreas ; rat ; Public aspects of medicine ; RA1-1270
Subject code	571
Language	Persian
Publishing date	2019-05-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical Trial of Intraperitoneal Administration of Ketamine Combined with Bupivacaine on Pain Status after Laparoscopic Cholecystectomy

Parvin Ziaei / Saeed Kargar / Mohammad Hossein Dehghan / Farzan Madadizadeh / Hamid Reza Jamshidi

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 30, Iss 11, Pp 6107-

2023 Volume 6117

Abstract: Introduction: One of the most important problems that the patient faces after laparoscopic surgery is pain that is felt in the shoulders, back and abdomen. This study was designed to evaluate the effects of the combination of bupivacaine and ketamine and ...

Abstract	Introduction: One of the most important problems that the patient faces after laparoscopic surgery is pain that is felt in the shoulders, back and abdomen. This study was designed to evaluate the effects of the combination of bupivacaine and ketamine and its intraperitoneal injection on reducing shoulder pain after laparoscopic cholecystectomy. Methods: This was a double-blind randomized study that included 90 patients undergoing elective surgery for laparoscopic cholecystectomy in the age group of 18-65 years and of both sexes. After removal of the gallbladder, 20 cc of solution was injected intraperitoneally at the surgical site. Patients were randomly assigned to three groups receiving 10 cc 0.5% bupivacaine + 0.5cc ketamine, the second group received 10 cc of %0.5 bupivacaine and 10 cc normal saline, the third group (control) received 20 cc of normal saline intraperitoneally. The findings were analyzed using SPSS version 16 software and repeated measurement analysis of variance and Bonferroni's pairwise comparison test. Results: Analysis of variance showed that the mean pain scores were significantly different over time in each group (P<0.001). (P<0.001). Bonferroni paired comparison test showed that the lowest amount of pain was in the first group (p<0.05). Conclusion: According to the results of the present study, intraperitoneal injection of ketamine combined with bupivacaine significantly (p<0.001) reduces pain up to 8 hours after laparoscopic cholecystectomy.
Keywords	laparoscopic cholecystectomy ; shoulder pain ; intraperitoneal ; ketamine ; bupivacaine ; Medicine (General) ; R5-920
Subject code	796 ; 616
Language	Persian
Publishing date	2023-02-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protective Effect of Mito-TEMPO on Sodium Valproate-Induced Hepatotoxicity in Mice

Hamid Reza Jamshidi / Azadeh Emami / Hossein Golmohammadi / Fatemeh Tavakoli

Acta Medica Iranica, Vol 58, Iss

2020 Volume 7

Abstract: Introduction: Valproic acid is a broad-spectrum anticonvulsant drug that is also useful for other diseases such as bipolar disorder and migraine. The most important side effect of this drug is hepatotoxicity. Oxidative stress and mitochondrial ... ...

Abstract	Introduction: Valproic acid is a broad-spectrum anticonvulsant drug that is also useful for other diseases such as bipolar disorder and migraine. The most important side effect of this drug is hepatotoxicity. Oxidative stress and mitochondrial dysfunction play a role in the pathogenesis of liver toxicity of valproic acid. Mito-TEMPO is an antioxidant-based compound, which is selectively accumulated in mitochondria. The effects of its mitochondrial protection against oxidative damage in various pathologies, such as liver damage, have been observed. The aim of this study was to evaluate the protective effect of mito-TEMPO on liver toxicity induced by sodium valproate in mice. Methods: Animals were divided into five groups and treated intraperitonealy over a 4-week period. Group 1 received normal saline, served as vehicle control, group 2 treated with 12.5 mg/kg of sodium valproate, group 3 was treated with 1 mg/kg of Mito-TEMPO, group 4 received both sodium valproate (12.5 mg/kg) and Mito-TEMPO (1mg/kg), and group 5 received sodium valproate (12.5 mg/kg) and vitamin E (5mg/kg) served as positive control. At the end of the experiment, blood samples collected by cardiac puncture and all the animals were killed under ether anesthesia. Biochemical parameters including AST, ALT, ALP and GGT in serum samples and glutathione (GSH) and malondialdehyde (MDA) contents in liver homogenates were determined. Results: Findings of this study showed that activity of AST and ALT were significantly lower in the sodium valproate + mito-TEMPO treated animals as compared to sodium valproate group (group 2). Furthermore, mito-TEMPO was able to recover glutathione content (GSH) of liver tissue. Effect of mito-TEMPO on the activity of ALP and GGT and serum level of MDA was not significant. Conclusion: Taken collectively, mito-TEMPO has a protective role in sodium valproate hepatotoxicity. Considering the present results, further studies, in view of the potential therapeutic properties of mito-TEMPO in improving liver damage caused by the ...
Keywords	Mito-TEMPO ; Valproic acid ; Hepatotoxicity ; Medicine (General) ; R5-920
Subject code	630
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Improving the Results of Fire and Explosion Risk Assessment Method Using Fuzzy Logic in a Gas Refinery

Vahid Ahmadi Moshiran / Ali Karimi / Aysa Ghasemi Kuzeonan / Hamid Reza Jamshidi Slukloei

Archives of Occupational Health, Vol 4, Iss 3, Pp 600-

2020 Volume 605

Abstract: Background: The occurrence of fire and explosion accidents in the process industries is accompanied by the gradual release of large amounts of energy. The DOW Index is one of the methods of evaluating fire and explosion in the process industries. The ... ...

Abstract	Background: The occurrence of fire and explosion accidents in the process industries is accompanied by the gradual release of large amounts of energy. The DOW Index is one of the methods of evaluating fire and explosion in the process industries. The present study used the fuzzy logic method to improve the results of the fire and explosion risk analysis method and reduce their uncertainty (error in achieving the correct result). Methods: In the present cross-sectional study, having analyzed the gas separation process, the DOW index was applied to study high-risk equipment. Then, to optimize the behavior of the parameters affecting the DOW index, each weight parameter was assigned to between 0 and 1, and the membership functions of each degree of risk were determined based on the fuzzy rules classification system. The five selected linguistic variables based on membership functions were used to assess the risk level. Results: Considering butane, the level of fire and explosion risk was 231.3, which was less risky than the fuzzy logic result of 248.6. Methane risk was calculated according to the fire and explosion index of 262.1 while using fuzzy logic that was 265.6. The lowest risk difference was observed between the two methods for ethane (258.9 conventional method and 259.1 fuzzy method results). The risk level calculated by DOW for propane was 243.6, and the risk level was 255.1 while using fuzzy logic. Conclusion: Although both methods yielded a high degree of risk, fuzzy logic results indicated higher numerical values comparing to the conventional DOW method. Compared to the conventional DOW method, fuzzy logic results are closer to reality with higher confidence levels.
Keywords	fire and explosion index ; risk assessment ; dow ; fuzzy logic ; process unit ; Industrial medicine. Industrial hygiene ; RC963-969
Subject code	690
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Science, Yazd, Iran
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The protection quest is a primary key to sharing the neutralizing antibody response to cover against all emerging VOCs based on BIV1-CovIran studies

Maryam Shafaati / Kowsar Bagherzadeh / Majid Lotfinia / Hesam Karimi / Ali Teimoori / Mehdi Razazian / Sepideh Meidaninikjeh / Hamed Hosseini / Hamid Reza Jamshidi / Hasan Jalili / Asghar Abdoli

Heliyon, Vol 9, Iss 3, Pp e14108- (2023)

2023

Abstract: Over time, the antigenic evolution of emerging variants of SARS-CoV-2 has demanded the development of potential protective vaccines. Administration of additional doses of current vaccines based on the WT spike protein may boost immunity, but their ... ...

Abstract	Over time, the antigenic evolution of emerging variants of SARS-CoV-2 has demanded the development of potential protective vaccines. Administration of additional doses of current vaccines based on the WT spike protein may boost immunity, but their effectiveness has dwindled for patients with more recent variants. Here, we studied the neutralization activity of post-WT strain-based vaccination and a structural simulation in-silico based on the interactions of the RBD-hACE2 as the key to initiating infection among the VOCs of SARS-CoV-2. Our data display shows that WT sera showed a markedly greater reduction in Delta and Omicron, suggesting that the Wuhan-based vaccines may be more susceptible to breakthrough and new VOCs. According to the MD simulation, mutations of Omicron result in a significant change in the variant charge distribution throughout the binding interface that consequently alters the critical interface electrostatic potential in comparison to other variants. This observation provides new insights into immunization policy and next-generation vaccine development.
Keywords	SARS-CoV-2 ; Variants of concern ; Neutralizing antibody ; Molecular dynamic simulations ; Vaccine ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring the clinical benefit of ventilation therapy across various patient groups with COVID-19 using real-world data

Mohsen Abbasi-Kangevari / Ali Ghanbari / Mohammad-Reza Malekpour / Seyyed-Hadi Ghamari / Sina Azadnajafabad / Sahar Saeedi Moghaddam / Mohammad Keykhaei / Rosa Haghshenas / Ali Golestani / Mohammad-Mahdi Rashidi / Nazila Rezaei / Erfan Ghasemi / Negar Rezaei / Hamid Reza Jamshidi / Bagher Larijani

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 10

Abstract: Abstract Scarcity of ventilators during COVID-19 pandemic has urged public health authorities to develop prioritization recommendations and guidelines with the real-time decision-making process based on the resources and contexts. Nevertheless, patients ... ...

Abstract	Abstract Scarcity of ventilators during COVID-19 pandemic has urged public health authorities to develop prioritization recommendations and guidelines with the real-time decision-making process based on the resources and contexts. Nevertheless, patients with COVID-19 who will benefit the most from ventilation therapy have not been well-defined yet. Thus, the objective of this study was to investigate the benefit of ventilation therapy among various patient groups with COVID-19 admitted to hospitals, based on the real-world data of hospitalized adult patients. Data used in the longitudinal study included 599,340 records of hospitalized patients who were admitted from February 2020 to June 2021. All participants were categorized based on sex, age, city of residence, the hospitals' affiliated university, and their date of hospitalization. Age groups were defined as 18–39, 40–64, and more than 65-year-old participants. Two models were used in this study: in the first model, participants were assessed by their probability of receiving ventilation therapy during hospitalization based on demographic and clinical factors using mixed-effects logistic regression. In the second model, the clinical benefit of receiving ventilation therapy among various patient groups was quantified while considering the probability of receiving ventilation therapy during hospital admission, as estimated in the first model. The interaction coefficient in the second model indicated the difference in the slope of the logit probability of recovery for a one-unit increase in the probability of receiving ventilation therapy between the patients who received ventilation compared to those who did not while considering other factors constant. The interaction coefficient was used as an indicator to quantify the benefit of ventilation reception and possibly be used as a criterion for comparison among various patient groups. Among participants, 60,113 (10.0%) cases received ventilation therapy, 85,158 (14.2%) passed away due to COVID-19, and 514,182 ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Survey Prevalence of Musculoskeletal Disorders and Risk Assessment in Paddy Workers in Marvdasht in 2013

Hamid Reza Jamshidi / Hadi Daneshmandi / Abdollah Haghayegh

Majallah-i Dānishkadah-i ̒ulūm-i Pizishkī-i Niyshābūr, Vol 3, Iss 1, Pp 57-

2015 Volume 65

Abstract: Introduction and Aims Musculoskeletal disorders (MSDs) are one of the most important injuries of occupational health. This study was conducted with the objectives of determination of musculoskeletal disorders symptoms and ergonomics assessment of the ... ...

Abstract	Introduction and Aims Musculoskeletal disorders (MSDs) are one of the most important injuries of occupational health. This study was conducted with the objectives of determination of musculoskeletal disorders symptoms and ergonomics assessment of the risk of MSDs in paddy workers of Marvdasht city. Materials and Methods This cross-sectional study was performed among 300 male paddy workers with at least one year of job tenure. Nordic musculoskeletal disorders questionnaire (NMQ) and QEC method were used for determination of prevalence and risk assessment of MSDs respectively. Data were analyzed by SPSS v.19 using statistical tests including Mann-Whitney U and Chi-square. Results The results of this study showed that the feet (77.3 percent), lower back (73.3 percent) and wrist/hand (72 percent) had highest prevalence of symptoms of MSDs among workers. There was a significant association between the prevalence of these disorders and age, weight, height, job tenure and marital status. QEC technique showed that 65 percent of studied workers were in high and very high level of exposure to musculoskeletal risks. Chi- square statistical test revealed that between musculoskeletal symptoms and QEC risk level had no association. But, the results of this section showed that with increasing the QEC risk level, occurrence of musculoskeletal symptoms will be increased. Conclusion The prevalence of MSDs among studied workers is high. According to these results, awkward posture, lifting and carrying of heavy loads and flexion and twisting in lower back are the most common ergonomics problems in studied workers. * Corresponding Author: Shiraz University of Medical Sciences, Research Center for Health Sciences. Email: Daneshmand@sums.ac.ir
Keywords	Musculoskeletal Disorders ; Nordic Questionnaire ; QEC ; Paddy Workers ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	150
Language	Persian
Publishing date	2015-05-01T00:00:00Z
Publisher	Neyshabur University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Designing SQCRA as a Software to Semi-quantitative Chemical Risk Assessment in Workplace

Ali Karimi / Hamid Reza Jamshidi Slukloei / Samira Eslamizad

Muhandisī-i bihdāsht-i ḥirfah/ī, Vol 1, Iss 2, Pp 47-

2014 Volume 56

Abstract: Background & Objectives : The aim of chemical risk assessment is to identify and evaluate risks originated from chemicals usages. This study aims to design a practical tool for facilitating chemical risk assessment. Methods: The proposed software was ... ...

Abstract	Background & Objectives : The aim of chemical risk assessment is to identify and evaluate risks originated from chemicals usages. This study aims to design a practical tool for facilitating chemical risk assessment. Methods: The proposed software was derived from chemical risk assessment method which was recommended by Ministry of Human Resources of Malaysia. All of the processes in question are designed in operating system software. Based on some revisions, this software was developed using Visual Basic (VB) titled as SQCRA. The developed software was used for chemical risk assessment in Narges Vegetale Oil Company in Shiraz (center of Iran). Result: The output of software showed that the level of risk derived from sulfuric acid, phosphoric acid, aluminum sulphate, nickel catalyst, acetic acid used as a raw material were 2.4, 2.84, 2.3, 3.5 and 2.66, respectively. Moreover, risk rank and proposed control methods for each of these materials were determined. Conclusions : The developed software calculates the health risk level based on the degree of hazard and exposure in shorttime and without using risk matrix and chemical formula. After determining the risk rank, the software proposes the control procedures to reduce occupational exposure.
Keywords	Risk Assessment ; Chemicals ; Occupational Exposure ; Software of SQCRA ; Industrial medicine. Industrial hygiene ; RC963-969
Subject code	600
Language	Persian
Publishing date	2014-06-01T00:00:00Z
Publisher	Hamadan University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Medical Education in 21st-century

Hamid Reza Jamshidi

مجله ایرانی آموزش در علوم پزشکی, Vol 1, Iss 2, Pp 30-

2000 Volume 37

Abstract: Medical education play an important role in health of people in 20st-century, but this system has to change overtime. Medical education must respond to not only the demand of community at larg but also to changing in new technologies. Medical education ... ...

Abstract	Medical education play an important role in health of people in 20st-century, but this system has to change overtime. Medical education must respond to not only the demand of community at larg but also to changing in new technologies. Medical education have been criticized in last two decades of 20st-century, because of producing too many specialists focus on treatment instead of health, insufficient, training in ethics alternative medicine behavior and social sciences, care, of terminally ill and so on. This article attempts to discuss about the failure or weaknesses of current medical education and the different views to help train physicians to be better prepare .to meet the challenges of 21st-century.
Keywords	Medicine ; R ; Medicine (General) ; R5-920
Language	Persian
Publishing date	2000-12-01T00:00:00Z
Publisher	Isfahan University of Medical Sciences, Medical Education Development Center
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Socioeconomic inequality in infant mortality in Iran and across its provinces

Ahmad Reza Hosseinpoor / Kazem Mohammad / Reza Majdzadeh / Mohsen Naghavi / Farid Abolhassani / Angelica Sousa / Niko Speybroeck / Hamid Reza Jamshidi / Jeanette Vega

Bulletin of the World Health Organization, Vol 83, Iss 11, Pp 837-

2005 Volume 844

Abstract: OBJECTIVE: To measure the socioeconomic inequality in infant mortality in Iran * . METHODS: We analysed data from the provincially representative Demographic and Health Survey, which was done in Iran in 2000. We used a dichotomous hierarchical ordered ... ...

Abstract	OBJECTIVE: To measure the socioeconomic inequality in infant mortality in Iran * . METHODS: We analysed data from the provincially representative Demographic and Health Survey, which was done in Iran in 2000. We used a dichotomous hierarchical ordered probit model to develop an indicator of socioeconomic status of households. We assessed the inequality in infant mortality by using the odds ratio of infant mortality between the lowest and highest socioeconomic quintiles at both the provincial and national levels, and the concentration index, an inequality measure based on the entire socioeconomic distribution. RESULTS: We found a decreasing trend in the infant mortality rate in relation to socioeconomic quintiles. The poorest to richest odds ratio was 2.34 (95% CI = 1.78-3.09). The concentration index of infant mortality in Iran was -0.1789 (95% CI = -0.2193--0.1386). Furthermore, the inequality of infant mortality between the lowest and highest quintiles was significant and favoured the better-off in most of the provinces. However, this inequality varied between provinces. CONCLUSION: Socioeconomic inequality in infant mortality favours the better-off in the country as a whole and in most of its provinces, but the degree of this inequality varies between the provinces. As well as its national average, it is important to consider the provincial distribution of this indicator of population health.
Keywords	Mortalidad infantil ; Factores socioeconómicos ; Indicadores económicos ; Razón de diferencia ; Irán ; Public aspects of medicine ; RA1-1270 ; Medicine ; R
Subject code	338
Language	English
Publishing date	2005-11-01T00:00:00Z
Publisher	World Health Organization
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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